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P97604

- IL15_RAT

UniProt

P97604 - IL15_RAT

Protein

Interleukin-15

Gene

Il15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha By similarity.By similarity

    GO - Biological processi

    1. aging Source: RGD
    2. angiogenesis Source: RGD
    3. cell maturation Source: Ensembl
    4. cellular response to vitamin D Source: RGD
    5. extrathymic T cell selection Source: Ensembl
    6. hyaluronan metabolic process Source: RGD
    7. immune response Source: InterPro
    8. inflammatory response Source: RGD
    9. lymph node development Source: Ensembl
    10. natural killer cell differentiation Source: Ensembl
    11. negative regulation of smooth muscle cell proliferation Source: RGD
    12. NK T cell proliferation Source: Ensembl
    13. positive regulation of cell proliferation Source: RGD
    14. positive regulation of immune response Source: Ensembl
    15. positive regulation of interleukin-17 production Source: Ensembl
    16. positive regulation of natural killer cell differentiation Source: Ensembl
    17. positive regulation of natural killer cell proliferation Source: Ensembl
    18. positive regulation of T cell proliferation Source: Ensembl
    19. positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
    20. regulation of defense response to virus by host Source: Ensembl
    21. regulation of T cell differentiation Source: Ensembl
    22. response to nutrient levels Source: RGD
    23. skeletal muscle atrophy Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-15
    Short name:
    IL-15
    Gene namesi
    Name:Il15
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi2887. Il15.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. cytoplasm Source: Ensembl
    3. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 4819Sequence AnalysisPRO_0000015403Add
    BLAST
    Chaini49 – 162114Interleukin-15PRO_0000015404Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi83 ↔ 133By similarity
    Disulfide bondi90 ↔ 136By similarity
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP97604.

    Expressioni

    Gene expression databases

    GenevestigatoriP97604.

    Structurei

    3D structure databases

    ProteinModelPortaliP97604.
    SMRiP97604. Positions 46-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44071.
    GeneTreeiENSGT00390000016264.
    HOGENOMiHOG000113029.
    HOVERGENiHBG006142.
    InParanoidiP97604.
    KOiK05433.
    OMAiRSTSIQC.
    OrthoDBiEOG77Q4ZF.
    PhylomeDBiP97604.
    TreeFamiTF336199.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR020439. IL-15.
    IPR003443. IL-15/IL-21_fam.
    IPR020466. IL-15_mml.
    [Graphical view]
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    PRINTSiPR01947. INTLKN15MAML.
    PR01930. INTRLEUKIN15.
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P97604-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKILKPYMRN TSILYYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW    50
    IDVRYDLEKI ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH 100
    EYSNMTLNET VRNVLYLANS TLSSNKNVIE SGCKECEELE ERNFTEFLQS 150
    FIHIVQMFIN TS 162
    Length:162
    Mass (Da):18,804
    Last modified:May 1, 1997 - v1
    Checksum:iDA68097A83065AEA
    GO
    Isoform Short (identifier: P97604-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-96: Missing.

    Show »
    Length:146
    Mass (Da):17,025
    Checksum:iB7BB0E0430FAC751
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 9616Missing in isoform Short. 1 PublicationVSP_002662Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69272 mRNA. Translation: AAB41697.1.
    AF015719 mRNA. Translation: AAB94536.1.
    AF015718 mRNA. Translation: AAB94535.1.
    RefSeqiNP_037261.1. NM_013129.2. [P97604-1]
    XP_006255283.1. XM_006255221.1. [P97604-1]
    XP_006255284.1. XM_006255222.1. [P97604-1]
    XP_006255285.1. XM_006255223.1. [P97604-1]
    XP_006255286.1. XM_006255224.1. [P97604-1]
    XP_006255287.1. XM_006255225.1. [P97604-2]
    UniGeneiRn.2490.

    Genome annotation databases

    EnsembliENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439. [P97604-2]
    GeneIDi25670.
    KEGGirno:25670.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69272 mRNA. Translation: AAB41697.1 .
    AF015719 mRNA. Translation: AAB94536.1 .
    AF015718 mRNA. Translation: AAB94535.1 .
    RefSeqi NP_037261.1. NM_013129.2. [P97604-1 ]
    XP_006255283.1. XM_006255221.1. [P97604-1 ]
    XP_006255284.1. XM_006255222.1. [P97604-1 ]
    XP_006255285.1. XM_006255223.1. [P97604-1 ]
    XP_006255286.1. XM_006255224.1. [P97604-1 ]
    XP_006255287.1. XM_006255225.1. [P97604-2 ]
    UniGenei Rn.2490.

    3D structure databases

    ProteinModelPortali P97604.
    SMRi P97604. Positions 46-162.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P97604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004590 ; ENSRNOP00000004590 ; ENSRNOG00000003439 . [P97604-2 ]
    GeneIDi 25670.
    KEGGi rno:25670.

    Organism-specific databases

    CTDi 3600.
    RGDi 2887. Il15.

    Phylogenomic databases

    eggNOGi NOG44071.
    GeneTreei ENSGT00390000016264.
    HOGENOMi HOG000113029.
    HOVERGENi HBG006142.
    InParanoidi P97604.
    KOi K05433.
    OMAi RSTSIQC.
    OrthoDBi EOG77Q4ZF.
    PhylomeDBi P97604.
    TreeFami TF336199.

    Miscellaneous databases

    NextBioi 607603.
    PROi P97604.

    Gene expression databases

    Genevestigatori P97604.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR020439. IL-15.
    IPR003443. IL-15/IL-21_fam.
    IPR020466. IL-15_mml.
    [Graphical view ]
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    PRINTSi PR01947. INTLKN15MAML.
    PR01930. INTRLEUKIN15.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Intestinal epithelial cells both express and respond to interleukin 15."
      Reinecker H.C., Macdermott R.P., Mirau S., Dignass A., Podolsky D.K.
      Gastroenterology 111:1706-1713(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Strain: Sprague-Dawley.
      Tissue: Jejunum.
    2. Park J.-H.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
      Strain: Wistar.
      Tissue: Spleen.

    Entry informationi

    Entry nameiIL15_RAT
    AccessioniPrimary (citable) accession number: P97604
    Secondary accession number(s): O54847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3