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P97490

- ADCY8_MOUSE

UniProt

P97490 - ADCY8_MOUSE

Protein

Adenylate cyclase type 8

Gene

Adcy8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence By similarity.By similarity

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Enzyme regulationi

    Activated by calcium/calmodulin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi417 – 4171Magnesium 1PROSITE-ProRule annotations
    Metal bindingi417 – 4171Magnesium 2PROSITE-ProRule annotations
    Metal bindingi418 – 4181Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotations
    Metal bindingi461 – 4611Magnesium 1PROSITE-ProRule annotations
    Metal bindingi461 – 4611Magnesium 2PROSITE-ProRule annotations

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. long-term memory Source: MGI

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 8 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 8
    Adenylate cyclase type VIII
    Adenylyl cyclase 8
    Ca(2+)/calmodulin-activated adenylyl cyclase
    Gene namesi
    Name:Adcy8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1341110. Adcy8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12491249Adenylate cyclase type 8PRO_0000195706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi815 – 8151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi886 – 8861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP97490.

    PTM databases

    PhosphoSiteiP97490.

    Expressioni

    Gene expression databases

    CleanExiMM_ADCY8.
    GenevestigatoriP97490.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997019.
    STRINGi10090.ENSMUSP00000023007.

    Structurei

    3D structure databases

    ProteinModelPortaliP97490.
    SMRiP97490. Positions 400-585, 969-1143.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 180180CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini340 – 713374CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini913 – 1249337CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei714 – 73421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei736 – 75621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei785 – 80521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei829 – 84921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei859 – 87921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei892 – 91221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotations
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotations

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00680000099709.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiP97490.
    KOiK08048.
    OMAiDVRCLSG.
    OrthoDBiEOG7B8S30.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    P97490-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELSDVHCLS GSEELYTIQP TPPAGDDGSG SRPQRLLWQT AVRHITEQRF     50
    IHGHRGGGGG GVSRKASNPA GSGPNHHAPQ LSSDSVLPLY SLGPGERAHN 100
    TGGTKVFPER SGSGSASGSG GGGDLGFLHL DCAPSNSDFF LNGGYSYRGV 150
    IFPTLRNSFK SRDLERLYQR YFLGQRRKSE VVMNVLDVLT KLTLLVLHLS 200
    LASAPMDPLK GILLGFFTGI EVVICALVVV RKDNTSHTYL QYSGVVTWVA 250
    MTTQILAAGL GYGLLGDGIG YVLFTLFATY SMLPLPLTWA ILAGLGTSLL 300
    QVTLQVLIPR LAVFSINQVL AQVVLFMCMN TAGIFISYLS DRAQRQAFLE 350
    TRRCVEARLR LETENQRQER LVLSVLPRFV VLEMINDMTN VEDEHLQHQF 400
    HRIYIHRYEN VSILFADVKG FTNLSTTLSA QELVRMLNEL FARFDRLAHE 450
    HHCLRIKILG DCYYCVSGLP EPRRDHAHCC VEMGLSMIKT IRFVRSRTKH 500
    DVDMRIGIHS GSVLCGVLGL RKWQFDVWSW DVDIANKLES GGIPGRIHIS 550
    KATLDCLNGD YNVEEGHGKE RNEFLRKHNI ETYLIKQPEE SLLCLPEDIV 600
    KESVSCSDRR NSGATFTEGS WSPELPFDNI VGKQNTLAAL TRNSINLLPN 650
    HLAQALHVQS GPEEINKRIE HTIDLRSGDK LRREHIKPFS LMFKDSSLEH 700
    KYSQMRDEVF KSNLVCAFIV LLFITAIQSL LPSSRLMPMT IQFSILIMLH 750
    SALVLITTAE DYKCLPLILR KTCCWINETY LARNVIIFAS ILINFLGAVL 800
    NILWCDFDKS IPLKNLTFNS SAVFTDICSY PEYFVFTGVL AMVTCAVFLR 850
    LNSVLKLAVL LIMIAIYALL TETIYAGLFL SYDNLNHSGE DFLGTKEASL 900
    LLMAMFLLAV FYHGQQLEYT ARLDFLWRVQ AKEEINEMKE LREHNENMLR 950
    NILPSHVARH FLEKDRDNEE LYSQSYDAVG VMFASIPGFA DFYSQTEMNN 1000
    QGVECLRLLN EIIADFDELL GEDRFQDIEK IKTIGSTYMA VSGLSPEKQQ 1050
    CEDKWGHLCA LADFSLALTE SIQEINKHSF NNFELRIGIS HGSVVAGVIG 1100
    AKKPQYDIWG KTVNLASRMD STGVSGRIQV PEETYLILKD QGFAFDYRGE 1150
    IYVKGISEQE GKIKTYFLLG RVQPNPFILP PRRLPGQYSL AAVVLGLVQS 1200
    LNRQRQKQLL NENSNSGIIK SHYNRRTLLT PSGPEPGAQA EGTDKSDLP 1249
    Length:1,249
    Mass (Da):140,095
    Last modified:October 3, 2012 - v2
    Checksum:i26103B6E0DB9C701
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241A → V in AAB41885. 1 PublicationCurated
    Sequence conflicti59 – 591G → C in AAB41885. 1 PublicationCurated
    Sequence conflicti849 – 8491L → V in AAB41885. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85021 mRNA. Translation: AAB41885.1.
    AC116996 Genomic DNA. No translation available.
    AC160934 Genomic DNA. No translation available.
    CH466545 Genomic DNA. Translation: EDL29360.1.
    CH466545 Genomic DNA. Translation: EDL29361.1.
    CCDSiCCDS27506.1.
    RefSeqiNP_033753.2. NM_009623.2.
    UniGeneiMm.1425.

    Genome annotation databases

    EnsembliENSMUST00000023007; ENSMUSP00000023007; ENSMUSG00000022376.
    GeneIDi11514.
    KEGGimmu:11514.
    UCSCiuc007vzo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U85021 mRNA. Translation: AAB41885.1 .
    AC116996 Genomic DNA. No translation available.
    AC160934 Genomic DNA. No translation available.
    CH466545 Genomic DNA. Translation: EDL29360.1 .
    CH466545 Genomic DNA. Translation: EDL29361.1 .
    CCDSi CCDS27506.1.
    RefSeqi NP_033753.2. NM_009623.2.
    UniGenei Mm.1425.

    3D structure databases

    ProteinModelPortali P97490.
    SMRi P97490. Positions 400-585, 969-1143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997019.
    STRINGi 10090.ENSMUSP00000023007.

    Chemistry

    BindingDBi P97490.

    PTM databases

    PhosphoSitei P97490.

    Proteomic databases

    PRIDEi P97490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023007 ; ENSMUSP00000023007 ; ENSMUSG00000022376 .
    GeneIDi 11514.
    KEGGi mmu:11514.
    UCSCi uc007vzo.1. mouse.

    Organism-specific databases

    CTDi 114.
    MGIi MGI:1341110. Adcy8.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00680000099709.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi P97490.
    KOi K08048.
    OMAi DVRCLSG.
    OrthoDBi EOG7B8S30.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_198242. CREB phosphorylation through the activation of Adenylate Cyclase.
    REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    NextBioi 278926.
    PROi P97490.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ADCY8.
    Genevestigatori P97490.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse adenylyl cyclase type 8."
      Premont R.T.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiADCY8_MOUSE
    AccessioniPrimary (citable) accession number: P97490
    Secondary accession number(s): G3X8V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi