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Protein

Eotaxin

Gene

Ccl11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.By similarity

GO - Molecular functioni

  • chemokine activity Source: RGD

GO - Biological processi

  • actin filament organization Source: RGD
  • branching involved in mammary gland duct morphogenesis Source: Ensembl
  • chronic inflammatory response Source: RGD
  • eosinophil chemotaxis Source: RGD
  • ERK1 and ERK2 cascade Source: RGD
  • immune response Source: InterPro
  • mammary duct terminal end bud growth Source: Ensembl
  • mast cell chemotaxis Source: RGD
  • positive regulation of actin filament polymerization Source: Ensembl
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell migration Source: Ensembl
  • positive regulation of endothelial cell proliferation Source: Ensembl
  • regulation of cell shape Source: Ensembl
  • response to interleukin-13 Source: RGD
  • response to interleukin-4 Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3644. Ccl11.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

GenevisibleiP97545. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Structurei

3D structure databases

ProteinModelPortaliP97545.
SMRiP97545. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG7673DP.
PhylomeDBiP97545.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,851
Last modified:May 1, 1997 - v1
Checksum:i77375B4A038B3F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

3D structure databases

ProteinModelPortaliP97545.
SMRiP97545. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Organism-specific databases

CTDi6356.
RGDi3644. Ccl11.

Phylogenomic databases

eggNOGiNOG46290.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG7673DP.
PhylomeDBiP97545.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi609034.
PROiP97545.

Gene expression databases

GenevisibleiP97545. RN.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of rat eotaxin: ozone inhalation increases mRNA and protein expression in lungs of brown Norway rats."
    Ishi Y., Shirato M., Nomura A., Sakamoto T., Uchida Y., Ohtsuka M., Sagai M., Hasegawa S.
    Am. J. Physiol. 274:L171-L176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCCL11_RAT
AccessioniPrimary (citable) accession number: P97545
Secondary accession number(s): O08780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.