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Protein

Cell growth regulator with EF hand domain protein 1

Gene

Cgref1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi84 – 951PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi128 – 1392PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell cycle arrest Source: UniProtKB-KW
  • negative regulation of cell growth Source: RGD

Keywordsi

Biological processCell adhesion, Cell cycle, Growth arrest
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth regulator with EF hand domain protein 1
Alternative name(s):
Cell growth regulatory gene 11 protein
Hydrophobestin
Gene namesi
Name:Cgref1
Synonyms:Cgr11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620801 Cgref1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000007387622 – 281Cell growth regulator with EF hand domain protein 1Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineCombined sources1
Modified residuei228PhosphoserineCombined sources1

Post-translational modificationi

Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97586
PRIDEiP97586

PTM databases

iPTMnetiP97586
PhosphoSitePlusiP97586

Expressioni

Tissue specificityi

Expressed predominantly in whole brain and kidney, with limited expression in heart, lung, liver, and skeletal muscle and no expression in spleen and testis. Also expressed in pituitary gland, adrenal gland, digestive tract, and reproductive organs.1 Publication

Inductioni

By p53.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010586

Structurei

3D structure databases

ProteinModelPortaliP97586
SMRiP97586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 106EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 150EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Domaini

Both EF-hands are required for function.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J4PJ Eukaryota
ENOG41128UK LUCA
HOGENOMiHOG000074093
HOVERGENiHBG050931
InParanoidiP97586
PhylomeDBiP97586
TreeFamiTF315801

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRWLMQMLM LPLLLLPLGQ AAPKDGVARL DPEAQQQLTT NPFQPGPEQL
60 70 80 90 100
RRLRDYLKGL EKMEEDPEQM NREQVLLYLF ALHDFDQNGQ LDGLELLSML
110 120 130 140 150
TAALAPGAAH FPINPVILVV DMVLETQDLD GDGLMTPAEL INFPGEAPKR
160 170 180 190 200
AESLPPALQE PQPAGSQPLL ANSPLQSETQ QSLGTKEEIT SQVEAKRALE
210 220 230 240 250
PEQEAGHHIE TKVDALSPEG EARGQAESEG DAPGPREDAE RQVESKDNEG
260 270 280
EAKDLPAETL ETQNTPNVVE AHSIQLENDE I
Length:281
Mass (Da):30,835
Last modified:May 1, 1997 - v1
Checksum:iC8195BED34BB1549
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66470 mRNA Translation: AAC52950.1
RefSeqiNP_620787.2, NM_139087.2
UniGeneiRn.31842

Genome annotation databases

GeneIDi245918
KEGGirno:245918

Similar proteinsi

Entry informationi

Entry nameiCGRE1_RAT
AccessioniPrimary (citable) accession number: P97586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome