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Protein

Galectin-7

Gene

Lgals7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Gene namesi
Name:Lgals7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61951. Lgals7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Secreted By similarity

  • Note: May be secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 136136Galectin-7PRO_0000076942Add
BLAST

Proteomic databases

PaxDbiP97590.
PRIDEiP97590.

Expressioni

Gene expression databases

ExpressionAtlasiP97590. baseline and differential.
GenevisibleiP97590. RN.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027620.

Structurei

3D structure databases

ProteinModelPortaliP97590.
SMRiP97590. Positions 2-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 136131GalectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 767Beta-galactoside bindingSequence analysis

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP97590.
KOiK10092.
PhylomeDBiP97590.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF107. PTHR11346:SF107. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATHHKTPL PQGVRLGTVM RIRGVVPDQA GRFHVNLLCG EEQEADAALH
60 70 80 90 100
FNPRLDTSEV VFNTKQQGKW GREERGTGIP FQRGQPFEVL IITTEEGFKT
110 120 130
VIGDDEYLHF HHRMPSSNVR SVEVGGDVQL HSVKIF
Length:136
Mass (Da):15,285
Last modified:January 23, 2007 - v4
Checksum:i460D2CD3191BF294
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 54SATH → M (PubMed:9697310).Curated
Sequence conflicti47 – 471A → C in AAB40658 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67883 mRNA. Translation: AAB40658.1.
AF036941 mRNA. Translation: AAB88871.1.
RefSeqiNP_072104.2. NM_022582.2.
XP_006228730.1. XM_006228668.2.
XP_006228732.1. XM_006228670.2.
UniGeneiRn.6336.

Genome annotation databases

EnsembliENSRNOT00000084393; ENSRNOP00000068607; ENSRNOG00000020380.
GeneIDi29518.
KEGGirno:29518.
UCSCiRGD:61951. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67883 mRNA. Translation: AAB40658.1.
AF036941 mRNA. Translation: AAB88871.1.
RefSeqiNP_072104.2. NM_022582.2.
XP_006228730.1. XM_006228668.2.
XP_006228732.1. XM_006228670.2.
UniGeneiRn.6336.

3D structure databases

ProteinModelPortaliP97590.
SMRiP97590. Positions 2-136.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027620.

Proteomic databases

PaxDbiP97590.
PRIDEiP97590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000084393; ENSRNOP00000068607; ENSRNOG00000020380.
GeneIDi29518.
KEGGirno:29518.
UCSCiRGD:61951. rat.

Organism-specific databases

CTDi3963.
RGDi61951. Lgals7.

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiP97590.
KOiK10092.
PhylomeDBiP97590.

Miscellaneous databases

NextBioi609461.
PROiP97590.

Gene expression databases

ExpressionAtlasiP97590. baseline and differential.
GenevisibleiP97590. RN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030640. Galectin_7.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF107. PTHR11346:SF107. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lu J.X.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Mammary gland.
  2. "Galectin-7, a marker of all types of stratified epithelia."
    Magnaldo T., Fowlis D., Darmon M.
    Differentiation 63:159-168(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.

Entry informationi

Entry nameiLEG7_RAT
AccessioniPrimary (citable) accession number: P97590
Secondary accession number(s): O54958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.