SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P97577

- FEZ1_RAT

UniProt

P97577 - FEZ1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fasciculation and elongation protein zeta-1

Gene
Fez1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.2 Publications

GO - Molecular functioni

  1. protein binding Source: RGD
  2. protein kinase C binding Source: RGD
  3. protein N-terminus binding Source: RGD

GO - Biological processi

  1. axon guidance Source: RGD
  2. cellular response to growth factor stimulus Source: RGD
  3. establishment of mitochondrion localization Source: RGD
  4. positive regulation of neuron differentiation Source: RGD
  5. positive regulation of neuron projection development Source: RGD
  6. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:Fez1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi619708. Fez1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cell membrane
Note: Colocalizes with both, alpha- and gamma-tubulin By similarity. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta.

GO - Cellular componenti

  1. axon Source: RGD
  2. cell projection Source: RGD
  3. centrosome Source: Ensembl
  4. cytoplasm Source: RGD
  5. dendrite Source: RGD
  6. microtubule Source: UniProtKB-KW
  7. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Fasciculation and elongation protein zeta-1PRO_0000189527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.1 Publication
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP97577.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

GenevestigatoriP97577.

Interactioni

Subunit structurei

Homodimer. Interacts with UBE4B and SAP30L By similarity. Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 By similarity. Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation By similarity. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon.

Protein-protein interaction databases

BioGridi249603. 1 interaction.
STRINGi10116.ENSRNOP00000008285.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili231 – 29969 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 984Poly-Glu

Sequence similaritiesi

Belongs to the zygin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG273183.
GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiP97577.
OMAiEMMENSP.
OrthoDBiEOG7CCBRQ.
PhylomeDBiP97577.
TreeFamiTF313128.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97577-1 [UniParc]FASTAAdd to Basket

« Hide

MEAPLVSLDE EFEDIRPCCT EDPEEKPQSL YGTSPHHLED PSLSELENFS    50
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL 100
RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDTEIHE KEEEDEFIEK 150
SENDSGINEE PLLTADQVIE EIEEMMQNSP DPEEEVEVLE EEDGGEISSQ 200
ADSVLLQEMQ ALTQTFNNNW SYEGLRHMSG SELTELLDQV EGAIRDFSEE 250
LVHQLARRDE LEFEKEVKNS FITVLIEVQN KQKEQRELMK KRRKEKGLSL 300
QSSRIEKGNQ MPLKRFSMEG ISNILQSGIR QTFGSSGADR QYLNTVIPYE 350
KKSSPPSVED LQMLTNILFA MKEDNEKVPT LLTDYILKVL CPT 393
Length:393
Mass (Da):45,244
Last modified:May 1, 1997 - v1
Checksum:i62F1F9552E326C55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48249 mRNA. Translation: AAC71216.2.
U63740 mRNA. Translation: AAB40630.1.
BC087740 mRNA. Translation: AAH87740.1.
RefSeqiNP_112328.1. NM_031066.1.
XP_006242873.1. XM_006242811.1.
UniGeneiRn.5468.

Genome annotation databases

EnsembliENSRNOT00000008285; ENSRNOP00000008285; ENSRNOG00000006075.
GeneIDi81730.
KEGGirno:81730.
UCSCiRGD:619708. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U48249 mRNA. Translation: AAC71216.2 .
U63740 mRNA. Translation: AAB40630.1 .
BC087740 mRNA. Translation: AAH87740.1 .
RefSeqi NP_112328.1. NM_031066.1.
XP_006242873.1. XM_006242811.1.
UniGenei Rn.5468.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249603. 1 interaction.
STRINGi 10116.ENSRNOP00000008285.

Proteomic databases

PaxDbi P97577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008285 ; ENSRNOP00000008285 ; ENSRNOG00000006075 .
GeneIDi 81730.
KEGGi rno:81730.
UCSCi RGD:619708. rat.

Organism-specific databases

CTDi 9638.
RGDi 619708. Fez1.

Phylogenomic databases

eggNOGi NOG273183.
GeneTreei ENSGT00390000017627.
HOGENOMi HOG000019494.
HOVERGENi HBG005657.
InParanoidi P97577.
OMAi EMMENSP.
OrthoDBi EOG7CCBRQ.
PhylomeDBi P97577.
TreeFami TF313128.

Miscellaneous databases

NextBioi 615396.
PROi P97577.

Gene expression databases

Genevestigatori P97577.

Family and domain databases

InterProi IPR011680. FEZ.
IPR015642. FEZ_1.
[Graphical view ]
PANTHERi PTHR12394. PTHR12394. 1 hit.
PTHR12394:SF4. PTHR12394:SF4. 1 hit.
Pfami PF07763. FEZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein."
    Kuroda S., Nakagawa N., Tokunaga C., Tatematsu K., Tanizawa K.
    J. Cell Biol. 144:403-411(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PHOSPHORYLATION.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Zigins: a family of synaptotagmin-interacting proteins related to unc-76."
    Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility."
    Ikuta J., Maturana A., Fujita T., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
    Biochem. Biophys. Res. Commun. 353:127-132(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells."
    Fujita T., Maturana A.D., Ikuta J., Hamada J., Walchli S., Suzuki T., Sawa H., Wooten M.W., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
    Biochem. Biophys. Res. Commun. 361:605-610(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFEZ1_RAT
AccessioniPrimary (citable) accession number: P97577
Secondary accession number(s): Q62922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi