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Protein

Myelin transcription factor 1-like protein

Gene

Myt1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5831C2HC-type 1Add
BLAST
Zinc fingeri505 – 53531C2HC-type 2Add
BLAST
Zinc fingeri549 – 57931C2HC-type 3Add
BLAST
Zinc fingeri904 – 93431C2HC-type 4Add
BLAST
Zinc fingeri953 – 98331C2HC-type 5Add
BLAST
Zinc fingeri1006 – 103631C2HC-type 6Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1-like protein
Short name:
MyT1-L
Short name:
MyT1L
Alternative name(s):
Neural zinc finger factor 1
Short name:
NZF-1
Postmitotic neural gene 1 protein
Zinc finger protein Png-1
Gene namesi
Name:Myt1l
Synonyms:Kiaa1106, Nzf1, Png1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1100511. Myt1l.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11871187Myelin transcription factor 1-like proteinPRO_0000096674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei251 – 2511PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP97500.
PaxDbiP97500.
PRIDEiP97500.

PTM databases

iPTMnetiP97500.
PhosphoSiteiP97500.

Expressioni

Tissue specificityi

Brain.1 Publication

Developmental stagei

Expression is restricted to and present throughout the embryonic CNS and developing peripheral neural structures. In the embryonic CNS, expression is restricted to postmitotic neuronal regions. During the neurogenetic period (E11-E17) expression is associated temporally and spatially with the known generation of the first cortical neurons with known gradients of neuron production. Expression continues in developing post-mitotic cortical neurons throughout embryonic development and is expressed within 2 days of neuronal induction in P19 cells.1 Publication

Inductioni

Up-regulated by retinoic acid.1 Publication

Gene expression databases

CleanExiMM_MYT1L.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058264.

Structurei

3D structure databases

ProteinModelPortaliP97500.
SMRiP97500. Positions 28-60, 503-578, 903-1045.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1058 – 113275Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 200118Asp/Glu-richAdd
BLAST
Compositional biasi688 – 72134Ser-richAdd
BLAST

Sequence similaritiesi

Contains 6 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 5831C2HC-type 1Add
BLAST
Zinc fingeri505 – 53531C2HC-type 2Add
BLAST
Zinc fingeri549 – 57931C2HC-type 3Add
BLAST
Zinc fingeri904 – 93431C2HC-type 4Add
BLAST
Zinc fingeri953 – 98331C2HC-type 5Add
BLAST
Zinc fingeri1006 – 103631C2HC-type 6Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiP97500.
PhylomeDBiP97500.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVDSEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD
110 120 130 140 150
DKEEDDDEEF SEDNDEQGDD DDEDEVDRED EEEIEEEDDE DDDDDEDGDD
160 170 180 190 200
VEEEEEDDDE EEEEEEEEEE NEDHQMSCTR IMQDTDKDDN NNDEYDNYDE
210 220 230 240 250
LVAKSLLNLG KIAEDAAYRA RTESEMNSNT SNSLEDDSDK NENLGRKSEL
260 270 280 290 300
SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY
310 320 330 340 350
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR
360 370 380 390 400
SQPPNMSVRQ HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC
410 420 430 440 450
AKEDGCHERD DDTTSVNSDR SEEVFDMTKG NLTLLEKAIA LETERAKAMR
460 470 480 490 500
EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK SKSSDSHVKK PYYGKDPSRT
510 520 530 540 550
EKRESKCPTP GCDGTGHVTG LYPHHRSLSG CPHKDRVPPE ILAMHENVLK
560 570 580 590 600
CPTPGCTGRG HVNSNRNSHR SLSGCPIAAA EKLAKAQEKH QSCDVSKSNQ
610 620 630 640 650
ASDRVLRPMC FVKQLEIPQY GYRNNVPTTT PRSNLAKELE KYSKTSFEYN
660 670 680 690 700
SYDNHTYGKR AIAPKVQTRD ISPKGYDDAK RYCKNASPSS STTSSYAPSS
710 720 730 740 750
SSNLSCGGGS SASSTCSKSS FDYTHDMEAA HMAATAILNL STRCREMPQN
760 770 780 790 800
LSTKPQDLCT ARNPDMEVDE NGTLDLSMNK QRPRDSCCPV LTPLEPMSPQ
810 820 830 840 850
QQAVMNSRCF QLSEGDCWDL PVDYTKMKPR RVDEDEPKEI TPEDLDPFQE
860 870 880 890 900
ALEERRYPGE VTIPSPKPKY PQCKESKKDL ITLSGCPLAD KSIRSMLATS
910 920 930 940 950
SQELKCPTPG CDGSGHITGN YASHRSLSGC PRAKKSGIRI AQSKEDKEDQ
960 970 980 990 1000
EPIRCPVPGC DGQGHITGKY ASHRSASGCP LAAKRQKDGY LNGSQFSWKS
1010 1020 1030 1040 1050
VKTEGMSCPT PGCDGSGHVS GSFLTHRSLS GCPRATSAMK KAKLSGEQML
1060 1070 1080 1090 1100
TIKQRASNGI ENDEEIKQLD EEIKELNESN SQMEADMIKL RTQITTMESN
1110 1120 1130 1140 1150
LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH MDPINEQNFD
1160 1170 1180
AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV
Length:1,187
Mass (Da):132,958
Last modified:September 27, 2005 - v2
Checksum:i5CA1CD42182A8C09
GO
Isoform 2 (identifier: P97500-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     494-495: Missing.

Show »
Length:1,185
Mass (Da):132,773
Checksum:i793B56AFE4FCE173
GO
Isoform 3 (identifier: P97500-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-597: Missing.
     598-605: SNQASDRV → MTNRQYFP
     906-925: CPTPGCDGSGHITGNYASHR → LPVQGPSAIDHLLMFSDFLN
     926-1187: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):36,798
Checksum:i6D40ED3476709A29
GO
Isoform 4 (identifier: P97500-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-426: Missing.
     494-495: Missing.
     906-925: CPTPGCDGSGHITGNYASHR → LPVQGPSAIDHLLMFSDFLN
     926-1187: Missing.

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):55,272
Checksum:iE1B72D3F732F8439
GO

Sequence cautioni

The sequence AAC53457.1 differs from that shown. Reason: Frameshift at positions 633 and 644. Curated
The sequence BAC41467.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 252AI → L in AAC53457 (PubMed:9373037).Curated
Sequence conflicti99 – 991M → V in AAC53457 (PubMed:9373037).Curated
Sequence conflicti127 – 1271D → AS (PubMed:9130664).Curated
Sequence conflicti172 – 1721Missing in AAC53457 (PubMed:9373037).Curated
Sequence conflicti269 – 2691L → S in AAC53457 (PubMed:9373037).Curated
Sequence conflicti305 – 3051K → R in AAC53457 (PubMed:9373037).Curated
Sequence conflicti323 – 3231V → A in AAC53457 (PubMed:9373037).Curated
Sequence conflicti515 – 5151T → N in BAC34010 (PubMed:16141072).Curated
Sequence conflicti650 – 6501N → K in BAC34010 (PubMed:16141072).Curated
Sequence conflicti806 – 8061N → S (PubMed:16141072).Curated
Sequence conflicti1072 – 10721E → G in AAC53457 (PubMed:9373037).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 597597Missing in isoform 3. 1 PublicationVSP_015726Add
BLAST
Alternative sequencei1 – 426426Missing in isoform 4. 1 PublicationVSP_015727Add
BLAST
Alternative sequencei494 – 4952Missing in isoform 2 and isoform 4. 4 PublicationsVSP_015728
Alternative sequencei598 – 6058SNQASDRV → MTNRQYFP in isoform 3. 1 PublicationVSP_015729
Alternative sequencei906 – 92520CPTPG…YASHR → LPVQGPSAIDHLLMFSDFLN in isoform 3 and isoform 4. 1 PublicationVSP_015730Add
BLAST
Alternative sequencei926 – 1187262Missing in isoform 3 and isoform 4. 1 PublicationVSP_015731Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86338 mRNA. Translation: AAC53157.1.
AF004295 mRNA. Translation: AAC53457.1. Frameshift.
AK049967 mRNA. Translation: BAC34010.1.
AK076608 mRNA. Translation: BAC36413.1.
AB093283 mRNA. Translation: BAC41467.1. Different initiation.
BC131677 mRNA. Translation: AAI31678.1.
CCDSiCCDS49041.1. [P97500-2]
CCDS49042.1. [P97500-1]
PIRiT30189.
T46608.
UniGeneiMm.253067.
Mm.418721.

Genome annotation databases

UCSCiuc007ngi.1. mouse. [P97500-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86338 mRNA. Translation: AAC53157.1.
AF004295 mRNA. Translation: AAC53457.1. Frameshift.
AK049967 mRNA. Translation: BAC34010.1.
AK076608 mRNA. Translation: BAC36413.1.
AB093283 mRNA. Translation: BAC41467.1. Different initiation.
BC131677 mRNA. Translation: AAI31678.1.
CCDSiCCDS49041.1. [P97500-2]
CCDS49042.1. [P97500-1]
PIRiT30189.
T46608.
UniGeneiMm.253067.
Mm.418721.

3D structure databases

ProteinModelPortaliP97500.
SMRiP97500. Positions 28-60, 503-578, 903-1045.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058264.

PTM databases

iPTMnetiP97500.
PhosphoSiteiP97500.

Proteomic databases

MaxQBiP97500.
PaxDbiP97500.
PRIDEiP97500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007ngi.1. mouse. [P97500-3]

Organism-specific databases

MGIiMGI:1100511. Myt1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiP97500.
PhylomeDBiP97500.

Miscellaneous databases

PROiP97500.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYT1L.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development."
    Weiner J.A., Chun J.
    J. Comp. Neurol. 381:130-142(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, INDUCTION, DEVELOPMENTAL STAGE.
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system."
    Kim J.G., Armstrong R.C., Agoston D.V., Robinsky A., Wiese C., Nagle J., Hudson L.D.
    J. Neurosci. Res. 50:272-290(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Strain: C57BL/6J.
    Tissue: Hippocampus and Testis.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiMYT1L_MOUSE
AccessioniPrimary (citable) accession number: P97500
Secondary accession number(s): A2RRK5
, O08996, Q8C643, Q8C7L4, Q8CHB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.