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Protein

Galectin-7

Gene

Lgals7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61951. Lgals7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Secreted By similarity

  • Note: May be secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769421 – 136Galectin-7Add BLAST136

Proteomic databases

PaxDbiP97590.
PRIDEiP97590.

Expressioni

Gene expression databases

ExpressionAtlasiP97590. baseline and differential.
GenevisibleiP97590. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027620.

Structurei

3D structure databases

ProteinModelPortaliP97590.
SMRiP97590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP97590.
KOiK10092.
OMAiRHRMPLA.
PhylomeDBiP97590.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF118. PTHR11346:SF118. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SMARTiView protein in SMART
SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P97590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATHHKTPL PQGVRLGTVM RIRGVVPDQA GRFHVNLLCG EEQEADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL IITTEEGFKT
110 120 130
VIGDDEYLHF HHRMPSSNVR SVEVGGDVQL HSVKIF
Length:136
Mass (Da):15,285
Last modified:January 23, 2007 - v4
Checksum:i460D2CD3191BF294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 5SATH → M (PubMed:9697310).Curated4
Sequence conflicti47A → C in AAB40658 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67883 mRNA. Translation: AAB40658.1.
AF036941 mRNA. Translation: AAB88871.1.
RefSeqiNP_072104.2. NM_022582.2.
XP_006228732.1. XM_006228670.3.
UniGeneiRn.6336.

Genome annotation databases

EnsembliENSRNOT00000084393; ENSRNOP00000068607; ENSRNOG00000020380.
GeneIDi29518.
KEGGirno:29518.
UCSCiRGD:61951. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67883 mRNA. Translation: AAB40658.1.
AF036941 mRNA. Translation: AAB88871.1.
RefSeqiNP_072104.2. NM_022582.2.
XP_006228732.1. XM_006228670.3.
UniGeneiRn.6336.

3D structure databases

ProteinModelPortaliP97590.
SMRiP97590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027620.

Proteomic databases

PaxDbiP97590.
PRIDEiP97590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084393; ENSRNOP00000068607; ENSRNOG00000020380.
GeneIDi29518.
KEGGirno:29518.
UCSCiRGD:61951. rat.

Organism-specific databases

CTDi3963.
RGDi61951. Lgals7.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP97590.
KOiK10092.
OMAiRHRMPLA.
PhylomeDBiP97590.

Miscellaneous databases

PROiPR:P97590.

Gene expression databases

ExpressionAtlasiP97590. baseline and differential.
GenevisibleiP97590. RN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF118. PTHR11346:SF118. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SMARTiView protein in SMART
SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLEG7_RAT
AccessioniPrimary (citable) accession number: P97590
Secondary accession number(s): O54958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 121 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.