P97610 (SYT12_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-12

Alternative name(s):
Synaptotagmin XII
Short name=SytXII
Synaptotagmin-related gene 1 protein
Short name=Srg1

Gene names

Name:	Syt12
Synonyms:	Srg1, Sytr1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.
Subunit structure	Homodimer. Can also form heterodimers By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the synaptotagmin family. Contains 2 C2 domains.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of neurotransmitter secretion Non-traceable author statement Ref.1. Source: RGD
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Synaptotagmin-12		PRO_0000183974
Regions
	Topological domain	1 – 18	18	Vesicular Potential
	Transmembrane	19 – 39	21	Helical; Potential
	Topological domain	40 – 421	382	Cytoplasmic Potential
	Domain	168 – 272	105	C2 1
	Domain	285 – 388	104	C2 2

Sequences

	Sequence		Length	Mass (Da)
	P97610 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: C83F745FDD050897	FASTA	421	46,608
	10 20 30 40 50 60 MAVDVTEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR 70 80 90 100 110 120 YLQQKYGEAY VEAKLKRVPP WNAQRTTTRG PPSRKGSLSI EDTFESISEL GPLELMGREL 130 140 150 160 170 180 DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM DYDGASHTLH VAVLQGKDLL 190 200 210 220 230 240 EREEATFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSVPLDPTAL EEKSLRFSVF 250 260 270 280 290 300 GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL 310 320 330 340 350 360 TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA 370 380 390 400 410 420 IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PGASGMGTTH WNQMLATLRR PVSMWHPVRR N

References

[1]	"Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog." Thompson C.C. J. Neurosci. 16:7832-7840(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U71294 mRNA. Translation: AAC53019.1.
IPI	IPI00206394.
RefSeq	NP_620190.1. NM_138835.1.
UniGene	Rn.10682.
3D structure databases
ProteinModelPortal	P97610.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000026153.
PTM databases
PhosphoSite	P97610.
Proteomic databases
PRIDE	P97610.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026152; ENSRNOP00000026153; ENSRNOG00000019306.
GeneID	191595.
KEGG	rno:191595.
UCSC	RGD:621876. rat.
Organism-specific databases
CTD	91683.
RGD	621876. Syt12.
Phylogenomic databases
eggNOG	NOG299728.
GeneTree	ENSGT00700000104036.
HOGENOM	HOG000063703.
HOVERGEN	HBG057176.
InParanoid	P97610.
OrthoDB	EOG4DV5MC.
Gene expression databases
Genevestigator	P97610.
GermOnline	ENSRNOG00000019306. Rattus norvegicus.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. [Graphical view]
Pfam	PF00168. C2. 2 hits. [Graphical view]
SMART	SM00239. C2. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	622669.

Entry information

Entry name

SYT12_RAT

Accession

Primary (citable) accession number: P97610

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program