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Protein

Protein jagged-2

Gene

Jag2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative Notch ligand involved in the mediation of Notch signaling. May have a role in neurogenesis in the peripheral nervous system, limb development and in the adult brain.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • growth factor activity Source: UniProtKB
  • Notch binding Source: RGD

GO - Biological processi

  • auditory receptor cell fate commitment Source: UniProtKB
  • brain development Source: RGD
  • cell differentiation Source: UniProtKB
  • cell fate determination Source: UniProtKB
  • embryonic limb morphogenesis Source: UniProtKB
  • male gonad development Source: RGD
  • Notch signaling pathway Source: UniProtKB
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • regulation of cell differentiation Source: RGD
  • regulation of cell proliferation Source: UniProtKB
  • response to hypoxia Source: RGD
  • spermatogenesis Source: RGD
  • T cell differentiation Source: UniProtKB
  • thymic T cell selection Source: UniProtKB
  • wound healing Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein jagged-2
Short name:
Jagged2
Gene namesi
Name:Jag2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2938 Jag2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 1037ExtracellularSequence analysisAdd BLAST›1037
Transmembranei1038 – 1058HelicalSequence analysisAdd BLAST21
Topological domaini1059 – 1202CytoplasmicSequence analysisAdd BLAST144

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000055632‹1 – 1202Protein jagged-2Add BLAST›1202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 161By similarity
Disulfide bondi165 ↔ 177By similarity
Disulfide bondi185 ↔ 194By similarity
Disulfide bondi199 ↔ 210By similarity
Disulfide bondi203 ↔ 216By similarity
Disulfide bondi218 ↔ 227By similarity
Disulfide bondi230 ↔ 241By similarity
Disulfide bondi236 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
Disulfide bondi265 ↔ 277By similarity
Disulfide bondi271 ↔ 287By similarity
Disulfide bondi289 ↔ 298By similarity
Disulfide bondi305 ↔ 316By similarity
Disulfide bondi310 ↔ 325By similarity
Disulfide bondi327 ↔ 336By similarity
Disulfide bondi343 ↔ 354By similarity
Disulfide bondi348 ↔ 363By similarity
Disulfide bondi365 ↔ 374By similarity
Disulfide bondi381 ↔ 392By similarity
Disulfide bondi386 ↔ 401By similarity
Disulfide bondi403 ↔ 412By similarity
Disulfide bondi419 ↔ 429By similarity
Disulfide bondi423 ↔ 438By similarity
Disulfide bondi440 ↔ 449By similarity
Disulfide bondi456 ↔ 467By similarity
Disulfide bondi461 ↔ 476By similarity
Disulfide bondi478 ↔ 487By similarity
Disulfide bondi495 ↔ 506By similarity
Disulfide bondi500 ↔ 515By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi544 ↔ 567Sequence analysis
Disulfide bondi561 ↔ 577Sequence analysis
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi579 ↔ 588By similarity
Disulfide bondi595 ↔ 606By similarity
Disulfide bondi600 ↔ 615By similarity
Disulfide bondi617 ↔ 626By similarity
Disulfide bondi633 ↔ 644By similarity
Disulfide bondi638 ↔ 653By similarity
Disulfide bondi655 ↔ 664By similarity
Disulfide bondi671 ↔ 682By similarity
Disulfide bondi676 ↔ 691By similarity
Disulfide bondi693 ↔ 702By similarity
Glycosylationi707N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi710 ↔ 721By similarity
Disulfide bondi715 ↔ 730By similarity
Disulfide bondi732 ↔ 741By similarity
Disulfide bondi748 ↔ 759By similarity
Disulfide bondi753 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi786 ↔ 797By similarity
Disulfide bondi791 ↔ 806By similarity
Disulfide bondi808 ↔ 817By similarity
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1080PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97607
PRIDEiP97607

Expressioni

Developmental stagei

At stage E12.5 it is detected in dorsal root ganglia, AER, and surface ectoderm. At E14.5, found as well in cranial ganglia, thymus and olfactory epithelia. At E16.5, found as well in salivary gland, tooth buds and hair follicles.

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • Notch binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019213

Structurei

3D structure databases

ProteinModelPortaliP97607
SMRiP97607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 194DSLPROSITE-ProRule annotationAdd BLAST45
Domaini195 – 228EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini229 – 259EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini261 – 299EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini301 – 337EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini339 – 375EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini377 – 413EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini415 – 450EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini452 – 488EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini490 – 527EGF-like 9PROSITE-ProRule annotationAdd BLAST38
Domaini529 – 589EGF-like 10; atypicalPROSITE-ProRule annotationAdd BLAST61
Domaini591 – 627EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini629 – 665EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini667 – 703EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini706 – 742EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini744 – 780EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini782 – 818EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
HOGENOMiHOG000113124
HOVERGENiHBG031645
InParanoidiP97607
PhylomeDBiP97607

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PANTHERiPTHR44097:SF1 PTHR44097:SF1, 1 hit
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 9 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 3 hits
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 7 hits

Sequencei

Sequence statusi: Fragment.

P97607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GACCDGDGRT TRAGGCGRDE CDTYVRVCLK EYQAKVTPTG PCSYGYGATP
60 70 80 90 100
VLGSNSFYLP PAGAAGDRAR ARSRTGGHQD PGLVVIPFQF AWPRSFTLIV
110 120 130 140 150
EAWDWDNDTT PDEELLIERV SHAGMINPED RWKSLHFSGH VAHLELQIRV
160 170 180 190 200
RCDENYYSAT CNKFCRPRND FFGHYTCDQY GNKACMDGWM GKECKEAVCK
210 220 230 240 250
QGCNLLHGGC TVPGECRCSY GWQGKFCDEC VPYPGCVHGS CVEPWHCDCE
260 270 280 290 300
TNWGGLLCDK DLNYCGSHHP CVNGGTCINA EPDQYLCACP DGYLGKNCER
310 320 330 340 350
AEHACASNPC ANGGSCHEVL SGFECHCPSG WSGPTCALDI DECASNPCAA
360 370 380 390 400
GGTCVDQVDG FECICPEQWV GATCQLDANE CEGKPCLNAF SCKNLIGGYY
410 420 430 440 450
CDCLPGWKGA NCHININDCH GQCQHGGTCK DLVNGYQCVC PRGFGGRHCE
460 470 480 490 500
LEYYKCASSP CRRGGICEDL VDGFRCHCPR GLSGPLCEVD VDLWCEPNPC
510 520 530 540 550
LNGARCYNLE DDYYCACPED FGGKNCSVPR ETCPGGACRV IDGCGFEAGS
560 570 580 590 600
RAHGAAPSGV CGPHGHCVSL PGGNFSCICD SGFTGTYCHE NIDDCMGQPC
610 620 630 640 650
RNGGTCIDEV DSFACFCPSG WEGELCDINP NDCLPDPCHS RGRCYDLVND
660 670 680 690 700
FYCVCDDGWK DKTCHSREFQ CDAYTCSNGG TCYDSGDTFR CACPPGWKGS
710 720 730 740 750
TCTIAKNSSC VPNPCVNGGT CVGSGDSFSC ICRDGWEGRT CTHNTNDCNP
760 770 780 790 800
LPCYNGGICV DGVNWFRCEC APGFAGPDCR INIDECQSSP CAYGATCVDE
810 820 830 840 850
INGYRCSCPP GRSGPRCQEV VIFTRPCWSR GVSFPHGSSW VEDCNSCRCL
860 870 880 890 900
DGHRDCSKVW CGWKPCLLSP QPSALSAQCP PGQQCREKAM GQCLQPPCEN
910 920 930 940 950
WGECTAEDPL PPSTPCLPRT THLDNNCARL TLHFNRDQVP QGTTVGAICS
960 970 980 990 1000
GIRALPATRA AARDRLLLLL CDRASSGASA VEVAVSFSPA RDLPDSSLIQ
1010 1020 1030 1040 1050
STAHAIVAAI TQRGNSSLLL AVTEVKVETV VMGGSSTGLL VPVLCSVFSV
1060 1070 1080 1090 1100
LWLACMVICV WWTRKRRKER ERSRLPRDES ANNQWAPLNP IRNPIERPGS
1110 1120 1130 1140 1150
SGLGTGGHKD VLYQCKNFTP PPRRAGEALP GPASHGAGGE DEEDEELSRG
1160 1170 1180 1190 1200
DGRLSRSREV PLTQIHQRPQ LLPGKASLLA PGPKVDNRAV RSTKDVRCAG

RE
Length:1,202
Mass (Da):129,705
Last modified:May 1, 1997 - v1
Checksum:i08CB44E5271FF8BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70050 mRNA Translation: AAC52946.1
UniGeneiRn.22459

Genome annotation databases

UCSCiRGD:2938 rat

Similar proteinsi

Entry informationi

Entry nameiJAG2_RAT
AccessioniPrimary (citable) accession number: P97607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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