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Protein

SWI/SNF complex subunit SMARCC1

Gene

Smarcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.2 PublicationsBy similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • ATP-dependent chromatin remodeling Source: MGI
  • chromatin remodeling Source: MGI
  • covalent chromatin modification Source: UniProtKB-KW
  • DNA packaging Source: MGI
  • insulin receptor signaling pathway Source: MGI
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • nervous system development Source: UniProtKB-KW
  • nucleosome disassembly Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • prostate gland development Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214858. RMTs methylate histone arginines.
R-MMU-8939243. RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SMARCC1
Alternative name(s):
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
SWI3-related protein
Short name:
BAF155
Gene namesi
Name:Smarcc1
Synonyms:Baf155, Srg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1203524. Smarcc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971161 – 1104SWI/SNF complex subunit SMARCC1Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei309PhosphoserineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei334PhosphothreonineBy similarity1
Modified residuei344N6-acetyllysineBy similarity1
Modified residuei345N6-acetyllysineCombined sources1
Modified residuei349PhosphoserineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Modified residuei358N6-acetyllysine; alternateBy similarity1
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei397PhosphothreonineBy similarity1
Modified residuei572PhosphoserineCombined sources1
Cross-linki591Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki738Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei775PhosphoserineCombined sources1
Cross-linki795Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei821PhosphoserineCombined sources1
Modified residuei824PhosphoserineCombined sources1
Cross-linki828Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki855Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei947N6-acetyllysineBy similarity1
Modified residuei1064Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP97496.
PaxDbiP97496.
PeptideAtlasiP97496.
PRIDEiP97496.

PTM databases

iPTMnetiP97496.
PhosphoSitePlusiP97496.
SwissPalmiP97496.

Expressioni

Tissue specificityi

Highly expressed in adult brain, testis and thymus.

Developmental stagei

Highly expressed in all organs except heart and liver (E12.5 and E14.5). The level of expression gradually diminishes as embryos develop, with expression restricted mostly to the CNS and thymus at E18.5. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000032481.
ExpressionAtlasiP97496. baseline and differential.
GenevisibleiP97496. MM.

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Interacts with NR3C1 and SMARD1. Interacts with TRIP12; leading to disrupt interaction between TRIP12 and SMARCE1 and prevent SMARCE1 ubiquitination (By similarity). Interacts with CEBPB (when not methylated)(PubMed:20111005). Interacts with KDM6B (PubMed:21095589).2 PublicationsBy similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203338. 33 interactors.
CORUMiP97496.
DIPiDIP-39986N.
IntActiP97496. 35 interactors.
MINTiMINT-4084777.
STRINGi10090.ENSMUSP00000086094.

Structurei

3D structure databases

ProteinModelPortaliP97496.
SMRiP97496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 545SWIRMPROSITE-ProRule annotationAdd BLAST98
Domaini617 – 668SANTPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili909 – 945Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 333Poly-Pro8
Compositional biasi768 – 862Glu-richAdd BLAST95
Compositional biasi866 – 877Poly-AlaAdd BLAST12
Compositional biasi977 – 1104Pro-richAdd BLAST128

Sequence similaritiesi

Belongs to the SMARCC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1279. Eukaryota.
COG5259. LUCA.
GeneTreeiENSGT00390000018166.
HOGENOMiHOG000047736.
HOVERGENiHBG054849.
InParanoidiP97496.
KOiK11649.
OMAiYKKYVHA.
OrthoDBiEOG091G06AJ.
PhylomeDBiP97496.
TreeFamiTF314710.

