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P97496

- SMRC1_MOUSE

UniProt

P97496 - SMRC1_MOUSE

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Protein
SWI/SNF complex subunit SMARCC1
Gene
Smarcc1, Baf155, Srg3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene By similarity. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.2 Publications

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. chromatin binding Source: MGI
  3. protein binding Source: IntAct

GO - Biological processi

  1. DNA packaging Source: MGI
  2. chromatin remodeling Source: Ensembl
  3. insulin receptor signaling pathway Source: MGI
  4. nervous system development Source: UniProtKB-KW
  5. nucleosome disassembly Source: Ensembl
  6. organ morphogenesis Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF complex subunit SMARCC1
Alternative name(s):
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
SWI3-related protein
Short name:
BAF155
Gene namesi
Name:Smarcc1
Synonyms:Baf155, Srg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1203524. Smarcc1.

Subcellular locationi

GO - Cellular componenti

  1. SWI/SNF complex Source: MGI
  2. XY body Source: UniProtKB
  3. intracellular Source: MGI
  4. nBAF complex Source: UniProtKB
  5. npBAF complex Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11041104SWI/SNF complex subunit SMARCC1
PRO_0000197116Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Phosphoserine By similarity
Modified residuei327 – 3271Phosphoserine1 Publication
Modified residuei329 – 3291Phosphoserine1 Publication
Modified residuei334 – 3341Phosphothreonine By similarity
Modified residuei344 – 3441N6-acetyllysine By similarity
Modified residuei345 – 3451N6-acetyllysine1 Publication
Modified residuei349 – 3491Phosphoserine By similarity
Modified residuei353 – 3531N6-acetyllysine By similarity
Modified residuei356 – 3561Phosphoserine By similarity
Modified residuei358 – 3581N6-acetyllysine By similarity
Modified residuei397 – 3971Phosphothreonine By similarity
Modified residuei572 – 5721Phosphoserine By similarity
Modified residuei821 – 8211Phosphoserine By similarity
Modified residuei824 – 8241Phosphoserine By similarity
Modified residuei947 – 9471N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP97496.
PaxDbiP97496.
PRIDEiP97496.

PTM databases

PhosphoSiteiP97496.

Expressioni

Tissue specificityi

Highly expressed in adult brain, testis and thymus.

Developmental stagei

Highly expressed in all organs except heart and liver (E12.5 and E14.5). The level of expression gradually diminishes as embryos develop, with expression restricted mostly to the CNS and thymus at E18.5. Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

ArrayExpressiP97496.
BgeeiP97496.
GenevestigatoriP97496.

Interactioni

Subunit structurei

Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with NR3C1 and SMARD1. Interacts with TRIP12; leading to disrupt interaction between TRIP12 and SMARCE1 and prevent SMARCE1 ubiquitination By similarity. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4Q3TKT45EBI-648047,EBI-1210244
Smarcb1Q9Z0H35EBI-648047,EBI-689365

Protein-protein interaction databases

BioGridi203338. 20 interactions.
DIPiDIP-39986N.
IntActiP97496. 13 interactions.
MINTiMINT-4084777.

Structurei

3D structure databases

ProteinModelPortaliP97496.
SMRiP97496. Positions 454-538, 606-675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 54598SWIRM
Add
BLAST
Domaini617 – 66852SANT
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili909 – 94537 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi326 – 3338Poly-Pro
Compositional biasi768 – 86295Glu-rich
Add
BLAST
Compositional biasi866 – 87712Poly-Ala
Add
BLAST
Compositional biasi977 – 1104128Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the SMARCC family.
Contains 1 SANT domain.
Contains 1 SWIRM domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5259.
GeneTreeiENSGT00390000018166.
HOGENOMiHOG000047736.
HOVERGENiHBG054849.
InParanoidiP97496.
KOiK11649.
OMAiYKKYVHA.
OrthoDBiEOG7T4MJH.
PhylomeDBiP97496.
TreeFamiTF314710.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000953. Chromo_domain/shadow.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97496-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAATAGGGPG AAAGAVGAGG AAAASGLAVY RRKDGGPASK FWESPDTVSQ     50
LDSVRVWLGK HYKKYVHADA PTNKTLAGLV VQLLQFQEDA FGKHVTNPAF 100
TKLPAKCFMD FKAGGTLCHI LGAAYKYKNE QGWRRFDLQN PSRMDRNVEM 150
FMNIEKTLVQ NNCLTRPNIY LIPDIDLKLA NKLKDIIKRH QGTFTDEKSK 200
ASHHIYPYPS SQEDEEWLRP VMRRDKQVLV HWGFYPDSYD TWVHSNDVDA 250
EIEDAPIPEK PWKVHVKWIL DTDVFNEWMN EEDYEVDENR KPVSFRQRIS 300
TKNEEPVRSP ERRDRKASAN SRKRKPSPSP PPPTATESRK KSGKKGQASL 350
YGKRRSQKEE DEQEDLTKDM EDPTPVPNIE EVVLPKNVNP KKDSENTPVK 400
GGTVADLDEQ DEEAVTTGGK EDEDPSKGDP SRSVDPGEDN VTEQTNHIII 450
PSYASWFDYN CIHVIERRAL PEFFNGKNKS KTPEIYLAYR NFMIDTYRLN 500
PQEYLTSTAC RRNLTGDVCA VMRVHAFLEQ WGLVNYQVDP ESRPMAMGPP 550
PTPHFNVLAD TPSGLVPLHL RSPQVPAAQQ MLNFPEKNKE KPIDLQNFGL 600
RTDIYSKKTL AKSKGASAGR EWTEQETLLL LEALEMYKDD WNKVSEHVGS 650
RTQDECILHF LRLPIEDPYL ENSDASLGPL AYQPVPFSQS GNPVMSTVAF 700
LASVVDPRVA SAAAKAALEE FSRVREEVPL ELVEAHVKKV QEAARASGKV 750
DPTYGLESSC IAGTGPDEPE KLEGSEEEKM ETDPDGQQPE KAENKVENES 800
DEGDKIQDRE NEKNTEKEQD SDVSEDVKPE EKENEENKEL TDTCKERESD 850
AGKKKVEHEI SEGNVATAAA AALASAATKA KHLAAVEERK IKSLVALLVE 900
TQMKKLEIKL RHFEELETIM DREKEALEQQ RQQLLTERQN FHMEQLKYAE 950
LRARQQMEQQ QQHGQTPQQA HQHTGGPGMA PLGATGHPGM MPHQQPPPYP 1000
LMHHQMPPPH PPQPGQIPGP GSMMPGQPMP GRMIPAVAAN IHPTGSGPTP 1050
PGMPPMPGNI LGPRVPLTAP NGMYPPPPQQ QQPPPPADGV PPPPAPGPPA 1100
SATP 1104
Length:1,104
Mass (Da):122,890
Last modified:January 4, 2005 - v2
Checksum:i9030545104B90CAF
GO
Isoform 2 (identifier: P97496-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1074-1104: YPPPPQQQQPPPPADGVPPPPAPGPPASATP → CK

Note: No experimental confirmation available.

Show »
Length:1,075
Mass (Da):120,091
Checksum:iDC6BDB5CD4C9A296
GO

Sequence cautioni

The sequence AAB42085.1 differs from that shown. Reason: Frameshift at positions 5, 32, 48, 563, 565, 679 and 682.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1074 – 110431YPPPP…ASATP → CK in isoform 2.
VSP_012489Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321G → S in AAB42085. 1 Publication
Sequence conflicti468 – 4681R → G in AAB42085. 1 Publication
Sequence conflicti498 – 4981R → C in AAB42085. 1 Publication
Sequence conflicti512 – 5121R → L in AAB42085. 1 Publication
Sequence conflicti883 – 8831L → P in AAB42085. 1 Publication
Sequence conflicti891 – 8911I → K in AAH53064. 1 Publication
Sequence conflicti952 – 9521R → L in AAH52423. 1 Publication
Sequence conflicti984 – 9841A → R in AAB42085. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85614 mRNA. Translation: AAB42085.1. Frameshift.
BC052423 mRNA. Translation: AAH52423.1.
BC053064 mRNA. Translation: AAH53064.1.
CCDSiCCDS23561.1. [P97496-1]
PIRiT30967.
RefSeqiNP_033237.2. NM_009211.2. [P97496-1]
UniGeneiMm.85410.

Genome annotation databases

EnsembliENSMUST00000088716; ENSMUSP00000086094; ENSMUSG00000032481. [P97496-1]
ENSMUST00000111969; ENSMUSP00000107600; ENSMUSG00000032481. [P97496-2]
GeneIDi20588.
KEGGimmu:20588.
UCSCiuc009rto.1. mouse. [P97496-2]
uc009rtp.1. mouse. [P97496-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85614 mRNA. Translation: AAB42085.1 . Frameshift.
BC052423 mRNA. Translation: AAH52423.1 .
BC053064 mRNA. Translation: AAH53064.1 .
CCDSi CCDS23561.1. [P97496-1 ]
PIRi T30967.
RefSeqi NP_033237.2. NM_009211.2. [P97496-1 ]
UniGenei Mm.85410.

3D structure databases

ProteinModelPortali P97496.
SMRi P97496. Positions 454-538, 606-675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203338. 20 interactions.
DIPi DIP-39986N.
IntActi P97496. 13 interactions.
MINTi MINT-4084777.

PTM databases

PhosphoSitei P97496.

Proteomic databases

MaxQBi P97496.
PaxDbi P97496.
PRIDEi P97496.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088716 ; ENSMUSP00000086094 ; ENSMUSG00000032481 . [P97496-1 ]
ENSMUST00000111969 ; ENSMUSP00000107600 ; ENSMUSG00000032481 . [P97496-2 ]
GeneIDi 20588.
KEGGi mmu:20588.
UCSCi uc009rto.1. mouse. [P97496-2 ]
uc009rtp.1. mouse. [P97496-1 ]

Organism-specific databases

CTDi 6599.
MGIi MGI:1203524. Smarcc1.

Phylogenomic databases

eggNOGi COG5259.
GeneTreei ENSGT00390000018166.
HOGENOMi HOG000047736.
HOVERGENi HBG054849.
InParanoidi P97496.
KOi K11649.
OMAi YKKYVHA.
OrthoDBi EOG7T4MJH.
PhylomeDBi P97496.
TreeFami TF314710.

Miscellaneous databases

NextBioi 298891.
PROi P97496.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97496.
Bgeei P97496.
Genevestigatori P97496.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000953. Chromo_domain/shadow.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
SSF52113. SSF52113. 2 hits.
PROSITEi PS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new mouse gene, SRG3, related to the SWI3 of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in a thymoma cell line."
    Jeon S.H., Kang M.G., Kim Y.H., Jin Y.H., Lee C., Chung H.-Y., Kwon H., Park S.D., Seong R.H.
    J. Exp. Med. 185:1827-1836(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-892 (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development."
    Kim J.K., Huh S.-O., Choi H., Lee K.-S., Shin D., Lee C., Nam J.-S., Kim H., Chung H., Lee H.W., Park S.D., Seong R.H.
    Mol. Cell. Biol. 21:7787-7795(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "An essential switch in subunit composition of a chromatin remodeling complex during neural development."
    Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T., Wu H., Aebersold R., Graef I.A., Crabtree G.R.
    Neuron 55:201-215(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, DEVELOPMENTAL STAGE.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND SER-329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSMRC1_MOUSE
AccessioniPrimary (citable) accession number: P97496
Secondary accession number(s): Q7TS80, Q7TT29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi