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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central
  2. potassium channel activity Source: RGD

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv2.3r
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621264. Kcnv1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini3 – 213211CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini235 – 2417ExtracellularSequence Analysis
Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini263 – 27917CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini301 – 31212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini335 – 34814CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei349 – 36921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini431 – 50373CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1PRO_0000308355Add
BLAST

Proteomic databases

PaxDbiP97557.

Expressioni

Tissue specificityi

Detected in brain, in neocortex, olfactory tubercle, hippocampus, dentate gyrus, piriform cortex and amygdala. Detected in Purkinje cells and granular cells of the cerebellum, in hippocampal CA4 neurons and neocortex pyramidal cells.1 Publication

Gene expression databases

GenevestigatoriP97557.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005556.

Structurei

3D structure databases

ProteinModelPortaliP97557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi395 – 4006Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiP97557.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiP97557.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P97557-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCLTVNVGG
60 70 80 90 100
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV
110 120 130 140 150
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI
160 170 180 190 200
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSQG PCPTVRQKLW
210 220 230 240 250
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY
260 270 280 290 300
VCISWFTGEF ILRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG
310 320 330 340 350
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG
360 370 380 390 400
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD
410 420 430 440 450
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ
460 470 480 490 500
REALKKLTKN IATDSYISVN LRDIYARSIM EMLRLKGRER ASTRSSGGDD

FWF
Length:503
Mass (Da):56,663
Last modified:May 1, 1997 - v1
Checksum:iDC559010D00D8E9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98564 mRNA. Translation: CAA67174.1.
RefSeqiNP_067729.1. NM_021697.1.
UniGeneiRn.42920.

Genome annotation databases

EnsembliENSRNOT00000005556; ENSRNOP00000005556; ENSRNOG00000004117.
GeneIDi60326.
KEGGirno:60326.
UCSCiRGD:621264. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98564 mRNA. Translation: CAA67174.1.
RefSeqiNP_067729.1. NM_021697.1.
UniGeneiRn.42920.

3D structure databases

ProteinModelPortaliP97557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005556.

Protein family/group databases

TCDBi1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbiP97557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005556; ENSRNOP00000005556; ENSRNOG00000004117.
GeneIDi60326.
KEGGirno:60326.
UCSCiRGD:621264. rat.

Organism-specific databases

CTDi27012.
RGDi621264. Kcnv1.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiP97557.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiP97557.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi611949.
PROiP97557.

Gene expression databases

GenevestigatoriP97557.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain."
    Castellano A., Chiara M.D., Mellstroem B., Molina A., Monje F., Naranjo J.R., Lopez-Barneo J.
    J. Neurosci. 17:4652-4661(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KCNB1, TISSUE SPECIFICITY.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry nameiKCNV1_RAT
AccessioniPrimary (citable) accession number: P97557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.