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Reviewed, UniProtKB/Swiss-Prot P97490 (ADCY8_MOUSE)

Last modified October 13, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Adenylate cyclase type 8
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type VIII
    ATP pyrophosphate-lyase 8
    Adenylyl cyclase 8
    Ca(2+)/calmodulin-activated adenylyl cyclase
Gene names
Name: Adcy8
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12491249Adenylate cyclase type 8
PRO_0000195706

Regions

Topological domain1 – 180180Cytoplasmic Potential
Transmembrane181 – 20121 Potential
Transmembrane210 – 23021 Potential
Transmembrane245 – 26521 Potential
Transmembrane272 – 29221 Potential
Transmembrane294 – 31421 Potential
Transmembrane319 – 33921 Potential
Topological domain340 – 713374Cytoplasmic Potential
Transmembrane714 – 73421 Potential
Transmembrane736 – 75621 Potential
Transmembrane785 – 80521 Potential
Transmembrane829 – 84921 Potential
Transmembrane859 – 87921 Potential
Transmembrane892 – 91221 Potential
Topological domain913 – 1249337Cytoplasmic Potential

Sites

Metal binding4171Magnesium 1 By similarity
Metal binding4171Magnesium 2 By similarity
Metal binding4181Magnesium 2; via carbonyl oxygen By similarity
Metal binding4611Magnesium 1 By similarity
Metal binding4611Magnesium 2 By similarity

Amino acid modifications

Glycosylation8151N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation8861N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P97490-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: B2FE5670E9A74DAF

FASTA1,249140,155
        10         20         30         40         50         60 
MELSDVHCLS GSEELYTIQP TPPVGDDGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGCG 

        70         80         90        100        110        120 
GVSRKASNPA GSGPNHHAPQ LSSDSVLPLY SLGPGERAHN TGGTKVFPER SGSGSASGSG 

       130        140        150        160        170        180 
GGGDLGFLHL DCAPSNSDFF LNGGYSYRGV IFPTLRNSFK SRDLERLYQR YFLGQRRKSE 

       190        200        210        220        230        240 
VVMNVLDVLT KLTLLVLHLS LASAPMDPLK GILLGFFTGI EVVICALVVV RKDNTSHTYL 

       250        260        270        280        290        300 
QYSGVVTWVA MTTQILAAGL GYGLLGDGIG YVLFTLFATY SMLPLPLTWA ILAGLGTSLL 

       310        320        330        340        350        360 
QVTLQVLIPR LAVFSINQVL AQVVLFMCMN TAGIFISYLS DRAQRQAFLE TRRCVEARLR 

       370        380        390        400        410        420 
LETENQRQER LVLSVLPRFV VLEMINDMTN VEDEHLQHQF HRIYIHRYEN VSILFADVKG 

       430        440        450        460        470        480 
FTNLSTTLSA QELVRMLNEL FARFDRLAHE HHCLRIKILG DCYYCVSGLP EPRRDHAHCC 

       490        500        510        520        530        540 
VEMGLSMIKT IRFVRSRTKH DVDMRIGIHS GSVLCGVLGL RKWQFDVWSW DVDIANKLES 

       550        560        570        580        590        600 
GGIPGRIHIS KATLDCLNGD YNVEEGHGKE RNEFLRKHNI ETYLIKQPEE SLLCLPEDIV 

       610        620        630        640        650        660 
KESVSCSDRR NSGATFTEGS WSPELPFDNI VGKQNTLAAL TRNSINLLPN HLAQALHVQS 

       670        680        690        700        710        720 
GPEEINKRIE HTIDLRSGDK LRREHIKPFS LMFKDSSLEH KYSQMRDEVF KSNLVCAFIV 

       730        740        750        760        770        780 
LLFITAIQSL LPSSRLMPMT IQFSILIMLH SALVLITTAE DYKCLPLILR KTCCWINETY 

       790        800        810        820        830        840 
LARNVIIFAS ILINFLGAVL NILWCDFDKS IPLKNLTFNS SAVFTDICSY PEYFVFTGVL 

       850        860        870        880        890        900 
AMVTCAVFVR LNSVLKLAVL LIMIAIYALL TETIYAGLFL SYDNLNHSGE DFLGTKEASL 

       910        920        930        940        950        960 
LLMAMFLLAV FYHGQQLEYT ARLDFLWRVQ AKEEINEMKE LREHNENMLR NILPSHVARH 

       970        980        990       1000       1010       1020 
FLEKDRDNEE LYSQSYDAVG VMFASIPGFA DFYSQTEMNN QGVECLRLLN EIIADFDELL 

      1030       1040       1050       1060       1070       1080 
GEDRFQDIEK IKTIGSTYMA VSGLSPEKQQ CEDKWGHLCA LADFSLALTE SIQEINKHSF 

      1090       1100       1110       1120       1130       1140 
NNFELRIGIS HGSVVAGVIG AKKPQYDIWG KTVNLASRMD STGVSGRIQV PEETYLILKD 

      1150       1160       1170       1180       1190       1200 
QGFAFDYRGE IYVKGISEQE GKIKTYFLLG RVQPNPFILP PRRLPGQYSL AAVVLGLVQS 

      1210       1220       1230       1240 
LNRQRQKQLL NENSNSGIIK SHYNRRTLLT PSGPEPGAQA EGTDKSDLP

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References

[1]"Cloning of mouse adenylyl cyclase type 8."
Premont R.T.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U85021 mRNA. Translation: AAB41885.1.
IPIIPI00125645.
UniGeneMm.1425

3D structure databases

HSSPHSSP built from PDB template 1CUL based on UniProtKB P30803.
ModBaseSearch...

Protein-protein interaction databases

STRINGP97490.

PTM databases

PhosphoSiteP97490.

Proteomic databases

PRIDEP97490.

Genome annotation databases

EnsemblENSMUST00000023007; ENSMUSP00000023007; ENSMUSG00000022376; Mus musculus. [Genome view]
UCSCuc007vzo.1. mouse.

Organism-specific databases

MGIMGI:1341110. Adcy8.

Phylogenomic databases

HOGENOMP97490.
HOVERGENP97490.

Enzyme and pathway databases

BRENDA4.6.1.1. 244.

Gene expression databases

ArrayExpressP97490.
BgeeP97490.
CleanExMM_ADCY8.
GenevestigatorP97490.
GermOnlineENSMUSG00000022376. Mus musculus.

Family and domain databases

InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Aden_cycl-like.
[Graphical view]
Gene3DG3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameADCY8_MOUSE
AccessionPrimary (citable) accession number: P97490
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 13, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents