Fasciculation and elongation protein zeta-1

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P97577 (FEZ1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Fasciculation and elongation protein zeta-1

Alternative name(s):
Zygin I
Zygin-1

Gene names

Name:

Fez1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules. Ref.4 Ref.5
Subunit structure	Homodimer. Interacts with UBE4B and SAP30L By similarity. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 By similarity. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation By similarity. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon.
Subcellular location	Cytoplasm › cytoskeleton › centrosome By similarity. Cell membrane. Note: Co-localizes with both, alpha- and gamma-tubulin By similarity. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta.
Tissue specificity	Brain.
Post-translational modification	Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination. Ref.1 Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 By similarity.
Sequence similarities	Belongs to the zygin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane Microtubule
Domain	Coiled coil
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement Ref.1. Source: RGD cellular response to growth factor stimulus Inferred from expression pattern Ref.5. Source: RGD establishment of mitochondrion localization Inferred from mutant phenotype Ref.5. Source: RGD positive regulation of neuron differentiation Inferred from direct assay Ref.1. Source: RGD positive regulation of neuron projection development Inferred from mutant phenotype Ref.5. Source: RGD transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	axon Inferred from direct assay PubMed 19199094. Source: RGD centrosome Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay PubMed 19199094. Source: RGD dendrite Inferred from direct assay PubMed 19199094. Source: RGD microtubule Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 393

393

Fasciculation and elongation protein zeta-1

PRO_0000189527

Regions

Coiled coil

231 – 299

Potential

Compositional bias

95 – 98

Poly-Glu

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

317

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P97577 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 62F1F9552E326C55
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FASTA

393

45,244

        10         20         30         40         50         60 
MEAPLVSLDE EFEDIRPCCT EDPEEKPQSL YGTSPHHLED PSLSELENFS SEIISFKSME 

        70         80         90        100        110        120 
DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL RDEEVWDALT DNYIPSLSED 

       130        140        150        160        170        180 
WRDPNIEALN GNSSDTEIHE KEEEDEFIEK SENDSGINEE PLLTADQVIE EIEEMMQNSP 

       190        200        210        220        230        240 
DPEEEVEVLE EEDGGEISSQ ADSVLLQEMQ ALTQTFNNNW SYEGLRHMSG SELTELLDQV 

       250        260        270        280        290        300 
EGAIRDFSEE LVHQLARRDE LEFEKEVKNS FITVLIEVQN KQKEQRELMK KRRKEKGLSL 

       310        320        330        340        350        360 
QSSRIEKGNQ MPLKRFSMEG ISNILQSGIR QTFGSSGADR QYLNTVIPYE KKSSPPSVED 

       370        380        390 
LQMLTNILFA MKEDNEKVPT LLTDYILKVL CPT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein." Kuroda S., Nakagawa N., Tokunaga C., Tatematsu K., Tanizawa K. J. Cell Biol. 144:403-411(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"Zigins: a family of synaptotagmin-interacting proteins related to unc-76." Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility." Ikuta J., Maturana A., Fujita T., Okajima T., Tatematsu K., Tanizawa K., Kuroda S. Biochem. Biophys. Res. Commun. 353:127-132(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells." Fujita T., Maturana A.D., Ikuta J., Hamada J., Walchli S., Suzuki T., Sawa H., Wooten M.W., Okajima T., Tatematsu K., Tanizawa K., Kuroda S. Biochem. Biophys. Res. Commun. 361:605-610(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U48249 mRNA. Translation: AAC71216.2. U63740 mRNA. Translation: AAB40630.1. BC087740 mRNA. Translation: AAH87740.1.
IPI	IPI00205599.
RefSeq	NP_112328.1. NM_031066.1.
UniGene	Rn.5468.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000008285.
Proteomic databases
PaxDb	P97577.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000008285; ENSRNOP00000008285; ENSRNOG00000006075.
GeneID	81730.
KEGG	rno:81730.
UCSC	RGD:619708. rat.
Organism-specific databases
CTD	9638.
RGD	619708. Fez1.
Phylogenomic databases
eggNOG	NOG273183.
GeneTree	ENSGT00390000017627.
HOGENOM	HOG000019494.
HOVERGEN	HBG005657.
InParanoid	P97577.
OMA	EMMENSP.
OrthoDB	EOG4SF967.
Gene expression databases
Genevestigator	P97577.
GermOnline	ENSRNOG00000006075. Rattus norvegicus.
Family and domain databases
InterPro	IPR011680. FEZ. IPR015642. FEZ_1. [Graphical view]
PANTHER	PTHR12394. PTHR12394. 1 hit. PTHR12394:SF4. PTHR12394:SF4. 1 hit.
Pfam	PF07763. FEZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615396.

Entry information

Entry name

FEZ1_RAT

Accession

Primary (citable) accession number: P97577
Secondary accession number(s): Q62922

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents