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Protein

Eotaxin

Gene

Ccl11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.By similarity

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3644. Ccl11.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000519824 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94O-linked (GalNAc...)By similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97545.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007335.
GenevisibleiP97545. RN.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Structurei

3D structure databases

ProteinModelPortaliP97545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP97545.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,851
Last modified:May 1, 1997 - v1
Checksum:i77375B4A038B3F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

3D structure databases

ProteinModelPortaliP97545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Proteomic databases

PaxDbiP97545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Organism-specific databases

CTDi6356.
RGDi3644. Ccl11.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP97545.
TreeFamiTF334888.

Miscellaneous databases

PROiP97545.

Gene expression databases

BgeeiENSRNOG00000007335.
GenevisibleiP97545. RN.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_RAT
AccessioniPrimary (citable) accession number: P97545
Secondary accession number(s): O08780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.