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P97592

- MCPT4_RAT

UniProt

P97592 - MCPT4_RAT

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Protein

Mast cell protease 4

Gene

Mcpt4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei109 – 1091Charge relay systemBy similarity
Active sitei202 – 2021Charge relay systemBy similarity

GO - Molecular functioni

  1. heparin binding Source: RGD
  2. peptide binding Source: RGD
  3. serine-type endopeptidase activity Source: RGD

GO - Biological processi

  1. proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 4 (EC:3.4.21.-)
Short name:
rMCP-4
Alternative name(s):
Mast cell protease IV
Short name:
rMCP-IV
Gene namesi
Name:Mcpt4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi3064. Mcpt4.

Subcellular locationi

Secreted. Cytoplasmic granule
Note: Secretory granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 202Activation peptidePRO_0000027445
Chaini21 – 246226Mast cell protease 4PRO_0000027446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP97592.
PRIDEiP97592.

Expressioni

Tissue specificityi

Mast cells.

Gene expression databases

GenevestigatoriP97592.

Structurei

3D structure databases

ProteinModelPortaliP97592.
SMRiP97592. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP97592.
KOiK01362.
OMAiCHGREIT.
OrthoDBiEOG7RRF7Z.
PhylomeDBiP97592.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97592-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMALLKI VTEEGHVTFC
60 70 80 90 100
GGFLISLQFV LTAAHCHGRE ITVTLGAHDM SKRESTQQKI KVVKQIFPLK
110 120 130 140 150
YNLFSNFRDI MLLKLEQKAV LTPSVNVIPL PQSSDIIKPG TMCLAAGWGQ
160 170 180 190 200
TGVKEPNSNT LREVMLRIME MKACKDYRHY DNRFQICVGI PQMLKLAYKG
210 220 230 240
DSGGPLVCAG VAHGIVSHGP GRGIPPIIFT RISSYVSWIN RVIRGN
Length:246
Mass (Da):27,042
Last modified:May 1, 1997 - v1
Checksum:i412FF51D05098778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67907 mRNA. Translation: AAB48260.1.
RefSeqiNP_062194.1. NM_019321.2.
UniGeneiRn.10698.

Genome annotation databases

EnsembliENSRNOT00000027918; ENSRNOP00000027918; ENSRNOG00000024785.
GeneIDi54270.
KEGGirno:54270.
UCSCiRGD:3064. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67907 mRNA. Translation: AAB48260.1 .
RefSeqi NP_062194.1. NM_019321.2.
UniGenei Rn.10698.

3D structure databases

ProteinModelPortali P97592.
SMRi P97592. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.005.

Proteomic databases

PaxDbi P97592.
PRIDEi P97592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027918 ; ENSRNOP00000027918 ; ENSRNOG00000024785 .
GeneIDi 54270.
KEGGi rno:54270.
UCSCi RGD:3064. rat.

Organism-specific databases

CTDi 17227.
RGDi 3064. Mcpt4.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118895.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P97592.
KOi K01362.
OMAi CHGREIT.
OrthoDBi EOG7RRF7Z.
PhylomeDBi P97592.
TreeFami TF333630.

Miscellaneous databases

NextBioi 610828.

Gene expression databases

Genevestigatori P97592.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations."
    Lutzelschwab C., Pejler G., Aveskogh M., Hellman L.
    J. Exp. Med. 185:13-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiMCPT4_RAT
AccessioniPrimary (citable) accession number: P97592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3