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Protein

Mast cell protease 4

Gene

Mcpt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei109 – 1091Charge relay systemBy similarity
Active sitei202 – 2021Charge relay systemBy similarity

GO - Molecular functioni

  • heparin binding Source: RGD
  • peptide binding Source: RGD
  • serine-type endopeptidase activity Source: RGD

GO - Biological processi

  • protein processing Source: GO_Central
  • proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 4 (EC:3.4.21.-)
Short name:
rMCP-4
Alternative name(s):
Mast cell protease IV
Short name:
rMCP-IV
Gene namesi
Name:Mcpt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi3064. Mcpt4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027445
Chaini21 – 246226Mast cell protease 4PRO_0000027446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP97592.
PRIDEiP97592.

Expressioni

Tissue specificityi

Mast cells.

Gene expression databases

GenevestigatoriP97592.

Structurei

3D structure databases

ProteinModelPortaliP97592.
SMRiP97592. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP97592.
KOiK01362.
OMAiCHGREIT.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97592.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMALLKI VTEEGHVTFC
60 70 80 90 100
GGFLISLQFV LTAAHCHGRE ITVTLGAHDM SKRESTQQKI KVVKQIFPLK
110 120 130 140 150
YNLFSNFRDI MLLKLEQKAV LTPSVNVIPL PQSSDIIKPG TMCLAAGWGQ
160 170 180 190 200
TGVKEPNSNT LREVMLRIME MKACKDYRHY DNRFQICVGI PQMLKLAYKG
210 220 230 240
DSGGPLVCAG VAHGIVSHGP GRGIPPIIFT RISSYVSWIN RVIRGN
Length:246
Mass (Da):27,042
Last modified:May 1, 1997 - v1
Checksum:i412FF51D05098778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67907 mRNA. Translation: AAB48260.1.
RefSeqiNP_062194.1. NM_019321.2.
UniGeneiRn.10698.

Genome annotation databases

EnsembliENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
GeneIDi54270.
KEGGirno:54270.
UCSCiRGD:3064. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67907 mRNA. Translation: AAB48260.1.
RefSeqiNP_062194.1. NM_019321.2.
UniGeneiRn.10698.

3D structure databases

ProteinModelPortaliP97592.
SMRiP97592. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.005.

Proteomic databases

PaxDbiP97592.
PRIDEiP97592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
GeneIDi54270.
KEGGirno:54270.
UCSCiRGD:3064. rat.

Organism-specific databases

CTDi17227.
RGDi3064. Mcpt4.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP97592.
KOiK01362.
OMAiCHGREIT.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97592.
TreeFamiTF333630.

Miscellaneous databases

NextBioi610828.
PROiP97592.

Gene expression databases

GenevestigatoriP97592.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
    Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
    J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiMCPT4_RAT
AccessioniPrimary (citable) accession number: P97592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: April 29, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.