Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97583

- BKRB1_RAT

UniProt

P97583 - BKRB1_RAT

Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

    GO - Molecular functioni

    1. bradykinin receptor activity Source: RGD
    2. peptide binding Source: RGD

    GO - Biological processi

    1. cell migration Source: RGD
    2. G-protein coupled receptor signaling pathway Source: RGD
    3. inflammatory response Source: RGD
    4. negative regulation of blood pressure Source: RGD
    5. negative regulation of cell growth Source: RGD
    6. negative regulation of protein phosphorylation Source: RGD
    7. positive regulation of leukocyte migration Source: RGD
    8. positive regulation of release of sequestered calcium ion into cytosol Source: RGD
    9. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
    10. response to lipopolysaccharide Source: RGD
    11. response to mechanical stimulus Source: InterPro
    12. sensory perception of pain Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B1 bradykinin receptor
    Short name:
    B1R
    Short name:
    BK-1 receptor
    Alternative name(s):
    Kinin B1 receptor
    Short name:
    KB1
    Gene namesi
    Name:Bdkrb1
    Synonyms:B1bkr, Bkr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi620401. Bdkrb1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: RGD
    3. neuron projection Source: RGD
    4. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337B1 bradykinin receptorPRO_0000069187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 199PROSITE-ProRule annotation
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP97583.

    Expressioni

    Tissue specificityi

    Expressed in bladder, lung, duodenum, kidney, uterus, thymus, salivary gland, testis, prostate, macrophages, aorta, spleen and heart.

    Inductioni

    By lipopolysaccharide (LPS), four hours after treatment levels show an increase in many tissues. After 12 hours maximum levels are observed in the heart.2 Publications

    Gene expression databases

    GenevestigatoriP97583.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005953.

    Structurei

    3D structure databases

    ProteinModelPortaliP97583.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini105 – 12117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 16422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 21732ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini239 – 26123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 33711CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG327312.
    GeneTreeiENSGT00720000108671.
    HOGENOMiHOG000010314.
    HOVERGENiHBG103183.
    InParanoidiP97583.
    KOiK03915.
    OMAiPYHFFAF.
    OrthoDBiEOG7K9K36.
    PhylomeDBiP97583.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97583-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASEVLLELQ PSNRSLQAPA NITSCESALE DWDLLYRVLP GFVITICFFG    50
    LLGNLLVLSF FLLPWRQWWW QQRQRQQRLT IAEIYLANLA ASDLVFVLGL 100
    PFWAENIGNR FNWPFGTDLC RVVSGVIKAN LFVSIFLVVA ISQDRYRLLV 150
    YPMTSWGYRR RRQAQATCLL IWVAGGLLSI PTFLLRSVKV VPDLNVSACI 200
    LLFPHEAWHF ARMVELNVLG FLLPVTAIIF FNYHILASLR GQKEASRTRC 250
    GGPKGSKTTG LILTLVASFL VCWCPYHFFA FLDFLVQVRV IQDCSWKEIT 300
    DLGLQLANFF AFVNSCLNPL IYVFAGRLLK TRVLGTL 337
    Length:337
    Mass (Da):38,378
    Last modified:November 1, 1999 - v2
    Checksum:i226828DF0F26BA8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66107 mRNA. Translation: AAC78505.2.
    AJ132230 mRNA. Translation: CAA10610.1.
    AF009899 Genomic DNA. Translation: AAB63592.1.
    AF114406 Genomic DNA. Translation: AAD29286.1.
    RefSeqiNP_110478.1. NM_030851.1.
    UniGeneiRn.10762.

    Genome annotation databases

    EnsembliENSRNOT00000005953; ENSRNOP00000005953; ENSRNOG00000004488.
    GeneIDi81509.
    KEGGirno:81509.
    UCSCiRGD:620401. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66107 mRNA. Translation: AAC78505.2 .
    AJ132230 mRNA. Translation: CAA10610.1 .
    AF009899 Genomic DNA. Translation: AAB63592.1 .
    AF114406 Genomic DNA. Translation: AAD29286.1 .
    RefSeqi NP_110478.1. NM_030851.1.
    UniGenei Rn.10762.

    3D structure databases

    ProteinModelPortali P97583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005953.

    Chemistry

    BindingDBi P97583.
    ChEMBLi CHEMBL4613.
    GuidetoPHARMACOLOGYi 41.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi P97583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005953 ; ENSRNOP00000005953 ; ENSRNOG00000004488 .
    GeneIDi 81509.
    KEGGi rno:81509.
    UCSCi RGD:620401. rat.

    Organism-specific databases

    CTDi 623.
    RGDi 620401. Bdkrb1.

    Phylogenomic databases

    eggNOGi NOG327312.
    GeneTreei ENSGT00720000108671.
    HOGENOMi HOG000010314.
    HOVERGENi HBG103183.
    InParanoidi P97583.
    KOi K03915.
    OMAi PYHFFAF.
    OrthoDBi EOG7K9K36.
    PhylomeDBi P97583.
    TreeFami TF330024.

    Miscellaneous databases

    NextBioi 614979.
    PROi P97583.

    Gene expression databases

    Genevestigatori P97583.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001186. Brdyknn_1_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00425. BRADYKININR.
    PR00993. BRADYKINNB1R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of rat bradykinin B1 receptor."
      Ni A., Chai K.X., Chao L., Chao J.
      Biochim. Biophys. Acta 1442:177-185(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: Sprague-Dawley.
    2. "Molecular characterisation of cloned bradykinin B1 receptors from rat and human."
      Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P.
      Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: Sprague-Dawley.
      Tissue: Urinary bladder.
    3. "Molecular cloning of a rat kinin B1 receptor gene."
      Oliveira S.M., Araujo R.C., Pesquero J.L., Bader M., Pesquero J.B.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-Dawley.
    4. "Rat bradykinin B1 gene, promoter region, exon 1, intron 1, and exon 2."
      Schanstra J.P., Girolami J.P., Bascands J.L.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-15.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiBKRB1_RAT
    AccessioniPrimary (citable) accession number: P97583
    Secondary accession number(s): O35782, Q9R250
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3