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P97594

- MCPT8_RAT

UniProt

P97594 - MCPT8_RAT

Protein

Mast cell protease 8

Gene

Mcpt8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei108 – 1081Charge relay systemBy similarity
    Active sitei201 – 2011Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mast cell protease 8 (EC:3.4.21.-)
    Short name:
    rMCP-8
    Alternative name(s):
    Mast cell protease VIII
    Short name:
    rMCP-VIII
    Gene namesi
    Name:Mcpt8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi3067. Mcpt8.

    Subcellular locationi

    Secreted. Cytoplasmic granule
    Note: Secretory granules.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 202Activation peptidePRO_0000027447
    Chaini21 – 248228Mast cell protease 8PRO_0000027448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi142 ↔ 207PROSITE-ProRule annotation
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP97594.
    PRIDEiP97594.

    Expressioni

    Tissue specificityi

    Mast cells.

    Gene expression databases

    GenevestigatoriP97594.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027950.

    Structurei

    3D structure databases

    ProteinModelPortaliP97594.
    SMRiP97594. Positions 21-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 243223Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115234.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    KOiK01362.
    OMAiNTQIFER.
    OrthoDBiEOG7RRF7Z.
    PhylomeDBiP97594.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97594-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLFLFFLVA ILPVNTEGGE IIWGTESKPH SRPYMASLMF YYGNSYRHYC    50
    GGFLVAKDIV MTAAHCNGSN IKVTLGAHNI KKQEKTQVIA VVKAKPHENY 100
    DRHSRFNDIM LLKLERKAQL NGAVKTIALP RSQDWVKPGQ VCTVAGWGCL 150
    ANCSLSNTLQ EVNLEVQEGQ KCEDMSRNYN DSIQLCVGNP SEGKATGKGD 200
    SGGPFVCDGV AQGIVSYRLC TGTLPRVFTR ISSFIPWIQK TMKLLQQS 248
    Length:248
    Mass (Da):27,486
    Last modified:May 1, 1997 - v1
    Checksum:i913178B7F033DD8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67911 mRNA. Translation: AAB48264.1.
    RefSeqiNP_067609.1. NM_021598.2.
    XP_003751517.1. XM_003751469.2.
    UniGeneiRn.55163.

    Genome annotation databases

    EnsembliENSRNOT00000027950; ENSRNOP00000027950; ENSRNOG00000047190.
    ENSRNOT00000072426; ENSRNOP00000067099; ENSRNOG00000049991.
    GeneIDi29269.
    691603.
    KEGGirno:29269.
    rno:691603.
    UCSCiRGD:3067. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67911 mRNA. Translation: AAB48264.1 .
    RefSeqi NP_067609.1. NM_021598.2.
    XP_003751517.1. XM_003751469.2.
    UniGenei Rn.55163.

    3D structure databases

    ProteinModelPortali P97594.
    SMRi P97594. Positions 21-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027950.

    Protein family/group databases

    MEROPSi S01.009.

    Proteomic databases

    PaxDbi P97594.
    PRIDEi P97594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027950 ; ENSRNOP00000027950 ; ENSRNOG00000047190 .
    ENSRNOT00000072426 ; ENSRNOP00000067099 ; ENSRNOG00000049991 .
    GeneIDi 29269.
    691603.
    KEGGi rno:29269.
    rno:691603.
    UCSCi RGD:3067. rat.

    Organism-specific databases

    CTDi 17231.
    RGDi 3067. Mcpt8.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115234.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    KOi K01362.
    OMAi NTQIFER.
    OrthoDBi EOG7RRF7Z.
    PhylomeDBi P97594.
    TreeFami TF333630.

    Miscellaneous databases

    NextBioi 608612.

    Gene expression databases

    Genevestigatori P97594.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
      Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
      J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiMCPT8_RAT
    AccessioniPrimary (citable) accession number: P97594
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3