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Reviewed, UniProtKB/Swiss-Prot P97528 (CNTN6_RAT)

Last modified November 4, 2008. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Contactin-6
Alternative name(s):
    Neural recognition molecule NB-3
Gene names
Name: Cntn6
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length1028 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination.

Subcellular location

Cell membrane; Lipid-anchor › GPI-anchor.

Tissue specificity

Specifically expressed in neuronal cells. In brain, it is expressed in spinal cord, cerebrum and cerebellum. At E17, it is expressed hippocampus, cerebellum, and the brain stem. Strongly expressed after birth with a maximum level between postnatal day 0 and 21, which corresponds to the time frame of oligodendrogliogenesis.

Developmental stage

Expressed at low level during embryogenesis. Highly expressed after birth.

Sequence similarities

Belongs to the immunoglobulin superfamily. Contactin family.

Contains 4 fibronectin type-III domains.

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

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Ontologies

Keywords

   Biological processCell adhesion
Notch signaling pathway
   Cellular componentCell membrane
Membrane
   DomainImmunoglobulin domain
Repeat
Signal
   PTMGPI-anchor
Glycoprotein
Lipoprotein

Gene Ontology (GO)

   Biological processNotch signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentanchored to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 999980Contactin-6
PRO_0000014731
Propeptide1000 – 102829Removed in mature form Potential
PRO_0000014732

Regions

Domain32 – 11786Ig-like C2-type 1
Domain122 – 20887Ig-like C2-type 2
Domain227 – 30882Ig-like C2-type 3
Domain318 – 40285Ig-like C2-type 4
Domain408 – 49588Ig-like C2-type 5
Domain499 – 58789Ig-like C2-type 6
Domain597 – 69397Fibronectin type-III 1
Domain700 – 79697Fibronectin type-III 2
Domain802 – 89796Fibronectin type-III 3
Domain903 – 99290Fibronectin type-III 4

Amino acid modifications

Lipidation9991GPI-anchor amidated serine Potential
Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Glycosylation6591N-linked (GlcNAc...) Potential
Glycosylation7651N-linked (GlcNAc...) Potential
Glycosylation8601N-linked (GlcNAc...) Potential
Glycosylation8651N-linked (GlcNAc...) Potential
Glycosylation8951N-linked (GlcNAc...) Potential
Glycosylation9311N-linked (GlcNAc...) Potential
Glycosylation9561N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 100 By similarity
Disulfide bond144 ↔ 196 By similarity
Disulfide bond249 ↔ 297 By similarity
Disulfide bond339 ↔ 386 By similarity
Disulfide bond431 ↔ 479 By similarity
Disulfide bond521 ↔ 577 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P97528-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 47EFD8A370CF4923

FASTA1,028114,065
        10         20         30         40         50         60 
MRLLWKLVIL LPLINSCAGE SRFTRPIFIQ EPQDVIFPLD LSRSEIILSC TASGYPSPHY 

        70         80         90        100        110        120 
RWKQNGTDID FSMTYHYRLD GGSLAISSPR TDQDIGIYQC LATNPVGTIL SRKAKLQFAY 

       130        140        150        160        170        180 
IEDFETKSRS TVSVREGQGV VLLCGPPPHF GELSYDWTFN DNPLYVQEDK RRFVSQNTGN 

       190        200        210        220        230        240 
LYIAKVEPSD VGNYTCFVTN KEAHRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA 

       250        260        270        280        290        300 
KDSSVKLECF ALGNPVPDIS WRRLDGSPMP GKVKYSNSQA TLEIPKFQQE DEGFYECVAG 

       310        320        330        340        350        360 
NLRGRNLAKG QLIFYAPPEW EQKIQNTYLS IYDSLFWECK ASGNPNPSYT WLKNGERLNT 

       370        380        390        400        410        420 
EERIQTENGT LIITMLNVSD SGIYQCAAEN KYQTIYANAE LRVLASAPDF SKNPIKKISV 

       430        440        450        460        470        480 
VQVGGDISIE CKPNAFPKAS ISWKRGTENL KQSKRVFFLE DGSLKICNVT RSDAGSYTCV 

       490        500        510        520        530        540 
ATNQFGNGKS SGSLIVKERT VITVPPSKMD VTVGESIVLP CQVSHDPTME VLFVWYFNGD 

       550        560        570        580        590        600 
VIDLKKGVAH FERIGGESVG DLMIRNIQLG HSGKYLCTVQ TTLERLSAVA DIIVRGPPGP 

       610        620        630        640        650        660 
PEDVKVEHIS STTSQLSWRP GPDNNSPIQI FTIQTRTPFS VGWQAVATVP EILNGQTYNA 

       670        680        690        700        710        720 
TVIGLSPWVE YEFRVVAGNN IGIGEPSKPS ELLRTKASIP NVAPVNINGG GGSRSELVIT 

       730        740        750        760        770        780 
WEPIPEELQN GEGFGYIIMF RPVGSTTWMK EKVALVESSK FIYRNESIMP LSPFEVKVGV 

       790        800        810        820        830        840 
YNNEGEGSLS TVSIVYSGED EPRLAPRGTS VQSFSASDME VSWNAIAWNR NTGRVLGYEV 

       850        860        870        880        890        900 
LYWTDNSKES MIGKIRVSGN VTTKNITGLR ANTIYFASVR AYNTAGTGPS SPPVNVTTKK 

       910        920        930        940        950        960 
SPPSQPPANI AWKLSNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT HVLETNNTSA 

       970        980        990       1000       1010       1020 
ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSV GVQILKPSTQ FLTMVGFFYC 


FVIQPLSR

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References

[1]"Novel neural adhesion molecules in the contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain."
Ogawa J., Kaneko H., Masuda T., Nagata S., Hosoya H., Watanabe K.
Neurosci. Lett. 218:173-176(1996) [PubMed: 8945756] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Brain.
[2]Erratum
Ogawa J., Kaneko H., Masuda T., Nagata S., Hosoya H., Watanabe K.
Neurosci. Lett. 221:221-223(1997)
[3]"Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup."
Takeda Y., Akasaka K., Lee S., Kobayashi S., Kawano H., Murayama S., Takahashi N., Hashimoto K., Kano M., Asano M., Sudo K., Iwakura Y., Watanabe K.
J. Neurobiol. 56:252-265(2003) [PubMed: 12884264] [Abstract]
Cited for: GPI-ANCHOR.
[4]"NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes."
Cui X.-Y., Hu Q.-D., Tekaya M., Shimoda Y., Ang B.-T., Nie D.-Y., Sun L., Hu W.-P., Karsak M., Duka T., Takeda Y., Ou L.-Y., Dawe G.S., Yu F.-G., Ahmed S., Jin L.-H., Schachner M., Watanabe K., Arsenijevic Y., Xiao Z.-C.
J. Biol. Chem. 279:25858-25865(2004) [PubMed: 15082708] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH NOTCH1.

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Cross-references

Sequence databases

D87248 mRNA. Translation: BAA13320.1.
RefSeqNP_037357.1.
UniGeneRn.10644

3D structure databases

HSSPHSSP built from PDB template 1IIL based on UniProtKB Q9UQH9.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000032517. Rattus norvegicus. [Contig view]
GeneID27256.
KEGGrno:27256.

Organism-specific databases

RGD62008. Cntn6.

Phylogenomic databases

HOVERGENP97528.

Gene expression databases

ArrayExpressP97528.
GermOnlineENSRNOG00000032517. Rattus norvegicus.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 2 hits.
G3DSA:2.60.40.10. Ig-like_fold. 6 hits.
PfamPF00041. fn3. 4 hits.
PF07679. I-set. 3 hits.
PF00047. ig. 3 hits.
[Graphical view]
SMARTSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 5 hits.
[Graphical view]
PROSITEPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608067.

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Entry information

Entry nameCNTN6_RAT
AccessionPrimary (citable) accession number: P97528
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: November 4, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents