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Protein

Synaptotagmin-12

Gene

Syt12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

GO - Biological processi

  • long-term synaptic potentiation Source: InterPro
  • regulation of neurotransmitter secretion Source: RGD
  • spontaneous exocytosis of neurotransmitter Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-12
Alternative name(s):
Synaptotagmin XII
Short name:
SytXII
Synaptotagmin-related gene 1 protein
Short name:
Srg1
Gene namesi
Name:Syt12
Synonyms:Srg1, Sytr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621876. Syt12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818VesicularSequence analysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Topological domaini40 – 421382CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Synaptotagmin-12PRO_0000183974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971PhosphoserineCombined sources
Modified residuei99 – 991PhosphoserineCombined sources
Modified residuei214 – 2141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97610.
PRIDEiP97610.

PTM databases

PhosphoSiteiP97610.

Expressioni

Gene expression databases

GenevisibleiP97610. RN.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026153.

Structurei

3D structure databases

ProteinModelPortaliP97610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 272105C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 388104C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiP97610.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG77Q4WK.
PhylomeDBiP97610.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS
60 70 80 90 100
PSPFPNYDYR YLQQKYGEAY VEAKLKRVPP WNAQRTTTRG PPSRKGSLSI
110 120 130 140 150
EDTFESISEL GPLELMGREL DLAPYGTLRK SQSADSLNSI SSVSNTFGQD
160 170 180 190 200
FTLGQVEVSM DYDGASHTLH VAVLQGKDLL EREEATFESC FMRVSLLPDE
210 220 230 240 250
QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF GIDEDERNVS
260 270 280 290 300
TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL
310 320 330 340 350
TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF
360 370 380 390 400
NEAMIFSVPA IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGASGMGTTH
410 420
WNQMLATLRR PVSMWHPVRR N
Length:421
Mass (Da):46,608
Last modified:May 1, 1997 - v1
Checksum:iC83F745FDD050897
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71294 mRNA. Translation: AAC53019.1.
RefSeqiNP_620190.1. NM_138835.1.
XP_008758293.1. XM_008760071.1.
XP_008758294.1. XM_008760072.1.
UniGeneiRn.10682.

Genome annotation databases

EnsembliENSRNOT00000026152; ENSRNOP00000026153; ENSRNOG00000019306.
GeneIDi191595.
KEGGirno:191595.
UCSCiRGD:621876. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U71294 mRNA. Translation: AAC53019.1.
RefSeqiNP_620190.1. NM_138835.1.
XP_008758293.1. XM_008760071.1.
XP_008758294.1. XM_008760072.1.
UniGeneiRn.10682.

3D structure databases

ProteinModelPortaliP97610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026153.

PTM databases

PhosphoSiteiP97610.

Proteomic databases

PaxDbiP97610.
PRIDEiP97610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026152; ENSRNOP00000026153; ENSRNOG00000019306.
GeneIDi191595.
KEGGirno:191595.
UCSCiRGD:621876. rat.

Organism-specific databases

CTDi91683.
RGDi621876. Syt12.

Phylogenomic databases

eggNOGiENOG410IT3K. Eukaryota.
ENOG411011E. LUCA.
GeneTreeiENSGT00830000128339.
HOGENOMiHOG000063703.
HOVERGENiHBG057176.
InParanoidiP97610.
KOiK19912.
OMAiWTSGSFP.
OrthoDBiEOG77Q4WK.
PhylomeDBiP97610.
TreeFamiTF315600.

Miscellaneous databases

NextBioi622669.
PROiP97610.

Gene expression databases

GenevisibleiP97610. RN.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR030537. SYT12.
[Graphical view]
PANTHERiPTHR10024:SF252. PTHR10024:SF252. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog."
    Thompson C.C.
    J. Neurosci. 16:7832-7840(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-99 AND SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYT12_RAT
AccessioniPrimary (citable) accession number: P97610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.