B1 bradykinin receptor - Rattus norvegicus (Rat)

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P97583 (BKRB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
B1 bradykinin receptor
Short name=B1R
Short name=BK-1 receptor

Alternative name(s):
Kinin B1 receptor
Short name=KB1

Gene names

Name:	Bdkrb1
Synonyms:	B1bkr, Bkr

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in bladder, lung, duodenum, kidney, uterus, thymus, salivary gland, testis, prostate, macrophages, aorta, spleen and heart.
Induction	By lipopolysaccharide (LPS), four hours after treatment levels show an increase in many tissues. After 12 hours maximum levels are observed in the heart. Ref.1 Ref.2
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from mutant phenotype PubMed 20411591. Source: RGD elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from mutant phenotype PubMed 12411434. Source: RGD negative regulation of blood pressure Inferred from mutant phenotype PubMed 15253105 PubMed 16507603. Source: RGD negative regulation of cell growth Inferred from mutant phenotype PubMed 16497153. Source: RGD negative regulation of protein phosphorylation Inferred from mutant phenotype PubMed 16497153. Source: RGD positive regulation of leukocyte migration Inferred from mutant phenotype PubMed 12522068. Source: RGD positive regulation of release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 15576455. Source: RGD protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 15319421. Source: RGD response to lipopolysaccharide Inferred from expression pattern PubMed 19561153. Source: RGD sensory perception of pain Inferred from mutant phenotype PubMed 12927641. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuron projection Inferred from direct assay PubMed 12927641. Source: RGD plasma membrane Inferred from direct assay PubMed 14515994. Source: RGD
Molecular_function	bradykinin receptor activity Inferred from direct assay PubMed 12025968. Source: RGD peptide binding Inferred from physical interaction Ref.2. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 337

337

B1 bradykinin receptor

PRO_0000069187

Regions

Topological domain

1 – 41

Extracellular Potential

Transmembrane

42 – 62

Helical; Name=1; Potential

Topological domain

63 – 83

Cytoplasmic Potential

Transmembrane

84 – 104

Helical; Name=2; Potential

Topological domain

105 – 121

Extracellular Potential

Transmembrane

122 – 142

Helical; Name=3; Potential

Topological domain

143 – 164

Cytoplasmic Potential

Transmembrane

165 – 185

Helical; Name=4; Potential

Topological domain

186 – 217

Extracellular Potential

Transmembrane

218 – 238

Helical; Name=5; Potential

Topological domain

239 – 261

Cytoplasmic Potential

Transmembrane

262 – 282

Helical; Name=6; Potential

Topological domain

283 – 305

Extracellular Potential

Transmembrane

306 – 326

Helical; Name=7; Potential

Topological domain

327 – 337

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

195

N-linked (GlcNAc...) Potential

Disulfide bond

120 ↔ 199

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P97583 [UniParc].

Last modified November 1, 1999. Version 2.
Checksum: 226828DF0F26BA8E
Show »

FASTA

337

38,378

        10         20         30         40         50         60 
MASEVLLELQ PSNRSLQAPA NITSCESALE DWDLLYRVLP GFVITICFFG LLGNLLVLSF 

        70         80         90        100        110        120 
FLLPWRQWWW QQRQRQQRLT IAEIYLANLA ASDLVFVLGL PFWAENIGNR FNWPFGTDLC 

       130        140        150        160        170        180 
RVVSGVIKAN LFVSIFLVVA ISQDRYRLLV YPMTSWGYRR RRQAQATCLL IWVAGGLLSI 

       190        200        210        220        230        240 
PTFLLRSVKV VPDLNVSACI LLFPHEAWHF ARMVELNVLG FLLPVTAIIF FNYHILASLR 

       250        260        270        280        290        300 
GQKEASRTRC GGPKGSKTTG LILTLVASFL VCWCPYHFFA FLDFLVQVRV IQDCSWKEIT 

       310        320        330 
DLGLQLANFF AFVNSCLNPL IYVFAGRLLK TRVLGTL

« Hide

References

[1]	"Molecular cloning and expression of rat bradykinin B1 receptor." Ni A., Chai K.X., Chao L., Chao J. Biochim. Biophys. Acta 1442:177-185(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Strain: Sprague-Dawley.
[2]	"Molecular characterisation of cloned bradykinin B1 receptors from rat and human." Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P. Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Strain: Sprague-Dawley. Tissue: Urinary bladder.
[3]	"Molecular cloning of a rat kinin B1 receptor gene." Oliveira S.M., Araujo R.C., Pesquero J.L., Bader M., Pesquero J.B. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley.
[4]	"Rat bradykinin B1 gene, promoter region, exon 1, intron 1, and exon 2." Schanstra J.P., Girolami J.P., Bascands J.L. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-15. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U66107 mRNA. Translation: AAC78505.2. AJ132230 mRNA. Translation: CAA10610.1. AF009899 Genomic DNA. Translation: AAB63592.1. AF114406 Genomic DNA. Translation: AAD29286.1.
IPI	IPI00205635.
RefSeq	NP_110478.1. NM_030851.1.
UniGene	Rn.10762.
3D structure databases
ProteinModelPortal	P97583.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005953.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	P97583.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000005953; ENSRNOP00000005953; ENSRNOG00000004488.
GeneID	81509.
KEGG	rno:81509.
UCSC	RGD:620401. rat.
Organism-specific databases
CTD	623.
RGD	620401. Bdkrb1.
Phylogenomic databases
eggNOG	NOG327312.
GeneTree	ENSGT00700000104167.
HOGENOM	HOG000010314.
HOVERGEN	HBG103183.
InParanoid	P97583.
KO	K03915.
OMA	PYHFFAF.
OrthoDB	EOG4WH8M4.
Gene expression databases
Genevestigator	P97583.
GermOnline	ENSRNOG00000004488. Rattus norvegicus.
Family and domain databases
InterPro	IPR001186. Brdyknn_1_rcpt. IPR000496. Brdyknn_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00425. BRADYKININR. PR00993. BRADYKINNB1R. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P97583.
ChEMBL	CHEMBL4613.
NextBio	614979.

Entry information

Entry name

BKRB1_RAT

Accession

Primary (citable) accession number: P97583
Secondary accession number(s): O35782, Q9R250

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents