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Protein

SWI/SNF complex subunit SMARCC1

Gene

Smarcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: MGI
  • chromatin remodeling Source: MGI
  • DNA packaging Source: MGI
  • insulin receptor signaling pathway Source: MGI
  • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • nervous system development Source: UniProtKB-KW
  • nucleosome disassembly Source: MGI
  • organ morphogenesis Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_319868. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SMARCC1
Alternative name(s):
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
SWI3-related protein
Short name:
BAF155
Gene namesi
Name:Smarcc1
Synonyms:Baf155, Srg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1203524. Smarcc1.

Subcellular locationi

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • intracellular Source: MGI
  • nBAF complex Source: UniProtKB
  • npBAF complex Source: UniProtKB
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • protein complex Source: MGI
  • SWI/SNF complex Source: MGI
  • XY body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11041104SWI/SNF complex subunit SMARCC1PRO_0000197116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091PhosphoserineBy similarity
Modified residuei327 – 3271Phosphoserine1 Publication
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei334 – 3341PhosphothreonineBy similarity
Modified residuei344 – 3441N6-acetyllysineBy similarity
Modified residuei345 – 3451N6-acetyllysine1 Publication
Modified residuei349 – 3491PhosphoserineBy similarity
Modified residuei353 – 3531N6-acetyllysineBy similarity
Modified residuei356 – 3561PhosphoserineBy similarity
Modified residuei358 – 3581N6-acetyllysineBy similarity
Modified residuei397 – 3971PhosphothreonineBy similarity
Modified residuei572 – 5721PhosphoserineBy similarity
Modified residuei821 – 8211PhosphoserineBy similarity
Modified residuei824 – 8241PhosphoserineBy similarity
Modified residuei947 – 9471N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97496.
PaxDbiP97496.
PRIDEiP97496.

PTM databases

PhosphoSiteiP97496.

Expressioni

Tissue specificityi

Highly expressed in adult brain, testis and thymus.

Developmental stagei

Highly expressed in all organs except heart and liver (E12.5 and E14.5). The level of expression gradually diminishes as embryos develop, with expression restricted mostly to the CNS and thymus at E18.5. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

BgeeiP97496.
GenevisibleiP97496. MM.

Interactioni

Subunit structurei

Component of a number of multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Interacts with NR3C1 and SMARD1. Interacts with TRIP12; leading to disrupt interaction between TRIP12 and SMARCE1 and prevent SMARCE1 ubiquitination (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with CEBPB (when not methylated)(PubMed:20111005).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4Q3TKT46EBI-648047,EBI-1210244
Smarcb1Q9Z0H35EBI-648047,EBI-689365
Smarcd1Q614663EBI-648047,EBI-371529

Protein-protein interaction databases

BioGridi203338. 19 interactions.
DIPiDIP-39986N.
IntActiP97496. 16 interactions.
MINTiMINT-4084777.
STRINGi10090.ENSMUSP00000086094.

Structurei

3D structure databases

ProteinModelPortaliP97496.
SMRiP97496. Positions 454-538, 606-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 54598SWIRMPROSITE-ProRule annotationAdd
BLAST
Domaini617 – 66852SANTPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili909 – 94537Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi326 – 3338Poly-Pro
Compositional biasi768 – 86295Glu-richAdd
BLAST
Compositional biasi866 – 87712Poly-AlaAdd
BLAST
Compositional biasi977 – 1104128Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SMARCC family.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5259.
GeneTreeiENSGT00390000018166.
HOGENOMiHOG000047736.
HOVERGENiHBG054849.
InParanoidiP97496.
KOiK11649.
OMAiYKKYVHA.
OrthoDBiEOG7T4MJH.
PhylomeDBiP97496.
TreeFamiTF314710.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR030087. BAF155.
IPR001357. BRCT_dom.
IPR000953. Chromo/shadow_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12802:SF9. PTHR12802:SF9. 1 hit.
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P97496-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATAGGGPG AAAGAVGAGG AAAASGLAVY RRKDGGPASK FWESPDTVSQ
60 70 80 90 100
LDSVRVWLGK HYKKYVHADA PTNKTLAGLV VQLLQFQEDA FGKHVTNPAF
110 120 130 140 150
TKLPAKCFMD FKAGGTLCHI LGAAYKYKNE QGWRRFDLQN PSRMDRNVEM
160 170 180 190 200
FMNIEKTLVQ NNCLTRPNIY LIPDIDLKLA NKLKDIIKRH QGTFTDEKSK
210 220 230 240 250
ASHHIYPYPS SQEDEEWLRP VMRRDKQVLV HWGFYPDSYD TWVHSNDVDA
260 270 280 290 300
EIEDAPIPEK PWKVHVKWIL DTDVFNEWMN EEDYEVDENR KPVSFRQRIS
310 320 330 340 350
TKNEEPVRSP ERRDRKASAN SRKRKPSPSP PPPTATESRK KSGKKGQASL
360 370 380 390 400
YGKRRSQKEE DEQEDLTKDM EDPTPVPNIE EVVLPKNVNP KKDSENTPVK
410 420 430 440 450
GGTVADLDEQ DEEAVTTGGK EDEDPSKGDP SRSVDPGEDN VTEQTNHIII
460 470 480 490 500
PSYASWFDYN CIHVIERRAL PEFFNGKNKS KTPEIYLAYR NFMIDTYRLN
510 520 530 540 550
PQEYLTSTAC RRNLTGDVCA VMRVHAFLEQ WGLVNYQVDP ESRPMAMGPP
560 570 580 590 600
PTPHFNVLAD TPSGLVPLHL RSPQVPAAQQ MLNFPEKNKE KPIDLQNFGL
610 620 630 640 650
RTDIYSKKTL AKSKGASAGR EWTEQETLLL LEALEMYKDD WNKVSEHVGS
660 670 680 690 700
RTQDECILHF LRLPIEDPYL ENSDASLGPL AYQPVPFSQS GNPVMSTVAF
710 720 730 740 750
LASVVDPRVA SAAAKAALEE FSRVREEVPL ELVEAHVKKV QEAARASGKV
760 770 780 790 800
DPTYGLESSC IAGTGPDEPE KLEGSEEEKM ETDPDGQQPE KAENKVENES
810 820 830 840 850
DEGDKIQDRE NEKNTEKEQD SDVSEDVKPE EKENEENKEL TDTCKERESD
860 870 880 890 900
AGKKKVEHEI SEGNVATAAA AALASAATKA KHLAAVEERK IKSLVALLVE
910 920 930 940 950
TQMKKLEIKL RHFEELETIM DREKEALEQQ RQQLLTERQN FHMEQLKYAE
960 970 980 990 1000
LRARQQMEQQ QQHGQTPQQA HQHTGGPGMA PLGATGHPGM MPHQQPPPYP
1010 1020 1030 1040 1050
LMHHQMPPPH PPQPGQIPGP GSMMPGQPMP GRMIPAVAAN IHPTGSGPTP
1060 1070 1080 1090 1100
PGMPPMPGNI LGPRVPLTAP NGMYPPPPQQ QQPPPPADGV PPPPAPGPPA

SATP
Length:1,104
Mass (Da):122,890
Last modified:January 4, 2005 - v2
Checksum:i9030545104B90CAF
GO
Isoform 2 (identifier: P97496-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1104: YPPPPQQQQPPPPADGVPPPPAPGPPASATP → CK

Note: No experimental confirmation available.
Show »
Length:1,075
Mass (Da):120,091
Checksum:iDC6BDB5CD4C9A296
GO

Sequence cautioni

The sequence AAB42085.1 differs from that shown. Reason: Frameshift at positions 5, 32, 48, 563, 565, 679 and 682. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321G → S in AAB42085 (PubMed:9151708).Curated
Sequence conflicti468 – 4681R → G in AAB42085 (PubMed:9151708).Curated
Sequence conflicti498 – 4981R → C in AAB42085 (PubMed:9151708).Curated
Sequence conflicti512 – 5121R → L in AAB42085 (PubMed:9151708).Curated
Sequence conflicti883 – 8831L → P in AAB42085 (PubMed:9151708).Curated
Sequence conflicti891 – 8911I → K in AAH53064 (PubMed:15489334).Curated
Sequence conflicti952 – 9521R → L in AAH52423 (PubMed:15489334).Curated
Sequence conflicti984 – 9841A → R in AAB42085 (PubMed:9151708).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1074 – 110431YPPPP…ASATP → CK in isoform 2. 1 PublicationVSP_012489Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85614 mRNA. Translation: AAB42085.1. Frameshift.
BC052423 mRNA. Translation: AAH52423.1.
BC053064 mRNA. Translation: AAH53064.1.
CCDSiCCDS23561.1. [P97496-1]
PIRiT30967.
RefSeqiNP_033237.2. NM_009211.2. [P97496-1]
UniGeneiMm.85410.

Genome annotation databases

EnsembliENSMUST00000088716; ENSMUSP00000086094; ENSMUSG00000032481. [P97496-1]
ENSMUST00000197984; ENSMUSP00000142611; ENSMUSG00000032481. [P97496-2]
GeneIDi20588.
KEGGimmu:20588.
UCSCiuc009rto.1. mouse. [P97496-2]
uc009rtp.1. mouse. [P97496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85614 mRNA. Translation: AAB42085.1. Frameshift.
BC052423 mRNA. Translation: AAH52423.1.
BC053064 mRNA. Translation: AAH53064.1.
CCDSiCCDS23561.1. [P97496-1]
PIRiT30967.
RefSeqiNP_033237.2. NM_009211.2. [P97496-1]
UniGeneiMm.85410.

3D structure databases

ProteinModelPortaliP97496.
SMRiP97496. Positions 454-538, 606-675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203338. 19 interactions.
DIPiDIP-39986N.
IntActiP97496. 16 interactions.
MINTiMINT-4084777.
STRINGi10090.ENSMUSP00000086094.

PTM databases

PhosphoSiteiP97496.

Proteomic databases

MaxQBiP97496.
PaxDbiP97496.
PRIDEiP97496.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088716; ENSMUSP00000086094; ENSMUSG00000032481. [P97496-1]
ENSMUST00000197984; ENSMUSP00000142611; ENSMUSG00000032481. [P97496-2]
GeneIDi20588.
KEGGimmu:20588.
UCSCiuc009rto.1. mouse. [P97496-2]
uc009rtp.1. mouse. [P97496-1]

Organism-specific databases

CTDi6599.
MGIiMGI:1203524. Smarcc1.

Phylogenomic databases

eggNOGiCOG5259.
GeneTreeiENSGT00390000018166.
HOGENOMiHOG000047736.
HOVERGENiHBG054849.
InParanoidiP97496.
KOiK11649.
OMAiYKKYVHA.
OrthoDBiEOG7T4MJH.
PhylomeDBiP97496.
TreeFamiTF314710.

Enzyme and pathway databases

ReactomeiREACT_319868. RMTs methylate histone arginines.

Miscellaneous databases

ChiTaRSiSmarcc1. mouse.
NextBioi298891.
PROiP97496.
SOURCEiSearch...

Gene expression databases

BgeeiP97496.
GenevisibleiP97496. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR030087. BAF155.
IPR001357. BRCT_dom.
IPR000953. Chromo/shadow_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12802:SF9. PTHR12802:SF9. 1 hit.
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line."
    Jeon S.H., Kang M.G., Kim Y.H., Jin Y.H., Lee C., Chung H.-Y., Kwon H., Park S.D., Seong R.H.
    J. Exp. Med. 185:1827-1836(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-892 (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development."
    Kim J.K., Huh S.-O., Choi H., Lee K.-S., Shin D., Lee C., Nam J.-S., Kim H., Chung H., Lee H.W., Park S.D., Seong R.H.
    Mol. Cell. Biol. 21:7787-7795(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
    Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
    Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, DEVELOPMENTAL STAGE.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. "Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."
    Kowenz-Leutz E., Pless O., Dittmar G., Knoblich M., Leutz A.
    EMBO J. 29:1105-1115(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CEBPB.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSMRC1_MOUSE
AccessioniPrimary (citable) accession number: P97496
Secondary accession number(s): Q7TS80, Q7TT29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 22, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.