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Protein

GrpE protein homolog 1, mitochondrial

Gene

Grpel1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: GO_Central
  • ATPase activator activity Source: RGD
  • chaperone binding Source: InterPro
  • protein homodimerization activity Source: RGD
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Gene namesi
Name:Grpel1
Synonyms:Grepel1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi70947 Grpel1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27Mitochondrion1 PublicationAdd BLAST27
ChainiPRO_000001305128 – 217GrpE protein homolog 1, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei120N6-succinyllysineBy similarity1
Modified residuei215N6-acetyllysine; alternateBy similarity1
Modified residuei215N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP97576
PRIDEiP97576

PTM databases

iPTMnetiP97576
PhosphoSitePlusiP97576
SwissPalmiP97576

Expressioni

Tissue specificityi

Ubiquitous. Particularly abundant in heart, kidney and liver.

Gene expression databases

BgeeiENSRNOG00000006593
ExpressionAtlasiP97576 baseline and differential
GenevisibleiP97576 RN

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

GO - Molecular functioni

  • chaperone binding Source: InterPro
  • protein homodimerization activity Source: RGD
  • unfolded protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi249476, 3 interactors
STRINGi10116.ENSRNOP00000008930

Structurei

3D structure databases

ProteinModelPortaliP97576
SMRiP97576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003 Eukaryota
COG0576 LUCA
GeneTreeiENSGT00390000005589
HOGENOMiHOG000252083
HOVERGENiHBG051846
InParanoidiP97576
KOiK03687
PhylomeDBiP97576
TreeFamiTF105284

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCVRLAR RSLPALALSF RPSPRLLCTA TKQKNNGQNL EEDLGHCEPK
60 70 80 90 100
TDPSSADKTL LEEKVKLEEQ LKETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQSVPKEEV SNNNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLDPIGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKDA
Length:217
Mass (Da):24,297
Last modified:June 1, 1998 - v2
Checksum:i59A30DA6FC54C6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62940 mRNA Translation: AAC53534.1
BC097312 mRNA Translation: AAH97312.1
RefSeqiNP_077813.1, NM_024487.4
UniGeneiRn.10630

Genome annotation databases

EnsembliENSRNOT00000008932; ENSRNOP00000008930; ENSRNOG00000006593
GeneIDi79563
KEGGirno:79563

Similar proteinsi

Entry informationi

Entry nameiGRPE1_RAT
AccessioniPrimary (citable) accession number: P97576
Secondary accession number(s): Q4QRA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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