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Protein

Heat shock protein beta-6

Gene

Hspb6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • structural constituent of eye lens Source: InterPro

GO - Biological processi

  • regulation of muscle contraction Source: RGD
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-6
Short name:
HspB6
Alternative name(s):
Heat shock 20 kDa-like protein p20
Gene namesi
Name:Hspb6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621554. Hspb6.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates to nuclear foci during heat shock.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Heat shock protein beta-6PRO_0000125940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei157 – 1571PhosphoserineCombined sources

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP97541.
PRIDEiP97541.

PTM databases

iPTMnetiP97541.
PhosphoSiteiP97541.

Expressioni

Tissue specificityi

Widely expressed. High expression in muscle tissues.

Gene expression databases

GenevisibleiP97541. RN.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi251372. 1 interaction.
STRINGi10116.ENSRNOP00000028401.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi74 – 796Combined sources
Helixi85 – 873Combined sources
Beta strandi88 – 936Combined sources
Beta strandi96 – 10510Combined sources
Beta strandi113 – 12210Combined sources
Beta strandi133 – 1364Combined sources
Beta strandi140 – 1467Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WJ5X-ray1.12A65-162[»]
ProteinModelPortaliP97541.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP97541.

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiP97541.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG7WHHBK.
PhylomeDBiP97541.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIRVPVQPS WLRRASAPLP GFSTPGRLFD QRFGEGLLEA ELASLCPAAI
60 70 80 90 100
APYYLRAPSV ALPTAQVPTD PGYFSVLLDV KHFSPEEISV KVVGDHVEVH
110 120 130 140 150
ARHEERPDEH GFIAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQATPAS
160
AQASLPSPPA AK
Length:162
Mass (Da):17,505
Last modified:May 1, 1997 - v1
Checksum:i91561D8813EBFC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29960 mRNA. Translation: BAA06227.1.
PIRiA53814.
RefSeqiNP_620242.1. NM_138887.1.
UniGeneiRn.3201.

Genome annotation databases

EnsembliENSRNOT00000028401; ENSRNOP00000028401; ENSRNOG00000020922.
GeneIDi192245.
KEGGirno:192245.
UCSCiRGD:621554. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29960 mRNA. Translation: BAA06227.1.
PIRiA53814.
RefSeqiNP_620242.1. NM_138887.1.
UniGeneiRn.3201.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WJ5X-ray1.12A65-162[»]
ProteinModelPortaliP97541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251372. 1 interaction.
STRINGi10116.ENSRNOP00000028401.

PTM databases

iPTMnetiP97541.
PhosphoSiteiP97541.

Proteomic databases

PaxDbiP97541.
PRIDEiP97541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028401; ENSRNOP00000028401; ENSRNOG00000020922.
GeneIDi192245.
KEGGirno:192245.
UCSCiRGD:621554. rat.

Organism-specific databases

CTDi126393.
RGDi621554. Hspb6.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiP97541.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG7WHHBK.
PhylomeDBiP97541.
TreeFamiTF105049.

Miscellaneous databases

EvolutionaryTraceiP97541.
PROiP97541.

Gene expression databases

GenevisibleiP97541. RN.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a 20-kDa protein (p20) highly homologous to small heat shock proteins: developmental and physiological changes in rat hindlimb muscles."
    Inaguma Y., Hasegawa K., Kato K., Nishida Y.
    Gene 178:145-150(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Soleus muscle.
  2. "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin."
    Kato K., Goto S., Inaguma Y., Hasegawa K., Morishita R., Asano T.
    J. Biol. Chem. 269:15302-15309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-162, CHARACTERIZATION.
    Tissue: Muscle.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-157, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20."
    Bagneris C., Bateman O.A., Naylor C.E., Cronin N., Boelens W.C., Keep N.H., Slingsby C.
    J. Mol. Biol. 392:1242-1252(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.12 ANGSTROMS) OF 65-162, HOMODIMER.

Entry informationi

Entry nameiHSPB6_RAT
AccessioniPrimary (citable) accession number: P97541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.