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Protein

Transcription factor GATA-5

Gene

Gata5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (PubMed:9119112). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 22025GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27425GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: MGI
  • enhancer sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  • sequence-specific DNA binding transcription factor activity Source: MGI
  • transcription regulatory region DNA binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to BMP stimulus Source: MGI
  • intestinal epithelial cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-5
Alternative name(s):
GATA-binding factor 5
Gene namesi
Name:Gata5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109497. Gata5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Transcription factor GATA-5PRO_0000083419Add
BLAST

Proteomic databases

PRIDEiP97489.

PTM databases

PhosphoSiteiP97489.

Expressioni

Gene expression databases

BgeeiP97489.
CleanExiMM_GATA5.
ExpressionAtlasiP97489. baseline and differential.
GenevisibleiP97489. MM.

Interactioni

Protein-protein interaction databases

BioGridi199842. 5 interactions.
STRINGi10090.ENSMUSP00000015771.

Structurei

3D structure databases

ProteinModelPortaliP97489.
SMRiP97489. Positions 192-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri196 – 22025GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27425GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP97489.
KOiK17896.
OMAiGHFESSV.
OrthoDBiEOG7CCBRF.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028372. TF_GATA-5.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF148. PTHR10071:SF148. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQSLALAQS PGQGTYADSG AFLHSSGTGS PVFVAPTRMP SMLPYLPSCE
60 70 80 90 100
PGSQAPALAA HSSWTQAVAA DSSAFGSGSP HPPAAHPPGA TTFPFAHSPP
110 120 130 140 150
GSGSGGSAGV RDGGAFQGAL LAREQYPTPL GRPMGASYPT TYPAYMSSDV
160 170 180 190 200
APSWTSGAFD SSILHGLQAR PGGLPGRRTS FVPDFLEEFP GEGRECVNCG
210 220 230 240 250
ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL SSSRRSGLCC
260 270 280 290 300
SNCHTATTTL WRRNSEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK
310 320 330 340 350
PKNPAKIKGS SGSTANTTAS SPTLLNSESS ATTLKAESSL ASPVCAGPTI
360 370 380 390 400
TSQASSPADE SLASSHLEFK FEPEDFAFTS SSMSPQAGLS GVLRQETWCA

LALA
Length:404
Mass (Da):42,114
Last modified:July 27, 2011 - v2
Checksum:i6C0990A85D594F0C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671A → T in AAB47506 (PubMed:9119112).Curated
Sequence conflicti302 – 3021K → E in AAB47506 (PubMed:9119112).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84725 mRNA. Translation: AAB47506.1.
AK132020 mRNA. Translation: BAE20945.1.
AK142213 mRNA. Translation: BAE24979.1.
AL663027 Genomic DNA. Translation: CAM16220.1.
CH466626 Genomic DNA. Translation: EDL07330.1.
CCDSiCCDS17175.1.
RefSeqiNP_032119.2. NM_008093.2.
XP_006500617.1. XM_006500554.2.
UniGeneiMm.388880.

Genome annotation databases

EnsembliENSMUST00000015771; ENSMUSP00000015771; ENSMUSG00000015627.
GeneIDi14464.
KEGGimmu:14464.
UCSCiuc008oix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84725 mRNA. Translation: AAB47506.1.
AK132020 mRNA. Translation: BAE20945.1.
AK142213 mRNA. Translation: BAE24979.1.
AL663027 Genomic DNA. Translation: CAM16220.1.
CH466626 Genomic DNA. Translation: EDL07330.1.
CCDSiCCDS17175.1.
RefSeqiNP_032119.2. NM_008093.2.
XP_006500617.1. XM_006500554.2.
UniGeneiMm.388880.

3D structure databases

ProteinModelPortaliP97489.
SMRiP97489. Positions 192-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199842. 5 interactions.
STRINGi10090.ENSMUSP00000015771.

PTM databases

PhosphoSiteiP97489.

Proteomic databases

PRIDEiP97489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015771; ENSMUSP00000015771; ENSMUSG00000015627.
GeneIDi14464.
KEGGimmu:14464.
UCSCiuc008oix.2. mouse.

Organism-specific databases

CTDi140628.
MGIiMGI:109497. Gata5.

Phylogenomic databases

eggNOGiCOG5641.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP97489.
KOiK17896.
OMAiGHFESSV.
OrthoDBiEOG7CCBRF.
TreeFamiTF315391.

Enzyme and pathway databases

ReactomeiREACT_280010. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi286108.
PROiP97489.
SOURCEiSearch...

Gene expression databases

BgeeiP97489.
CleanExiMM_GATA5.
ExpressionAtlasiP97489. baseline and differential.
GenevisibleiP97489. MM.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR028372. TF_GATA-5.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF148. PTHR10071:SF148. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development."
    Morrisey E.E., Ip H.S., Tang Z., Lu M.M., Parmacek M.S.
    Dev. Biol. 183:21-36(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGATA5_MOUSE
AccessioniPrimary (citable) accession number: P97489
Secondary accession number(s): Q3UQR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.