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P97545 (CCL11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene names
Name:Ccl11
Synonyms:Scya11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from genetic interaction PubMed 12413953. Source: RGD

actin filament organization

Inferred from direct assay PubMed 12413953. Source: RGD

branching involved in mammary gland duct morphogenesis

Inferred from electronic annotation. Source: Ensembl

chronic inflammatory response

Inferred from expression pattern PubMed 10861753. Source: RGD

eosinophil chemotaxis

Inferred from direct assay Ref.2. Source: RGD

immune response

Inferred from electronic annotation. Source: InterPro

mammary duct terminal end bud growth

Inferred from electronic annotation. Source: Ensembl

mast cell chemotaxis

Inferred from direct assay PubMed 12413953. Source: RGD

positive regulation of Rac GTPase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin filament polymerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

response to interleukin-4

Inferred from expression pattern PubMed 11071660. Source: RGD

   Cellular_componentextracellular space

Inferred from direct assay Ref.2. Source: RGD

   Molecular_functionchemokine activity

Inferred from direct assay Ref.2. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9774Eotaxin
PRO_0000005198

Amino acid modifications

Glycosylation941O-linked (GalNAc...) By similarity
Disulfide bond32 ↔ 57 By similarity
Disulfide bond33 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97545 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 77375B4A038B3F6B

FASTA9710,851
        10         20         30         40         50         60 
MQLSTALLFL LLTATSFTSQ VLAHPGSIPT SCCFTMTSKK IPNTLLKSYK RITNNRCTLK 

        70         80         90 
AIVFKTKLGK EICADPKKKW VQDATKHLDQ KLQTPKP 

« Hide

References

[1]"Conserved structure and tissue expression of rat eotaxin."
Williams C.M., Newton D.J., Wilson S.A., Williams T.J., Coleman J.W., Flanagan B.F.
Immunogenetics 47:178-180(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of rat eotaxin: ozone inhalation increases mRNA and protein expression in lungs of brown Norway rats."
Ishi Y., Shirato M., Nomura A., Sakamoto T., Uchida Y., Ohtsuka M., Sagai M., Hasegawa S.
Am. J. Physiol. 274:L171-L176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08358 mRNA. Translation: CAA69645.1.
U96637 mRNA. Translation: AAB65775.1.
RefSeqNP_062078.1. NM_019205.1.
UniGeneRn.10632.

3D structure databases

ProteinModelPortalP97545.
SMRP97545. Positions 25-97.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009756; ENSRNOP00000009756; ENSRNOG00000007335.
GeneID29397.
KEGGrno:29397.

Organism-specific databases

CTD6356.
RGD3644. Ccl11.

Phylogenomic databases

eggNOGNOG46290.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP97545.
KOK16597.
OMATKEICAD.
OrthoDBEOG7673DP.
PhylomeDBP97545.
TreeFamTF334888.

Gene expression databases

GenevestigatorP97545.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609034.
PROP97545.

Entry information

Entry nameCCL11_RAT
AccessionPrimary (citable) accession number: P97545
Secondary accession number(s): O08780
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families