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Protein

Mitochondrial carnitine/acylcarnitine carrier protein

Gene

Slc25a20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.

GO - Biological processi

  • transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14443.

Protein family/group databases

TCDBi2.A.29.8.1. the mitochondrial carrier (mc) family.

Chemistry databases

SwissLipidsiSLP:000001592.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carnitine/acylcarnitine carrier protein
Alternative name(s):
Carnitine/acylcarnitine translocase
Short name:
CAC
Solute carrier family 25 member 20
Gene namesi
Name:Slc25a20
Synonyms:Cact
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621443. Slc25a20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 31Helical; Name=1Sequence analysisAdd BLAST19
Topological domaini32 – 73Mitochondrial matrixSequence analysisAdd BLAST42
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 112CytoplasmicSequence analysisAdd BLAST19
Transmembranei113 – 131Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini132 – 170Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei171 – 190Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini191 – 211CytoplasmicSequence analysisAdd BLAST21
Transmembranei212 – 230Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini231 – 267Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei268 – 287Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini288 – 301CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906312 – 301Mitochondrial carnitine/acylcarnitine carrier proteinAdd BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei148N6-acetyllysineBy similarity1
Modified residuei157N6-acetyllysineBy similarity1
Modified residuei170N6-acetyllysine; alternateBy similarity1
Modified residuei170N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP97521.
PRIDEiP97521.

PTM databases

iPTMnetiP97521.
PhosphoSitePlusiP97521.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027520.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BMNmodel-A5-289[»]
ProteinModelPortaliP97521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 99Solcar 1Add BLAST92
Repeati108 – 196Solcar 2Add BLAST89
Repeati207 – 293Solcar 3Add BLAST87

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiP97521.
PhylomeDBiP97521.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP
60 70 80 90 100
MYSGTIDCFR KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKRLQ
110 120 130 140 150
QKSPEDELTY PQLFTAGMLS GVFTTGIMTP GERIKCLLQI QASSGKNKYS
160 170 180 190 200
GTLDCAKKLY QEFGIRGFYK GTALTLMRDV PASGMYFMTY EWLKNLFTPQ
210 220 230 240 250
GKSVHDLSVP RVLVAGGFRG IFNWVVAIPP DVLKSRFQTA PPGKYPNGFR
260 270 280 290 300
DVLRELIREE GVTSLYKGFN AVMIRAFPAN AACFLGFEIP MKILNWIAPN

L
Length:301
Mass (Da):33,154
Last modified:May 1, 1997 - v1
Checksum:i4A4284B4FF9D7439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97831 mRNA. Translation: CAA66410.1.
UniGeneiRn.3289.

Genome annotation databases

UCSCiRGD:621443. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97831 mRNA. Translation: CAA66410.1.
UniGeneiRn.3289.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BMNmodel-A5-289[»]
ProteinModelPortaliP97521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027520.

Chemistry databases

ChEMBLiCHEMBL2173.
SwissLipidsiSLP:000001592.

Protein family/group databases

TCDBi2.A.29.8.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP97521.
PhosphoSitePlusiP97521.

Proteomic databases

PaxDbiP97521.
PRIDEiP97521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621443. rat.

Organism-specific databases

RGDi621443. Slc25a20.

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiP97521.
PhylomeDBiP97521.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14443.

Miscellaneous databases

PROiP97521.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCAT_RAT
AccessioniPrimary (citable) accession number: P97521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.