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P97499 (TEP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Telomerase protein component 1
Alternative name(s):
Telomerase-associated protein 1
Short name=Telomerase protein 1
p240
p80 telomerase homolog
Gene names
Name:Tep1
Synonyms:Tp1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length2629 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC By similarity. Ref.4

Subunit structure

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs.

Subcellular location

Nucleus Probable. Chromosome › telomere.

Tissue specificity

Ubiquitous. Ref.1 Ref.2

Sequence similarities

Contains 1 NACHT domain.

Contains 4 TEP1 N-terminal repeats.

Contains 1 TROVE domain.

Contains 21 WD repeats.

Ontologies

Keywords
   Cellular componentChromosome
Nucleus
Telomere
   DomainRepeat
WD repeat
   LigandATP-binding
Nucleotide-binding
RNA-binding
   Molecular functionRibonucleoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentchromosome, telomeric region

Inferred from electronic annotation. Source: UniProtKB-SubCell

soluble fraction

Inferred from direct assay. Source: MGI

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from mutant phenotype. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 26292629Telomerase protein component 1
PRO_0000050983

Regions

Repeat1 – 3030TEP1 N-terminal 1
Repeat31 – 6030TEP1 N-terminal 2
Repeat61 – 9030TEP1 N-terminal 3
Repeat91 – 12030TEP1 N-terminal 4
Domain227 – 685459TROVE
Domain1171 – 1578408NACHT
Repeat1420 – 146243WD 1
Repeat1681 – 172040WD 2
Repeat1723 – 176139WD 3
Repeat1764 – 180340WD 4
Repeat1805 – 184440WD 5
Repeat1847 – 188640WD 6
Repeat1889 – 193042WD 7
Repeat1932 – 197140WD 8
Repeat1974 – 201340WD 9
Repeat2015 – 205440WD 10
Repeat2067 – 210640WD 11
Repeat2113 – 215139WD 12
Repeat2154 – 219138WD 13
Repeat2193 – 224149WD 14
Repeat2244 – 228239WD 15
Repeat2285 – 232440WD 16
Repeat2326 – 236237WD 17
Repeat2375 – 242450WD 18
Repeat2467 – 250741WD 19
Repeat2555 – 259238WD 20
Repeat2594 – 262835WD 21
Nucleotide binding1177 – 11848ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P97499 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 62F73691F900A77B

FASTA2,629291,460
        10         20         30         40         50         60 
MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ CLTMLSDLQP 

        70         80         90        100        110        120 
TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS HPDVLSLENQ CLATLPTVKS 

       130        140        150        160        170        180 
TALTSPLLQG LHISHTAQAD LHSLKTSNCL LPELPTKKTP CFSEELDLPP GPRALKSMSA 

       190        200        210        220        230        240 
TAQVQEVALG QWCVSKEKEF QEEESTEVPM PLYSLSLEEE EVEAPVLKLT SGDSGFHPET 

       250        260        270        280        290        300 
TDQVLQEKKM ALLTLLCSAL ASNVNVKDAS DLTRASILEV CSALASLEPE FILKASLYAR 

       310        320        330        340        350        360 
QQLNLRDIAN TVLAVAALLP ACRPHVRRYY SAIVHLPSDW IQVAEFYQSL AEGDEKKLVS 

       370        380        390        400        410        420 
LPACLRAAMT DKFAEFDEYQ LAKYNPRKHR SKRRSRQPPR PQKTERPFSE RGKCFPKSLW 

       430        440        450        460        470        480 
PLKNEQITFE AAYNAMPEKN RLPRFTLKKL VEYLHIHKPA QHVQALLGYR YPATLELFSR 

       490        500        510        520        530        540 
SHLPGPWESS RAGQRMKLRR PETWERELSL RGNKASVWEE LIDNGKLPFM AMLRNLCNLL 

       550        560        570        580        590        600 
RTGISARHHE LVLQRLQHEK SVVHSRQFPF RFLNAHDSID KLEAQLRSKA SPFPSNTTLM 

       610        620        630        640        650        660 
KRIMIRNSKK NRRPASRKHL CTLTRRQLRA AMTIPVMYEQ LKREKLRLHK ARQWNCDVEL 

       670        680        690        700        710        720 
LERYRQALET AVNLSVKHNL SPMPGRTLLV YLTDANADRL CPKSHSQGPP LNYVLLLIGM 

       730        740        750        760        770        780 
MVARAEQVTV CLCGGGFVKT PVLTADEGIL KTAIKLQAQV QELEGNDEWP LDTFGKYLLS 

       790        800        810        820        830        840 
LAVQRTPIDR VILFGQRMDT ELLKVAKQII WQHVNSKCLF VGVLLQKTQY ISPNLNPNDV 

       850        860        870        880        890        900 
TLSGCTDGIL KFIAEHGASR LLEHVGQLDK LFKIPPPPGK TQAPSLRPLE ENIPGPLGPI 

       910        920        930        940        950        960 
SQHGWRNIRL FISSTFRDMH GERDLLMRSV LPALQARVFP HRISLHAIDL RWGITEEETR 

       970        980        990       1000       1010       1020 
RNRQLEVCLG EVENSQLFVG ILGSRYGYIP PSYDLPDHPH FHWTHEYPSG RSVTEMEVMQ 

      1030       1040       1050       1060       1070       1080 
FLNRGQRSQP SAQALIYFRD PDFLSSVPDA WKPDFISESE EAAHRVSELK RYLHEQKEVT 

      1090       1100       1110       1120       1130       1140 
CRSYSCEWGG VAAGRPYTGG LEEFGQLVLQ DVWSMIQKQH LQPGAQLEQP TSISEDDLIQ 

      1150       1160       1170       1180       1190       1200 
TSFQQLKTPT SPARPRLLQD TVQQLLLPHG RLSLVTGQAG QGKTAFLASL VSALKVPDQP 

      1210       1220       1230       1240       1250       1260 
NEPPFVFFHF AAARPDQCLA LNLLRRLCTH LRQKLGELSA LPSTYRGLVW ELQQKLLLKF 

      1270       1280       1290       1300       1310       1320 
AQSLQPAQTL VLIIDGADKL VDRNGQLISD WIPKSLPRRV HLVLSVSSDS GLGETLQQSQ 

      1330       1340       1350       1360       1370       1380 
GAYVVALGSL VPSSRAQLVR EELALYGKRL EESPFNNQMR LLLAKQGSSL PLYLHLVTDY 

      1390       1400       1410       1420       1430       1440 
LRLFTLYEQV SERLRTLPAT LPLLLQHILS TLEQEHGHDV LPQALTALEV TRSGLTVDQL 

      1450       1460       1470       1480       1490       1500 
HAILSTWLIL PKETKSWEEV LAASHSGNPF PLCPFAYLVQ SLRSLLGEGP VERPGARLCL 

      1510       1520       1530       1540       1550       1560 
SDGPLRTTIK RRYGKRLGLE KTAHVLIAAH LWKTCDPDAS GTFRSCPPEA LKDLPYHLLQ 

      1570       1580       1590       1600       1610       1620 
SGNHGLLAEF LTNLHVVAAY LEVGLVPDLL EAHVLYASSK PEANQKLPAA DVAVFHTFLR 

      1630       1640       1650       1660       1670       1680 
QQASLLTQYP LLLLQQAASQ PEESPVCCQA PLLTQRWHDQ FTLKWINKPQ TLKGQQSLSL 

      1690       1700       1710       1720       1730       1740 
TMSSSPTAVA FSPNGQRAAV GTASGTIYLL NLKTWQEEKA VVSGCDGISS FAFLSDTALF 

      1750       1760       1770       1780       1790       1800 
LTTFDGHLEL WDLQHGCWVF QTKAHQYQIT GCCLSPDRRL LATVCLGGYL KLWDTVRGQL 

      1810       1820       1830       1840       1850       1860 
AFQYTHPKSL NCVAFHPEGQ VVATGSWAGS ITFFQADGLK VTKELGAPGP SVCSLAFNKP 

      1870       1880       1890       1900       1910       1920 
GKIVAVGRID GTVELWAWQE GARLAAFPAQ CGCVSAVLFL HAGDRFLTAG EDGKAQLWSG 

      1930       1940       1950       1960       1970       1980 
FLGRPRGCLG SLPLSPALSV ALNPDGDQVA VGYREDGINI YKISSGSQGP QHQELNVAVS 

      1990       2000       2010       2020       2030       2040 
ALVWLSPSVL VSGAEDGSLH GWMFKGDSLH SLWLLSRYQK PVLGLAASRE LMAAASEDFT 

      2050       2060       2070       2080       2090       2100 
VRLWPRQLLT QPHVHAVELP CCAELRGHEG PVCCCSFSPD GGILATAGRD RNLLCWDMKI 

      2110       2120       2130       2140       2150       2160 
AQAPLLIHTF SSCHRDWITG CAWTKDNILV SCSSDGSVGL WNPEAGQQLG QFSGHQSAVS 

