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P97594

- MCPT8_RAT

UniProt

P97594 - MCPT8_RAT

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Protein
Mast cell protease 8
Gene
Mcpt8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system By similarity
Active sitei108 – 1081Charge relay system By similarity
Active sitei201 – 2011Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. granzyme-mediated apoptotic signaling pathway Source: RefGenome
  2. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 8 (EC:3.4.21.-)
Short name:
rMCP-8
Alternative name(s):
Mast cell protease VIII
Short name:
rMCP-VIII
Gene namesi
Name:Mcpt8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi3067. Mcpt8.

Subcellular locationi

Secreted. Cytoplasmic granule
Note: Secretory granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. secretory granule Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 202Activation peptide
PRO_0000027447
Chaini21 – 248228Mast cell protease 8
PRO_0000027448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi142 ↔ 207 By similarity
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi172 ↔ 186 By similarity
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP97594.
PRIDEiP97594.

Expressioni

Tissue specificityi

Mast cells.

Gene expression databases

GenevestigatoriP97594.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027950.

Structurei

3D structure databases

ProteinModelPortaliP97594.
SMRiP97594. Positions 21-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 243223Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00740000115234.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
KOiK01362.
OMAiNTQIFER.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97594.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97594-1 [UniParc]FASTAAdd to Basket

« Hide

MFLFLFFLVA ILPVNTEGGE IIWGTESKPH SRPYMASLMF YYGNSYRHYC    50
GGFLVAKDIV MTAAHCNGSN IKVTLGAHNI KKQEKTQVIA VVKAKPHENY 100
DRHSRFNDIM LLKLERKAQL NGAVKTIALP RSQDWVKPGQ VCTVAGWGCL 150
ANCSLSNTLQ EVNLEVQEGQ KCEDMSRNYN DSIQLCVGNP SEGKATGKGD 200
SGGPFVCDGV AQGIVSYRLC TGTLPRVFTR ISSFIPWIQK TMKLLQQS 248
Length:248
Mass (Da):27,486
Last modified:May 1, 1997 - v1
Checksum:i913178B7F033DD8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67911 mRNA. Translation: AAB48264.1.
RefSeqiNP_067609.1. NM_021598.2.
XP_003751517.1. XM_003751469.2.
UniGeneiRn.55163.

Genome annotation databases

EnsembliENSRNOT00000027950; ENSRNOP00000027950; ENSRNOG00000047190.
ENSRNOT00000072426; ENSRNOP00000067099; ENSRNOG00000049991.
GeneIDi29269.
691603.
KEGGirno:29269.
rno:691603.
UCSCiRGD:3067. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67911 mRNA. Translation: AAB48264.1 .
RefSeqi NP_067609.1. NM_021598.2.
XP_003751517.1. XM_003751469.2.
UniGenei Rn.55163.

3D structure databases

ProteinModelPortali P97594.
SMRi P97594. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027950.

Protein family/group databases

MEROPSi S01.009.

Proteomic databases

PaxDbi P97594.
PRIDEi P97594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027950 ; ENSRNOP00000027950 ; ENSRNOG00000047190 .
ENSRNOT00000072426 ; ENSRNOP00000067099 ; ENSRNOG00000049991 .
GeneIDi 29269.
691603.
KEGGi rno:29269.
rno:691603.
UCSCi RGD:3067. rat.

Organism-specific databases

CTDi 17231.
RGDi 3067. Mcpt8.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00740000115234.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
KOi K01362.
OMAi NTQIFER.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P97594.
TreeFami TF333630.

Miscellaneous databases

NextBioi 608612.

Gene expression databases

Genevestigatori P97594.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
    Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
    J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiMCPT8_RAT
AccessioniPrimary (citable) accession number: P97594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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