ID BKRB1_RAT Reviewed; 337 AA. AC P97583; O35782; Q9R250; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 2. DT 27-MAR-2024, entry version 153. DE RecName: Full=B1 bradykinin receptor; DE Short=B1R; DE Short=BK-1 receptor; DE AltName: Full=Kinin B1 receptor; DE Short=KB1; GN Name=Bdkrb1; Synonyms=B1bkr, Bkr; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION. RC STRAIN=Sprague-Dawley; RX PubMed=9804950; DOI=10.1016/s0167-4781(98)00163-8; RA Ni A., Chai K.X., Chao L., Chao J.; RT "Molecular cloning and expression of rat bradykinin B1 receptor."; RL Biochim. Biophys. Acta 1442:177-185(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION. RC STRAIN=Sprague-Dawley; TISSUE=Urinary bladder; RX PubMed=10422787; DOI=10.1016/s0014-2999(99)00315-5; RA Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., RA Docherty R.J., Webb M., Bevan S.J., McIntyre P.; RT "Molecular characterisation of cloned bradykinin B1 receptors from rat and RT human."; RL Eur. J. Pharmacol. 374:423-433(1999). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sprague-Dawley; RA Oliveira S.M., Araujo R.C., Pesquero J.L., Bader M., Pesquero J.B.; RT "Molecular cloning of a rat kinin B1 receptor gene."; RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE OF 1-15. RC STRAIN=Sprague-Dawley; RA Schanstra J.P., Girolami J.P., Bascands J.L.; RT "Rat bradykinin B1 gene, promoter region, exon 1, intron 1, and exon 2."; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This is a receptor for bradykinin. Could be a factor in CC chronic pain and inflammation. {ECO:0000250|UniProtKB:P46663}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P46663}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Expressed in bladder, lung, duodenum, kidney, CC uterus, thymus, salivary gland, testis, prostate, macrophages, aorta, CC spleen and heart. CC -!- INDUCTION: By lipopolysaccharide (LPS), four hours after treatment CC levels show an increase in many tissues. After 12 hours maximum levels CC are observed in the heart. {ECO:0000269|PubMed:10422787, CC ECO:0000269|PubMed:9804950}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Bradykinin receptor subfamily. BDKRB1 sub-subfamily. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U66107; AAC78505.2; -; mRNA. DR EMBL; AJ132230; CAA10610.1; -; mRNA. DR EMBL; AF009899; AAB63592.1; -; Genomic_DNA. DR EMBL; AF114406; AAD29286.1; -; Genomic_DNA. DR RefSeq; NP_110478.1; NM_030851.1. DR RefSeq; XP_008763083.1; XM_008764861.2. DR AlphaFoldDB; P97583; -. DR SMR; P97583; -. DR STRING; 10116.ENSRNOP00000005953; -. DR BindingDB; P97583; -. DR ChEMBL; CHEMBL4613; -. DR DrugCentral; P97583; -. DR GuidetoPHARMACOLOGY; 41; -. DR GlyCosmos; P97583; 3 sites, No reported glycans. DR GlyGen; P97583; 3 sites. DR PhosphoSitePlus; P97583; -. DR PaxDb; 10116-ENSRNOP00000005953; -. DR Ensembl; ENSRNOT00000005953.4; ENSRNOP00000005953.2; ENSRNOG00000004488.4. DR Ensembl; ENSRNOT00055048490; ENSRNOP00055039857; ENSRNOG00055028026. DR Ensembl; ENSRNOT00060037544; ENSRNOP00060030942; ENSRNOG00060021683. DR Ensembl; ENSRNOT00065045867; ENSRNOP00065037638; ENSRNOG00065026555. DR GeneID; 81509; -. DR KEGG; rno:81509; -. DR UCSC; RGD:620401; rat. DR AGR; RGD:620401; -. DR CTD; 623; -. DR RGD; 620401; Bdkrb1. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01030000234534; -. DR HOGENOM; CLU_009579_8_3_1; -. DR InParanoid; P97583; -. DR OMA; YLTFVHT; -. DR OrthoDB; 4730030at2759; -. DR PhylomeDB; P97583; -. DR TreeFam; TF330024; -. DR Reactome; R-RNO-375276; Peptide ligand-binding receptors. DR Reactome; R-RNO-416476; G alpha (q) signalling events. DR Reactome; R-RNO-418594; G alpha (i) signalling events. DR PRO; PR:P97583; -. DR Proteomes; UP000002494; Chromosome 6. DR Bgee; ENSRNOG00000004488; Expressed in stomach and 4 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004947; F:bradykinin receptor activity; IDA:RGD. DR GO; GO:0042277; F:peptide binding; IPI:RGD. DR GO; GO:0016477; P:cell migration; IMP:RGD. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD. DR GO; GO:0030308; P:negative regulation of cell growth; IMP:RGD. DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD. DR GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD. DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:RGD. DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IDA:RGD. DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD. DR GO; GO:0009612; P:response to mechanical stimulus; IEA:InterPro. DR CDD; cd15380; 7tmA_BK-1; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR001186; Brdyknn_1_rcpt. DR InterPro; IPR000496; Brdyknn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF948; B2 BRADYKININ RECEPTOR; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00425; BRADYKININR. DR PRINTS; PR00993; BRADYKINNB1R. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR Genevisible; P97583; RN. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..337 FT /note="B1 bradykinin receptor" FT /id="PRO_0000069187" FT TOPO_DOM 1..41 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 42..62 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 63..83 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 84..104 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 105..121 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 122..142 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 143..164 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 165..185 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 186..217 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 218..238 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 239..261 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 262..282 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 283..305 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 306..326 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 327..337 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 13 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 21 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 195 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 120..199 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 337 AA; 38378 MW; 226828DF0F26BA8E CRC64; MASEVLLELQ PSNRSLQAPA NITSCESALE DWDLLYRVLP GFVITICFFG LLGNLLVLSF FLLPWRQWWW QQRQRQQRLT IAEIYLANLA ASDLVFVLGL PFWAENIGNR FNWPFGTDLC RVVSGVIKAN LFVSIFLVVA ISQDRYRLLV YPMTSWGYRR RRQAQATCLL IWVAGGLLSI PTFLLRSVKV VPDLNVSACI LLFPHEAWHF ARMVELNVLG FLLPVTAIIF FNYHILASLR GQKEASRTRC GGPKGSKTTG LILTLVASFL VCWCPYHFFA FLDFLVQVRV IQDCSWKEIT DLGLQLANFF AFVNSCLNPL IYVFAGRLLK TRVLGTL //