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Protein

GrpE protein homolog 1, mitochondrial

Gene

Grpel1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Gene namesi
Name:Grpel1
Synonyms:Grepel1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi70947. Grpel1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion1 PublicationAdd
BLAST
Chaini28 – 217190GrpE protein homolog 1, mitochondrialPRO_0000013051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941N6-acetyllysine; alternateBy similarity
Modified residuei94 – 941N6-succinyllysine; alternateBy similarity
Modified residuei100 – 1001N6-acetyllysineBy similarity
Modified residuei120 – 1201N6-succinyllysineBy similarity
Modified residuei215 – 2151N6-acetyllysine; alternateBy similarity
Modified residuei215 – 2151N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP97576.
PRIDEiP97576.

PTM databases

iPTMnetiP97576.
PhosphoSiteiP97576.

Expressioni

Tissue specificityi

Ubiquitous. Particularly abundant in heart, kidney and liver.

Gene expression databases

BgeeiENSRNOG00000006593.
ExpressionAtlasiP97576. baseline and differential.
GenevisibleiP97576. RN.

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

Protein-protein interaction databases

BioGridi249476. 3 interactions.
STRINGi10116.ENSRNOP00000008930.

Structurei

3D structure databases

ProteinModelPortaliP97576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiP97576.
KOiK03687.
PhylomeDBiP97576.
TreeFamiTF105284.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCVRLAR RSLPALALSF RPSPRLLCTA TKQKNNGQNL EEDLGHCEPK
60 70 80 90 100
TDPSSADKTL LEEKVKLEEQ LKETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQSVPKEEV SNNNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLDPIGAKF DPYEHEALFH TPVEGKEPGT VALVSKVGYK
210
LHGRTLRPAL VGVVKDA
Length:217
Mass (Da):24,297
Last modified:June 1, 1998 - v2
Checksum:i59A30DA6FC54C6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62940 mRNA. Translation: AAC53534.1.
BC097312 mRNA. Translation: AAH97312.1.
RefSeqiNP_077813.1. NM_024487.4.
UniGeneiRn.10630.

Genome annotation databases

EnsembliENSRNOT00000008932; ENSRNOP00000008930; ENSRNOG00000006593.
GeneIDi79563.
KEGGirno:79563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62940 mRNA. Translation: AAC53534.1.
BC097312 mRNA. Translation: AAH97312.1.
RefSeqiNP_077813.1. NM_024487.4.
UniGeneiRn.10630.

3D structure databases

ProteinModelPortaliP97576.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249476. 3 interactions.
STRINGi10116.ENSRNOP00000008930.

PTM databases

iPTMnetiP97576.
PhosphoSiteiP97576.

Proteomic databases

PaxDbiP97576.
PRIDEiP97576.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008932; ENSRNOP00000008930; ENSRNOG00000006593.
GeneIDi79563.
KEGGirno:79563.

Organism-specific databases

CTDi80273.
RGDi70947. Grpel1.

Phylogenomic databases

eggNOGiKOG3003. Eukaryota.
COG0576. LUCA.
GeneTreeiENSGT00390000005589.
HOGENOMiHOG000252083.
HOVERGENiHBG051846.
InParanoidiP97576.
KOiK03687.
PhylomeDBiP97576.
TreeFamiTF105284.

Miscellaneous databases

PROiP97576.

Gene expression databases

BgeeiENSRNOG00000006593.
ExpressionAtlasiP97576. baseline and differential.
GenevisibleiP97576. RN.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE1_RAT
AccessioniPrimary (citable) accession number: P97576
Secondary accession number(s): Q4QRA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.