P97499 (TEP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Telomerase protein component 1 Alternative name(s): Telomerase-associated protein 1 Short name=Telomerase protein 1 p240 p80 telomerase homolog | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 2629 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC By similarity. Ref.4 |
| Subunit structure | Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs. |
| Subcellular location | Nucleus Probable. Chromosome › telomere. |
| Tissue specificity | |
| Sequence similarities | Contains 1 NACHT domain. Contains 4 TEP1 N-terminal repeats. Contains 1 TROVE domain. Contains 21 WD repeats. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Chromosome Nucleus Telomere |
| Domain | Repeat WD repeat |
| Ligand | ATP-binding Nucleotide-binding RNA-binding |
| Molecular function | Ribonucleoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fractionInferred from direct assay. Source: MGI |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA bindingInferred from mutant phenotype. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2629 | 2629 | Telomerase protein component 1 | PRO_0000050983 | |||||
Regions | |||||||||
| Repeat | 1 – 30 | 30 | TEP1 N-terminal 1 | ||||||
| Repeat | 31 – 60 | 30 | TEP1 N-terminal 2 | ||||||
| Repeat | 61 – 90 | 30 | TEP1 N-terminal 3 | ||||||
| Repeat | 91 – 120 | 30 | TEP1 N-terminal 4 | ||||||
| Domain | 227 – 685 | 459 | TROVE | ||||||
| Domain | 1171 – 1578 | 408 | NACHT | ||||||
| Repeat | 1420 – 1462 | 43 | WD 1 | ||||||
| Repeat | 1681 – 1720 | 40 | WD 2 | ||||||
| Repeat | 1723 – 1761 | 39 | WD 3 | ||||||
| Repeat | 1764 – 1803 | 40 | WD 4 | ||||||
| Repeat | 1805 – 1844 | 40 | WD 5 | ||||||
| Repeat | 1847 – 1886 | 40 | WD 6 | ||||||
| Repeat | 1889 – 1930 | 42 | WD 7 | ||||||
| Repeat | 1932 – 1971 | 40 | WD 8 | ||||||
| Repeat | 1974 – 2013 | 40 | WD 9 | ||||||
| Repeat | 2015 – 2054 | 40 | WD 10 | ||||||
| Repeat | 2067 – 2106 | 40 | WD 11 | ||||||
| Repeat | 2113 – 2151 | 39 | WD 12 | ||||||
| Repeat | 2154 – 2191 | 38 | WD 13 | ||||||
| Repeat | 2193 – 2241 | 49 | WD 14 | ||||||
| Repeat | 2244 – 2282 | 39 | WD 15 | ||||||
| Repeat | 2285 – 2324 | 40 | WD 16 | ||||||
| Repeat | 2326 – 2362 | 37 | WD 17 | ||||||
| Repeat | 2375 – 2424 | 50 | WD 18 | ||||||
| Repeat | 2467 – 2507 | 41 | WD 19 | ||||||
| Repeat | 2555 – 2592 | 38 | WD 20 | ||||||
| Repeat | 2594 – 2628 | 35 | WD 21 | ||||||
| Nucleotide binding | 1177 – 1184 | 8 | ATP Potential | ||||||
Sequences
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References
| [1] | "A mammalian telomerase-associated protein." Harrington L., McPhail T., Mar V., Zhou W., Oulton R., Bass M.B., Arruda I., Robinson M.O. Science 275:973-977(1997) [PubMed: 9020079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, RNA-BINDING, IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX. |
| [2] | "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family." Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F. Cell 88:875-884(1997) [PubMed: 9118230] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [3] | "Vaults and telomerase share a common subunit, TEP1." Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H. J. Biol. Chem. 274:32712-32717(1999) [PubMed: 10551828] [Abstract] Cited for: RNA-BINDING. |
| [4] | "The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle." Kickhoefer V.A., Liu Y., Kong L.B., Snow B.E., Stewart P.L., Harrington L., Rome L.H. J. Cell Biol. 152:157-164(2001) [PubMed: 11149928] [Abstract] Cited for: FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION, IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U86137 mRNA. Translation: AAC53043.1. |
| IPI | IPI00125667. |
| PIR | T30987. |
| RefSeq | NP_033377.1. NM_009351.2. |
| UniGene | Mm.318736. |
3D structure databases | |
| ProteinModelPortal | P97499. |
| SMR | P97499. Positions 1160-1198, 1678-1963, 2009-2399. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P97499. |
PTM databases | |
| PhosphoSite | P97499. |
Proteomic databases | |
| PRIDE | P97499. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281. |
| GeneID | 21745. |
| KEGG | mmu:21745. |
| UCSC | uc007tlt.1. mouse. |
Organism-specific databases | |
| CTD | 7011. |
| MGI | MGI:109573. Tep1. |
Phylogenomic databases | |
| eggNOG | roNOG09840. |
| HOGENOM | HBG282400. |
| HOVERGEN | HBG059633. |
| InParanoid | P97499. |
| OMA | SVPDAWK. |
| OrthoDB | EOG4001HG. |
| PhylomeDB | P97499. |
Gene expression databases | |
| ArrayExpress | P97499. |
| Bgee | P97499. |
| CleanEx | MM_TEP1. |
| Genevestigator | P97499. |
| GermOnline | ENSMUSG00000006281. Mus musculus. |
Family and domain databases | |
| InterPro | IPR007111. NACHT_NTPase. IPR008850. TEP1_N. IPR008858. TROVE. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view] |
| Gene3D | G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 5 hits. |
| KO | K11127. |
| Pfam | PF05386. TEP1_N. 4 hits. PF05731. TROVE. 1 hit. PF00400. WD40. 10 hits. [Graphical view] |
| SMART | SM00320. WD40. 16 hits. [Graphical view] |
| SUPFAM | SSF50978. WD40_like. 5 hits. |
| PROSITE | PS50837. NACHT. 1 hit. PS51226. TEP1_N. 4 hits. PS50988. TROVE. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 8 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 301032. |
| SOURCE | Search... |
Entry information
| Entry name | TEP1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P97499 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with