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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 3

Gene

Lilrb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).3 Publications

GO - Biological processi

  • B cell homeostasis Source: MGI
  • B cell mediated immunity Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • myeloid dendritic cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 3
Short name:
LIR-3
Short name:
Leukocyte immunoglobulin-like receptor 3
Alternative name(s):
Cell-surface glycoprotein p91
Paired immunoglobulin-like receptor B
Short name:
PIR-B
Gene namesi
Name:Lilrb3
Synonyms:Pirb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:894311. Lilrb3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 642ExtracellularSequence analysisAdd BLAST618
Transmembranei643 – 663HelicalSequence analysisAdd BLAST21
Topological domaini664 – 841CytoplasmicSequence analysisAdd BLAST178

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi794Y → F: Abolishes interaction with PTPN6/SHP-1 and PTPN11/SHP-2; when associated with F-824. 2 Publications1
Mutagenesisi824Y → F: Abolishes interaction with PTPN6/SHP-1 and PTPN11/SHP-2; when associated with F-794. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000041470825 – 841Leukocyte immunoglobulin-like receptor subfamily B member 3Add BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Disulfide bondi246 ↔ 295PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi343 ↔ 395PROSITE-ProRule annotation
Disulfide bondi444 ↔ 495PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi544 ↔ 595PROSITE-ProRule annotation
Modified residuei684PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei794Phosphotyrosine; by LYN1 Publication1
Modified residuei824Phosphotyrosine; by LYN1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-794 and Tyr-824 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97484.
PaxDbiP97484.
PRIDEiP97484.

PTM databases

iPTMnetiP97484.
PhosphoSitePlusiP97484.

Expressioni

Tissue specificityi

Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000058818.
GenevisibleiP97484. MM.

Interactioni

Subunit structurei

Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.3 Publications

Protein-protein interaction databases

DIPiDIP-59889N.
STRINGi10090.ENSMUSP00000077546.

Structurei

3D structure databases

ProteinModelPortaliP97484.
SMRiP97484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 116Ig-like C2-type 1Add BLAST90
Domaini118 – 220Ig-like C2-type 2Add BLAST103
Domaini239 – 297Ig-like C2-type 3Add BLAST59
Domaini308 – 428Ig-like C2-type 4Add BLAST121
Domaini424 – 513Ig-like C2-type 5Add BLAST90
Domaini537 – 618Ig-like C2-type 6Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi711 – 716ITIM motif 1By similarity6
Motifi792 – 797ITIM motif 2By similarity6
Motifi822 – 827ITIM motif 3By similarity6

Domaini

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK.1 Publication

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
GeneTreeiENSGT00760000119033.
HOVERGENiHBG074353.
InParanoidiP97484.
KOiK06512.
OMAiCESWHND.
OrthoDBiEOG091G0D6W.
PhylomeDBiP97484.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTFTALLR LGLTLSLWIP VLTGSLPKPI LRVQPDSVVS RRTKVTFLCE
60 70 80 90 100
ETIGANEYRL YKDGKLYKTV TKNKQKPENK AEFSFSNVDL SNAGQYRCSY
110 120 130 140 150
STQYKSSGYS DLLELVVTGH YWTPSLLAQA SPVVTSGGYV TLQCESWHND
160 170 180 190 200
HKFILTVEGP QKLSWTQDSQ YNYSTRKYHA LFSVGPVTPN QRWICRCYSY
210 220 230 240 250
DRNRPYVWSP PSESVELLVS GNLQKPTIKA EPGSVITSKR AMTIWCQGNL
260 270 280 290 300
DAEVYFLHNE KSQKTQSTQT LQEPGNKGKF FIPSVTLQHA GQYRCYCYGS
310 320 330 340 350
AGWSQPSDTL ELVVTGIYEY YEPRLSVLPS PVVTAGGNMT LHCASDFPYD
360 370 380 390 400
KFILTKEDKK FGNSLDTEHI SSSGQYRALF IIGPTTPTHT GAFRCYGYYK
410 420 430 440 450
NAPQLWSVPS ALQQILISGL SKKPSLLTHQ GHILDPGMTL TLQCFSDINY
460 470 480 490 500
DRFALHKVGG ADIMQHSSQQ TDTGFSVANF TLGYVSSSTG GQYRCYGAHN
510 520 530 540 550
LSSEWSASSE PLDILITGQL PLTPSLSVQP NHTVHSGETV SLLCWSMDSV
560 570 580 590 600
DTFILSKEGS AQQPLRLKSK SHDQQSQAEF SMSAVTSHLS GTYRCYGAQD
610 620 630 640 650
SSFYLLSSAS APVELTVSGP IETSTPPPTM SMPLGGLHMY LKALIGVSVA
660 670 680 690 700
FILFLFIFIF ILLRRRHRGK FRKDVQKEKD LQLSSGAEEP ITRKGELQKR
710 720 730 740 750
PNPAAATQEE SLYASVEDMQ TEDGVELNSW TPPEEDPQGE TYAQVKPSRL
760 770 780 790 800
RKAGHVSPSV MSREQLNTEY EQAEEGQGAN NQAAESGESQ DVTYAQLCSR
810 820 830 840
TLRQGAAASP LSQAGEAPEE PSVYATLAAA RPEAVPKDME Q
Length:841
Mass (Da):93,054
Last modified:May 1, 1997 - v1
Checksum:i33E9B3C51F44FF3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83172 mRNA. Translation: AAB40934.1.
AC130680 Genomic DNA. No translation available.
AC171680 Genomic DNA. No translation available.
CCDSiCCDS39730.1.
RefSeqiNP_035225.2. NM_011095.2.
UniGeneiMm.326531.
Mm.440814.

Genome annotation databases

EnsembliENSMUST00000078451; ENSMUSP00000077546; ENSMUSG00000058818.
GeneIDi18733.
KEGGimmu:18733.
UCSCiuc009ewb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83172 mRNA. Translation: AAB40934.1.
AC130680 Genomic DNA. No translation available.
AC171680 Genomic DNA. No translation available.
CCDSiCCDS39730.1.
RefSeqiNP_035225.2. NM_011095.2.
UniGeneiMm.326531.
Mm.440814.

3D structure databases

ProteinModelPortaliP97484.
SMRiP97484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59889N.
STRINGi10090.ENSMUSP00000077546.

PTM databases

iPTMnetiP97484.
PhosphoSitePlusiP97484.

Proteomic databases

MaxQBiP97484.
PaxDbiP97484.
PRIDEiP97484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078451; ENSMUSP00000077546; ENSMUSG00000058818.
GeneIDi18733.
KEGGimmu:18733.
UCSCiuc009ewb.2. mouse.

Organism-specific databases

CTDi18733.
MGIiMGI:894311. Lilrb3.

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
GeneTreeiENSGT00760000119033.
HOVERGENiHBG074353.
InParanoidiP97484.
KOiK06512.
OMAiCESWHND.
OrthoDBiEOG091G0D6W.
PhylomeDBiP97484.
TreeFamiTF336644.

Miscellaneous databases

PROiP97484.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058818.
GenevisibleiP97484. MM.

Family and domain databases

Gene3Di2.60.40.10. 6 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
PF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB3_MOUSE
AccessioniPrimary (citable) accession number: P97484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on chromosome 7.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.