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P97497

- SHBG_MOUSE

UniProt

P97497 - SHBG_MOUSE

Protein

Sex hormone-binding globulin

Gene

Shbg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration By similarity.By similarity

    GO - Molecular functioni

    1. steroid binding Source: UniProtKB-KW

    GO - Biological processi

    1. primary spermatocyte growth Source: Ensembl

    Keywords - Ligandi

    Lipid-binding, Steroid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sex hormone-binding globulin
    Short name:
    SHBG
    Alternative name(s):
    Sex steroid-binding protein
    Short name:
    SBP
    Testis-specific androgen-binding protein
    Short name:
    ABP
    Gene namesi
    Name:Shbg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98295. Shbg.

    Subcellular locationi

    Secreted By similarity
    Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030By similarityAdd
    BLAST
    Chaini31 – 403373Sex hormone-binding globulinPRO_0000032558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi194 ↔ 218PROSITE-ProRule annotation
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi363 ↔ 391PROSITE-ProRule annotation
    Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP97497.

    Expressioni

    Gene expression databases

    BgeeiP97497.
    CleanExiMM_SHBG.
    GenevestigatoriP97497.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000005334.

    Structurei

    3D structure databases

    ProteinModelPortaliP97497.
    SMRiP97497. Positions 43-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 218173Laminin G-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini225 – 391167Laminin G-like 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 laminin G-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG39525.
    GeneTreeiENSGT00530000063339.
    HOGENOMiHOG000285982.
    HOVERGENiHBG017800.
    InParanoidiQ0VB52.
    OMAiEIQLHNH.
    OrthoDBiEOG71K639.
    PhylomeDBiP97497.
    TreeFamiTF334367.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    [Graphical view]
    PfamiPF00054. Laminin_G_1. 1 hit.
    [Graphical view]
    SMARTiSM00282. LamG. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97497-1 [UniParc]FASTAAdd to Basket

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    MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN    50
    GPGQEPVMVM TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG 100
    LRAGQLEIQL HNAWARLTVG FGPRLDDGRW HPVELKMNGD SLLLWVDGKE 150
    MLCLRQISAS LADHSQRSMR IALGGLLLPT SKLRFPLVPA LDGCIRRDIW 200
    LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD IPQPHADPWT 250
    FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP 300
    LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL 350
    GALPGESSSA SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR 400
    TSH 403
    Length:403
    Mass (Da):44,816
    Last modified:May 1, 1997 - v1
    Checksum:i5198DDD1CDC23530
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85644 mRNA. Translation: AAB42088.1.
    BC120785 mRNA. Translation: AAI20786.1.
    BC120787 mRNA. Translation: AAI20788.1.
    CCDSiCCDS24899.1.
    RefSeqiNP_035497.1. NM_011367.2.
    UniGeneiMm.1431.

    Genome annotation databases

    EnsembliENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
    GeneIDi20415.
    KEGGimmu:20415.
    UCSCiuc007jqp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85644 mRNA. Translation: AAB42088.1 .
    BC120785 mRNA. Translation: AAI20786.1 .
    BC120787 mRNA. Translation: AAI20788.1 .
    CCDSi CCDS24899.1.
    RefSeqi NP_035497.1. NM_011367.2.
    UniGenei Mm.1431.

    3D structure databases

    ProteinModelPortali P97497.
    SMRi P97497. Positions 43-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000005334.

    Proteomic databases

    PRIDEi P97497.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005334 ; ENSMUSP00000005334 ; ENSMUSG00000005202 .
    GeneIDi 20415.
    KEGGi mmu:20415.
    UCSCi uc007jqp.2. mouse.

    Organism-specific databases

    CTDi 6462.
    MGIi MGI:98295. Shbg.

    Phylogenomic databases

    eggNOGi NOG39525.
    GeneTreei ENSGT00530000063339.
    HOGENOMi HOG000285982.
    HOVERGENi HBG017800.
    InParanoidi Q0VB52.
    OMAi EIQLHNH.
    OrthoDBi EOG71K639.
    PhylomeDBi P97497.
    TreeFami TF334367.

    Miscellaneous databases

    NextBioi 298408.
    PROi P97497.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97497.
    CleanExi MM_SHBG.
    Genevestigatori P97497.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001791. Laminin_G.
    [Graphical view ]
    Pfami PF00054. Laminin_G_1. 1 hit.
    [Graphical view ]
    SMARTi SM00282. LamG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS50025. LAM_G_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The androgen-binding protein gene is expressed in CD1 mouse testis."
      Wang Y.-M., Sullivan P.M., Petrusz P., Yarbrough W.G., Joseph D.R.
      Mol. Cell. Endocrinol. 63:85-92(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiSHBG_MOUSE
    AccessioniPrimary (citable) accession number: P97497
    Secondary accession number(s): Q0VB52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3