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P97545

- CCL11_RAT

UniProt

P97545 - CCL11_RAT

Protein

Eotaxin

Gene

Ccl11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: RGD

    GO - Biological processi

    1. actin filament organization Source: RGD
    2. branching involved in mammary gland duct morphogenesis Source: Ensembl
    3. chronic inflammatory response Source: RGD
    4. eosinophil chemotaxis Source: RGD
    5. ERK1 and ERK2 cascade Source: RGD
    6. immune response Source: InterPro
    7. mammary duct terminal end bud growth Source: Ensembl
    8. mast cell chemotaxis Source: RGD
    9. positive regulation of actin filament polymerization Source: Ensembl
    10. positive regulation of angiogenesis Source: Ensembl
    11. positive regulation of cell migration Source: Ensembl
    12. positive regulation of endothelial cell proliferation Source: Ensembl
    13. positive regulation of Rac GTPase activity Source: Ensembl
    14. regulation of cell shape Source: Ensembl
    15. response to interleukin-4 Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eotaxin
    Alternative name(s):
    C-C motif chemokine 11
    Eosinophil chemotactic protein
    Small-inducible cytokine A11
    Gene namesi
    Name:Ccl11
    Synonyms:Scya11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi3644. Ccl11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9774EotaxinPRO_0000005198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 57By similarity
    Disulfide bondi33 ↔ 73By similarity
    Glycosylationi94 – 941O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP97545.

    Structurei

    3D structure databases

    ProteinModelPortaliP97545.
    SMRiP97545. Positions 25-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46290.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP97545.
    KOiK16597.
    OMAiCFTMTSK.
    OrthoDBiEOG7673DP.
    PhylomeDBiP97545.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97545-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK   50
    RITNNRCTLK AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP 97
    Length:97
    Mass (Da):10,851
    Last modified:May 1, 1997 - v1
    Checksum:i77375B4A038B3F6B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08358 mRNA. Translation: CAA69645.1.
    U96637 mRNA. Translation: AAB65775.1.
    RefSeqiNP_062078.1. NM_019205.1.
    UniGeneiRn.10632.

    Genome annotation databases

    EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
    GeneIDi29397.
    KEGGirno:29397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08358 mRNA. Translation: CAA69645.1 .
    U96637 mRNA. Translation: AAB65775.1 .
    RefSeqi NP_062078.1. NM_019205.1.
    UniGenei Rn.10632.

    3D structure databases

    ProteinModelPortali P97545.
    SMRi P97545. Positions 25-97.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009756 ; ENSRNOP00000009756 ; ENSRNOG00000007335 .
    GeneIDi 29397.
    KEGGi rno:29397.

    Organism-specific databases

    CTDi 6356.
    RGDi 3644. Ccl11.

    Phylogenomic databases

    eggNOGi NOG46290.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P97545.
    KOi K16597.
    OMAi CFTMTSK.
    OrthoDBi EOG7673DP.
    PhylomeDBi P97545.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 609034.
    PROi P97545.

    Gene expression databases

    Genevestigatori P97545.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of rat eotaxin: ozone inhalation increases mRNA and protein expression in lungs of brown Norway rats."
      Ishi Y., Shirato M., Nomura A., Sakamoto T., Uchida Y., Ohtsuka M., Sagai M., Hasegawa S.
      Am. J. Physiol. 274:L171-L176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCCL11_RAT
    AccessioniPrimary (citable) accession number: P97545
    Secondary accession number(s): O08780
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3