Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial carnitine/acylcarnitine carrier protein

Gene

Slc25a20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.

GO - Molecular functioni

GO - Biological processi

  • carnitine transmembrane transport Source: RGD
  • carnitine transport Source: GO_Central
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14443

Protein family/group databases

TCDBi2.A.29.8.1 the mitochondrial carrier (mc) family

Chemistry databases

SwissLipidsiSLP:000001592

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine/acylcarnitine carrier protein
Alternative name(s):
Carnitine/acylcarnitine translocase
Short name:
CAC
Solute carrier family 25 member 20
Gene namesi
Name:Slc25a20
Synonyms:Cact
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621443 Slc25a20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 31Helical; Name=1Sequence analysisAdd BLAST19
Topological domaini32 – 73Mitochondrial matrixSequence analysisAdd BLAST42
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 112CytoplasmicSequence analysisAdd BLAST19
Transmembranei113 – 131Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini132 – 170Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei171 – 190Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini191 – 211CytoplasmicSequence analysisAdd BLAST21
Transmembranei212 – 230Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini231 – 267Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei268 – 287Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini288 – 301CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906312 – 301Mitochondrial carnitine/acylcarnitine carrier proteinAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei148N6-acetyllysineBy similarity1
Modified residuei157N6-acetyllysineBy similarity1
Modified residuei170N6-acetyllysine; alternateBy similarity1
Modified residuei170N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP97521
PRIDEiP97521

PTM databases

CarbonylDBiP97521
iPTMnetiP97521
PhosphoSitePlusiP97521

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027520

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BMNmodel-A5-289[»]
ProteinModelPortaliP97521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 99Solcar 1Add BLAST92
Repeati108 – 196Solcar 2Add BLAST89
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
HOGENOMiHOG000168307
HOVERGENiHBG003500
InParanoidiP97521
PhylomeDBiP97521

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP
60 70 80 90 100
MYSGTIDCFR KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKRLQ
110 120 130 140 150
QKSPEDELTY PQLFTAGMLS GVFTTGIMTP GERIKCLLQI QASSGKNKYS
160 170 180 190 200
GTLDCAKKLY QEFGIRGFYK GTALTLMRDV PASGMYFMTY EWLKNLFTPQ
210 220 230 240 250
GKSVHDLSVP RVLVAGGFRG IFNWVVAIPP DVLKSRFQTA PPGKYPNGFR
260 270 280 290 300
DVLRELIREE GVTSLYKGFN AVMIRAFPAN AACFLGFEIP MKILNWIAPN

L
Length:301
Mass (Da):33,154
Last modified:May 1, 1997 - v1
Checksum:i4A4284B4FF9D7439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97831 mRNA Translation: CAA66410.1
UniGeneiRn.3289

Genome annotation databases

UCSCiRGD:621443 rat

Similar proteinsi

Entry informationi

Entry nameiMCAT_RAT
AccessioniPrimary (citable) accession number: P97521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health