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P97594

- MCPT8_RAT

UniProt

P97594 - MCPT8_RAT

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Protein

Mast cell protease 8

Gene

Mcpt8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei108 – 1081Charge relay systemBy similarity
Active sitei201 – 2011Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 8 (EC:3.4.21.-)
Short name:
rMCP-8
Alternative name(s):
Mast cell protease VIII
Short name:
rMCP-VIII
Gene namesi
Name:Mcpt8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi3067. Mcpt8.

Subcellular locationi

Secreted. Cytoplasmic granule
Note: Secretory granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027447
Chaini21 – 248228Mast cell protease 8PRO_0000027448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi142 ↔ 207PROSITE-ProRule annotation
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP97594.
PRIDEiP97594.

Expressioni

Tissue specificityi

Mast cells.

Gene expression databases

GenevestigatoriP97594.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027950.

Structurei

3D structure databases

ProteinModelPortaliP97594.
SMRiP97594. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 243223Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP97594.
KOiK01362.
OMAiNTQIFER.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97594.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97594-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLFLFFLVA ILPVNTEGGE IIWGTESKPH SRPYMASLMF YYGNSYRHYC
60 70 80 90 100
GGFLVAKDIV MTAAHCNGSN IKVTLGAHNI KKQEKTQVIA VVKAKPHENY
110 120 130 140 150
DRHSRFNDIM LLKLERKAQL NGAVKTIALP RSQDWVKPGQ VCTVAGWGCL
160 170 180 190 200
ANCSLSNTLQ EVNLEVQEGQ KCEDMSRNYN DSIQLCVGNP SEGKATGKGD
210 220 230 240
SGGPFVCDGV AQGIVSYRLC TGTLPRVFTR ISSFIPWIQK TMKLLQQS
Length:248
Mass (Da):27,486
Last modified:May 1, 1997 - v1
Checksum:i913178B7F033DD8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67911 mRNA. Translation: AAB48264.1.
RefSeqiNP_067609.1. NM_021598.2.
XP_003751517.1. XM_003751469.3.
UniGeneiRn.55163.

Genome annotation databases

EnsembliENSRNOT00000027950; ENSRNOP00000027950; ENSRNOG00000047190.
ENSRNOT00000072426; ENSRNOP00000067099; ENSRNOG00000049991.
GeneIDi29269.
691603.
KEGGirno:29269.
rno:691603.
UCSCiRGD:3067. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67911 mRNA. Translation: AAB48264.1 .
RefSeqi NP_067609.1. NM_021598.2.
XP_003751517.1. XM_003751469.3.
UniGenei Rn.55163.

3D structure databases

ProteinModelPortali P97594.
SMRi P97594. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027950.

Protein family/group databases

MEROPSi S01.009.

Proteomic databases

PaxDbi P97594.
PRIDEi P97594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027950 ; ENSRNOP00000027950 ; ENSRNOG00000047190 .
ENSRNOT00000072426 ; ENSRNOP00000067099 ; ENSRNOG00000049991 .
GeneIDi 29269.
691603.
KEGGi rno:29269.
rno:691603.
UCSCi RGD:3067. rat.

Organism-specific databases

CTDi 17231.
RGDi 3067. Mcpt8.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118895.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P97594.
KOi K01362.
OMAi NTQIFER.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P97594.
TreeFami TF333630.

Miscellaneous databases

NextBioi 608612.

Gene expression databases

Genevestigatori P97594.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
    Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
    J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiMCPT8_RAT
AccessioniPrimary (citable) accession number: P97594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3