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P97592

- MCPT4_RAT

UniProt

P97592 - MCPT4_RAT

Protein

Mast cell protease 4

Gene

Mcpt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. heparin binding Source: RGD
    2. peptide binding Source: RGD
    3. serine-type endopeptidase activity Source: RGD

    GO - Biological processi

    1. proteolysis Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mast cell protease 4 (EC:3.4.21.-)
    Short name:
    rMCP-4
    Alternative name(s):
    Mast cell protease IV
    Short name:
    rMCP-IV
    Gene namesi
    Name:Mcpt4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi3064. Mcpt4.

    Subcellular locationi

    Secreted. Cytoplasmic granule
    Note: Secretory granules.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 202Activation peptidePRO_0000027445
    Chaini21 – 246226Mast cell protease 4PRO_0000027446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP97592.
    PRIDEiP97592.

    Expressioni

    Tissue specificityi

    Mast cells.

    Gene expression databases

    GenevestigatoriP97592.

    Structurei

    3D structure databases

    ProteinModelPortaliP97592.
    SMRiP97592. Positions 21-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115279.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP97592.
    KOiK01362.
    OMAiCHGREIT.
    OrthoDBiEOG7RRF7Z.
    PhylomeDBiP97592.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMALLKI VTEEGHVTFC    50
    GGFLISLQFV LTAAHCHGRE ITVTLGAHDM SKRESTQQKI KVVKQIFPLK 100
    YNLFSNFRDI MLLKLEQKAV LTPSVNVIPL PQSSDIIKPG TMCLAAGWGQ 150
    TGVKEPNSNT LREVMLRIME MKACKDYRHY DNRFQICVGI PQMLKLAYKG 200
    DSGGPLVCAG VAHGIVSHGP GRGIPPIIFT RISSYVSWIN RVIRGN 246
    Length:246
    Mass (Da):27,042
    Last modified:May 1, 1997 - v1
    Checksum:i412FF51D05098778
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67907 mRNA. Translation: AAB48260.1.
    RefSeqiNP_062194.1. NM_019321.2.
    UniGeneiRn.10698.

    Genome annotation databases

    EnsembliENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
    GeneIDi54270.
    KEGGirno:54270.
    UCSCiRGD:3064. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67907 mRNA. Translation: AAB48260.1 .
    RefSeqi NP_062194.1. NM_019321.2.
    UniGenei Rn.10698.

    3D structure databases

    ProteinModelPortali P97592.
    SMRi P97592. Positions 21-243.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.005.

    Proteomic databases

    PaxDbi P97592.
    PRIDEi P97592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027918 ; ENSRNOP00000027918 ; ENSRNOG00000024785 .
    GeneIDi 54270.
    KEGGi rno:54270.
    UCSCi RGD:3064. rat.

    Organism-specific databases

    CTDi 17227.
    RGDi 3064. Mcpt4.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115279.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P97592.
    KOi K01362.
    OMAi CHGREIT.
    OrthoDBi EOG7RRF7Z.
    PhylomeDBi P97592.
    TreeFami TF333630.

    Miscellaneous databases

    NextBioi 610828.

    Gene expression databases

    Genevestigatori P97592.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
      Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
      J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiMCPT4_RAT
    AccessioniPrimary (citable) accession number: P97592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3