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P97493

- THIOM_MOUSE

UniProt

P97493 - THIOM_MOUSE

Protein

Thioredoxin, mitochondrial

Gene

Txn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential By similarity. Possesses a dithiol-reducing activity.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei84 – 841Deprotonates C-terminal active site CysBy similarity
    Active sitei90 – 901NucleophileBy similarity
    Sitei91 – 911Contributes to redox potential valueBy similarity
    Sitei92 – 921Contributes to redox potential valueBy similarity
    Active sitei93 – 931NucleophileBy similarity

    GO - Molecular functioni

    1. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. cellular response to nutrient levels Source: Ensembl
    3. glycerol ether metabolic process Source: InterPro
    4. response to axon injury Source: Ensembl
    5. response to drug Source: Ensembl
    6. response to glucose Source: Ensembl
    7. response to hormone Source: Ensembl
    8. response to hypoxia Source: Ensembl
    9. response to nutrient Source: Ensembl
    10. response to organic cyclic compound Source: Ensembl
    11. response to oxidative stress Source: Ensembl

    Keywords - Biological processi

    Electron transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin, mitochondrial
    Short name:
    MTRX
    Short name:
    Mt-Trx
    Alternative name(s):
    Thioredoxin-2
    Gene namesi
    Name:Txn2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1929468. Txn2.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. mitochondrion Source: MGI
    3. neuronal cell body Source: Ensembl
    4. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5959MitochondrionBy similarityAdd
    BLAST
    Chaini60 – 166107Thioredoxin, mitochondrialPRO_0000034151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi90 ↔ 93Redox-activePROSITE-ProRule annotation
    Modified residuei152 – 1521N6-acetyllysine; alternateBy similarity
    Modified residuei152 – 1521N6-succinyllysine; alternate1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    MaxQBiP97493.
    PaxDbiP97493.
    PRIDEiP97493.

    PTM databases

    PhosphoSiteiP97493.

    Expressioni

    Gene expression databases

    BgeeiP97493.
    CleanExiMM_TXN2.
    GenevestigatoriP97493.

    Interactioni

    Protein-protein interaction databases

    IntActiP97493. 1 interaction.
    MINTiMINT-4137662.
    STRINGi10090.ENSMUSP00000105370.

    Structurei

    3D structure databases

    ProteinModelPortaliP97493.
    SMRiP97493. Positions 60-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 166106ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thioredoxin family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Transit peptide

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00530000064086.
    HOGENOMiHOG000292977.
    HOVERGENiHBG009243.
    InParanoidiA2A440.
    KOiK03671.
    OMAiSFNVQDH.
    PhylomeDBiP97493.
    TreeFamiTF314517.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PANTHERiPTHR10438. PTHR10438. 1 hit.
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
    PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97493-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQRLLLGRF LTSVISRKPP QGVWASLTSK TLQTPQYNAG GLTVMPSPAR    50
    TVHTTRVCLT TFNVQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL 100
    EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAIK NGDVVDKFVG 150
    IKDEDQLEAF LKKLIG 166
    Length:166
    Mass (Da):18,255
    Last modified:May 1, 1997 - v1
    Checksum:iC9A803DF571F3A7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85089 mRNA. Translation: AAB41900.1.
    AK002358 mRNA. Translation: BAB22037.1.
    AK010917 mRNA. Translation: BAB27267.1.
    AK147164 mRNA. Translation: BAE27729.1.
    AK149855 mRNA. Translation: BAE29126.1.
    AK167754 mRNA. Translation: BAE39789.1.
    AK167925 mRNA. Translation: BAE39930.1.
    AK168322 mRNA. Translation: BAE40261.1.
    AL583886 Genomic DNA. Translation: CAM23427.1.
    BC068182 mRNA. Translation: AAH68182.1.
    CCDSiCCDS27606.1.
    RefSeqiNP_064297.1. NM_019913.5.
    UniGeneiMm.291917.
    Mm.462887.

    Genome annotation databases

    EnsembliENSMUST00000005487; ENSMUSP00000005487; ENSMUSG00000005354.
    ENSMUST00000109748; ENSMUSP00000105370; ENSMUSG00000005354.
    GeneIDi56551.
    KEGGimmu:56551.
    UCSCiuc007wof.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85089 mRNA. Translation: AAB41900.1 .
    AK002358 mRNA. Translation: BAB22037.1 .
    AK010917 mRNA. Translation: BAB27267.1 .
    AK147164 mRNA. Translation: BAE27729.1 .
    AK149855 mRNA. Translation: BAE29126.1 .
    AK167754 mRNA. Translation: BAE39789.1 .
    AK167925 mRNA. Translation: BAE39930.1 .
    AK168322 mRNA. Translation: BAE40261.1 .
    AL583886 Genomic DNA. Translation: CAM23427.1 .
    BC068182 mRNA. Translation: AAH68182.1 .
    CCDSi CCDS27606.1.
    RefSeqi NP_064297.1. NM_019913.5.
    UniGenei Mm.291917.
    Mm.462887.

    3D structure databases

    ProteinModelPortali P97493.
    SMRi P97493. Positions 60-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97493. 1 interaction.
    MINTi MINT-4137662.
    STRINGi 10090.ENSMUSP00000105370.

    PTM databases

    PhosphoSitei P97493.

    Proteomic databases

    MaxQBi P97493.
    PaxDbi P97493.
    PRIDEi P97493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005487 ; ENSMUSP00000005487 ; ENSMUSG00000005354 .
    ENSMUST00000109748 ; ENSMUSP00000105370 ; ENSMUSG00000005354 .
    GeneIDi 56551.
    KEGGi mmu:56551.
    UCSCi uc007wof.1. mouse.

    Organism-specific databases

    CTDi 25828.
    MGIi MGI:1929468. Txn2.

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00530000064086.
    HOGENOMi HOG000292977.
    HOVERGENi HBG009243.
    InParanoidi A2A440.
    KOi K03671.
    OMAi SFNVQDH.
    PhylomeDBi P97493.
    TreeFami TF314517.

    Enzyme and pathway databases

    Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    ChiTaRSi TXN2. mouse.
    NextBioi 312931.
    PROi P97493.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97493.
    CleanExi MM_TXN2.
    Genevestigatori P97493.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    PANTHERi PTHR10438. PTHR10438. 1 hit.
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01068. thioredoxin. 1 hit.
    PROSITEi PS00194. THIOREDOXIN_1. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Miranda-Vizuete A., Gustafsson J.-A., Spyrou G.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and DBA/2.
      Tissue: Bone marrow, Kidney and Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice."
      Nonn L., Williams R.R., Erickson R.P., Powis G.
      Mol. Cell. Biol. 23:916-922(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-152, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTHIOM_MOUSE
    AccessioniPrimary (citable) accession number: P97493
    Secondary accession number(s): A2A440, Q545D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3