Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P97557

- KCNV1_RAT

UniProt

P97557 - KCNV1_RAT

Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. potassium channel activity Source: RGD

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily V member 1
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv2.3r
    Voltage-gated potassium channel subunit Kv8.1
    Gene namesi
    Name:Kcnv1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi621264. Kcnv1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1PRO_0000308355Add
    BLAST

    Proteomic databases

    PaxDbiP97557.

    Expressioni

    Tissue specificityi

    Detected in brain, in neocortex, olfactory tubercle, hippocampus, dentate gyrus, piriform cortex and amygdala. Detected in Purkinje cells and granular cells of the cerebellum, in hippocampal CA4 neurons and neocortex pyramidal cells.1 Publication

    Gene expression databases

    GenevestigatoriP97557.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005556.

    Structurei

    3D structure databases

    ProteinModelPortaliP97557.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini3 – 213211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 2417ExtracellularSequence Analysis
    Topological domaini263 – 27917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini301 – 31212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 34814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 50373CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei214 – 23421Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei280 – 30021Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei349 – 36921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi395 – 4006Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00730000110784.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiP97557.
    KOiK04934.
    OMAiGMTIAQC.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiP97557.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P97557-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCLTVNVGG    50
    SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV 100
    DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI 150
    DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSQG PCPTVRQKLW 200
    DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY 250
    VCISWFTGEF ILRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG 300
    SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG 350
    LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD 400
    IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ 450
    REALKKLTKN IATDSYISVN LRDIYARSIM EMLRLKGRER ASTRSSGGDD 500
    FWF 503
    Length:503
    Mass (Da):56,663
    Last modified:May 1, 1997 - v1
    Checksum:iDC559010D00D8E9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98564 mRNA. Translation: CAA67174.1.
    RefSeqiNP_067729.1. NM_021697.1.
    UniGeneiRn.42920.

    Genome annotation databases

    EnsembliENSRNOT00000005556; ENSRNOP00000005556; ENSRNOG00000004117.
    GeneIDi60326.
    KEGGirno:60326.
    UCSCiRGD:621264. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98564 mRNA. Translation: CAA67174.1 .
    RefSeqi NP_067729.1. NM_021697.1.
    UniGenei Rn.42920.

    3D structure databases

    ProteinModelPortali P97557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005556.

    Protein family/group databases

    TCDBi 1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

    Proteomic databases

    PaxDbi P97557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005556 ; ENSRNOP00000005556 ; ENSRNOG00000004117 .
    GeneIDi 60326.
    KEGGi rno:60326.
    UCSCi RGD:621264. rat.

    Organism-specific databases

    CTDi 27012.
    RGDi 621264. Kcnv1.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00730000110784.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi P97557.
    KOi K04934.
    OMAi GMTIAQC.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi P97557.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 611949.
    PROi P97557.

    Gene expression databases

    Genevestigatori P97557.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003970. K_chnl_volt-dep_Kv8.1.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF38. PTHR11537:SF38. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01493. KV8CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain."
      Castellano A., Chiara M.D., Mellstroem B., Molina A., Monje F., Naranjo J.R., Lopez-Barneo J.
      J. Neurosci. 17:4652-4661(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KCNB1, TISSUE SPECIFICITY.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiKCNV1_RAT
    AccessioniPrimary (citable) accession number: P97557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3