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Protein

Peroxisomal acyl-coenzyme A oxidase 2

Gene

Acox2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids.1 Publication

Catalytic activityi

(25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestan-26-oyl-CoA + reduced acceptor.1 Publication

Cofactori

FADBy similarity

GO - Molecular functioni

  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity Source: RGD
  • acyl-CoA dehydrogenase activity Source: GO_Central
  • acyl-CoA oxidase activity Source: InterPro
  • FAD binding Source: InterPro
  • fatty acid binding Source: RGD
  • flavin adenine dinucleotide binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14328
BRENDAi1.17.99.3 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 2By similarity (EC:1.17.99.31 Publication)
Alternative name(s):
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidaseBy similarity
Trihydroxycoprostanoyl-CoA oxidase1 Publication
Short name:
THCA-CoA oxidaseBy similarity
Short name:
THCCox
Gene namesi
Name:Acox2Imported
Synonyms:ThcoxImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628684 Acox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046841 – 681Peroxisomal acyl-coenzyme A oxidase 2Add BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Modified residuei9PhosphoserineBy similarity1
Modified residuei66N6-succinyllysineBy similarity1
Modified residuei137N6-succinyllysineBy similarity1
Modified residuei303N6-succinyllysineBy similarity1
Modified residuei453N6-succinyllysineBy similarity1
Modified residuei561N6-succinyllysineBy similarity1
Modified residuei667N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97562
PRIDEiP97562

PTM databases

CarbonylDBiP97562
iPTMnetiP97562
PhosphoSitePlusiP97562

Expressioni

Tissue specificityi

Most abundant in liver. Also expressed in kidney. Not present in any other tissues tested.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010260

Structurei

3D structure databases

ProteinModelPortaliP97562
SMRiP97562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi679 – 681Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
HOGENOMiHOG000181256
HOVERGENiHBG050451
InParanoidiP97562
PhylomeDBiP97562

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

P97562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSPMHRVSL GDHWSWQVHP DIDSERHSPS FSVERLTNIL DGGLPNTVLR
60 70 80 90 100
RKVESIIQSD PVFNLKKLYF MTREELYEDA IQKRFHLEKL AWSLGWSEDG
110 120 130 140 150
PERIYANRVL DGNVNLSLHG VAMNAIRSLG SDEQIAKWGQ LCKNFQIITT
160 170 180 190 200
YAQTELGHGT YLQGLETEAT YDEARQELVI HSPTMTSTKW WPGDLGWSVT
210 220 230 240 250
HAVVLAQLTC LGVRHGMHAF IVPIRSLEDH TPLPGITVGD IGPKMGLEHI
260 270 280 290 300
DNGFLQLNHV RVPRENMLSR FAEVLPDGTY QRLGTPQSNY LGMLVTRVQL
310 320 330 340 350
LCKGILPSLQ KACIIATRYS VIRHQSRLRP SDPEAKILEY QTQQQKLLPQ
360 370 380 390 400
LAVSYAFHFT ATSLSEFFHS SYSAILKRDF SLLPELHALS TGMKATFADF
410 420 430 440 450
CAQGAEICRR ACGGHGYSKL SGLPTLVARA TASCTYEGEN TVLYLQVARF
460 470 480 490 500
LMKSYLQAQA SPGATPQKPL PQSVMYIATQ RPARCSAQTA ADFRCPDVYT
510 520 530 540 550
TAWAYVSTRL IRDAAHRTQT LMKSGVDQHD AWNQTTVIHL QAAKAHCYFI
560 570 580 590 600
TVKNFKEAVE KLDKEPEIQR VLQRLCDLYA LHGVLTNSGD FLHDGFLSGA
610 620 630 640 650
QVDMAREAFL DLLPLIRKDA ILLTDAFDFS DHCLNSALGC YDGHVYERLF
660 670 680
EWAQKYPANT QENPAYKKYI RPLMLGWRHK M
Length:681
Mass (Da):76,799
Last modified:May 1, 1997 - v1
Checksum:i3599D71365D38932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95189 mRNA Translation: CAA64488.1
UniGeneiRn.10622

Similar proteinsi

Entry informationi

Entry nameiACOX2_RAT
AccessioniPrimary (citable) accession number: P97562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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