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Protein

DnaJ homolog subfamily B member 9

Gene

Dnajb9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 9
Alternative name(s):
Microvascular endothelial differentiation gene 1 protein
Short name:
Mdg-1
Gene namesi
Name:Dnajb9
Synonyms:Mdg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3070. Dnajb9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
  • extracellular exosome Source: Ensembl
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000007103424 – 222DnaJ homolog subfamily B member 9Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97554.
PRIDEiP97554.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004006.
GenevisibleiP97554. RN.

Interactioni

Subunit structurei

Interacts with DERL1.By similarity

Protein-protein interaction databases

IntActiP97554. 6 interactors.
STRINGi10116.ENSRNOP00000005363.

Structurei

3D structure databases

ProteinModelPortaliP97554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 90JPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133735.
HOGENOMiHOG000290187.
HOVERGENiHBG051372.
InParanoidiP97554.
KOiK09515.
OMAiATPQSIF.
OrthoDBiEOG091G15JG.
PhylomeDBiP97554.
TreeFamiTF105143.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPQSVFVF AICILMITEL ILASKNYYDI LGVPKSASER QIKKAFHKLA
60 70 80 90 100
MKYHPDKNKS PDAEAKFREI AEAYETLSDA NRRKEYDIIG HSAFTNGKGQ
110 120 130 140 150
RSNGSPFEQS FNFNFDDLFK DFNLFGQNQN TRSKKHFENH FQTRQDGSSR
160 170 180 190 200
QRHHFQEFSF GGGLFDDMFE DMEKMFSFSG FDSTNRRTVQ TENRFHGSSK
210 220
HCRTVTQRRG NMVTTYTDCS GQ
Length:222
Mass (Da):25,717
Last modified:March 1, 2001 - v2
Checksum:i08BF5347F20B65DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98993 mRNA. Translation: CAA67434.2.
BC070915 mRNA. Translation: AAH70915.1.
RefSeqiNP_036831.2. NM_012699.2.
XP_006240127.1. XM_006240065.3.
UniGeneiRn.29778.

Genome annotation databases

EnsembliENSRNOT00000005363; ENSRNOP00000005363; ENSRNOG00000004006.
GeneIDi24908.
KEGGirno:24908.
UCSCiRGD:3070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98993 mRNA. Translation: CAA67434.2.
BC070915 mRNA. Translation: AAH70915.1.
RefSeqiNP_036831.2. NM_012699.2.
XP_006240127.1. XM_006240065.3.
UniGeneiRn.29778.

3D structure databases

ProteinModelPortaliP97554.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97554. 6 interactors.
STRINGi10116.ENSRNOP00000005363.

Proteomic databases

PaxDbiP97554.
PRIDEiP97554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005363; ENSRNOP00000005363; ENSRNOG00000004006.
GeneIDi24908.
KEGGirno:24908.
UCSCiRGD:3070. rat.

Organism-specific databases

CTDi4189.
RGDi3070. Dnajb9.

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00860000133735.
HOGENOMiHOG000290187.
HOVERGENiHBG051372.
InParanoidiP97554.
KOiK09515.
OMAiATPQSIF.
OrthoDBiEOG091G15JG.
PhylomeDBiP97554.
TreeFamiTF105143.

Miscellaneous databases

PROiP97554.

Gene expression databases

BgeeiENSRNOG00000004006.
GenevisibleiP97554. RN.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJB9_RAT
AccessioniPrimary (citable) accession number: P97554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was initially reported to localize in the nucleus (PubMed:11525638). However, it was later shown to localize in the endoplasmic reticulum lumen.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.