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P97490

- ADCY8_MOUSE

UniProt

P97490 - ADCY8_MOUSE

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Protein
Adenylate cyclase type 8
Gene
Adcy8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulationi

Activated by calcium/calmodulin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi417 – 4171Magnesium 1 By similarity
Metal bindingi417 – 4171Magnesium 2 By similarity
Metal bindingi418 – 4181Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi461 – 4611Magnesium 1 By similarity
Metal bindingi461 – 4611Magnesium 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. adenylate cyclase activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. long-term memory Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 8 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 8
Adenylate cyclase type VIII
Adenylyl cyclase 8
Ca(2+)/calmodulin-activated adenylyl cyclase
Gene namesi
Name:Adcy8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1341110. Adcy8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 180180Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Transmembranei210 – 23021Helical; Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Reviewed prediction
Add
BLAST
Transmembranei272 – 29221Helical; Reviewed prediction
Add
BLAST
Transmembranei294 – 31421Helical; Reviewed prediction
Add
BLAST
Transmembranei319 – 33921Helical; Reviewed prediction
Add
BLAST
Topological domaini340 – 713374Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei714 – 73421Helical; Reviewed prediction
Add
BLAST
Transmembranei736 – 75621Helical; Reviewed prediction
Add
BLAST
Transmembranei785 – 80521Helical; Reviewed prediction
Add
BLAST
Transmembranei829 – 84921Helical; Reviewed prediction
Add
BLAST
Transmembranei859 – 87921Helical; Reviewed prediction
Add
BLAST
Transmembranei892 – 91221Helical; Reviewed prediction
Add
BLAST
Topological domaini913 – 1249337Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12491249Adenylate cyclase type 8
PRO_0000195706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi815 – 8151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi886 – 8861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP97490.

PTM databases

PhosphoSiteiP97490.

Expressioni

Gene expression databases

CleanExiMM_ADCY8.
GenevestigatoriP97490.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997019.
STRINGi10090.ENSMUSP00000023007.

Structurei

3D structure databases

ProteinModelPortaliP97490.
SMRiP97490. Positions 400-585, 969-1143.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00680000099709.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiP97490.
KOiK08048.
OMAiDVRCLSG.
OrthoDBiEOG7B8S30.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97490-1 [UniParc]FASTAAdd to Basket

« Hide

MELSDVHCLS GSEELYTIQP TPPAGDDGSG SRPQRLLWQT AVRHITEQRF     50
IHGHRGGGGG GVSRKASNPA GSGPNHHAPQ LSSDSVLPLY SLGPGERAHN 100
TGGTKVFPER SGSGSASGSG GGGDLGFLHL DCAPSNSDFF LNGGYSYRGV 150
IFPTLRNSFK SRDLERLYQR YFLGQRRKSE VVMNVLDVLT KLTLLVLHLS 200
LASAPMDPLK GILLGFFTGI EVVICALVVV RKDNTSHTYL QYSGVVTWVA 250
MTTQILAAGL GYGLLGDGIG YVLFTLFATY SMLPLPLTWA ILAGLGTSLL 300
QVTLQVLIPR LAVFSINQVL AQVVLFMCMN TAGIFISYLS DRAQRQAFLE 350
TRRCVEARLR LETENQRQER LVLSVLPRFV VLEMINDMTN VEDEHLQHQF 400
HRIYIHRYEN VSILFADVKG FTNLSTTLSA QELVRMLNEL FARFDRLAHE 450
HHCLRIKILG DCYYCVSGLP EPRRDHAHCC VEMGLSMIKT IRFVRSRTKH 500
DVDMRIGIHS GSVLCGVLGL RKWQFDVWSW DVDIANKLES GGIPGRIHIS 550
KATLDCLNGD YNVEEGHGKE RNEFLRKHNI ETYLIKQPEE SLLCLPEDIV 600
KESVSCSDRR NSGATFTEGS WSPELPFDNI VGKQNTLAAL TRNSINLLPN 650
HLAQALHVQS GPEEINKRIE HTIDLRSGDK LRREHIKPFS LMFKDSSLEH 700
KYSQMRDEVF KSNLVCAFIV LLFITAIQSL LPSSRLMPMT IQFSILIMLH 750
SALVLITTAE DYKCLPLILR KTCCWINETY LARNVIIFAS ILINFLGAVL 800
NILWCDFDKS IPLKNLTFNS SAVFTDICSY PEYFVFTGVL AMVTCAVFLR 850
LNSVLKLAVL LIMIAIYALL TETIYAGLFL SYDNLNHSGE DFLGTKEASL 900
LLMAMFLLAV FYHGQQLEYT ARLDFLWRVQ AKEEINEMKE LREHNENMLR 950
NILPSHVARH FLEKDRDNEE LYSQSYDAVG VMFASIPGFA DFYSQTEMNN 1000
QGVECLRLLN EIIADFDELL GEDRFQDIEK IKTIGSTYMA VSGLSPEKQQ 1050
CEDKWGHLCA LADFSLALTE SIQEINKHSF NNFELRIGIS HGSVVAGVIG 1100
AKKPQYDIWG KTVNLASRMD STGVSGRIQV PEETYLILKD QGFAFDYRGE 1150
IYVKGISEQE GKIKTYFLLG RVQPNPFILP PRRLPGQYSL AAVVLGLVQS 1200
LNRQRQKQLL NENSNSGIIK SHYNRRTLLT PSGPEPGAQA EGTDKSDLP 1249
Length:1,249
Mass (Da):140,095
Last modified:October 3, 2012 - v2
Checksum:i26103B6E0DB9C701
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241A → V in AAB41885. 1 Publication
Sequence conflicti59 – 591G → C in AAB41885. 1 Publication
Sequence conflicti849 – 8491L → V in AAB41885. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85021 mRNA. Translation: AAB41885.1.
AC116996 Genomic DNA. No translation available.
AC160934 Genomic DNA. No translation available.
CH466545 Genomic DNA. Translation: EDL29360.1.
CH466545 Genomic DNA. Translation: EDL29361.1.
CCDSiCCDS27506.1.
RefSeqiNP_033753.2. NM_009623.2.
UniGeneiMm.1425.

Genome annotation databases

EnsembliENSMUST00000023007; ENSMUSP00000023007; ENSMUSG00000022376.
GeneIDi11514.
KEGGimmu:11514.
UCSCiuc007vzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U85021 mRNA. Translation: AAB41885.1 .
AC116996 Genomic DNA. No translation available.
AC160934 Genomic DNA. No translation available.
CH466545 Genomic DNA. Translation: EDL29360.1 .
CH466545 Genomic DNA. Translation: EDL29361.1 .
CCDSi CCDS27506.1.
RefSeqi NP_033753.2. NM_009623.2.
UniGenei Mm.1425.

3D structure databases

ProteinModelPortali P97490.
SMRi P97490. Positions 400-585, 969-1143.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4997019.
STRINGi 10090.ENSMUSP00000023007.

Chemistry

BindingDBi P97490.

PTM databases

PhosphoSitei P97490.

Proteomic databases

PRIDEi P97490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023007 ; ENSMUSP00000023007 ; ENSMUSG00000022376 .
GeneIDi 11514.
KEGGi mmu:11514.
UCSCi uc007vzo.1. mouse.

Organism-specific databases

CTDi 114.
MGIi MGI:1341110. Adcy8.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00680000099709.
HOGENOMi HOG000006941.
HOVERGENi HBG050458.
InParanoidi P97490.
KOi K08048.
OMAi DVRCLSG.
OrthoDBi EOG7B8S30.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

NextBioi 278926.
PROi P97490.
SOURCEi Search...

Gene expression databases

CleanExi MM_ADCY8.
Genevestigatori P97490.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse adenylyl cyclase type 8."
    Premont R.T.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiADCY8_MOUSE
AccessioniPrimary (citable) accession number: P97490
Secondary accession number(s): G3X8V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi