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Protein

Thioredoxin, mitochondrial

Gene

Txn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Deprotonates C-terminal active site CysBy similarity1
Active sitei90NucleophileBy similarity1
Sitei91Contributes to redox potential valueBy similarity1
Sitei92Contributes to redox potential valueBy similarity1
Active sitei93NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin, mitochondrial
Short name:
MTRX
Short name:
Mt-Trx
Alternative name(s):
Thioredoxin-2
Gene namesi
Name:Txn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929468 Txn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 59MitochondrionBy similarityAdd BLAST59
ChainiPRO_000003415160 – 166Thioredoxin, mitochondrialAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 93Redox-activePROSITE-ProRule annotation
Modified residuei152N6-acetyllysine; alternateBy similarity1
Modified residuei152N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP97493
MaxQBiP97493
PaxDbiP97493
PeptideAtlasiP97493
PRIDEiP97493

PTM databases

iPTMnetiP97493
PhosphoSitePlusiP97493

Expressioni

Gene expression databases

BgeeiENSMUSG00000005354
CleanExiMM_TXN2
ExpressionAtlasiP97493 baseline and differential
GenevisibleiP97493 MM

Interactioni

Protein-protein interaction databases

IntActiP97493, 1 interactor
MINTiP97493
STRINGi10090.ENSMUSP00000005487

Structurei

3D structure databases

ProteinModelPortaliP97493
SMRiP97493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 166ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0910 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00530000064086
HOGENOMiHOG000292977
HOVERGENiHBG009243
InParanoidiP97493
KOiK03671
OMAiCRMLTPR
OrthoDBiEOG091G0UDG
PhylomeDBiP97493
TreeFamiTF314517

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRLLLGRF LTSVISRKPP QGVWASLTSK TLQTPQYNAG GLTVMPSPAR
60 70 80 90 100
TVHTTRVCLT TFNVQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL
110 120 130 140 150
EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAIK NGDVVDKFVG
160
IKDEDQLEAF LKKLIG
Length:166
Mass (Da):18,255
Last modified:May 1, 1997 - v1
Checksum:iC9A803DF571F3A7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85089 mRNA Translation: AAB41900.1
AK002358 mRNA Translation: BAB22037.1
AK010917 mRNA Translation: BAB27267.1
AK147164 mRNA Translation: BAE27729.1
AK149855 mRNA Translation: BAE29126.1
AK167754 mRNA Translation: BAE39789.1
AK167925 mRNA Translation: BAE39930.1
AK168322 mRNA Translation: BAE40261.1
AL583886 Genomic DNA No translation available.
BC068182 mRNA Translation: AAH68182.1
CCDSiCCDS27606.1
RefSeqiNP_064297.1, NM_019913.5
UniGeneiMm.291917
Mm.462887

Genome annotation databases

EnsembliENSMUST00000005487; ENSMUSP00000005487; ENSMUSG00000005354
ENSMUST00000109748; ENSMUSP00000105370; ENSMUSG00000005354
GeneIDi56551
KEGGimmu:56551
UCSCiuc007wof.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTHIOM_MOUSE
AccessioniPrimary (citable) accession number: P97493
Secondary accession number(s): A2A440, Q545D5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health