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Protein

Contactin-5

Gene

Cntn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system.1 Publication

GO - Biological processi

  • cell adhesion Source: RGD
  • sensory perception of sound Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-5
Alternative name(s):
Neural recognition molecule NB-2
Gene namesi
Name:Cntn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621302. Cntn5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001472119 – 1072Contactin-5Add BLAST1054
PropeptideiPRO_00000147221073 – 1099Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 173PROSITE-ProRule annotation
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi217 ↔ 269PROSITE-ProRule annotation
Disulfide bondi322 ↔ 369PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi411 ↔ 458PROSITE-ProRule annotation
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi503 ↔ 551PROSITE-ProRule annotation
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi593 ↔ 650PROSITE-ProRule annotation
Glycosylationi779N-linked (GlcNAc...)Sequence analysis1
Glycosylationi816N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1002N-linked (GlcNAc...)Sequence analysis1
Lipidationi1072GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP97527.
PRIDEiP97527.

Expressioni

Tissue specificityi

Specifically expressed in the nervous system. Expressed in cerebrum and cerebellum but at low level in spinal chord. In brain, it is expressed in highly restricted regions at postnatal day 7, such as the auditory pathway, including the cochlear nucleus, superior olive, inferior colliculus, medial geniculate nucleus and auditory cortex. Expressed in the accessory olfactory bulb, glomerular and mitral cell layers in the olfactory bulb, anterior thalamic nuclei, layers II-IV of the cerebral cortex, dentate gyrus of the hippocampus and external granule cells and Purkinje cells of the cerebellum. Also expressed in the piriform cortex, inferior olive and facial nucleus. Weakly or not expressed in other parts of the brain.2 Publications

Developmental stagei

Expressed after birth, reaching a maximum at postnatal day 14 in the cerebrum and postnatal day 3 in the cerebellum. Then, it decreases abruptly thereafter (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000007038.

Interactioni

Subunit structurei

Interacts with PTPRG.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009418.

Structurei

3D structure databases

ProteinModelPortaliP97527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 190Ig-like C2-type 1Add BLAST92
Domaini196 – 282Ig-like C2-type 2Add BLAST87
Domaini300 – 385Ig-like C2-type 3Add BLAST86
Domaini390 – 474Ig-like C2-type 4Add BLAST85
Domaini480 – 569Ig-like C2-type 5Add BLAST90
Domaini571 – 660Ig-like C2-type 6Add BLAST90
Domaini673 – 771Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini776 – 873Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini878 – 972Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST95
Domaini977 – 1067Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOVERGENiHBG051047.
InParanoidiP97527.
KOiK06763.
PhylomeDBiP97527.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSWRLILF LSFTSCLSEY SEALSGLSTS YAALLRIKKS STSSAFGSKS
60 70 80 90 100
RPRYSSPSLG TLSVSPPSWR GAAQQYHSPV NLYHSPDAFR QDESVDYGPV
110 120 130 140 150
FVQEPDDIIF PTDSDEKKVA LNCEVRGNPS PTYRWLRNGT EIDLESDYRY
160 170 180 190 200
SMIDGTFIIN NPSESRDSGL YQCLATNTFG SILSREATLQ FAYLGNFSGR
210 220 230 240 250
TRSAVSVREG QGVVLMCSPP PHSPEIIYSW VFNEFPSFVA EDSRRFISQE
260 270 280 290 300
TGNLYISKVQ TSDVGSYICL VKNAVTNARV LSPPTPLTLR NDGVMGEYEP
310 320 330 340 350
KIEVHFPTTV TAAKGTTVKM ECFALGNPVP TITWMKVNGY IPSKSRLRKS
360 370 380 390 400
QAVLEIPNLQ LDDAGIYECT AENSRGKNSF RGQLQIYTYP HWVQKLNDTQ
410 420 430 440 450
LDSGSPLQWE CKATGKPRPT YRWLKNGAPL LPQSRVDTAN GVLAIHSVNQ
460 470 480 490 500
SDAGMYQCLA ENKYGAIYAS AELKILASPP SFELNQVKKS IIVTKDREVL
510 520 530 540 550
IECKPQGSPK PAISWRKGDK AVRGNKRIAI LPDGSLRILN ASKADEGKYI
560 570 580 590 600
CQGVNIFGSA EIIASVSVKE PTRIELTPKR TELTVGESIV LNCKAMHDSS
610 620 630 640 650
LDVTFYWTLK GQPIDFEKEG GHFESIRAQA SSADLMIRNI LLMHAGRYGC
660 670 680 690 700
RVQTTADSVS DEAELLVRGP PGPPGVVIVE EITESTATLS WSPATDNHSP
710 720 730 740 750
ISSYNLQARS PFSLGWQTVK TVPEVITGDM ESAMAVDLNP WVEYEFRVVA
760 770 780 790 800
TNPIGTGDPS IPSRMIRTNE AVPKTAPSNV SGGSGRRHEL VIAWEPVSEE
810 820 830 840 850
FQNGEGFGYI VAFRPNGTRG WKEKMVTSSD ASKFIYRDES VPPLTPFEVK
860 870 880 890 900
VGVYNNKGDG PFSQIVVICS AEGEPTAAPT DVTATSVSVS EIFVVWKHVK
910 920 930 940 950
ESLGRPQGFE IGYWKDTEPE DSAETVRTRG NESFVMLTGL EGDTLYHLTV
960 970 980 990 1000
RAYNGAGYGP PSREVSATTK RHPPSEPPGN LRWEQQGSQV SLGWEPVRPL
1010 1020 1030 1040 1050
ANESEVMGYK VFYRQEGHSK GQVIETQKPQ AVVPLPEAGV YIIEVRAYSE
1060 1070 1080 1090
GGDGTASSQI RVPSYAGGKI TSAQSTLHSL SKWSSVTLLL ALMLPSSSW
Length:1,099
Mass (Da):120,603
Last modified:May 1, 1997 - v1
Checksum:i35BC5745164AD203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87212 mRNA. Translation: BAA13311.1.
RefSeqiNP_446198.1. NM_053746.1.
XP_017450897.1. XM_017595408.1.
XP_017450898.1. XM_017595409.1.
XP_017450899.1. XM_017595410.1.
UniGeneiRn.10643.

Genome annotation databases

GeneIDi114589.
KEGGirno:114589.
UCSCiRGD:621302. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87212 mRNA. Translation: BAA13311.1.
RefSeqiNP_446198.1. NM_053746.1.
XP_017450897.1. XM_017595408.1.
XP_017450898.1. XM_017595409.1.
XP_017450899.1. XM_017595410.1.
UniGeneiRn.10643.

3D structure databases

ProteinModelPortaliP97527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009418.

Proteomic databases

PaxDbiP97527.
PRIDEiP97527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114589.
KEGGirno:114589.
UCSCiRGD:621302. rat.

Organism-specific databases

CTDi53942.
RGDi621302. Cntn5.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOVERGENiHBG051047.
InParanoidiP97527.
KOiK06763.
PhylomeDBiP97527.

Miscellaneous databases

PROiP97527.

Gene expression databases

BgeeiENSRNOG00000007038.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032989. Contactin-5.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF51. PTHR10489:SF51. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN5_RAT
AccessioniPrimary (citable) accession number: P97527
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.