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Protein

Eotaxin

Gene

Ccl11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.By similarity

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3644. Ccl11.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 9774EotaxinPRO_0000005198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94 – 941O-linked (GalNAc...)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97545.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007335.
GenevisibleiP97545. RN.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Structurei

3D structure databases

ProteinModelPortaliP97545.
SMRiP97545. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP97545.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,851
Last modified:May 1, 1997 - v1
Checksum:i77375B4A038B3F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqiNP_062078.1. NM_019205.1.
UniGeneiRn.10632.

3D structure databases

ProteinModelPortaliP97545.
SMRiP97545. Positions 25-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009756.

Proteomic databases

PaxDbiP97545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneIDi29397.
KEGGirno:29397.

Organism-specific databases

CTDi6356.
RGDi3644. Ccl11.

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP97545.
KOiK16597.
OMAiRITNNRC.
OrthoDBiEOG091G14KV.
PhylomeDBiP97545.
TreeFamiTF334888.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.

Miscellaneous databases

PROiP97545.

Gene expression databases

BgeeiENSRNOG00000007335.
GenevisibleiP97545. RN.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_RAT
AccessioniPrimary (citable) accession number: P97545
Secondary accession number(s): O08780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.