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Protein

Contactin-6

Gene

Cntn6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • neuron differentiation Source: InterPro
  • Notch signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-6
Alternative name(s):
Neural recognition molecule NB-3
Gene namesi
Name:Cntn6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62008 Cntn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001473120 – 999Contactin-6Add BLAST980
PropeptideiPRO_00000147321000 – 1028Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi659N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei882PhosphotyrosineBy similarity1
Glycosylationi895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi956N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi999GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97528
PRIDEiP97528

Expressioni

Tissue specificityi

Specifically expressed in neuronal cells. In brain, it is expressed in spinal cord, cerebrum and cerebellum. At E17, it is expressed hippocampus, cerebellum, and the brain stem. Strongly expressed after birth with a maximum level between postnatal day 0 and 21, which corresponds to the time frame of oligodendrogliogenesis.2 Publications

Developmental stagei

Expressed at low level during embryogenesis. Highly expressed after birth.1 Publication

Interactioni

Subunit structurei

Interacts with PTPRG.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047690

Structurei

3D structure databases

ProteinModelPortaliP97528
SMRiP97528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 117Ig-like C2-type 1Add BLAST86
Domaini122 – 208Ig-like C2-type 2Add BLAST87
Domaini227 – 308Ig-like C2-type 3Add BLAST82
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 495Ig-like C2-type 5Add BLAST88
Domaini499 – 587Ig-like C2-type 6Add BLAST89
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 996Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
HOGENOMiHOG000059617
HOVERGENiHBG051047
InParanoidiP97528
KOiK06764
PhylomeDBiP97528

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033009 Contactin-6
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF6 PTHR43905:SF6, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLWKLVIL LPLINSCAGE SRFTRPIFIQ EPQDVIFPLD LSRSEIILSC
60 70 80 90 100
TASGYPSPHY RWKQNGTDID FSMTYHYRLD GGSLAISSPR TDQDIGIYQC
110 120 130 140 150
LATNPVGTIL SRKAKLQFAY IEDFETKSRS TVSVREGQGV VLLCGPPPHF
160 170 180 190 200
GELSYDWTFN DNPLYVQEDK RRFVSQNTGN LYIAKVEPSD VGNYTCFVTN
210 220 230 240 250
KEAHRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA KDSSVKLECF
260 270 280 290 300
ALGNPVPDIS WRRLDGSPMP GKVKYSNSQA TLEIPKFQQE DEGFYECVAG
310 320 330 340 350
NLRGRNLAKG QLIFYAPPEW EQKIQNTYLS IYDSLFWECK ASGNPNPSYT
360 370 380 390 400
WLKNGERLNT EERIQTENGT LIITMLNVSD SGIYQCAAEN KYQTIYANAE
410 420 430 440 450
LRVLASAPDF SKNPIKKISV VQVGGDISIE CKPNAFPKAS ISWKRGTENL
460 470 480 490 500
KQSKRVFFLE DGSLKICNVT RSDAGSYTCV ATNQFGNGKS SGSLIVKERT
510 520 530 540 550
VITVPPSKMD VTVGESIVLP CQVSHDPTME VLFVWYFNGD VIDLKKGVAH
560 570 580 590 600
FERIGGESVG DLMIRNIQLG HSGKYLCTVQ TTLERLSAVA DIIVRGPPGP
610 620 630 640 650
PEDVKVEHIS STTSQLSWRP GPDNNSPIQI FTIQTRTPFS VGWQAVATVP
660 670 680 690 700
EILNGQTYNA TVIGLSPWVE YEFRVVAGNN IGIGEPSKPS ELLRTKASIP
710 720 730 740 750
NVAPVNINGG GGSRSELVIT WEPIPEELQN GEGFGYIIMF RPVGSTTWMK
760 770 780 790 800
EKVALVESSK FIYRNESIMP LSPFEVKVGV YNNEGEGSLS TVSIVYSGED
810 820 830 840 850
EPRLAPRGTS VQSFSASDME VSWNAIAWNR NTGRVLGYEV LYWTDNSKES
860 870 880 890 900
MIGKIRVSGN VTTKNITGLR ANTIYFASVR AYNTAGTGPS SPPVNVTTKK
910 920 930 940 950
SPPSQPPANI AWKLSNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT
960 970 980 990 1000
HVLETNNTSA ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSV
1010 1020
GVQILKPSTQ FLTMVGFFYC FVIQPLSR
Length:1,028
Mass (Da):114,065
Last modified:May 1, 1997 - v1
Checksum:i47EFD8A370CF4923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87248 mRNA Translation: BAA13320.1
RefSeqiNP_037357.1, NM_013225.1
UniGeneiRn.10644

Genome annotation databases

GeneIDi27256
KEGGirno:27256

Similar proteinsi

Entry informationi

Entry nameiCNTN6_RAT
AccessioniPrimary (citable) accession number: P97528
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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