Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97577

- FEZ1_RAT

UniProt

P97577 - FEZ1_RAT

Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.2 Publications

    GO - Molecular functioni

    1. protein binding Source: RGD
    2. protein kinase C binding Source: RGD
    3. protein N-terminus binding Source: RGD

    GO - Biological processi

    1. axon guidance Source: RGD
    2. cellular response to growth factor stimulus Source: RGD
    3. establishment of mitochondrion localization Source: RGD
    4. positive regulation of neuron differentiation Source: RGD
    5. positive regulation of neuron projection development Source: RGD
    6. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fasciculation and elongation protein zeta-1
    Alternative name(s):
    Zygin I
    Zygin-1
    Gene namesi
    Name:Fez1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi619708. Fez1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell membrane
    Note: Colocalizes with both, alpha- and gamma-tubulin By similarity. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta.By similarity

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell projection Source: RGD
    3. centrosome Source: Ensembl
    4. cytoplasm Source: RGD
    5. dendrite Source: RGD
    6. microtubule Source: UniProtKB-KW
    7. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Fasciculation and elongation protein zeta-1PRO_0000189527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.1 Publication
    Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP97577.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    GenevestigatoriP97577.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with UBE4B and SAP30L By similarity. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 By similarity. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation By similarity. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon.By similarity

    Protein-protein interaction databases

    BioGridi249603. 1 interaction.
    STRINGi10116.ENSRNOP00000008285.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili231 – 29969Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 984Poly-Glu

    Sequence similaritiesi

    Belongs to the zygin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG273183.
    GeneTreeiENSGT00390000017627.
    HOGENOMiHOG000019494.
    HOVERGENiHBG005657.
    InParanoidiP97577.
    OMAiEMMENSP.
    OrthoDBiEOG7CCBRQ.
    PhylomeDBiP97577.
    TreeFamiTF313128.

    Family and domain databases

    InterProiIPR011680. FEZ.
    IPR015642. FEZ_1.
    [Graphical view]
    PANTHERiPTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF4. PTHR12394:SF4. 1 hit.
    PfamiPF07763. FEZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97577-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPLVSLDE EFEDIRPCCT EDPEEKPQSL YGTSPHHLED PSLSELENFS    50
    SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL 100
    RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDTEIHE KEEEDEFIEK 150
    SENDSGINEE PLLTADQVIE EIEEMMQNSP DPEEEVEVLE EEDGGEISSQ 200
    ADSVLLQEMQ ALTQTFNNNW SYEGLRHMSG SELTELLDQV EGAIRDFSEE 250
    LVHQLARRDE LEFEKEVKNS FITVLIEVQN KQKEQRELMK KRRKEKGLSL 300
    QSSRIEKGNQ MPLKRFSMEG ISNILQSGIR QTFGSSGADR QYLNTVIPYE 350
    KKSSPPSVED LQMLTNILFA MKEDNEKVPT LLTDYILKVL CPT 393
    Length:393
    Mass (Da):45,244
    Last modified:May 1, 1997 - v1
    Checksum:i62F1F9552E326C55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48249 mRNA. Translation: AAC71216.2.
    U63740 mRNA. Translation: AAB40630.1.
    BC087740 mRNA. Translation: AAH87740.1.
    RefSeqiNP_112328.1. NM_031066.1.
    XP_006242873.1. XM_006242811.1.
    UniGeneiRn.5468.

    Genome annotation databases

    EnsembliENSRNOT00000008285; ENSRNOP00000008285; ENSRNOG00000006075.
    GeneIDi81730.
    KEGGirno:81730.
    UCSCiRGD:619708. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U48249 mRNA. Translation: AAC71216.2 .
    U63740 mRNA. Translation: AAB40630.1 .
    BC087740 mRNA. Translation: AAH87740.1 .
    RefSeqi NP_112328.1. NM_031066.1.
    XP_006242873.1. XM_006242811.1.
    UniGenei Rn.5468.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249603. 1 interaction.
    STRINGi 10116.ENSRNOP00000008285.

    Proteomic databases

    PaxDbi P97577.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008285 ; ENSRNOP00000008285 ; ENSRNOG00000006075 .
    GeneIDi 81730.
    KEGGi rno:81730.
    UCSCi RGD:619708. rat.

    Organism-specific databases

    CTDi 9638.
    RGDi 619708. Fez1.

    Phylogenomic databases

    eggNOGi NOG273183.
    GeneTreei ENSGT00390000017627.
    HOGENOMi HOG000019494.
    HOVERGENi HBG005657.
    InParanoidi P97577.
    OMAi EMMENSP.
    OrthoDBi EOG7CCBRQ.
    PhylomeDBi P97577.
    TreeFami TF313128.

    Miscellaneous databases

    NextBioi 615396.
    PROi P97577.

    Gene expression databases

    Genevestigatori P97577.

    Family and domain databases

    InterProi IPR011680. FEZ.
    IPR015642. FEZ_1.
    [Graphical view ]
    PANTHERi PTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF4. PTHR12394:SF4. 1 hit.
    Pfami PF07763. FEZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein."
      Kuroda S., Nakagawa N., Tokunaga C., Tatematsu K., Tanizawa K.
      J. Cell Biol. 144:403-411(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Zigins: a family of synaptotagmin-interacting proteins related to unc-76."
      Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility."
      Ikuta J., Maturana A., Fujita T., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
      Biochem. Biophys. Res. Commun. 353:127-132(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells."
      Fujita T., Maturana A.D., Ikuta J., Hamada J., Walchli S., Suzuki T., Sawa H., Wooten M.W., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
      Biochem. Biophys. Res. Commun. 361:605-610(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiFEZ1_RAT
    AccessioniPrimary (citable) accession number: P97577
    Secondary accession number(s): Q62922
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3