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Protein

C5a anaphylatoxin chemotactic receptor 1

Gene

C5ar1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:9464523). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (By similarity). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:9464523).By similarity1 Publication

GO - Molecular functioni

  • complement component C5a binding Source: RGD
  • complement component C5a receptor activity Source: RGD
  • G-protein coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events
R-RNO-6798695 Neutrophil degranulation
R-RNO-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 1
Alternative name(s):
C5a anaphylatoxin chemotactic receptor
Short name:
C5a-R
Short name:
C5aR
CD_antigen: CD88
Gene namesi
Name:C5ar1
Synonyms:C5r1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi70553 C5ar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 61Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini62 – 72CytoplasmicSequence analysisAdd BLAST11
Transmembranei73 – 95Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini96 – 111ExtracellularSequence analysisAdd BLAST16
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 202ExtracellularSequence analysisAdd BLAST27
Transmembranei203 – 228Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini229 – 244CytoplasmicSequence analysisAdd BLAST16
Transmembranei245 – 267Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini268 – 284ExtracellularSequence analysisAdd BLAST17
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 352CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692151 – 352C5a anaphylatoxin chemotactic receptor 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei13SulfotyrosineBy similarity1
Modified residuei15SulfotyrosineBy similarity1
Disulfide bondi110 ↔ 189PROSITE-ProRule annotation
Modified residuei316PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei336PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1

Post-translational modificationi

Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.By similarity
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP97520
PRIDEiP97520

PTM databases

iPTMnetiP97520
PhosphoSitePlusiP97520

Expressioni

Gene expression databases

BgeeiENSRNOG00000047800
GenevisibleiP97520 RN

Interactioni

Subunit structurei

Homodimer. May also form higher-order oligomers (By similarity). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600).By similarity1 Publication

GO - Molecular functioni

  • complement component C5a binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064558

Chemistry databases

BindingDBiP97520

Structurei

3D structure databases

ProteinModelPortaliP97520
SMRiP97520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0K Eukaryota
ENOG410Y9HH LUCA
GeneTreeiENSGT00760000118990
HOVERGENiHBG107547
InParanoidiP97520
KOiK04010
OMAiYINCCIN
OrthoDBiEOG091G0DT8
PhylomeDBiP97520

Family and domain databases

InterProiView protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01104 ANPHYLATOXNR
PR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPISNDSSE ITYDYSDGTP NPDMPADGVY IPKMEPGDIA ALIIYLAVFL
60 70 80 90 100
VGVTGNALVV WVTAFEAKRT VNAIWFLNLA VADLLSCLAL PILFTSIVKH
110 120 130 140 150
NHWPFGDQAC IVLPSLILLN MYSSILLLAT ISADRFLLVF KPIWCQKFRR
160 170 180 190 200
PGLAWMACGV TWVLALLLTI PSFVFRRIHK DPYSDSILCN IDYSKGPFFI
210 220 230 240 250
EKAIAILRLM VGFVLPLLTL NICYTFLLIR TWSRKATRST KTLKVVMAVV
260 270 280 290 300
TCFFVFWLPY QVTGVILAWL PRSSSTFQSV ERLNSLCVSL AYINCCVNPI
310 320 330 340 350
IYVMAGQGFH GRLRRSLPSI IRNVLSEDSL GRDSKSFTRS TMDTSTQKSQ

AV
Length:352
Mass (Da):39,417
Last modified:May 1, 1997 - v1
Checksum:i30878580C12650DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09613 mRNA Translation: CAA70825.1
AB003042 mRNA Translation: BAA20263.1
BC078770 mRNA Translation: AAH78770.1
RefSeqiNP_446071.1, NM_053619.1
UniGeneiRn.10680

Genome annotation databases

EnsembliENSRNOT00000073034; ENSRNOP00000064558; ENSRNOG00000047800
GeneIDi113959
KEGGirno:113959

Similar proteinsi

Entry informationi

Entry nameiC5AR1_RAT
AccessioniPrimary (citable) accession number: P97520
Secondary accession number(s): O09088
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health