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P97490 (ADCY8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase type 8

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 8
Adenylate cyclase type VIII
Adenylyl cyclase 8
Ca(2+)/calmodulin-activated adenylyl cyclase
Gene names
Name:Adcy8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1249 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Enzyme regulation

Activated by calcium/calmodulin.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12491249Adenylate cyclase type 8
PRO_0000195706

Regions

Topological domain1 – 180180Cytoplasmic Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane245 – 26521Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane294 – 31421Helical; Potential
Transmembrane319 – 33921Helical; Potential
Topological domain340 – 713374Cytoplasmic Potential
Transmembrane714 – 73421Helical; Potential
Transmembrane736 – 75621Helical; Potential
Transmembrane785 – 80521Helical; Potential
Transmembrane829 – 84921Helical; Potential
Transmembrane859 – 87921Helical; Potential
Transmembrane892 – 91221Helical; Potential
Topological domain913 – 1249337Cytoplasmic Potential

Sites

Metal binding4171Magnesium 1 By similarity
Metal binding4171Magnesium 2 By similarity
Metal binding4181Magnesium 2; via carbonyl oxygen By similarity
Metal binding4611Magnesium 1 By similarity
Metal binding4611Magnesium 2 By similarity

Amino acid modifications

Glycosylation8151N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation8861N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict241A → V in AAB41885. Ref.1
Sequence conflict591G → C in AAB41885. Ref.1
Sequence conflict8491L → V in AAB41885. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P97490 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 26103B6E0DB9C701

FASTA1,249140,095
        10         20         30         40         50         60 
MELSDVHCLS GSEELYTIQP TPPAGDDGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG 

        70         80         90        100        110        120 
GVSRKASNPA GSGPNHHAPQ LSSDSVLPLY SLGPGERAHN TGGTKVFPER SGSGSASGSG 

       130        140        150        160        170        180 
GGGDLGFLHL DCAPSNSDFF LNGGYSYRGV IFPTLRNSFK SRDLERLYQR YFLGQRRKSE 

       190        200        210        220        230        240 
VVMNVLDVLT KLTLLVLHLS LASAPMDPLK GILLGFFTGI EVVICALVVV RKDNTSHTYL 

       250        260        270        280        290        300 
QYSGVVTWVA MTTQILAAGL GYGLLGDGIG YVLFTLFATY SMLPLPLTWA ILAGLGTSLL 

       310        320        330        340        350        360 
QVTLQVLIPR LAVFSINQVL AQVVLFMCMN TAGIFISYLS DRAQRQAFLE TRRCVEARLR 

       370        380        390        400        410        420 
LETENQRQER LVLSVLPRFV VLEMINDMTN VEDEHLQHQF HRIYIHRYEN VSILFADVKG 

       430        440        450        460        470        480 
FTNLSTTLSA QELVRMLNEL FARFDRLAHE HHCLRIKILG DCYYCVSGLP EPRRDHAHCC 

       490        500        510        520        530        540 
VEMGLSMIKT IRFVRSRTKH DVDMRIGIHS GSVLCGVLGL RKWQFDVWSW DVDIANKLES 

       550        560        570        580        590        600 
GGIPGRIHIS KATLDCLNGD YNVEEGHGKE RNEFLRKHNI ETYLIKQPEE SLLCLPEDIV 

       610        620        630        640        650        660 
KESVSCSDRR NSGATFTEGS WSPELPFDNI VGKQNTLAAL TRNSINLLPN HLAQALHVQS 

       670        680        690        700        710        720 
GPEEINKRIE HTIDLRSGDK LRREHIKPFS LMFKDSSLEH KYSQMRDEVF KSNLVCAFIV 

       730        740        750        760        770        780 
LLFITAIQSL LPSSRLMPMT IQFSILIMLH SALVLITTAE DYKCLPLILR KTCCWINETY 

       790        800        810        820        830        840 
LARNVIIFAS ILINFLGAVL NILWCDFDKS IPLKNLTFNS SAVFTDICSY PEYFVFTGVL 

       850        860        870        880        890        900 
AMVTCAVFLR LNSVLKLAVL LIMIAIYALL TETIYAGLFL SYDNLNHSGE DFLGTKEASL 

       910        920        930        940        950        960 
LLMAMFLLAV FYHGQQLEYT ARLDFLWRVQ AKEEINEMKE LREHNENMLR NILPSHVARH 

       970        980        990       1000       1010       1020 
FLEKDRDNEE LYSQSYDAVG VMFASIPGFA DFYSQTEMNN QGVECLRLLN EIIADFDELL 

      1030       1040       1050       1060       1070       1080 
GEDRFQDIEK IKTIGSTYMA VSGLSPEKQQ CEDKWGHLCA LADFSLALTE SIQEINKHSF 

      1090       1100       1110       1120       1130       1140 
NNFELRIGIS HGSVVAGVIG AKKPQYDIWG KTVNLASRMD STGVSGRIQV PEETYLILKD 

      1150       1160       1170       1180       1190       1200 
QGFAFDYRGE IYVKGISEQE GKIKTYFLLG RVQPNPFILP PRRLPGQYSL AAVVLGLVQS 

      1210       1220       1230       1240 
LNRQRQKQLL NENSNSGIIK SHYNRRTLLT PSGPEPGAQA EGTDKSDLP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse adenylyl cyclase type 8."
Premont R.T.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U85021 mRNA. Translation: AAB41885.1.
AC116996 Genomic DNA. No translation available.
AC160934 Genomic DNA. No translation available.
CH466545 Genomic DNA. Translation: EDL29360.1.
CH466545 Genomic DNA. Translation: EDL29361.1.
CCDSCCDS27506.1.
RefSeqNP_033753.2. NM_009623.2.
UniGeneMm.1425.

3D structure databases

ProteinModelPortalP97490.
SMRP97490. Positions 400-585, 969-1143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997019.
STRING10090.ENSMUSP00000023007.

Chemistry

BindingDBP97490.

PTM databases

PhosphoSiteP97490.

Proteomic databases

PRIDEP97490.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023007; ENSMUSP00000023007; ENSMUSG00000022376.
GeneID11514.
KEGGmmu:11514.
UCSCuc007vzo.1. mouse.

Organism-specific databases

CTD114.
MGIMGI:1341110. Adcy8.

Phylogenomic databases

eggNOGCOG2114.
GeneTreeENSGT00680000099709.
HOGENOMHOG000006941.
HOVERGENHBG050458.
InParanoidP97490.
KOK08048.
OMADVRCLSG.
OrthoDBEOG7B8S30.
TreeFamTF313845.

Gene expression databases

CleanExMM_ADCY8.
GenevestigatorP97490.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio278926.
PROP97490.
SOURCESearch...

Entry information

Entry nameADCY8_MOUSE
AccessionPrimary (citable) accession number: P97490
Secondary accession number(s): G3X8V9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot