Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor GATA-5

Gene

Gata5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (PubMed:9119112). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 220GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri250 – 274GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-5
Alternative name(s):
GATA-binding factor 5
Gene namesi
Name:Gata5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109497 Gata5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834191 – 404Transcription factor GATA-5Add BLAST404

Proteomic databases

MaxQBiP97489
PaxDbiP97489
PeptideAtlasiP97489
PRIDEiP97489

PTM databases

iPTMnetiP97489
PhosphoSitePlusiP97489

Expressioni

Gene expression databases

BgeeiENSMUSG00000015627
CleanExiMM_GATA5
GenevisibleiP97489 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199842, 5 interactors
STRINGi10090.ENSMUSP00000015771

Structurei

3D structure databases

ProteinModelPortaliP97489
SMRiP97489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri196 – 220GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri250 – 274GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiP97489
KOiK17896
OMAiAFPFAHS
OrthoDBiEOG091G0AUR
TreeFamiTF315391

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P97489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQSLALAQS PGQGTYADSG AFLHSSGTGS PVFVAPTRMP SMLPYLPSCE
60 70 80 90 100
PGSQAPALAA HSSWTQAVAA DSSAFGSGSP HPPAAHPPGA TTFPFAHSPP
110 120 130 140 150
GSGSGGSAGV RDGGAFQGAL LAREQYPTPL GRPMGASYPT TYPAYMSSDV
160 170 180 190 200
APSWTSGAFD SSILHGLQAR PGGLPGRRTS FVPDFLEEFP GEGRECVNCG
210 220 230 240 250
ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL SSSRRSGLCC
260 270 280 290 300
SNCHTATTTL WRRNSEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK
310 320 330 340 350
PKNPAKIKGS SGSTANTTAS SPTLLNSESS ATTLKAESSL ASPVCAGPTI
360 370 380 390 400
TSQASSPADE SLASSHLEFK FEPEDFAFTS SSMSPQAGLS GVLRQETWCA

LALA
Length:404
Mass (Da):42,114
Last modified:July 27, 2011 - v2
Checksum:i6C0990A85D594F0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67A → T in AAB47506 (PubMed:9119112).Curated1
Sequence conflicti302K → E in AAB47506 (PubMed:9119112).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84725 mRNA Translation: AAB47506.1
AK132020 mRNA Translation: BAE20945.1
AK142213 mRNA Translation: BAE24979.1
AL663027 Genomic DNA Translation: CAM16220.1
CH466626 Genomic DNA Translation: EDL07330.1
CCDSiCCDS17175.1
RefSeqiNP_032119.2, NM_008093.2
XP_006500617.1, XM_006500554.3
UniGeneiMm.388880

Genome annotation databases

EnsembliENSMUST00000015771; ENSMUSP00000015771; ENSMUSG00000015627
GeneIDi14464
KEGGimmu:14464
UCSCiuc008oix.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGATA5_MOUSE
AccessioniPrimary (citable) accession number: P97489
Secondary accession number(s): Q3UQR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health