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P97489

- GATA5_MOUSE

UniProt

P97489 - GATA5_MOUSE

Protein

Transcription factor GATA-5

Gene

Gata5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri196 – 22025GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27425GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. enhancer sequence-specific DNA binding Source: UniProtKB
    3. protein binding Source: BHF-UCL
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
    5. transcription regulatory region DNA binding Source: MGI
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cellular response to BMP stimulus Source: MGI
    2. intestinal epithelial cell differentiation Source: MGI
    3. positive regulation of transcription, DNA-templated Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. regulation of transcription, DNA-templated Source: MGI
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor GATA-5
    Alternative name(s):
    GATA-binding factor 5
    Gene namesi
    Name:Gata5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:109497. Gata5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Transcription factor GATA-5PRO_0000083419Add
    BLAST

    Proteomic databases

    PRIDEiP97489.

    PTM databases

    PhosphoSiteiP97489.

    Expressioni

    Gene expression databases

    ArrayExpressiP97489.
    BgeeiP97489.
    CleanExiMM_GATA5.
    GenevestigatoriP97489.

    Interactioni

    Protein-protein interaction databases

    BioGridi199842. 4 interactions.
    STRINGi10090.ENSMUSP00000015771.

    Structurei

    3D structure databases

    ProteinModelPortaliP97489.
    SMRiP97489. Positions 192-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri196 – 22025GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri250 – 27425GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    GeneTreeiENSGT00750000117615.
    HOGENOMiHOG000047700.
    HOVERGENiHBG051703.
    InParanoidiQ3UQR0.
    KOiK17896.
    OMAiGHFESSV.
    OrthoDBiEOG7CCBRF.
    TreeFamiTF315391.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR008013. GATA_N.
    IPR028372. TF_GATA-5.
    IPR016375. TF_GATA_4/5/6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF148. PTHR10071:SF148. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97489-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQSLALAQS PGQGTYADSG AFLHSSGTGS PVFVAPTRMP SMLPYLPSCE    50
    PGSQAPALAA HSSWTQAVAA DSSAFGSGSP HPPAAHPPGA TTFPFAHSPP 100
    GSGSGGSAGV RDGGAFQGAL LAREQYPTPL GRPMGASYPT TYPAYMSSDV 150
    APSWTSGAFD SSILHGLQAR PGGLPGRRTS FVPDFLEEFP GEGRECVNCG 200
    ALSTPLWRRD GTGHYLCNAC GLYHKMNGVN RPLVRPQKRL SSSRRSGLCC 250
    SNCHTATTTL WRRNSEGEPV CNACGLYMKL HGVPRPLAMK KESIQTRKRK 300
    PKNPAKIKGS SGSTANTTAS SPTLLNSESS ATTLKAESSL ASPVCAGPTI 350
    TSQASSPADE SLASSHLEFK FEPEDFAFTS SSMSPQAGLS GVLRQETWCA 400
    LALA 404
    Length:404
    Mass (Da):42,114
    Last modified:July 27, 2011 - v2
    Checksum:i6C0990A85D594F0C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671A → T in AAB47506. (PubMed:9119112)Curated
    Sequence conflicti302 – 3021K → E in AAB47506. (PubMed:9119112)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84725 mRNA. Translation: AAB47506.1.
    AK132020 mRNA. Translation: BAE20945.1.
    AK142213 mRNA. Translation: BAE24979.1.
    AL663027 Genomic DNA. Translation: CAM16220.1.
    CH466626 Genomic DNA. Translation: EDL07330.1.
    CCDSiCCDS17175.1.
    RefSeqiNP_032119.2. NM_008093.2.
    XP_006500617.1. XM_006500554.1.
    UniGeneiMm.388880.

    Genome annotation databases

    EnsembliENSMUST00000015771; ENSMUSP00000015771; ENSMUSG00000015627.
    GeneIDi14464.
    KEGGimmu:14464.
    UCSCiuc008oix.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U84725 mRNA. Translation: AAB47506.1 .
    AK132020 mRNA. Translation: BAE20945.1 .
    AK142213 mRNA. Translation: BAE24979.1 .
    AL663027 Genomic DNA. Translation: CAM16220.1 .
    CH466626 Genomic DNA. Translation: EDL07330.1 .
    CCDSi CCDS17175.1.
    RefSeqi NP_032119.2. NM_008093.2.
    XP_006500617.1. XM_006500554.1.
    UniGenei Mm.388880.

    3D structure databases

    ProteinModelPortali P97489.
    SMRi P97489. Positions 192-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199842. 4 interactions.
    STRINGi 10090.ENSMUSP00000015771.

    PTM databases

    PhosphoSitei P97489.

    Proteomic databases

    PRIDEi P97489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015771 ; ENSMUSP00000015771 ; ENSMUSG00000015627 .
    GeneIDi 14464.
    KEGGi mmu:14464.
    UCSCi uc008oix.2. mouse.

    Organism-specific databases

    CTDi 140628.
    MGIi MGI:109497. Gata5.

    Phylogenomic databases

    eggNOGi COG5641.
    GeneTreei ENSGT00750000117615.
    HOGENOMi HOG000047700.
    HOVERGENi HBG051703.
    InParanoidi Q3UQR0.
    KOi K17896.
    OMAi GHFESSV.
    OrthoDBi EOG7CCBRF.
    TreeFami TF315391.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 286108.
    PROi P97489.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97489.
    Bgeei P97489.
    CleanExi MM_GATA5.
    Genevestigatori P97489.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR008013. GATA_N.
    IPR028372. TF_GATA-5.
    IPR016375. TF_GATA_4/5/6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF148. PTHR10071:SF148. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development."
      Morrisey E.E., Ip H.S., Tang Z., Lu M.M., Parmacek M.S.
      Dev. Biol. 183:21-36(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGATA5_MOUSE
    AccessioniPrimary (citable) accession number: P97489
    Secondary accession number(s): Q3UQR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3