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P97592

- MCPT4_RAT

UniProt

P97592 - MCPT4_RAT

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Protein

Mast cell protease 4

Gene
Mcpt4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system By similarity
Active sitei109 – 1091Charge relay system By similarity
Active sitei202 – 2021Charge relay system By similarity

GO - Molecular functioni

  1. heparin binding Source: RGD
  2. peptide binding Source: RGD
  3. serine-type endopeptidase activity Source: RGD

GO - Biological processi

  1. proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 4 (EC:3.4.21.-)
Short name:
rMCP-4
Alternative name(s):
Mast cell protease IV
Short name:
rMCP-IV
Gene namesi
Name:Mcpt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi3064. Mcpt4.

Subcellular locationi

Secreted. Cytoplasmic granule
Note: Secretory granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. secretory granule Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027445
Chaini21 – 246226Mast cell protease 4PRO_0000027446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66 By similarity
Disulfide bondi143 ↔ 208 By similarity
Disulfide bondi174 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP97592.
PRIDEiP97592.

Expressioni

Tissue specificityi

Mast cells.

Gene expression databases

GenevestigatoriP97592.

Structurei

3D structure databases

ProteinModelPortaliP97592.
SMRiP97592. Positions 21-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00740000115279.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP97592.
KOiK01362.
OMAiCHGREIT.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97592.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97592-1 [UniParc]FASTAAdd to Basket

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MKALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMALLKI VTEEGHVTFC    50
GGFLISLQFV LTAAHCHGRE ITVTLGAHDM SKRESTQQKI KVVKQIFPLK 100
YNLFSNFRDI MLLKLEQKAV LTPSVNVIPL PQSSDIIKPG TMCLAAGWGQ 150
TGVKEPNSNT LREVMLRIME MKACKDYRHY DNRFQICVGI PQMLKLAYKG 200
DSGGPLVCAG VAHGIVSHGP GRGIPPIIFT RISSYVSWIN RVIRGN 246
Length:246
Mass (Da):27,042
Last modified:May 1, 1997 - v1
Checksum:i412FF51D05098778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67907 mRNA. Translation: AAB48260.1.
RefSeqiNP_062194.1. NM_019321.2.
UniGeneiRn.10698.

Genome annotation databases

EnsembliENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
GeneIDi54270.
KEGGirno:54270.
UCSCiRGD:3064. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67907 mRNA. Translation: AAB48260.1 .
RefSeqi NP_062194.1. NM_019321.2.
UniGenei Rn.10698.

3D structure databases

ProteinModelPortali P97592.
SMRi P97592. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.005.

Proteomic databases

PaxDbi P97592.
PRIDEi P97592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027918 ; ENSRNOP00000027918 ; ENSRNOG00000024785 .
GeneIDi 54270.
KEGGi rno:54270.
UCSCi RGD:3064. rat.

Organism-specific databases

CTDi 17227.
RGDi 3064. Mcpt4.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00740000115279.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P97592.
KOi K01362.
OMAi CHGREIT.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P97592.
TreeFami TF333630.

Miscellaneous databases

NextBioi 610828.

Gene expression databases

Genevestigatori P97592.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
    Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
    J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiMCPT4_RAT
AccessioniPrimary (citable) accession number: P97592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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