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Protein

B1 bradykinin receptor

Gene

Bdkrb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

GO - Molecular functioni

  1. bradykinin receptor activity Source: RGD
  2. peptide binding Source: RGD

GO - Biological processi

  1. cell migration Source: RGD
  2. G-protein coupled receptor signaling pathway Source: RGD
  3. inflammatory response Source: RGD
  4. negative regulation of blood pressure Source: RGD
  5. negative regulation of cell growth Source: RGD
  6. negative regulation of protein phosphorylation Source: RGD
  7. positive regulation of leukocyte migration Source: RGD
  8. positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  9. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  10. response to lipopolysaccharide Source: RGD
  11. response to mechanical stimulus Source: InterPro
  12. sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
B1 bradykinin receptor
Short name:
B1R
Short name:
BK-1 receptor
Alternative name(s):
Kinin B1 receptor
Short name:
KB1
Gene namesi
Name:Bdkrb1
Synonyms:B1bkr, Bkr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi620401. Bdkrb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 8321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 12117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini143 – 16422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini186 – 21732ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini239 – 26123CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini283 – 30523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei306 – 32621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini327 – 33711CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: RGD
  3. neuron projection Source: RGD
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337B1 bradykinin receptorPRO_0000069187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 199PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97583.

Expressioni

Tissue specificityi

Expressed in bladder, lung, duodenum, kidney, uterus, thymus, salivary gland, testis, prostate, macrophages, aorta, spleen and heart.

Inductioni

By lipopolysaccharide (LPS), four hours after treatment levels show an increase in many tissues. After 12 hours maximum levels are observed in the heart.2 Publications

Gene expression databases

GenevestigatoriP97583.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005953.

Structurei

3D structure databases

ProteinModelPortaliP97583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327312.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP97583.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiP97583.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97583-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEVLLELQ PSNRSLQAPA NITSCESALE DWDLLYRVLP GFVITICFFG
60 70 80 90 100
LLGNLLVLSF FLLPWRQWWW QQRQRQQRLT IAEIYLANLA ASDLVFVLGL
110 120 130 140 150
PFWAENIGNR FNWPFGTDLC RVVSGVIKAN LFVSIFLVVA ISQDRYRLLV
160 170 180 190 200
YPMTSWGYRR RRQAQATCLL IWVAGGLLSI PTFLLRSVKV VPDLNVSACI
210 220 230 240 250
LLFPHEAWHF ARMVELNVLG FLLPVTAIIF FNYHILASLR GQKEASRTRC
260 270 280 290 300
GGPKGSKTTG LILTLVASFL VCWCPYHFFA FLDFLVQVRV IQDCSWKEIT
310 320 330
DLGLQLANFF AFVNSCLNPL IYVFAGRLLK TRVLGTL
Length:337
Mass (Da):38,378
Last modified:November 1, 1999 - v2
Checksum:i226828DF0F26BA8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66107 mRNA. Translation: AAC78505.2.
AJ132230 mRNA. Translation: CAA10610.1.
AF009899 Genomic DNA. Translation: AAB63592.1.
AF114406 Genomic DNA. Translation: AAD29286.1.
RefSeqiNP_110478.1. NM_030851.1.
XP_008763083.1. XM_008764861.1.
UniGeneiRn.10762.

Genome annotation databases

EnsembliENSRNOT00000005953; ENSRNOP00000005953; ENSRNOG00000004488.
GeneIDi81509.
KEGGirno:81509.
UCSCiRGD:620401. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66107 mRNA. Translation: AAC78505.2.
AJ132230 mRNA. Translation: CAA10610.1.
AF009899 Genomic DNA. Translation: AAB63592.1.
AF114406 Genomic DNA. Translation: AAD29286.1.
RefSeqiNP_110478.1. NM_030851.1.
XP_008763083.1. XM_008764861.1.
UniGeneiRn.10762.

3D structure databases

ProteinModelPortaliP97583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005953.

Chemistry

BindingDBiP97583.
ChEMBLiCHEMBL4613.
GuidetoPHARMACOLOGYi41.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP97583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005953; ENSRNOP00000005953; ENSRNOG00000004488.
GeneIDi81509.
KEGGirno:81509.
UCSCiRGD:620401. rat.

Organism-specific databases

CTDi623.
RGDi620401. Bdkrb1.

Phylogenomic databases

eggNOGiNOG327312.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000010314.
HOVERGENiHBG103183.
InParanoidiP97583.
KOiK03915.
OMAiPYHFFAF.
OrthoDBiEOG7K9K36.
PhylomeDBiP97583.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_250028. Peptide ligand-binding receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi614979.
PROiP97583.

Gene expression databases

GenevestigatoriP97583.

Family and domain databases

InterProiIPR001186. Brdyknn_1_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00993. BRADYKINNB1R.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of rat bradykinin B1 receptor."
    Ni A., Chai K.X., Chao L., Chao J.
    Biochim. Biophys. Acta 1442:177-185(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: Sprague-Dawley.
  2. "Molecular characterisation of cloned bradykinin B1 receptors from rat and human."
    Jones C., Phillips E., Davis C., Arbuckle J., Yaqoob M., Burgess G.M., Docherty R.J., Webb M., Bevan S.J., McIntyre P.
    Eur. J. Pharmacol. 374:423-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: Sprague-Dawley.
    Tissue: Urinary bladder.
  3. "Molecular cloning of a rat kinin B1 receptor gene."
    Oliveira S.M., Araujo R.C., Pesquero J.L., Bader M., Pesquero J.B.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-Dawley.
  4. "Rat bradykinin B1 gene, promoter region, exon 1, intron 1, and exon 2."
    Schanstra J.P., Girolami J.P., Bascands J.L.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-15.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiBKRB1_RAT
AccessioniPrimary (citable) accession number: P97583
Secondary accession number(s): O35782, Q9R250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.