Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Telomerase protein component 1

Gene

Tep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1177 – 11848ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: MGI
  • p53 binding Source: MGI
  • RNA binding Source: UniProtKB
  • telomerase activity Source: Ensembl
  • telomerase RNA binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase protein component 1
Alternative name(s):
Telomerase-associated protein 1
Short name:
Telomerase protein 1
p240
p80 telomerase homolog
Gene namesi
Name:Tep1
Synonyms:Tp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109573. Tep1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • nuclear matrix Source: MGI
  • telomerase holoenzyme complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26292629Telomerase protein component 1PRO_0000050983Add
BLAST

Proteomic databases

EPDiP97499.
MaxQBiP97499.
PaxDbiP97499.
PeptideAtlasiP97499.
PRIDEiP97499.

PTM databases

iPTMnetiP97499.
PhosphoSiteiP97499.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiP97499.
CleanExiMM_TEP1.
GenevisibleiP97499. MM.

Interactioni

Subunit structurei

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97499. 1 interaction.
MINTiMINT-4137438.
STRINGi10090.ENSMUSP00000006444.

Structurei

3D structure databases

ProteinModelPortaliP97499.
SMRiP97499. Positions 1554-2584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3030TEP1 N-terminal 1Add
BLAST
Repeati31 – 6030TEP1 N-terminal 2Add
BLAST
Repeati61 – 9030TEP1 N-terminal 3Add
BLAST
Repeati91 – 12030TEP1 N-terminal 4Add
BLAST
Domaini227 – 685459TROVEPROSITE-ProRule annotationAdd
BLAST
Domaini1171 – 1578408NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati1420 – 146243WD 1Add
BLAST
Repeati1681 – 172040WD 2Add
BLAST
Repeati1723 – 176139WD 3Add
BLAST
Repeati1764 – 180340WD 4Add
BLAST
Repeati1805 – 184440WD 5Add
BLAST
Repeati1847 – 188640WD 6Add
BLAST
Repeati1889 – 193042WD 7Add
BLAST
Repeati1932 – 197140WD 8Add
BLAST
Repeati1974 – 201340WD 9Add
BLAST
Repeati2015 – 205440WD 10Add
BLAST
Repeati2067 – 210640WD 11Add
BLAST
Repeati2113 – 215139WD 12Add
BLAST
Repeati2154 – 219138WD 13Add
BLAST
Repeati2193 – 224149WD 14Add
BLAST
Repeati2244 – 228239WD 15Add
BLAST
Repeati2285 – 232440WD 16Add
BLAST
Repeati2326 – 236237WD 17Add
BLAST
Repeati2375 – 242450WD 18Add
BLAST
Repeati2467 – 250741WD 19Add
BLAST
Repeati2555 – 259238WD 20Add
BLAST
Repeati2594 – 262835WD 21Add
BLAST

