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P97557

- KCNV1_RAT

UniProt

P97557 - KCNV1_RAT

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Protein

Potassium voltage-gated channel subfamily V member 1

Gene

Kcnv1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. potassium channel activity Source: RGD

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily V member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv2.3r
Voltage-gated potassium channel subunit Kv8.1
Gene namesi
Name:Kcnv1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi621264. Kcnv1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2 (By similarity).By similarity

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Potassium voltage-gated channel subfamily V member 1PRO_0000308355Add
BLAST

Proteomic databases

PaxDbiP97557.

Expressioni

Tissue specificityi

Detected in brain, in neocortex, olfactory tubercle, hippocampus, dentate gyrus, piriform cortex and amygdala. Detected in Purkinje cells and granular cells of the cerebellum, in hippocampal CA4 neurons and neocortex pyramidal cells.1 Publication

Gene expression databases

GenevestigatoriP97557.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005556.

Structurei

3D structure databases

ProteinModelPortaliP97557.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini3 – 213211CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini235 – 2417ExtracellularSequence Analysis
Topological domaini263 – 27917CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini301 – 31212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini335 – 34814CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini431 – 50373CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei214 – 23421Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei280 – 30021Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei313 – 33422Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei349 – 36921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi395 – 4006Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiP97557.
KOiK04934.
OMAiGMTIAQC.
OrthoDBiEOG7CRTPP.
PhylomeDBiP97557.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P97557 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MDLSPRNRPL LDSSSLDSGS LTSLDSSVFC SEGEGEPLAL GDCLTVNVGG
60 70 80 90 100
SRFVLSQQAL SCFPHTRLGK LAVVVASYRR LGALAAAPSP LELCDDANPV
110 120 130 140 150
DNEYFFDRSS QAFRYVLHYY RTGRLHVMEQ LCALSFLQEI QYWGIDELSI
160 170 180 190 200
DSCCRDRYFR RKELSETLDF KKDTDDQESQ HESEQDFSQG PCPTVRQKLW
210 220 230 240 250
DILEKPGSST AARIFGVISI IFVAVSIVNM ALMSAELSWL NLQLLEILEY
260 270 280 290 300
VCISWFTGEF ILRFLCVKDR CHFLRKVPNI IDLLAILPFY ITLLVESLSG
310 320 330 340 350
SHTTQELENV GRLVQVLRLL RALRMLKLGR HSTGLRSLGM TITQCYEEVG
360 370 380 390 400
LLLLFLSVGI SIFSTIEYFA EQSIPDTTFT SVPCAWWWAT TSMTTVGYGD
410 420 430 440 450
IRPDTTTGKI VAFMCILSGI LVLALPIAII NDRFSACYFT LKLKEAAVRQ
460 470 480 490 500
REALKKLTKN IATDSYISVN LRDIYARSIM EMLRLKGRER ASTRSSGGDD

FWF
Length:503
Mass (Da):56,663
Last modified:May 1, 1997 - v1
Checksum:iDC559010D00D8E9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98564 mRNA. Translation: CAA67174.1.
RefSeqiNP_067729.1. NM_021697.1.
UniGeneiRn.42920.

Genome annotation databases

EnsembliENSRNOT00000005556; ENSRNOP00000005556; ENSRNOG00000004117.
GeneIDi60326.
KEGGirno:60326.
UCSCiRGD:621264. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98564 mRNA. Translation: CAA67174.1 .
RefSeqi NP_067729.1. NM_021697.1.
UniGenei Rn.42920.

3D structure databases

ProteinModelPortali P97557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005556.

Protein family/group databases

TCDBi 1.A.1.2.9. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

PaxDbi P97557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005556 ; ENSRNOP00000005556 ; ENSRNOG00000004117 .
GeneIDi 60326.
KEGGi rno:60326.
UCSCi RGD:621264. rat.

Organism-specific databases

CTDi 27012.
RGDi 621264. Kcnv1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi P97557.
KOi K04934.
OMAi GMTIAQC.
OrthoDBi EOG7CRTPP.
PhylomeDBi P97557.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 611949.
PROi P97557.

Gene expression databases

Genevestigatori P97557.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003970. K_chnl_volt-dep_Kv8.1.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF38. PTHR11537:SF38. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01493. KV8CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain."
    Castellano A., Chiara M.D., Mellstroem B., Molina A., Monje F., Naranjo J.R., Lopez-Barneo J.
    J. Neurosci. 17:4652-4661(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH KCNB1, TISSUE SPECIFICITY.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry nameiKCNV1_RAT
AccessioniPrimary (citable) accession number: P97557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3