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Protein

Protein jagged-2

Gene

Jag2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. May have a role in neurogenesis in the peripheral nervous system, limb development and in the adult brain.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • growth factor activity Source: UniProtKB
  • Notch binding Source: UniProtKB

GO - Biological processi

  • auditory receptor cell fate commitment Source: UniProtKB
  • brain development Source: RGD
  • cell differentiation Source: UniProtKB
  • cell fate determination Source: UniProtKB
  • embryonic limb morphogenesis Source: UniProtKB
  • male gonad development Source: RGD
  • Notch signaling pathway Source: UniProtKB
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • regulation of cell differentiation Source: RGD
  • regulation of cell proliferation Source: UniProtKB
  • response to hypoxia Source: RGD
  • spermatogenesis Source: RGD
  • T cell differentiation Source: UniProtKB
  • thymic T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Gene namesi
Name:Jag2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2938. Jag2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1037›1037ExtracellularSequence analysisAdd
BLAST
Transmembranei1038 – 105821HelicalSequence analysisAdd
BLAST
Topological domaini1059 – 1202144CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1202›1202Protein jagged-2PRO_0000055632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi152 ↔ 161By similarity
Disulfide bondi165 ↔ 177By similarity
Disulfide bondi185 ↔ 194By similarity
Disulfide bondi199 ↔ 210By similarity
Disulfide bondi203 ↔ 216By similarity
Disulfide bondi218 ↔ 227By similarity
Disulfide bondi230 ↔ 241By similarity
Disulfide bondi236 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
Disulfide bondi265 ↔ 277By similarity
Disulfide bondi271 ↔ 287By similarity
Disulfide bondi289 ↔ 298By similarity
Disulfide bondi305 ↔ 316By similarity
Disulfide bondi310 ↔ 325By similarity
Disulfide bondi327 ↔ 336By similarity
Disulfide bondi343 ↔ 354By similarity
Disulfide bondi348 ↔ 363By similarity
Disulfide bondi365 ↔ 374By similarity
Disulfide bondi381 ↔ 392By similarity
Disulfide bondi386 ↔ 401By similarity
Disulfide bondi403 ↔ 412By similarity
Disulfide bondi419 ↔ 429By similarity
Disulfide bondi423 ↔ 438By similarity
Disulfide bondi440 ↔ 449By similarity
Disulfide bondi456 ↔ 467By similarity
Disulfide bondi461 ↔ 476By similarity
Disulfide bondi478 ↔ 487By similarity
Disulfide bondi495 ↔ 506By similarity
Disulfide bondi500 ↔ 515By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi544 ↔ 567Sequence analysis
Disulfide bondi561 ↔ 577Sequence analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi579 ↔ 588By similarity
Disulfide bondi595 ↔ 606By similarity
Disulfide bondi600 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Glycosylationi707 – 7071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi710 ↔ 721By similarity
Disulfide bondi715 ↔ 730By similarity
Disulfide bondi732 ↔ 741By similarity
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Glycosylationi1015 – 10151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97607.
PRIDEiP97607.

Expressioni

Developmental stagei

At stage E12.5 it is detected in dorsal root ganglia, AER, and surface ectoderm. At E14.5, found as well in cranial ganglia, thymus and olfactory epithelia. At E16.5, found as well in salivary gland, tooth buds and hair follicles.

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • Notch binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019213.