Family and domain databases

CDDicd00024. CHROMO. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.10190. 1 hit.
InterProiView protein in InterPro
IPR030087. BAF155.
IPR036420. BRCT_dom_sf.
IPR000953. Chromo/chromo_shadow_dom.
IPR009057. Homeobox-like_sf.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR032450. SMARCC_N.
IPR007526. SWIRM.
IPR032448. SWIRM-assoc.
IPR036388. WH-like_DNA-bd_sf.
PANTHERiPTHR12802:SF9. PTHR12802:SF9. 1 hit.
PfamiView protein in Pfam
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
PF16496. SWIRM-assoc_2. 1 hit.
PF16498. SWIRM-assoc_3. 1 hit.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEiView protein in PROSITE
PS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATAGGGPG AAAGAVGAGG AAAASGLAVY RRKDGGPASK FWESPDTVSQ
60 70 80 90 100
LDSVRVWLGK HYKKYVHADA PTNKTLAGLV VQLLQFQEDA FGKHVTNPAF
110 120 130 140 150
TKLPAKCFMD FKAGGTLCHI LGAAYKYKNE QGWRRFDLQN PSRMDRNVEM
160 170 180 190 200
FMNIEKTLVQ NNCLTRPNIY LIPDIDLKLA NKLKDIIKRH QGTFTDEKSK
210 220 230 240 250
ASHHIYPYPS SQEDEEWLRP VMRRDKQVLV HWGFYPDSYD TWVHSNDVDA
260 270 280 290 300
EIEDAPIPEK PWKVHVKWIL DTDVFNEWMN EEDYEVDENR KPVSFRQRIS
310 320 330 340 350
TKNEEPVRSP ERRDRKASAN SRKRKPSPSP PPPTATESRK KSGKKGQASL
360 370 380 390 400
YGKRRSQKEE DEQEDLTKDM EDPTPVPNIE EVVLPKNVNP KKDSENTPVK
410 420 430 440 450
GGTVADLDEQ DEEAVTTGGK EDEDPSKGDP SRSVDPGEDN VTEQTNHIII
460 470 480 490 500
PSYASWFDYN CIHVIERRAL PEFFNGKNKS KTPEIYLAYR NFMIDTYRLN
510 520 530 540 550
PQEYLTSTAC RRNLTGDVCA VMRVHAFLEQ WGLVNYQVDP ESRPMAMGPP
560 570 580 590 600
PTPHFNVLAD TPSGLVPLHL RSPQVPAAQQ MLNFPEKNKE KPIDLQNFGL
610 620 630 640 650
RTDIYSKKTL AKSKGASAGR EWTEQETLLL LEALEMYKDD WNKVSEHVGS
660 670 680 690 700
RTQDECILHF LRLPIEDPYL ENSDASLGPL AYQPVPFSQS GNPVMSTVAF
710 720 730 740 750
LASVVDPRVA SAAAKAALEE FSRVREEVPL ELVEAHVKKV QEAARASGKV
760 770 780 790 800
DPTYGLESSC IAGTGPDEPE KLEGSEEEKM ETDPDGQQPE KAENKVENES
810 820 830 840 850
DEGDKIQDRE NEKNTEKEQD SDVSEDVKPE EKENEENKEL TDTCKERESD
860 870 880 890 900
AGKKKVEHEI SEGNVATAAA AALASAATKA KHLAAVEERK IKSLVALLVE
910 920 930 940 950
TQMKKLEIKL RHFEELETIM DREKEALEQQ RQQLLTERQN FHMEQLKYAE
960 970 980 990 1000
LRARQQMEQQ QQHGQTPQQA HQHTGGPGMA PLGATGHPGM MPHQQPPPYP
1010 1020 1030 1040 1050
LMHHQMPPPH PPQPGQIPGP GSMMPGQPMP GRMIPAVAAN IHPTGSGPTP
1060 1070 1080 1090 1100
PGMPPMPGNI LGPRVPLTAP NGMYPPPPQQ QQPPPPADGV PPPPAPGPPA

SATP
Length:1,104
Mass (Da):122,890
Last modified:January 4, 2005 - v2
Checksum:i9030545104B90CAF
GO
Isoform 2 (identifier: P97496-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1104: YPPPPQQQQPPPPADGVPPPPAPGPPASATP → CK

Note: No experimental confirmation available.
Show »
Length:1,075
Mass (Da):120,091
Checksum:iDC6BDB5CD4C9A296
GO

Sequence cautioni

The sequence AAB42085 differs from that shown. Reason: Frameshift at positions 5, 32, 48, 563, 565, 679 and 682.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132G → S in AAB42085 (PubMed:9151708).Curated1
Sequence conflicti468R → G in AAB42085 (PubMed:9151708).Curated1
Sequence conflicti498R → C in AAB42085 (PubMed:9151708).Curated1
Sequence conflicti512R → L in AAB42085 (PubMed:9151708).Curated1
Sequence conflicti883L → P in AAB42085 (PubMed:9151708).Curated1
Sequence conflicti891I → K in AAH53064 (PubMed:15489334).Curated1
Sequence conflicti952R → L in AAH52423 (PubMed:15489334).Curated1
Sequence conflicti984A → R in AAB42085 (PubMed:9151708).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124891074 – 1104YPPPP…ASATP → CK in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85614 mRNA. Translation: AAB42085.1. Frameshift.
BC052423 mRNA. Translation: AAH52423.1.
BC053064 mRNA. Translation: AAH53064.1.
CCDSiCCDS23561.1. [P97496-1]
PIRiT30967.
RefSeqiNP_033237.2. NM_009211.2. [P97496-1]
UniGeneiMm.85410.

Genome annotation databases

EnsembliENSMUST00000088716; ENSMUSP00000086094; ENSMUSG00000032481. [P97496-1]
ENSMUST00000197984; ENSMUSP00000142611; ENSMUSG00000032481. [P97496-2]
GeneIDi20588.
KEGGimmu:20588.
UCSCiuc009rto.1. mouse. [P97496-2]
uc009rtp.1. mouse. [P97496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMRC1_MOUSE
AccessioniPrimary (citable) accession number: P97496
Secondary accession number(s): Q7TS80, Q7TT29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 22, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families