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P97604 (IL15_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-15

Short name=IL-15
Gene names
Name:Il15
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNK T cell proliferation

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from expression pattern PubMed 17135303. Source: RGD

angiogenesis

Traceable author statement PubMed 14581351. Source: RGD

cell maturation

Inferred from electronic annotation. Source: Ensembl

cellular response to vitamin D

Inferred from expression pattern PubMed 15637289. Source: RGD

extrathymic T cell selection

Inferred from electronic annotation. Source: Ensembl

hyaluronan metabolic process

Inferred from direct assay PubMed 17667861. Source: RGD

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from expression pattern PubMed 12572774. Source: RGD

lymph node development

Inferred from electronic annotation. Source: Ensembl

natural killer cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 17667861. Source: RGD

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 9826341. Source: RGD

positive regulation of immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay Ref.1. Source: RGD

regulation of T cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of defense response to virus by host

Inferred from electronic annotation. Source: Ensembl

response to nutrient levels

Inferred from expression pattern PubMed 19396981. Source: RGD

skeletal muscle atrophy

Inferred from expression pattern PubMed 17135303. Source: RGD

   Cellular_componentcell surface

Inferred from direct assay PubMed 16002563. Source: RGD

cytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 17667861. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P97604-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P97604-2)

The sequence of this isoform differs from the canonical sequence as follows:
     81-96: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 4819 Potential
PRO_0000015403
Chain49 – 162114Interleukin-15
PRO_0000015404

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 133 By similarity
Disulfide bond90 ↔ 136 By similarity

Natural variations

Alternative sequence81 – 9616Missing in isoform Short.
VSP_002662

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: DA68097A83065AEA

FASTA16218,804
        10         20         30         40         50         60 
MKILKPYMRN TSILYYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW IDVRYDLEKI 

        70         80         90        100        110        120 
ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS 

       130        140        150        160 
TLSSNKNVIE SGCKECEELE ERNFTEFLQS FIHIVQMFIN TS 

« Hide

Isoform Short [UniParc].

Checksum: B7BB0E0430FAC751
Show »

FASTA14617,025

References

[1]"Intestinal epithelial cells both express and respond to interleukin 15."
Reinecker H.C., Macdermott R.P., Mirau S., Dignass A., Podolsky D.K.
Gastroenterology 111:1706-1713(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
Strain: Sprague-Dawley.
Tissue: Jejunum.
[2]Park J.-H.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
Strain: Wistar.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U69272 mRNA. Translation: AAB41697.1.
AF015719 mRNA. Translation: AAB94536.1.
AF015718 mRNA. Translation: AAB94535.1.
RefSeqNP_037261.1. NM_013129.2. [P97604-1]
XP_006255283.1. XM_006255221.1. [P97604-1]
XP_006255284.1. XM_006255222.1. [P97604-1]
XP_006255285.1. XM_006255223.1. [P97604-1]
XP_006255286.1. XM_006255224.1. [P97604-1]
XP_006255287.1. XM_006255225.1. [P97604-2]
UniGeneRn.2490.

3D structure databases

ProteinModelPortalP97604.
SMRP97604. Positions 46-162.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP97604.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004590; ENSRNOP00000004590; ENSRNOG00000003439. [P97604-2]
GeneID25670.
KEGGrno:25670.

Organism-specific databases

CTD3600.
RGD2887. Il15.

Phylogenomic databases

eggNOGNOG44071.
GeneTreeENSGT00390000016264.
HOGENOMHOG000113029.
HOVERGENHBG006142.
InParanoidP97604.
KOK05433.
OMARSTSIQC.
OrthoDBEOG77Q4ZF.
PhylomeDBP97604.
TreeFamTF336199.

Gene expression databases

GenevestigatorP97604.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR020439. IL-15.
IPR003443. IL-15/IL-21_fam.
IPR020466. IL-15_mml.
[Graphical view]
PfamPF02372. IL15. 1 hit.
[Graphical view]
PRINTSPR01947. INTLKN15MAML.
PR01930. INTRLEUKIN15.
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio607603.
PROP97604.

Entry information

Entry nameIL15_RAT
AccessionPrimary (citable) accession number: P97604
Secondary accession number(s): O54847
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families