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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

Tnfrsf8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8By similarity
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen: CD30By similarity
Gene namesi
Name:Tnfrsf8Imported
Synonyms:Cd30By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3879. Tnfrsf8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 255ExtracellularSequence analysisAdd BLAST237
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 493CytoplasmicSequence analysisAdd BLAST217

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003457619 – 493Tumor necrosis factor receptor superfamily member 8Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 121PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97525.
PRIDEiP97525.

Expressioni

Tissue specificityi

Very low level of expression. Detected in spleen, thymus and lung. Highly expressed in HTLV-1 infected T-cell lines.

Inductioni

By phytohemagglutinin (PHA) in spleen T-cells.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247144. 2 interactors.
STRINGi10116.ENSRNOP00000022967.

Structurei

3D structure databases

ProteinModelPortaliP97525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 66TNFR-Cys 1Add BLAST39
Repeati68 – 106TNFR-Cys 2Add BLAST39
Repeati107 – 150TNFR-Cys 3Add BLAST44

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAX. Eukaryota.
ENOG410YM0N. LUCA.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiP97525.
KOiK05145.
PhylomeDBiP97525.

Family and domain databases

CDDicd13409. TNFRSF8. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
IPR034002. TNFRSF8_N.
PRINTSiPR01923. TNFACTORR8.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS50050. TNFR_NGFR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLKAAGL LFLGMLQAFP KDRPLDTTCT GDLSYYPGEA ARNCCYQCPS
60 70 80 90 100
GLSPTQPCPQ GPATARNSVI LTTTSNEDGK CTACVTCLPG LVEKAPCSGN
110 120 130 140 150
SPRICECQPG MYCSTPAVNS CARCSEKTVV KFPDTAEKNT ICELPSPGSG
160 170 180 190 200
PNGSNPDDCK TLTSHTTPQA IPTLESPAND SVRSLLPKQV TDFVNEGATK
210 220 230 240 250
LVKVPESSSS KASMPSPDPG NAEMNMTLKL PPPGTVPDIS TSENSMEPAS
260 270 280 290 300
TASTLSLLVD ARTSSRMQPT SPLSTGTPFL DPGTMLFWVA MVVLLVGSAS
310 320 330 340 350
FLLCYWKACW RRFQRKFHLN YLQQTFQPKM EQVDSCPTEK LTQLQRSGSV
360 370 380 390 400
TDSSAGHTLS PLSPPAVETG ASVGTACLET LPLLDDSITG NSFAPREPPE
410 420 430 440 450
PRVSTEHTNN RIEKIYIMKA DTAIVGSVKT EVPEGRAPVG STESELEAEL
460 470 480 490
EVDHTPHYPE QETEPPLGSC TEVMFSVEEG GKEDHEPTTV SEK
Length:493
Mass (Da):52,658
Last modified:May 1, 1997 - v1
Checksum:i40BE75033B3CBB7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42117 mRNA. Translation: BAA07699.1.
PIRiJC5486.
RefSeqiNP_062008.1. NM_019135.1.
UniGeneiRn.11322.

Genome annotation databases

GeneIDi25069.
KEGGirno:25069.
UCSCiRGD:3879. rat.

Similar proteinsi

Entry informationi

Entry nameiTNR8_RAT
AccessioniPrimary (citable) accession number: P97525
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1997
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome