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Protein

Sex hormone-binding globulin

Gene

Shbg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).By similarity

GO - Molecular functioni

Keywordsi

LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sex hormone-binding globulin
Short name:
SHBG
Alternative name(s):
Sex steroid-binding protein
Short name:
SBP
Testis-specific androgen-binding protein
Short name:
ABP
Gene namesi
Name:Shbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98295 Shbg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000003255831 – 403Sex hormone-binding globulinAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi194 ↔ 218PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi363 ↔ 391PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97497
PeptideAtlasiP97497
PRIDEiP97497

PTM databases

PhosphoSitePlusiP97497

Expressioni

Gene expression databases

BgeeiENSMUSG00000005202
CleanExiMM_SHBG
ExpressionAtlasiP97497 baseline and differential
GenevisibleiP97497 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005334

Structurei

3D structure databases

ProteinModelPortaliP97497
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 218Laminin G-like 1PROSITE-ProRule annotationAdd BLAST173
Domaini225 – 391Laminin G-like 2PROSITE-ProRule annotationAdd BLAST167

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKW6 Eukaryota
ENOG410YKMT LUCA
GeneTreeiENSGT00530000063339
HOGENOMiHOG000285982
HOVERGENiHBG017800
InParanoidiP97497
OMAiEIQLHNH
OrthoDBiEOG091G0D6A
PhylomeDBiP97497
TreeFamiTF334367

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS50025 LAM_G_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN
60 70 80 90 100
GPGQEPVMVM TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG
110 120 130 140 150
LRAGQLEIQL HNAWARLTVG FGPRLDDGRW HPVELKMNGD SLLLWVDGKE
160 170 180 190 200
MLCLRQISAS LADHSQRSMR IALGGLLLPT SKLRFPLVPA LDGCIRRDIW
210 220 230 240 250
LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD IPQPHADPWT
260 270 280 290 300
FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP
310 320 330 340 350
LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL
360 370 380 390 400
GALPGESSSA SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR

TSH
Length:403
Mass (Da):44,816
Last modified:May 1, 1997 - v1
Checksum:i5198DDD1CDC23530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85644 mRNA Translation: AAB42088.1
BC120785 mRNA Translation: AAI20786.1
BC120787 mRNA Translation: AAI20788.1
CCDSiCCDS24899.1
RefSeqiNP_035497.1, NM_011367.2
XP_011247139.1, XM_011248837.2
UniGeneiMm.1431

Genome annotation databases

EnsembliENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202
GeneIDi20415
KEGGimmu:20415
UCSCiuc007jqp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSHBG_MOUSE
AccessioniPrimary (citable) accession number: P97497
Secondary accession number(s): Q0VB52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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