      2170       2180       2190       2200       2210       2220 
AVVAVEEHIV SVSRDGTLKV WDHQGVELTS IPAHSGPISQ CAAALEPRPG GQPGSELLVV 

      2230       2240       2250       2260       2270       2280 
TVGLDGATKL WHPLLVCQIR TLQGHSGPVT AAAASEASGL LLTSDDSSVQ LWQIPKEADD 

      2290       2300       2310       2320       2330       2340 
SYKPRSSVAI TAVAWAPDGS MVVSGNEAGE LTLWQQAKAV ATAQAPGRVS HLIWYSANSF 

      2350       2360       2370       2380       2390       2400 
FVLSANENVS EWQVGLRKGS TSTSSSLHLK RVLQEDWGVL TGLGLAPDGQ SLILMKEDVE 

      2410       2420       2430       2440       2450       2460 
LLEMKPGSIP SSICRRYGVH SSILCTSKEY GLFYLQQGDS GLLSILEQKE SGEFEEILDF 

      2470       2480       2490       2500       2510       2520 
NLNLNNPNGS PVSITQAKPE SESSLLCATS DGMLWNLSEC TSEGEWIVDN IWQKKAKKPK 

      2530       2540       2550       2560       2570       2580 
TQTLETELSP HSELDFSIDC WIDPTNLKAQ QCKKIHLGSV TALHVLPGLL VTASKDRDVK 

      2590       2600       2610       2620 
LWERPSMQLL GLFRCEGPVS CLEPWMEPSS PLQLAVGDTQ GNLYFLSWE

« Hide

References

[1]"A mammalian telomerase-associated protein."
Harrington L., McPhail T., Mar V., Zhou W., Oulton R., Bass M.B., Arruda I., Robinson M.O.
Science 275:973-977(1997) [PubMed: 9020079] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, RNA-BINDING, IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX.
[2]"TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family."
Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F.
Cell 88:875-884(1997) [PubMed: 9118230] [Abstract]
Cited for: TISSUE SPECIFICITY.
[3]"Vaults and telomerase share a common subunit, TEP1."
Kickhoefer V.A., Stephen A.G., Harrington L., Robinson M.O., Rome L.H.
J. Biol. Chem. 274:32712-32717(1999) [PubMed: 10551828] [Abstract]
Cited for: RNA-BINDING.
[4]"The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle."
Kickhoefer V.A., Liu Y., Kong L.B., Snow B.E., Stewart P.L., Harrington L., Rome L.H.
J. Cell Biol. 152:157-164(2001) [PubMed: 11149928] [Abstract]
Cited for: FUNCTION IN VAULT RNA LOCALIZATION/STABILIZATION, IDENTIFICATION IN THE VAULTS RIBONUCLEOPROTEIN PARTICLE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U86137 mRNA. Translation: AAC53043.1.
IPIIPI00125667.
PIRT30987.
RefSeqNP_033377.1. NM_009351.2.
UniGeneMm.318736.

3D structure databases

ProteinModelPortalP97499.
SMRP97499. Positions 1160-1198, 1678-1963, 2009-2399.
ModBaseSearch...

Protein-protein interaction databases

STRINGP97499.

PTM databases

PhosphoSiteP97499.

Proteomic databases

PRIDEP97499.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006444; ENSMUSP00000006444; ENSMUSG00000006281.
GeneID21745.
KEGGmmu:21745.
UCSCuc007tlt.1. mouse.

Organism-specific databases

CTD7011.
MGIMGI:109573. Tep1.

Phylogenomic databases

eggNOGroNOG09840.
HOGENOMHBG282400.
HOVERGENHBG059633.
InParanoidP97499.
OMASVPDAWK.
OrthoDBEOG4001HG.
PhylomeDBP97499.

Gene expression databases

ArrayExpressP97499.
BgeeP97499.
CleanExMM_TEP1.
GenevestigatorP97499.
GermOnlineENSMUSG00000006281. Mus musculus.

Family and domain databases

InterProIPR007111. NACHT_NTPase.
IPR008850. TEP1_N.
IPR008858. TROVE.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 5 hits.
KOK11127.
PfamPF05386. TEP1_N. 4 hits.
PF05731. TROVE. 1 hit.
PF00400. WD40. 10 hits.
[Graphical view]
SMARTSM00320. WD40. 16 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 5 hits.
PROSITEPS50837. NACHT. 1 hit.
PS51226. TEP1_N. 4 hits.
PS50988. TROVE. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 8 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301032.
SOURCESearch...

Entry information

Entry nameTEP1_MOUSE
AccessionPrimary (citable) accession number: P97499
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 1997
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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