Sequence similaritiesi

Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 4 TEP1 N-terminal repeats.PROSITE-ProRule annotation
Contains 1 TROVE domain.PROSITE-ProRule annotation
Contains 21 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
KOG4155. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00840000129872.
HOGENOMiHOG000154545.
HOVERGENiHBG059633.
InParanoidiP97499.
KOiK11127.
OMAiAQLWKTC.
OrthoDBiEOG7W6WJT.
PhylomeDBiP97499.
TreeFamiTF328424.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR025139. DUF4062.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
IPR008850. TEP1_N.
IPR008858. TROVE_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
PF05386. TEP1_N. 4 hits.
PF05731. TROVE. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 16 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
PS51226. TEP1_N. 4 hits.
PS50988. TROVE. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ
60 70 80 90 100
CLTMLSDLQP TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS
110 120 130 140 150
HPDVLSLENQ CLATLPTVKS TALTSPLLQG LHISHTAQAD LHSLKTSNCL
160 170 180 190 200
LPELPTKKTP CFSEELDLPP GPRALKSMSA TAQVQEVALG QWCVSKEKEF
210 220 230 240 250
QEEESTEVPM PLYSLSLEEE EVEAPVLKLT SGDSGFHPET TDQVLQEKKM
260 270 280 290 300
ALLTLLCSAL ASNVNVKDAS DLTRASILEV CSALASLEPE FILKASLYAR
310 320 330 340 350
QQLNLRDIAN TVLAVAALLP ACRPHVRRYY SAIVHLPSDW IQVAEFYQSL
360 370 380 390 400
AEGDEKKLVS LPACLRAAMT DKFAEFDEYQ LAKYNPRKHR SKRRSRQPPR
410 420 430 440 450
PQKTERPFSE RGKCFPKSLW PLKNEQITFE AAYNAMPEKN RLPRFTLKKL
460 470 480 490 500
VEYLHIHKPA QHVQALLGYR YPATLELFSR SHLPGPWESS RAGQRMKLRR
510 520 530 540 550
PETWERELSL RGNKASVWEE LIDNGKLPFM AMLRNLCNLL RTGISARHHE
560 570 580 590 600
LVLQRLQHEK SVVHSRQFPF RFLNAHDSID KLEAQLRSKA SPFPSNTTLM
610 620 630 640 650
KRIMIRNSKK NRRPASRKHL CTLTRRQLRA AMTIPVMYEQ LKREKLRLHK
660 670 680 690 700
ARQWNCDVEL LERYRQALET AVNLSVKHNL SPMPGRTLLV YLTDANADRL
710 720 730 740 750
CPKSHSQGPP LNYVLLLIGM MVARAEQVTV CLCGGGFVKT PVLTADEGIL
760 770 780 790 800
KTAIKLQAQV QELEGNDEWP LDTFGKYLLS LAVQRTPIDR VILFGQRMDT
810 820 830 840 850
ELLKVAKQII WQHVNSKCLF VGVLLQKTQY ISPNLNPNDV TLSGCTDGIL
860 870 880 890 900
KFIAEHGASR LLEHVGQLDK LFKIPPPPGK TQAPSLRPLE ENIPGPLGPI
910 920 930 940 950
SQHGWRNIRL FISSTFRDMH GERDLLMRSV LPALQARVFP HRISLHAIDL
960 970 980 990 1000
RWGITEEETR RNRQLEVCLG EVENSQLFVG ILGSRYGYIP PSYDLPDHPH
1010 1020 1030 1040 1050
FHWTHEYPSG RSVTEMEVMQ FLNRGQRSQP SAQALIYFRD PDFLSSVPDA
1060 1070 1080 1090 1100
WKPDFISESE EAAHRVSELK RYLHEQKEVT CRSYSCEWGG VAAGRPYTGG
1110 1120 1130 1140 1150
LEEFGQLVLQ DVWSMIQKQH LQPGAQLEQP TSISEDDLIQ TSFQQLKTPT
1160 1170 1180 1190 1200
SPARPRLLQD TVQQLLLPHG RLSLVTGQAG QGKTAFLASL VSALKVPDQP
1210 1220 1230 1240 1250
NEPPFVFFHF AAARPDQCLA LNLLRRLCTH LRQKLGELSA LPSTYRGLVW
1260 1270 1280 1290 1300
ELQQKLLLKF AQSLQPAQTL VLIIDGADKL VDRNGQLISD WIPKSLPRRV
1310 1320 1330 1340 1350
HLVLSVSSDS GLGETLQQSQ GAYVVALGSL VPSSRAQLVR EELALYGKRL
1360 1370 1380 1390 1400
EESPFNNQMR LLLAKQGSSL PLYLHLVTDY LRLFTLYEQV SERLRTLPAT
1410 1420 1430 1440 1450
LPLLLQHILS TLEQEHGHDV LPQALTALEV TRSGLTVDQL HAILSTWLIL
1460 1470 1480 1490 1500
PKETKSWEEV LAASHSGNPF PLCPFAYLVQ SLRSLLGEGP VERPGARLCL
1510 1520 1530 1540 1550
SDGPLRTTIK RRYGKRLGLE KTAHVLIAAH LWKTCDPDAS GTFRSCPPEA
1560 1570 1580 1590 1600
LKDLPYHLLQ SGNHGLLAEF LTNLHVVAAY LEVGLVPDLL EAHVLYASSK
1610 1620 1630 1640 1650
PEANQKLPAA DVAVFHTFLR QQASLLTQYP LLLLQQAASQ PEESPVCCQA
1660 1670 1680 1690 1700
PLLTQRWHDQ FTLKWINKPQ TLKGQQSLSL TMSSSPTAVA FSPNGQRAAV
1710 1720 1730 1740 1750
GTASGTIYLL NLKTWQEEKA VVSGCDGISS FAFLSDTALF LTTFDGHLEL
1760 1770 1780 1790 1800
WDLQHGCWVF QTKAHQYQIT GCCLSPDRRL LATVCLGGYL KLWDTVRGQL
1810 1820 1830 1840 1850
AFQYTHPKSL NCVAFHPEGQ VVATGSWAGS ITFFQADGLK VTKELGAPGP
1860 1870 1880 1890 1900
SVCSLAFNKP GKIVAVGRID GTVELWAWQE GARLAAFPAQ CGCVSAVLFL
1910 1920 1930 1940 1950
HAGDRFLTAG EDGKAQLWSG FLGRPRGCLG SLPLSPALSV ALNPDGDQVA
1960 1970 1980 1990 2000
VGYREDGINI YKISSGSQGP QHQELNVAVS ALVWLSPSVL VSGAEDGSLH
2010 2020 2030 2040 2050
GWMFKGDSLH SLWLLSRYQK PVLGLAASRE LMAAASEDFT VRLWPRQLLT
2060 2070 2080 2090 2100
QPHVHAVELP CCAELRGHEG PVCCCSFSPD GGILATAGRD RNLLCWDMKI
2110 2120 2130 2140 2150
AQAPLLIHTF SSCHRDWITG CAWTKDNILV SCSSDGSVGL WNPEAGQQLG
2160 2170 2180 2190 2200
QFSGHQSAVS AVVAVEEHIV SVSRDGTLKV WDHQGVELTS IPAHSGPISQ
2210 2220 2230 2240 2250
CAAALEPRPG GQPGSELLVV TVGLDGATKL WHPLLVCQIR TLQGHSGPVT
2260 2270 2280 2290 2300
AAAASEASGL LLTSDDSSVQ LWQIPKEADD SYKPRSSVAI TAVAWAPDGS
2310 2320 2330 2340 2350
MVVSGNEAGE LTLWQQAKAV ATAQAPGRVS HLIWYSANSF FVLSANENVS
2360 2370 2380 2390 2400
EWQVGLRKGS TSTSSSLHLK RVLQEDWGVL TGLGLAPDGQ SLILMKEDVE
2410 2420 2430 2440 2450
LLEMKPGSIP SSICRRYGVH SSILCTSKEY GLFYLQQGDS GLLSILEQKE
2460 2470 2480 2490 2500
SGEFEEILDF NLNLNNPNGS PVSITQAKPE SESSLLCATS DGMLWNLSEC
2510 2520 2530 2540 2550
TSEGEWIVDN IWQKKAKKPK TQTLETELSP HSELDFSIDC WIDPTNLKAQ
2560 2570 2580 2590 2600
QCKKIHLGSV TALHVLPGLL VTASKDRDVK LWERPSMQLL GLFRCEGPVS
2610 2620
CLEPWMEPSS PLQLAVGDTQ GNLYFLSWE
Length:2,629
Mass (Da):291,460
Last modified:May 1, 1997 - v1
Checksum:i62F73691F900A77B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86137 mRNA. Translation: AAC53043.1.
CCDSiCCDS36907.1.
PIRiT30987.
RefSeqiNP_033377.1. NM_009351.2.
UniGeneiMm.318736.

Genome annotation databases

EnsembliENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281.
GeneIDi21745.
KEGGimmu:21745.
UCSCiuc007tlt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86137 mRNA. Translation: AAC53043.1.
CCDSiCCDS36907.1.
PIRiT30987.
RefSeqiNP_033377.1. NM_009351.2.
UniGeneiMm.318736.

3D structure databases

ProteinModelPortaliP97499.
SMRiP97499. Positions 1554-2584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97499. 1 interaction.
MINTiMINT-4137438.
STRINGi10090.ENSMUSP00000006444.

PTM databases

iPTMnetiP97499.
PhosphoSiteiP97499.

Proteomic databases

EPDiP97499.
MaxQBiP97499.
PaxDbiP97499.
PeptideAtlasiP97499.
PRIDEiP97499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281.
GeneIDi21745.
KEGGimmu:21745.
UCSCiuc007tlt.1. mouse.

Organism-specific databases

CTDi7011.
MGIiMGI:109573. Tep1.

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
KOG4155. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00840000129872.
HOGENOMiHOG000154545.
HOVERGENiHBG059633.
InParanoidiP97499.
KOiK11127.
OMAiAQLWKTC.
OrthoDBiEOG7W6WJT.
PhylomeDBiP97499.
TreeFamiTF328424.

Miscellaneous databases

PROiP97499.
SOURCEiSearch...

Gene expression databases

BgeeiP97499.
CleanExiMM_TEP1.
GenevisibleiP97499. MM.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR025139. DUF4062.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
IPR008850. TEP1_N.
IPR008858. TROVE_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
PF05386. TEP1_N. 4 hits.
PF05731. TROVE. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 16 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
PS51226. TEP1_N. 4 hits.
PS50988. TROVE. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, RNA-BINDING, IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
  2. "TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family."
    Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F.
    Cell 88:875-884(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. Cited for: RNA-BINDING.
  4. "The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle."
    Kickhoefer V.A., Liu Y., Kong L.B., Snow B.E., Stewart P.L., Harrington L., Rome L.H.
    J. Cell Biol. 152:157-164(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION, IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Liver, Lung, Pancreas and Testis.

Entry informationi

Entry nameiTEP1_MOUSE
AccessioniPrimary (citable) accession number: P97499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.