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P97592 (MCPT4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mast cell protease 4

Short name=rMCP-4
EC=3.4.21.-
Alternative name(s):
Mast cell protease IV
Short name=rMCP-IV
Gene names
Name:Mcpt4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted. Cytoplasmic granule. Note: Secretory granules.

Tissue specificity

Mast cells.

Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 202Activation peptide
PRO_0000027445
Chain21 – 246226Mast cell protease 4
PRO_0000027446

Regions

Domain21 – 244224Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1091Charge relay system By similarity
Active site2021Charge relay system By similarity

Amino acid modifications

Disulfide bond50 ↔ 66 By similarity
Disulfide bond143 ↔ 208 By similarity
Disulfide bond174 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97592 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 412FF51D05098778

FASTA24627,042
        10         20         30         40         50         60 
MKALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMALLKI VTEEGHVTFC GGFLISLQFV 

        70         80         90        100        110        120 
LTAAHCHGRE ITVTLGAHDM SKRESTQQKI KVVKQIFPLK YNLFSNFRDI MLLKLEQKAV 

       130        140        150        160        170        180 
LTPSVNVIPL PQSSDIIKPG TMCLAAGWGQ TGVKEPNSNT LREVMLRIME MKACKDYRHY 

       190        200        210        220        230        240 
DNRFQICVGI PQMLKLAYKG DSGGPLVCAG VAHGIVSHGP GRGIPPIIFT RISSYVSWIN 


RVIRGN 

« Hide

References

[1]"Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67907 mRNA. Translation: AAB48260.1.
RefSeqNP_062194.1. NM_019321.2.
UniGeneRn.10698.

3D structure databases

ProteinModelPortalP97592.
SMRP97592. Positions 21-243.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.005.

Proteomic databases

PaxDbP97592.
PRIDEP97592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
GeneID54270.
KEGGrno:54270.
UCSCRGD:3064. rat.

Organism-specific databases

CTD17227.
RGD3064. Mcpt4.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00740000115279.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP97592.
KOK01362.
OMACHGREIT.
OrthoDBEOG7RRF7Z.
TreeFamTF333630.

Gene expression databases

GenevestigatorP97592.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610828.

Entry information

Entry nameMCPT4_RAT
AccessionPrimary (citable) accession number: P97592
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries