P97497 (SHBG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sex hormone-binding globulin
Short name=SHBG

Alternative name(s):
Sex steroid-binding protein
Short name=SBP
Testis-specific androgen-binding protein
Short name=ABP

Gene names

Name:

Shbg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted By similarity. Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis By similarity.
Sequence similarities	Contains 2 laminin G-like domains.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Lipid-binding Steroid-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	primary spermatocyte growth Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	steroid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	By similarity
	Chain	31 – 403	373	Sex hormone-binding globulin		PRO_0000032558
Regions
	Domain	46 – 218	173	Laminin G-like 1
	Domain	225 – 391	167	Laminin G-like 2
Amino acid modifications
	Glycosylation	274	1	N-linked (GlcNAc...) Potential
	Glycosylation	284	1	N-linked (GlcNAc...) Potential
	Glycosylation	397	1	N-linked (GlcNAc...) Potential
	Disulfide bond	194 ↔ 218		By similarity
	Disulfide bond	363 ↔ 391		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97497 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 5198DDD1CDC23530	FASTA	403	44,816
	10 20 30 40 50 60 MEKRDSVALH WRLLLLLLLL MPPPTHQGRA LRHIDPIQSA QDPPAKYLSN GPGQEPVMVM 70 80 90 100 110 120 TIDLTKISKP HSSFEFRTWD PEGVIFYGDT NTEDDWFLLG LRAGQLEIQL HNAWARLTVG 130 140 150 160 170 180 FGPRLDDGRW HPVELKMNGD SLLLWVDGKE MLCLRQISAS LADHSQRSMR IALGGLLLPT 190 200 210 220 230 240 SKLRFPLVPA LDGCIRRDIW LGHQAQLSAS PRTSLGNCDV DLQPGLFFPP GTHAEFSLQD 250 260 270 280 290 300 IPQPHADPWT FSLELGFKLV DGSGQLLALG TGTNSSWLNI HLQNQSVVLS SEAEPKVVLP 310 320 330 340 350 360 LDVGLPLQLT LDRVKVVLSQ GPKMEVLSMS LLRPASLWRL WSHPQGHLSL GALPGESSSA 370 380 390 400 SFCLSDFWVQ GQRLDIDQAL SRSQDIWTHS CPQRPSNDTR TSH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The androgen-binding protein gene is expressed in CD1 mouse testis." Wang Y.-M., Sullivan P.M., Petrusz P., Yarbrough W.G., Joseph D.R. Mol. Cell. Endocrinol. 63:85-92(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U85644 mRNA. Translation: AAB42088.1. BC120785 mRNA. Translation: AAI20786.1. BC120787 mRNA. Translation: AAI20788.1.
IPI	IPI00125663.
RefSeq	NP_035497.1. NM_011367.2.
UniGene	Mm.1431.
3D structure databases
ProteinModelPortal	P97497.
SMR	P97497. Positions 43-218.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000005334.
Proteomic databases
PRIDE	P97497.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000005334; ENSMUSP00000005334; ENSMUSG00000005202.
GeneID	20415.
KEGG	mmu:20415.
UCSC	uc007jqp.2. mouse.
Organism-specific databases
CTD	6462.
MGI	MGI:98295. Shbg.
Phylogenomic databases
eggNOG	NOG39525.
GeneTree	ENSGT00530000063339.
HOGENOM	HOG000285982.
HOVERGEN	HBG017800.
InParanoid	Q0VB52.
OMA	EIQLHNH.
OrthoDB	EOG4RFKTB.
Gene expression databases
Bgee	P97497.
CleanEx	MM_SHBG.
Genevestigator	P97497.
GermOnline	ENSMUSG00000005202. Mus musculus.
Family and domain databases
Gene3D	2.60.120.200. 2 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001791. Laminin_G. [Graphical view]
Pfam	PF00054. Laminin_G_1. 1 hit. [Graphical view]
SMART	SM00282. LamG. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS50025. LAM_G_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298408.
SOURCE	Search...

Entry information

Entry name

SHBG_MOUSE

Accession

Primary (citable) accession number: P97497
Secondary accession number(s): Q0VB52

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program