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P97497 (SHBG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sex hormone-binding globulin

Short name=SHBG
Alternative name(s):
Sex steroid-binding protein
Short name=SBP
Testis-specific androgen-binding protein
Short name=ABP
Gene names
Name:Shbg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity. Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis By similarity.

Sequence similarities

Contains 2 laminin G-like domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandLipid-binding
Steroid-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprimary spermatocyte growth

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsteroid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 By similarity
Chain31 – 403373Sex hormone-binding globulin
PRO_0000032558

Regions

Domain46 – 218173Laminin G-like 1
Domain225 – 391167Laminin G-like 2

Amino acid modifications

Glycosylation2741N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3971N-linked (GlcNAc...) Potential
Disulfide bond194 ↔ 218 By similarity
Disulfide bond363 ↔ 391 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97497 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 5198DDD1CDC23530

FASTA40344,816
        10         20         30         40         50         60 
MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN GPGQEPVMVM 

        70         80         90        100        110        120 
TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG LRAGQLEIQL HNAWARLTVG 

       130        140        150        160        170        180 
FGPRLDDGRW HPVELKMNGD SLLLWVDGKE MLCLRQISAS LADHSQRSMR IALGGLLLPT 

       190        200        210        220        230        240 
SKLRFPLVPA LDGCIRRDIW LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD 

       250        260        270        280        290        300 
IPQPHADPWT FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP 

       310        320        330        340        350        360 
LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL GALPGESSSA 

       370        380        390        400 
SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR TSH 

« Hide

References

« Hide 'large scale' references
[1]"The androgen-binding protein gene is expressed in CD1 mouse testis."
Wang Y.-M., Sullivan P.M., Petrusz P., Yarbrough W.G., Joseph D.R.
Mol. Cell. Endocrinol. 63:85-92(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U85644 mRNA. Translation: AAB42088.1.
BC120785 mRNA. Translation: AAI20786.1.
BC120787 mRNA. Translation: AAI20788.1.
CCDSCCDS24899.1.
RefSeqNP_035497.1. NM_011367.2.
UniGeneMm.1431.

3D structure databases

ProteinModelPortalP97497.
SMRP97497. Positions 43-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000005334.

Proteomic databases

PRIDEP97497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
GeneID20415.
KEGGmmu:20415.
UCSCuc007jqp.2. mouse.

Organism-specific databases

CTD6462.
MGIMGI:98295. Shbg.

Phylogenomic databases

eggNOGNOG39525.
GeneTreeENSGT00530000063339.
HOGENOMHOG000285982.
HOVERGENHBG017800.
InParanoidQ0VB52.
OMAEIQLHNH.
OrthoDBEOG71K639.
PhylomeDBP97497.
TreeFamTF334367.

Gene expression databases

BgeeP97497.
CleanExMM_SHBG.
GenevestigatorP97497.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
[Graphical view]
PfamPF00054. Laminin_G_1. 1 hit.
[Graphical view]
SMARTSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298408.
PROP97497.
SOURCESearch...

Entry information

Entry nameSHBG_MOUSE
AccessionPrimary (citable) accession number: P97497
Secondary accession number(s): Q0VB52
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot