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P97608

- OPLA_RAT

UniProt

P97608 - OPLA_RAT

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Protein

5-oxoprolinase

Gene
Oplah
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Catalytic activityi

ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate.

GO - Molecular functioni

  1. 5-oxoprolinase (ATP-hydrolyzing) activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-10109.

Names & Taxonomyi

Protein namesi
Recommended name:
5-oxoprolinase (EC:3.5.2.9)
Alternative name(s):
5-oxo-L-prolinase
Short name:
5-OPase
Pyroglutamase
Gene namesi
Name:Oplah
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620956. Oplah.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128812885-oxoprolinasePRO_0000208579Add
BLAST

Proteomic databases

PaxDbiP97608.
PRIDEiP97608.

Expressioni

Tissue specificityi

Well expressed in testis, kidney and liver.

Gene expression databases

GenevestigatoriP97608.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016424.

Structurei

3D structure databases

ProteinModelPortaliP97608.

Family & Domainsi

Sequence similaritiesi

Belongs to the oxoprolinase family.

Phylogenomic databases

eggNOGiCOG0146.
GeneTreeiENSGT00390000013463.
HOGENOMiHOG000047200.
HOVERGENiHBG007870.
InParanoidiP97608.
KOiK01469.
OMAiTERMINI.
OrthoDBiEOG78M013.
PhylomeDBiP97608.
TreeFamiTF300520.

Family and domain databases

InterProiIPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view]
PfamiPF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97608-1 [UniParc]FASTAAdd to Basket

« Hide

MGSPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG     50
IRRILEQEEG VLLPRGRPLD TSRIASIRMG TTVATNALLE RQGERVALLV 100
TRGFRDLLHI GTQARPDLFD LAVPMPEVLY EEVLEVDERV VLYRGEPGAG 150
SPVKGRTGDL LEIQQPVDLE ALRGKLEGLL SRGIHSLAVV LMHSYTWAQH 200
EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY LTPTIQRYVQ 250
GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSAT 300
TYHLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN 350
TVAAGGGSRL FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR 400
LLPASFPCIF GPGEDQPLSP EASRKALEAV AMEVNSFLTN GPCPASQLSL 450
EEVAMGFVRV ANEAMCRPIR ALTQARGHDP SAHVLACFGG AGGQHACAIA 500
RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT PETFAQLDQR 550
LSRLEEQCVD ALQVQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPATA 600
CSPRAGDFGA AFVERYMREF GFIIPERPVV VDDVRVRGTG RSGLQLEDTP 650
KIQTGPPHVE KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST 700
ILVEPGCQAE VTDTGDIRIS VGAEGPSMAD TRLDPIQLSI FSHRFMSIAE 750
QMGRILQRTA ISTNIKERLD FSCALFGPDG GLVSNAPHIP VHLGAMQETV 800
QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW PGQTRPVFYV 850
ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
LRAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ 950
AYMGHIQANA ELAVRDMLRA FGTSRQARGL PLEVSAEDHM DDGSPICLRV 1000
QINLSQGSAV FDFTGSGSEV FGNLNAPRAI TLSALIYCLR CLVGRDIPLN 1050
QGCLAPVRVI IPKGSILDPS PEAAVVGGNV LTSQRVVDVI LGAFGACSAS 1100
QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM TNTRITDPEI 1150
LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 1200
FQPYGLHGGE PGARGLNLLI RKDGRTVNLG GKTSVTVYPG DVFCLHTPGG 1250
GGYGDPEDPA PPPGSPPLFP AFPERGSVFE YRRAQEAV 1288
Length:1,288
Mass (Da):137,720
Last modified:February 15, 2005 - v2
Checksum:i23DA4809D60D5730
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441A → P in AAC52955. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70825 mRNA. Translation: AAC52955.1.
BC085330 mRNA. Translation: AAH85330.1.
PIRiT42756.
RefSeqiNP_446356.1. NM_053904.1.
XP_006241836.1. XM_006241774.1.
XP_006241837.1. XM_006241775.1.
UniGeneiRn.3066.

Genome annotation databases

EnsembliENSRNOT00000016424; ENSRNOP00000016424; ENSRNOG00000011781.
GeneIDi116684.
KEGGirno:116684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70825 mRNA. Translation: AAC52955.1 .
BC085330 mRNA. Translation: AAH85330.1 .
PIRi T42756.
RefSeqi NP_446356.1. NM_053904.1.
XP_006241836.1. XM_006241774.1.
XP_006241837.1. XM_006241775.1.
UniGenei Rn.3066.

3D structure databases

ProteinModelPortali P97608.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016424.

Proteomic databases

PaxDbi P97608.
PRIDEi P97608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016424 ; ENSRNOP00000016424 ; ENSRNOG00000011781 .
GeneIDi 116684.
KEGGi rno:116684.

Organism-specific databases

CTDi 26873.
RGDi 620956. Oplah.

Phylogenomic databases

eggNOGi COG0146.
GeneTreei ENSGT00390000013463.
HOGENOMi HOG000047200.
HOVERGENi HBG007870.
InParanoidi P97608.
KOi K01469.
OMAi TERMINI.
OrthoDBi EOG78M013.
PhylomeDBi P97608.
TreeFami TF300520.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-10109.

Miscellaneous databases

NextBioi 619536.
PROi P97608.

Gene expression databases

Genevestigatori P97608.

Family and domain databases

InterProi IPR008040. Hydant_A_N.
IPR002821. Hydantoinase_A.
IPR003692. Hydantoinase_B.
[Graphical view ]
Pfami PF05378. Hydant_A_N. 1 hit.
PF01968. Hydantoinase_A. 1 hit.
PF02538. Hydantoinase_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning."
    Ye G.-J., Breslow E., Meister A.
    J. Biol. Chem. 271:32293-32300(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. Erratum
    Ye G.-J., Breslow E., Meister A.
    J. Biol. Chem. 272:4646-4646(1997)
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiOPLA_RAT
AccessioniPrimary (citable) accession number: P97608
Secondary accession number(s): Q5U3Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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