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Protein

Prostaglandin reductase 1

Gene

Ptgr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity).By similarity

Catalytic activityi

A n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H.
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+ = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei178NADPBy similarity1
Binding sitei193NADPBy similarity1
Binding sitei217NADPBy similarity1
Binding sitei321NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 155NADPBy similarity4
Nucleotide bindingi239 – 245NADPBy similarity7
Nucleotide bindingi270 – 272NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • response to antineoplastic agent Source: RGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin reductase 1 (EC:1.3.1.-)
Short name:
PRG-1
Alternative name(s):
15-oxoprostaglandin 13-reductase (EC:1.3.1.48)
Dithiolethione-inducible gene 1 protein
Short name:
D3T-inducible gene 1 protein
Short name:
DIG-1
NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC:1.3.1.74)
Gene namesi
Name:Ptgr1
Synonyms:Dig1, Ltb4dh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621195 Ptgr1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4166

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180691 – 329Prostaglandin reductase 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineBy similarity1
Modified residuei20PhosphoserineBy similarity1
Modified residuei178N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP97584
PRIDEiP97584

PTM databases

iPTMnetiP97584
PhosphoSitePlusiP97584

Expressioni

Inductioni

Up-regulated by 1,2-dithiole-3-thione (D3T).1 Publication

Gene expression databases

BgeeiENSRNOG00000015072
GenevisibleiP97584 RN

Interactioni

Subunit structurei

Monomer or homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020335

Chemistry databases

BindingDBiP97584

Structurei

3D structure databases

ProteinModelPortaliP97584
SMRiP97584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi250 – 257Pro-rich8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1196 Eukaryota
COG2130 LUCA
GeneTreeiENSGT00390000009335
HOGENOMiHOG000294663
HOVERGENiHBG055024
InParanoidiP97584
KOiK13948
OMAiRMNDSKS
OrthoDBiEOG091G0F5B
PhylomeDBiP97584
TreeFamiTF324201

Family and domain databases

CDDicd08294 leukotriene_B4_DH_like, 1 hit
InterProiView protein in InterPro
IPR013149 ADH_C
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR014190 PTGR1
PfamiView protein in Pfam
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02825 B4_12hDH, 1 hit

Sequencei

Sequence statusi: Complete.

P97584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQAKTWTLK KHFEGFPTDS NFELRTTELP PLNNGEVLLE ALFLSVDPYM
60 70 80 90 100
RVAAKKLKEG DSMMGEQVAR VVESKNSAFP TGTIVVALLG WTSHSISDGN
110 120 130 140 150
GLRKLPAEWP DKLPLSLALG TVGMPGLTAY FGLLDICGLK GGETVLVNAA
160 170 180 190 200
AGAVGSVVGQ IAKLKGCKVV GTAGSDEKVA YLKKLGFDVA FNYKTVKSLE
210 220 230 240 250
EALRTASPDG YDCYFDNVGG EFSNTVILQM KTFGRIAICG AISQYNRTGP
260 270 280 290 300
CPPGPSPEVI IYQQLRMEGF IVTRWQGEVR QKALTDLMNW VSEGKIRYHE
310 320
YITEGFEKMP AAFMGMLKGD NLGKTIVKA
Length:329
Mass (Da):35,718
Last modified:May 1, 2000 - v3
Checksum:i8E91165086A05BA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66322 mRNA Translation: AAB88912.2
BC089775 mRNA Translation: AAH89775.1
RefSeqiNP_620218.1, NM_138863.2
UniGeneiRn.10656

Genome annotation databases

EnsembliENSRNOT00000020335; ENSRNOP00000020335; ENSRNOG00000015072
GeneIDi192227
KEGGirno:192227
UCSCiRGD:621195 rat

Similar proteinsi

Entry informationi

Entry nameiPTGR1_RAT
AccessioniPrimary (citable) accession number: P97584
Secondary accession number(s): Q5EBD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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