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P97609 (HAIR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein hairless
Gene names
Name:Hr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1181 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a transcription regulator controlling one of the phases of hair growth By similarity.

Subcellular location

Nucleus.

Domain

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors (Ref.2). Ref.2

Sequence similarities

Contains 1 JmjC domain.

Sequence caution

The sequence AAC53018.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11811181Protein hairless
PRO_0000083892

Regions

Domain938 – 1149212JmjC
Zinc finger594 – 61926C6-type
Motif560 – 5645LXXLL motif 1
Motif752 – 7565LXXLL motif 2

Experimental info

Mutagenesis563 – 5642LL → AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 752-L--A-756. Ref.2
Mutagenesis755 – 7562LL → AA: Decreases RORA protein stability. Strongly decreases RORA protein stability; when associated with 560-L--A-564. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P97609 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 834B7029CF8E88F0

FASTA1,181127,307
        10         20         30         40         50         60 
MESMPSFLKD TPAWEKTAPV NGIVGQEPGT SPQDGLHHGA LCLGEPVPFW RGVLSAPDSW 

        70         80         90        100        110        120 
LPPGFLQGPK DTLSVVEGEG SRNGERKANW LGSKEGLRWK EAMLAHPLAF CGPACPPRYG 

       130        140        150        160        170        180 
PLIPEHSSGH PKSDPVAFRP LHCPFLLETK ILERAPFWVP TCLPPYLMSS LPPERSYDWP 

       190        200        210        220        230        240 
LAPSPWVYSG SQPKVPSAFS LGSKGFYHKD PNILRPAKEP LAASESGMLG LAPGGHLQQA 

       250        260        270        280        290        300 
CDAEGPSLHQ RDGETGAGRQ QNLCPVFLGY PDTVPRTPWP SCPPGLVHTL GNVWAGPGSN 

       310        320        330        340        350        360 
SFGYQLGPPV TPRCPSPGPP TPPGGCCSSH LPAREGDPGP CRKCQDSPEG SSSGPGESSE 

       370        380        390        400        410        420 
ERNKAGSRAS PPSHHTKLKK TWLTRHSEQF ECPGGCPGKG ESPATGLRAL KRAGSPEVQG 

       430        440        450        460        470        480 
ARGPAPKRPS HTFPGTGRQG ARAWQETPET STGSKAEAQQ QEEQRGPRDG RIRLRESRLE 

       490        500        510        520        530        540 
DTSCQHHLAG VTQCPSCVQA AGEVEILTSH SQKSHKLPLE EKPLEEDSCA TSEEGGGSSP 

       550        560        570        580        590        600 
EASINKGLAK HLLSGLGDRL CRLLRKEREA LAWAQREGQG PAMTEDSPGI PHCCSRCHHG 

       610        620        630        640        650        660 
LFNTHWRCSH CSHRLCVACG RIAGAGKNRE KTGSREQRTD DCAQEAGHAA CSLILTQFVS 

       670        680        690        700        710        720 
SQALAELSTV MHQVWAKFDI RGHCFCQVDA RVWAPGDGGQ QKEPTEKTPP APQLSCNGDS 

       730        740        750        760        770        780 
NRTKDIKEET PDSTESPAED RAGRSPLPCP SLCELLASTA VKLCLGHERI HMAFAPVTPA 

       790        800        810        820        830        840 
LPSDDRITNI LDSIIAQVVE RKIQEKALGP GLRAGSGLRK GLSLPLSPVR TQLSPPGALL 

       850        860        870        880        890        900 
WLQEPRPKHG FRLFQEHWRQ GQPVLVSGIQ KTLRLSLWGM EALGTLGGQV QTLTALGPPQ 

       910        920        930        940        950        960 
PTSLDSTAFW KGFSHPEARP KLDEGSVLLL HRPLGDKDES RVENLASSLP LPEYCAHQGK 

       970        980        990       1000       1010       1020 
LNLASYLPLG LTLHPLEPQL WAAYGVNSHR GHLGTKNLCV EVSDLISILV HAEAQLPPWY 

      1030       1040       1050       1060       1070       1080 
RAQKDFLSGL DGEGLWSPGS QTSTVWHVFR AQDAQRIRRF LQMVCPAGAG TLEPGAPGSC 

      1090       1100       1110       1120       1130       1140 
YLDSGLRRRL REEWGVSCWT LLQAPGEAVL VPAGAPHQVQ GLVSTISVTQ HFLSPETSAL 

      1150       1160       1170       1180 
SAQLCHQGAS LPPDHRMLYA QMDRAVFQAV KVAVGTLQEA K 

« Hide

References

[1]"Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog."
Thompson C.C.
J. Neurosci. 16:7832-7840(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation."
Moraitis A.N., Giguere V.
J. Biol. Chem. 278:52511-52518(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN, MUTAGENESIS OF 563-LEU-LEU-564 AND 756-LEU-LEU-756.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U71293 mRNA. Translation: AAC53018.1. Different initiation.
UniGeneRn.41543.

3D structure databases

ProteinModelPortalP97609.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248853. 4 interactions.
STRING10116.ENSRNOP00000015716.

Proteomic databases

PaxDbP97609.
PRIDEP97609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

KEGGrno:60563.
UCSCRGD:620634. rat.

Organism-specific databases

CTD55806.
RGD620634. Hr.

Phylogenomic databases

eggNOGNOG243648.
HOGENOMHOG000293150.
HOVERGENHBG000171.
InParanoidP97609.
PhylomeDBP97609.

Gene expression databases

GenevestigatorP97609.

Family and domain databases

InterProIPR003347. JmjC_dom.
[Graphical view]
PfamPF02373. JmjC. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612242.
PROP97609.

Entry information

Entry nameHAIR_RAT
AccessionPrimary (citable) accession number: P97609
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families