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P97557 (KCNV1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv2.3r
Voltage-gated potassium channel subunit Kv8.1
Gene names
Name:Kcnv1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes By similarity. Ref.1

Subunit structure

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 By similarity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 By similarity.

Tissue specificity

Detected in brain, in neocortex, olfactory tubercle, hippocampus, dentate gyrus, piriform cortex and amygdala. Detected in Purkinje cells and granular cells of the cerebellum, in hippocampal CA4 neurons and neocortex pyramidal cells. Ref.1

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Potassium voltage-gated channel subfamily V member 1
PRO_0000308355

Regions

Topological domain3 – 213211Cytoplasmic Potential
Transmembrane214 – 23421Helical; Name=Segment S1; Potential
Topological domain235 – 2417Extracellular Potential
Transmembrane242 – 26221Helical; Name=Segment S2; Potential
Topological domain263 – 27917Cytoplasmic Potential
Transmembrane280 – 30021Helical; Name=Segment S3; Potential
Topological domain301 – 31212Extracellular Potential
Transmembrane313 – 33422Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain335 – 34814Cytoplasmic Potential
Transmembrane349 – 36921Helical; Name=Segment S5; Potential
Transmembrane410 – 43021Helical; Name=Segment S6; Potential
Topological domain431 – 50373Cytoplasmic Potential
Motif395 – 4006Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
P97557 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: DC559010D00D8E9E

FASTA50356,663
        10         20         30         40         50         60 
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCLTVNVGG SRFVLSQQAL 

        70         80         90        100        110        120 
SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV DNEYFFDRSS QAFRYVLHYY 

       130        140        150        160        170        180 
RTGRLHVMEQ LCALSFLQEI QYWGIDELSI DSCCRDRYFR RKELSETLDF KKDTDDQESQ 

       190        200        210        220        230        240 
HESEQDFSQG PCPTVRQKLW DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL 

       250        260        270        280        290        300 
NLQLLEILEY VCISWFTGEF ILRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG 

       310        320        330        340        350        360 
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG LLLLFLSVGI 

       370        380        390        400        410        420 
SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD IRPDTTTGKI VAFMCILSGI 

       430        440        450        460        470        480 
LVLALPIAII NDRFSACYFT LKLKEAAVRQ REALKKLTKN IATDSYISVN LRDIYARSIM 

       490        500 
EMLRLKGRER ASTRSSGGDD FWF

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References

[1]"Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain."
Castellano A., Chiara M.D., Mellstroem B., Molina A., Monje F., Naranjo J.R., Lopez-Barneo J.
J. Neurosci. 17:4652-4661(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KCNB1, TISSUE SPECIFICITY.
Tissue: Brain and Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X98564 mRNA. Translation: CAA67174.1.
IPIIPI00205525.
RefSeqNP_067729.1. NM_021697.1.
UniGeneRn.42920.

3D structure databases

HSSPHSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortalP97557.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005556.

Protein family/group databases

TCDB1.A.1.2.9. voltage-gated ion channel (VIC) superfamily.

Proteomic databases

PaxDbP97557.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005556; ENSRNOP00000005556; ENSRNOG00000004117.
GeneID60326.
KEGGrno:60326.
UCSCRGD:621264. rat.

Organism-specific databases

CTD27012.
RGD621264. Kcnv1.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00680000099716.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidP97557.
KOK04934.
OMADRCHFLR.
OrthoDBEOG4BRWKP.

Gene expression databases

GenevestigatorP97557.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio611949.

Entry information

Entry nameKCNV1_RAT
AccessionPrimary (citable) accession number: P97557
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1997
Last modified: April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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