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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

Tnfrsf8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen: CD30
Gene namesi
Name:Tnfrsf8
Synonyms:Cd30
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3879. Tnfrsf8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 255237ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27621HelicalSequence analysisAdd
BLAST
Topological domaini277 – 493217CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 493475Tumor necrosis factor receptor superfamily member 8PRO_0000034576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 121PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97525.
PRIDEiP97525.

Expressioni

Tissue specificityi

Very low level of expression. Detected in spleen, thymus and lung. Highly expressed in HTLV-1 infected T-cell lines.

Inductioni

By phytohemagglutinin (PHA) in spleen T-cells.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.By similarity

Protein-protein interaction databases

BioGridi247144. 2 interactions.
STRINGi10116.ENSRNOP00000022967.

Structurei

3D structure databases

ProteinModelPortaliP97525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6639TNFR-Cys 1Add
BLAST
Repeati68 – 10639TNFR-Cys 2Add
BLAST
Repeati107 – 15044TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAX. Eukaryota.
ENOG410YM0N. LUCA.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiP97525.
KOiK05145.
PhylomeDBiP97525.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97525-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLKAAGL LFLGMLQAFP KDRPLDTTCT GDLSYYPGEA ARNCCYQCPS
60 70 80 90 100
GLSPTQPCPQ GPATARNSVI LTTTSNEDGK CTACVTCLPG LVEKAPCSGN
110 120 130 140 150
SPRICECQPG MYCSTPAVNS CARCSEKTVV KFPDTAEKNT ICELPSPGSG
160 170 180 190 200
PNGSNPDDCK TLTSHTTPQA IPTLESPAND SVRSLLPKQV TDFVNEGATK
210 220 230 240 250
LVKVPESSSS KASMPSPDPG NAEMNMTLKL PPPGTVPDIS TSENSMEPAS
260 270 280 290 300
TASTLSLLVD ARTSSRMQPT SPLSTGTPFL DPGTMLFWVA MVVLLVGSAS
310 320 330 340 350
FLLCYWKACW RRFQRKFHLN YLQQTFQPKM EQVDSCPTEK LTQLQRSGSV
360 370 380 390 400
TDSSAGHTLS PLSPPAVETG ASVGTACLET LPLLDDSITG NSFAPREPPE
410 420 430 440 450
PRVSTEHTNN RIEKIYIMKA DTAIVGSVKT EVPEGRAPVG STESELEAEL
460 470 480 490
EVDHTPHYPE QETEPPLGSC TEVMFSVEEG GKEDHEPTTV SEK
Length:493
Mass (Da):52,658
Last modified:May 1, 1997 - v1
Checksum:i40BE75033B3CBB7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42117 mRNA. Translation: BAA07699.1.
PIRiJC5486.
RefSeqiNP_062008.1. NM_019135.1.
UniGeneiRn.11322.

Genome annotation databases

GeneIDi25069.
KEGGirno:25069.
UCSCiRGD:3879. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42117 mRNA. Translation: BAA07699.1.
PIRiJC5486.
RefSeqiNP_062008.1. NM_019135.1.
UniGeneiRn.11322.

3D structure databases

ProteinModelPortaliP97525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247144. 2 interactions.
STRINGi10116.ENSRNOP00000022967.

Proteomic databases

PaxDbiP97525.
PRIDEiP97525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25069.
KEGGirno:25069.
UCSCiRGD:3879. rat.

Organism-specific databases

CTDi943.
RGDi3879. Tnfrsf8.

Phylogenomic databases

eggNOGiENOG410IZAX. Eukaryota.
ENOG410YM0N. LUCA.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiP97525.
KOiK05145.
PhylomeDBiP97525.

Miscellaneous databases

PROiP97525.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR8_RAT
AccessioniPrimary (citable) accession number: P97525
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.