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Protein

Interleukin-15

Gene

Il15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • angiogenesis Source: RGD
  • cell maturation Source: Ensembl
  • cellular response to vitamin D Source: RGD
  • extrathymic T cell selection Source: Ensembl
  • hyaluronan metabolic process Source: RGD
  • immune response Source: GO_Central
  • inflammatory response Source: RGD
  • lymph node development Source: Ensembl
  • natural killer cell differentiation Source: Ensembl
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • NK T cell proliferation Source: Ensembl
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of immune response Source: Ensembl
  • positive regulation of interleukin-17 production Source: Ensembl
  • positive regulation of natural killer cell differentiation Source: Ensembl
  • positive regulation of natural killer cell proliferation Source: Ensembl
  • positive regulation of T cell proliferation Source: Ensembl
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  • regulation of defense response to virus by host Source: Ensembl
  • regulation of T cell differentiation Source: Ensembl
  • response to nutrient levels Source: RGD
  • signal transduction Source: GO_Central
  • skeletal muscle atrophy Source: RGD
  • tyrosine phosphorylation of Stat5 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15
Short name:
IL-15
Gene namesi
Name:Il15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2887. Il15.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: RGD
  • cytoplasm Source: Ensembl
  • extracellular space Source: RGD
  • nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 4819Sequence AnalysisPRO_0000015403Add
BLAST
Chaini49 – 162114Interleukin-15PRO_0000015404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi83 ↔ 133By similarity
Disulfide bondi90 ↔ 136By similarity
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97604.

Expressioni

Gene expression databases

GenevisibleiP97604. RN.

Structurei

3D structure databases

ProteinModelPortaliP97604.
SMRiP97604. Positions 46-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44071.
GeneTreeiENSGT00390000016264.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiP97604.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG77Q4ZF.
PhylomeDBiP97604.
TreeFamiTF336199.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P97604-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILKPYMRN TSILYYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVIE SGCKECEELE ERNFTEFLQS
160
FIHIVQMFIN TS
Length:162
Mass (Da):18,804
Last modified:May 1, 1997 - v1
Checksum:iDA68097A83065AEA
GO
Isoform Short (identifier: P97604-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-96: Missing.

Show »
Length:146
Mass (Da):17,025
Checksum:iB7BB0E0430FAC751
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 9616Missing in isoform Short. 1 PublicationVSP_002662Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69272 mRNA. Translation: AAB41697.1.
AF015719 mRNA. Translation: AAB94536.1.
AF015718 mRNA. Translation: AAB94535.1.
RefSeqiNP_037261.1. NM_013129.2. [P97604-1]
XP_008770585.1. XM_008772363.1. [P97604-2]
UniGeneiRn.2490.

Genome annotation databases

EnsembliENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439. [P97604-1]
GeneIDi25670.
KEGGirno:25670.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69272 mRNA. Translation: AAB41697.1.
AF015719 mRNA. Translation: AAB94536.1.
AF015718 mRNA. Translation: AAB94535.1.
RefSeqiNP_037261.1. NM_013129.2. [P97604-1]
XP_008770585.1. XM_008772363.1. [P97604-2]
UniGeneiRn.2490.

3D structure databases

ProteinModelPortaliP97604.
SMRiP97604. Positions 46-162.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP97604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439. [P97604-1]
GeneIDi25670.
KEGGirno:25670.

Organism-specific databases

CTDi3600.
RGDi2887. Il15.

Phylogenomic databases

eggNOGiNOG44071.
GeneTreeiENSGT00390000016264.
HOGENOMiHOG000113029.
HOVERGENiHBG006142.
InParanoidiP97604.
KOiK05433.
OMAiRSTSIQC.
OrthoDBiEOG77Q4ZF.
PhylomeDBiP97604.
TreeFamiTF336199.

Miscellaneous databases

NextBioi607603.
PROiP97604.

Gene expression databases

GenevisibleiP97604. RN.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamiPF02372. IL15. 1 hit.
[Graphical view]
PRINTSiPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Intestinal epithelial cells both express and respond to interleukin 15."
    Reinecker H.C., Macdermott R.P., Mirau S., Dignass A., Podolsky D.K.
    Gastroenterology 111:1706-1713(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Strain: Sprague-Dawley.
    Tissue: Jejunum.
  2. Park J.-H.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: Wistar.
    Tissue: Spleen.

Entry informationi

Entry nameiIL15_RAT
AccessioniPrimary (citable) accession number: P97604
Secondary accession number(s): O54847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.