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Protein

Neogenin

Gene

Neo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: InterPro
  • cell adhesion Source: UniProtKB-KW
  • iron ion homeostasis Source: InterPro
  • negative regulation of neuron death Source: RGD
  • positive regulation of BMP signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neogenin
Gene namesi
Name:Neo1
Synonyms:Ngn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619837. Neo1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini3 – 1074ExtracellularSequence analysisAdd BLAST1072
Transmembranei1075 – 1095HelicalSequence analysisAdd BLAST21
Topological domaini1096 – 1377CytoplasmicSequence analysisAdd BLAST282

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 2Sequence analysis›2
ChainiPRO_00000150453 – 1377NeogeninAdd BLAST1375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi43 ↔ 98PROSITE-ProRule annotation
Disulfide bondi142 ↔ 190PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi239 ↔ 289PROSITE-ProRule annotation
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi331 ↔ 379PROSITE-ProRule annotation
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1
Glycosylationi608N-linked (GlcNAc...)Sequence analysis1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1
Glycosylationi878N-linked (GlcNAc...)Sequence analysis1
Modified residuei1147PhosphoserineBy similarity1
Modified residuei1163PhosphoserineCombined sources1
Modified residuei1167PhosphothreonineBy similarity1
Modified residuei1317PhosphoserineBy similarity1
Modified residuei1320PhosphothreonineBy similarity1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1350PhosphoserineBy similarity1
Modified residuei1351PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP97603.

PTM databases

iPTMnetiP97603.
PhosphoSitePlusiP97603.
SwissPalmiP97603.
UniCarbKBiP97603.

Interactioni

Subunit structurei

Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP97603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 114Ig-like C2-type 1Add BLAST94
Domaini121 – 206Ig-like C2-type 2Add BLAST86
Domaini198 – 305Ig-like C2-type 3Add BLAST108
Domaini310 – 395Ig-like C2-type 4Add BLAST86
Domaini410 – 504Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini510 – 600Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini605 – 700Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini710 – 800Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini825 – 924Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini926 – 1023Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1087 – 1090Poly-Val4

Domaini

The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.By similarity

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005455.
InParanoidiP97603.
PhylomeDBiP97603.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033024. Neogenin.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF55. PTHR10489:SF55. 2 hits.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAAKNGSPPQ SAGASVRTFT PLYFLVEPVD TLSVRGSSVI LNCSAYSEPS
60 70 80 90 100
PNIEWKKDGT FLNLVSDDRR QLLPDGSLFI SNVVHSKHNK PDEGFYQCVA
110 120 130 140 150
TVDNLGTIVS RTAKLAVAGL PRFTSQPEPS SIYVGNSGIL NCEVNADLVP
160 170 180 190 200
FVRWEQNRQP LLLDDRIVKL PSGTLVISNA TEGDEGLYRC IVESGGPPKF
210 220 230 240 250
SDEAELKVLQ ESEEMLDLVF LMRPSSMIKV IGQSAVLPCV ASGLPAPVIR
260 270 280 290 300
WMKNEDVLDT ESSGRLALLA GGSLEISDVT EDDAGTYFCV ADNGNKTIEA
310 320 330 340 350
QAELTVQVPP EFLKQPANIY ARESMDIVFE CEVTGKPAPT VKWVKNGDVV
360 370 380 390 400
IPSDYFKIVK EHNLQVLGLV KSDEGFYQCI AENDVGNAQA GAQLIILEHA
410 420 430 440 450
PATTGPLPSA PRDVVASLVS TRFIKLTWRT PASDPHGDNL TYSVFYTKEG
460 470 480 490 500
VARERVENTS QPGEMQVTIQ NLMPATVYIF KVMAQNKHGS GESSAPLRVE
510 520 530 540 550
TQPEVQLPGP APNIRAYATS PTSITVTWET PLSGNGEIQN YKLYYMEKGT
560 570 580 590 600
DKEQDVDVSS HSYTINGLKK YTEYSFRVVA YNKHGPGVST QDVAVRTLSD
610 620 630 640 650
VPSAAPQNLS LEVRNSKSIV IHWQPPSSAT QNGQITGYKI RYRKASRKSD
660 670 680 690 700
VTETVVTGTQ LSQLIEGLDR GTEYNFRVAA LTVNGTGPAT DWLSAETFES
710 720 730 740 750
DLDESRVPEV PSSLHVRPLV TSIVVSWTPP ENQNIVVRGY AIGYGIGSPH
760 770 780 790 800
AQTIKVDYKQ RYYTIENLDP SSHYVITLKA FNNVGEGIPL YESAVTRPHT
810 820 830 840 850
DTSEVDLFVI NAPYTPVPDP TPMMPPVGVQ ASILSHDTIR ITWADNSLPK
860 870 880 890 900
HQKITDSRYY TVRWKTNIPA NTKYKNANAT TLSYLVTGLK PNTLYEFSVM
910 920 930 940 950
VTKGRRSSTW SMTAHGATFE LVPTSPPKDV TVVSKEGKPR TIIVNWQPPS
960 970 980 990 1000
EANGKITGYI IYYSTDVNAE IHDWVIEPVV GNRLTHQIQE LTLDTPYYFK
1010 1020 1030 1040 1050
IQARNSKGMG PMSEAVQFRT PKADSSDKMP NDQALGSAGK GGRLPDLGSD
1060 1070 1080 1090 1100
YKPPMSGSNS PHGSPTSPLD SNMLLVIIVS IGVITIVVVV IIAVFCTRRT
1110 1120 1130 1140 1150
TSHQKKKRAA CKSVNGSHKY KGNCKDVKPP DLWIHHERLE LKPIDKSPDP
1160 1170 1180 1190 1200
NPVMTDTPIP RNSQDITPVD NSMDSNIHQR RNSYRGHESE DSMSTLAGRR
1210 1220 1230 1240 1250
GMRPKMMMPF DSQPPQQSVR NTPSTDTMPA SSSQTCCTDH QDPEGATSSS
1260 1270 1280 1290 1300
YLASSQEEDS GQSLPTAHVR PSHPLKSFAV PAIPPPGPPI YDPALPSTPL
1310 1320 1330 1340 1350
LSQQALNHHL HSVKTASIGT LGRSRPPMPV VVPSAPEVQE ATRMLEDSES
1360 1370
SYEPDELTKE MAHLEGLMKD LNAITTA
Length:1,377
Mass (Da):150,638
Last modified:May 1, 1997 - v1
Checksum:iE514ED8ABD1A63A9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68726 mRNA. Translation: AAB41100.1.
UniGeneiRn.10667.

Genome annotation databases

UCSCiRGD:619837. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68726 mRNA. Translation: AAB41100.1.
UniGeneiRn.10667.

3D structure databases

ProteinModelPortaliP97603.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP97603.
PhosphoSitePlusiP97603.
SwissPalmiP97603.
UniCarbKBiP97603.

Proteomic databases

PRIDEiP97603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619837. rat.

Organism-specific databases

RGDi619837. Neo1.

Phylogenomic databases

HOVERGENiHBG005455.
InParanoidiP97603.
PhylomeDBiP97603.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033024. Neogenin.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF55. PTHR10489:SF55. 2 hits.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEO1_RAT
AccessioniPrimary (citable) accession number: P97603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.