Structurei

3D structure databases

ProteinModelPortaliP97607.
SMRiP97607. Positions 152-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 19445DSLPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 22834EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 25931EGF-like 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini261 – 29939EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini301 – 33737EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 37537EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini377 – 41337EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini415 – 45036EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini452 – 48837EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini490 – 52738EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 58961EGF-like 10; atypicalPROSITE-ProRule annotationAdd
BLAST
Domaini591 – 62737EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini629 – 66537EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini667 – 70337EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini706 – 74237EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini744 – 78037EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini782 – 81837EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 16 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiP97607.
PhylomeDBiP97607.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 10 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P97607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GACCDGDGRT TRAGGCGRDE CDTYVRVCLK EYQAKVTPTG PCSYGYGATP
60 70 80 90 100
VLGSNSFYLP PAGAAGDRAR ARSRTGGHQD PGLVVIPFQF AWPRSFTLIV
110 120 130 140 150
EAWDWDNDTT PDEELLIERV SHAGMINPED RWKSLHFSGH VAHLELQIRV
160 170 180 190 200
RCDENYYSAT CNKFCRPRND FFGHYTCDQY GNKACMDGWM GKECKEAVCK
210 220 230 240 250
QGCNLLHGGC TVPGECRCSY GWQGKFCDEC VPYPGCVHGS CVEPWHCDCE
260 270 280 290 300
TNWGGLLCDK DLNYCGSHHP CVNGGTCINA EPDQYLCACP DGYLGKNCER
310 320 330 340 350
AEHACASNPC ANGGSCHEVL SGFECHCPSG WSGPTCALDI DECASNPCAA
360 370 380 390 400
GGTCVDQVDG FECICPEQWV GATCQLDANE CEGKPCLNAF SCKNLIGGYY
410 420 430 440 450
CDCLPGWKGA NCHININDCH GQCQHGGTCK DLVNGYQCVC PRGFGGRHCE
460 470 480 490 500
LEYYKCASSP CRRGGICEDL VDGFRCHCPR GLSGPLCEVD VDLWCEPNPC
510 520 530 540 550
LNGARCYNLE DDYYCACPED FGGKNCSVPR ETCPGGACRV IDGCGFEAGS
560 570 580 590 600
RAHGAAPSGV CGPHGHCVSL PGGNFSCICD SGFTGTYCHE NIDDCMGQPC
610 620 630 640 650
RNGGTCIDEV DSFACFCPSG WEGELCDINP NDCLPDPCHS RGRCYDLVND
660 670 680 690 700
FYCVCDDGWK DKTCHSREFQ CDAYTCSNGG TCYDSGDTFR CACPPGWKGS
710 720 730 740 750
TCTIAKNSSC VPNPCVNGGT CVGSGDSFSC ICRDGWEGRT CTHNTNDCNP
760 770 780 790 800
LPCYNGGICV DGVNWFRCEC APGFAGPDCR INIDECQSSP CAYGATCVDE
810 820 830 840 850
INGYRCSCPP GRSGPRCQEV VIFTRPCWSR GVSFPHGSSW VEDCNSCRCL
860 870 880 890 900
DGHRDCSKVW CGWKPCLLSP QPSALSAQCP PGQQCREKAM GQCLQPPCEN
910 920 930 940 950
WGECTAEDPL PPSTPCLPRT THLDNNCARL TLHFNRDQVP QGTTVGAICS
960 970 980 990 1000
GIRALPATRA AARDRLLLLL CDRASSGASA VEVAVSFSPA RDLPDSSLIQ
1010 1020 1030 1040 1050
STAHAIVAAI TQRGNSSLLL AVTEVKVETV VMGGSSTGLL VPVLCSVFSV
1060 1070 1080 1090 1100
LWLACMVICV WWTRKRRKER ERSRLPRDES ANNQWAPLNP IRNPIERPGS
1110 1120 1130 1140 1150
SGLGTGGHKD VLYQCKNFTP PPRRAGEALP GPASHGAGGE DEEDEELSRG
1160 1170 1180 1190 1200
DGRLSRSREV PLTQIHQRPQ LLPGKASLLA PGPKVDNRAV RSTKDVRCAG

RE
Length:1,202
Mass (Da):129,705
Last modified:May 1, 1997 - v1
Checksum:i08CB44E5271FF8BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70050 mRNA. Translation: AAC52946.1.
UniGeneiRn.22459.

Genome annotation databases

UCSCiRGD:2938. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70050 mRNA. Translation: AAC52946.1.
UniGeneiRn.22459.

3D structure databases

ProteinModelPortaliP97607.
SMRiP97607. Positions 152-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019213.

Proteomic databases

PaxDbiP97607.
PRIDEiP97607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2938. rat.

Organism-specific databases

RGDi2938. Jag2.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000113124.
HOVERGENiHBG031645.
InParanoidiP97607.
PhylomeDBiP97607.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR033108. Jag2.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PANTHERiPTHR24044:SF316. PTHR24044:SF316. 1 hit.
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 10 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 16 hits.
SM00179. EGF_CA. 14 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 10 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Jagged2: a serrate-like gene expressed during rat embryogenesis."
    Shawber C., Boulter J., Lindsell C.E., Weinmaster G.
    Dev. Biol. 180:370-376(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiJAG2_RAT
AccessioniPrimary (citable) accession number: P97607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.