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Protein

Sex hormone-binding globulin

Gene

Shbg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).By similarity

GO - Molecular functioni

  1. steroid binding Source: UniProtKB-KW

GO - Biological processi

  1. primary spermatocyte growth Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex hormone-binding globulin
Short name:
SHBG
Alternative name(s):
Sex steroid-binding protein
Short name:
SBP
Testis-specific androgen-binding protein
Short name:
ABP
Gene namesi
Name:Shbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98295. Shbg.

Subcellular locationi

Secreted By similarity
Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030By similarityAdd
BLAST
Chaini31 – 403373Sex hormone-binding globulinPRO_0000032558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi194 ↔ 218PROSITE-ProRule annotation
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi363 ↔ 391PROSITE-ProRule annotation
Glycosylationi397 – 3971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97497.

Expressioni

Gene expression databases

BgeeiP97497.
CleanExiMM_SHBG.
GenevestigatoriP97497.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005334.

Structurei

3D structure databases

ProteinModelPortaliP97497.
SMRiP97497. Positions 43-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 218173Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini225 – 391167Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39525.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000285982.
HOVERGENiHBG017800.
InParanoidiP97497.
OMAiEIQLHNH.
OrthoDBiEOG71K639.
PhylomeDBiP97497.
TreeFamiTF334367.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN
60 70 80 90 100
GPGQEPVMVM TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG
110 120 130 140 150
LRAGQLEIQL HNAWARLTVG FGPRLDDGRW HPVELKMNGD SLLLWVDGKE
160 170 180 190 200
MLCLRQISAS LADHSQRSMR IALGGLLLPT SKLRFPLVPA LDGCIRRDIW
210 220 230 240 250
LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD IPQPHADPWT
260 270 280 290 300
FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP
310 320 330 340 350
LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL
360 370 380 390 400
GALPGESSSA SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR

TSH
Length:403
Mass (Da):44,816
Last modified:April 30, 1997 - v1
Checksum:i5198DDD1CDC23530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85644 mRNA. Translation: AAB42088.1.
BC120785 mRNA. Translation: AAI20786.1.
BC120787 mRNA. Translation: AAI20788.1.
CCDSiCCDS24899.1.
RefSeqiNP_035497.1. NM_011367.2.
UniGeneiMm.1431.

Genome annotation databases

EnsembliENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
GeneIDi20415.
KEGGimmu:20415.
UCSCiuc007jqp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85644 mRNA. Translation: AAB42088.1.
BC120785 mRNA. Translation: AAI20786.1.
BC120787 mRNA. Translation: AAI20788.1.
CCDSiCCDS24899.1.
RefSeqiNP_035497.1. NM_011367.2.
UniGeneiMm.1431.

3D structure databases

ProteinModelPortaliP97497.
SMRiP97497. Positions 43-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005334.

Proteomic databases

PRIDEiP97497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
GeneIDi20415.
KEGGimmu:20415.
UCSCiuc007jqp.2. mouse.

Organism-specific databases

CTDi6462.
MGIiMGI:98295. Shbg.

Phylogenomic databases

eggNOGiNOG39525.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000285982.
HOVERGENiHBG017800.
InParanoidiP97497.
OMAiEIQLHNH.
OrthoDBiEOG71K639.
PhylomeDBiP97497.
TreeFamiTF334367.

Miscellaneous databases

NextBioi298408.
PROiP97497.
SOURCEiSearch...

Gene expression databases

BgeeiP97497.
CleanExiMM_SHBG.
GenevestigatoriP97497.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The androgen-binding protein gene is expressed in CD1 mouse testis."
    Wang Y.-M., Sullivan P.M., Petrusz P., Yarbrough W.G., Joseph D.R.
    Mol. Cell. Endocrinol. 63:85-92(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSHBG_MOUSE
AccessioniPrimary (citable) accession number: P97497
Secondary accession number(s): Q0VB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: April 30, 1997
Last modified: February 3, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.