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P97497

- SHBG_MOUSE

UniProt

P97497 - SHBG_MOUSE

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Protein

Sex hormone-binding globulin

Gene
Shbg
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration By similarity.

GO - Molecular functioni

  1. steroid binding Source: UniProtKB-KW

GO - Biological processi

  1. primary spermatocyte growth Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex hormone-binding globulin
Short name:
SHBG
Alternative name(s):
Sex steroid-binding protein
Short name:
SBP
Testis-specific androgen-binding protein
Short name:
ABP
Gene namesi
Name:Shbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98295. Shbg.

Subcellular locationi

Secreted By similarity
Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis By similarity.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 By similarityAdd
BLAST
Chaini31 – 403373Sex hormone-binding globulinPRO_0000032558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi194 ↔ 218 By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi363 ↔ 391 By similarity
Glycosylationi397 – 3971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97497.

Expressioni

Gene expression databases

BgeeiP97497.
CleanExiMM_SHBG.
GenevestigatoriP97497.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005334.

Structurei

3D structure databases

ProteinModelPortaliP97497.
SMRiP97497. Positions 43-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 218173Laminin G-like 1Add
BLAST
Domaini225 – 391167Laminin G-like 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39525.
GeneTreeiENSGT00530000063339.
HOGENOMiHOG000285982.
HOVERGENiHBG017800.
InParanoidiQ0VB52.
OMAiEIQLHNH.
OrthoDBiEOG71K639.
PhylomeDBiP97497.
TreeFamiTF334367.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00054. Laminin_G_1. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97497-1 [UniParc]FASTAAdd to Basket

« Hide

MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN    50
GPGQEPVMVM TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG 100
LRAGQLEIQL HNAWARLTVG FGPRLDDGRW HPVELKMNGD SLLLWVDGKE 150
MLCLRQISAS LADHSQRSMR IALGGLLLPT SKLRFPLVPA LDGCIRRDIW 200
LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD IPQPHADPWT 250
FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP 300
LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL 350
GALPGESSSA SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR 400
TSH 403
Length:403
Mass (Da):44,816
Last modified:May 1, 1997 - v1
Checksum:i5198DDD1CDC23530
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85644 mRNA. Translation: AAB42088.1.
BC120785 mRNA. Translation: AAI20786.1.
BC120787 mRNA. Translation: AAI20788.1.
CCDSiCCDS24899.1.
RefSeqiNP_035497.1. NM_011367.2.
UniGeneiMm.1431.

Genome annotation databases

EnsembliENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
GeneIDi20415.
KEGGimmu:20415.
UCSCiuc007jqp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85644 mRNA. Translation: AAB42088.1 .
BC120785 mRNA. Translation: AAI20786.1 .
BC120787 mRNA. Translation: AAI20788.1 .
CCDSi CCDS24899.1.
RefSeqi NP_035497.1. NM_011367.2.
UniGenei Mm.1431.

3D structure databases

ProteinModelPortali P97497.
SMRi P97497. Positions 43-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000005334.

Proteomic databases

PRIDEi P97497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005334 ; ENSMUSP00000005334 ; ENSMUSG00000005202 .
GeneIDi 20415.
KEGGi mmu:20415.
UCSCi uc007jqp.2. mouse.

Organism-specific databases

CTDi 6462.
MGIi MGI:98295. Shbg.

Phylogenomic databases

eggNOGi NOG39525.
GeneTreei ENSGT00530000063339.
HOGENOMi HOG000285982.
HOVERGENi HBG017800.
InParanoidi Q0VB52.
OMAi EIQLHNH.
OrthoDBi EOG71K639.
PhylomeDBi P97497.
TreeFami TF334367.

Miscellaneous databases

NextBioi 298408.
PROi P97497.
SOURCEi Search...

Gene expression databases

Bgeei P97497.
CleanExi MM_SHBG.
Genevestigatori P97497.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00054. Laminin_G_1. 1 hit.
[Graphical view ]
SMARTi SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The androgen-binding protein gene is expressed in CD1 mouse testis."
    Wang Y.-M., Sullivan P.M., Petrusz P., Yarbrough W.G., Joseph D.R.
    Mol. Cell. Endocrinol. 63:85-92(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSHBG_MOUSE
AccessioniPrimary (citable) accession number: P97497
Secondary accession number(s): Q0VB52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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