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P97479

- MYO7A_MOUSE

UniProt

P97479 - MYO7A_MOUSE

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Protein

Unconventional myosin-VIIa

Gene
Myo7a, Myo7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1658ATP Inferred

GO - Molecular functioni

  1. actin-dependent ATPase activity Source: Ensembl
  2. ADP binding Source: Ensembl
  3. ATP binding Source: UniProtKB-KW
  4. calmodulin binding Source: UniProtKB
  5. microfilament motor activity Source: Ensembl
  6. protein binding Source: UniProtKB
  7. protein domain specific binding Source: MGI
  8. spectrin binding Source: MGI

GO - Biological processi

  1. actin filament-based movement Source: Ensembl
  2. auditory receptor cell differentiation Source: MGI
  3. auditory receptor cell stereocilium organization Source: MGI
  4. cell projection organization Source: MGI
  5. equilibrioception Source: Ensembl
  6. inner ear development Source: MGI
  7. inner ear morphogenesis Source: MGI
  8. inner ear receptor cell differentiation Source: MGI
  9. intracellular protein transport Source: MGI
  10. lysosome organization Source: UniProtKB
  11. mechanoreceptor differentiation Source: MGI
  12. phagocytosis Source: MGI
  13. phagolysosome assembly Source: MGI
  14. pigment granule localization Source: MGI
  15. pigment granule transport Source: MGI
  16. post-embryonic organ morphogenesis Source: MGI
  17. sensory perception Source: MGI
  18. sensory perception of light stimulus Source: MGI
  19. sensory perception of sound Source: UniProtKB
  20. visual perception Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Hearing, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VIIa
Gene namesi
Name:Myo7a
Synonyms:Myo7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:104510. Myo7a.

Subcellular locationi

Cytoplasm. Cytoplasmcell cortex. Cytoplasmcytoskeleton
Note: In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells By similarity. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin.1 Publication

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cell cortex Source: UniProtKB-SubCell
  3. cytoplasm Source: MGI
  4. cytosol Source: UniProtKB
  5. lysosomal membrane Source: UniProtKB
  6. melanosome Source: MGI
  7. microvillus Source: MGI
  8. myosin VII complex Source: Ensembl
  9. photoreceptor connecting cilium Source: MGI
  10. photoreceptor inner segment Source: UniProtKB
  11. photoreceptor outer segment Source: UniProtKB
  12. stereocilium Source: MGI
  13. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1189 – 11891A → E: Strongly reduced affinity for USH1G. 1 Publication
Mutagenesisi1473 – 14731F → Q: Reduced affinity for USH1G. 1 Publication

Keywords - Diseasei

Deafness, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22152215Unconventional myosin-VIIaPRO_0000123467Add
BLAST

Proteomic databases

MaxQBiP97479.
PaxDbiP97479.
PRIDEiP97479.

PTM databases

PhosphoSiteiP97479.

Expressioni

Tissue specificityi

Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver.3 Publications

Developmental stagei

In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus.

Gene expression databases

ArrayExpressiP97479.
BgeeiP97479.
CleanExiMM_MYO7A.
GenevestigatoriP97479.

Interactioni

Subunit structurei

Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. May interact with CALM By similarity. Binds MYRIP and WHRN. Interacts with PLEKHB1 (via PH domain). Identified in a complex with USH1C and USH1G. Interacts with RPE65. Interacts with PCDH15. Interacts with TWF2.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ush1gQ80T114EBI-1149557,EBI-7418889

Protein-protein interaction databases

IntActiP97479. 2 interactions.
MINTiMINT-1896820.

Structurei

Secondary structure

1
2215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1001 – 10088
Helixi1032 – 104817
Helixi1070 – 10756
Turni1076 – 10794
Helixi1084 – 10885
Helixi1150 – 116314
Helixi1165 – 11673
Helixi1168 – 117811
Helixi1185 – 120117
Turni1206 – 12083
Helixi1209 – 12179
Turni1221 – 12233
Helixi1224 – 123714
Helixi1246 – 12549
Beta strandi1258 – 12647
Beta strandi1269 – 12746
Helixi1280 – 129011
Beta strandi1299 – 13057
Beta strandi1308 – 13136
Helixi1319 – 133113
Turni1332 – 13343
Helixi1337 – 13393
Beta strandi1343 – 13486
Helixi1357 – 13593
Helixi1361 – 137616
Helixi1385 – 140016
Helixi1406 – 141611
Helixi1419 – 14213
Beta strandi1424 – 14263
Helixi1428 – 144417
Helixi1451 – 146515
Turni1467 – 14693
Beta strandi1472 – 148211
Beta strandi1487 – 14948
Beta strandi1497 – 15015
Beta strandi1507 – 15126
Helixi1513 – 15153
Beta strandi1516 – 15227
Beta strandi1564 – 15663
Beta strandi1569 – 15746
Beta strandi1579 – 15835
Helixi1587 – 160418
Beta strandi1607 – 16126
Beta strandi1632 – 16343
Helixi1640 – 16456
Beta strandi1646 – 16538
Turni1654 – 16563
Beta strandi1659 – 16635
Helixi1664 – 16663
Beta strandi1667 – 16693
Helixi1678 – 16847

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PVLX-ray2.80A965-1687[»]
ProteinModelPortaliP97479.
SMRiP97479. Positions 993-1686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 741677Myosin motorAdd
BLAST
Domaini745 – 76521IQ 1Add
BLAST
Domaini768 – 78821IQ 2Add
BLAST
Domaini791 – 81121IQ 3Add
BLAST
Domaini814 – 83421IQ 4Add
BLAST
Domaini837 – 85721IQ 5Add
BLAST
Domaini1017 – 1253237MyTH4 1Add
BLAST
Domaini1258 – 1602345FERM 1Add
BLAST
Domaini1603 – 167270SH3Add
BLAST
Domaini1747 – 1896150MyTH4 2Add
BLAST
Domaini1902 – 2205304FERM 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni632 – 6398Actin-binding Inferred

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili858 – 93578 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 2 FERM domains.
Contains 5 IQ domains.
Contains 2 MyTH4 domains.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00750000117545.
HOGENOMiHOG000007836.
HOVERGENiHBG052557.
KOiK10359.
OMAiTPWHNPS.
OrthoDBiEOG7QG433.
TreeFamiTF335306.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97479-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP     50
QNATHIKPMH PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS 100
ILVAVNPYQL LSIYSPEHIR QYTNKKIGEM PPHIFAIADN CYFNMKRNNR 150
DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL EATPILEAFG 200
NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQAPDER 250
NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN 300
IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP 350
SLATAASLLE VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK 400
GIYGRLFVWI VEKINAAIYK PPPLEVKNSR RSIGLLDIFG FENFTVNSFE 450
QLCINFANEH LQQFFVRHVF KLEQEEYDLE SIDWLHIEFT DNQEALDMIA 500
NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP PKNSHETQFG 550
INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG 600
AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH 650
LCVRQLRYSG MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD 700
LRGTCQRMAE AVLGTHDDWQ IGKTKIFLKD HHDMLLEVER DKAITDRVIL 750
LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG HHCRKNYELI RLGFLRLQAL 800
HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV ITVQAYARGM 850
IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER 900
LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL 950
GTSGSLPGQE GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK 1000
FAKFAATYFQ GTTTHSYTRR PLKQPLLYHD DEGDQLAALA VWITILRFMG 1050
DLPEPKYHTA MSDGSEKIPV MTKIYETLGK KTYKRELQAL QGEGETQLPE 1100
GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN SMLEDRPTSN 1150
LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG 1200
CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ 1250
ATKSKKPIML PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS 1300
LYIALFDKVS SLGSGSDHVM DAISQCEQYA KEQGAQERNA PWRLFFRKEV 1350
FTPWHNPSED NVATNLIYQQ VVRGVKFGEY RCEKEDDLAE LASQQYFVDY 1400
GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK KGIYAQRRTD 1450
SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF 1500
VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP 1550
AGPCSPCWSC RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG 1600
LRKRSKYVVA LQDNPNPAGE ESGFLSFAKG DLIILDHDTG EQVMNSGWAN 1650
GINERTKQRG DFPTDCVYVM PTVTLPPREI VALVTMTPDQ RQDVVRLLQL 1700
RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG KDRLWSHTRE 1750
PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF 1800
EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL 1850
LPHVQRFLQS RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT 1900
QIFHKVYFPD DTDEAFEVES STKAKDFCQN IASRLLLKSS EGFSLFVKIA 1950
DKVISVPEND FFFDFVRHLT DWIKKARPIK DGIVPSLTYQ VFFMKKLWTT 2000
TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL IYRVKFEEDK 2050
SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF 2100
LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT 2150
THPFTKISNW SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ 2200
MLTAMSKQRN SRSGR 2215
Length:2,215
Mass (Da):254,939
Last modified:July 27, 2011 - v2
Checksum:iD942FC7674B75EC7
GO
Isoform 2 (identifier: P97479-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1523-1560: Missing.

Show »
Length:2,177
Mass (Da):251,097
Checksum:iB11BA144AE43B63D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411R → P in sh-1.
Natural varianti502 – 5021R → P in sh-1.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1523 – 156038Missing in isoform 2. VSP_042238Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851L → R in AAB40708. 1 Publication
Sequence conflicti238 – 2381E → S in AAB40708. 1 Publication
Sequence conflicti589 – 5891I → V in AAB40708. 1 Publication
Sequence conflicti682 – 6821V → G in AAB40708. 1 Publication
Sequence conflicti1156 – 11561F → L in AAB40708. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81453 mRNA. Translation: AAB40708.1.
AC115022 Genomic DNA. No translation available.
AC119880 Genomic DNA. No translation available.
AC157792 Genomic DNA. No translation available.
AY821853 mRNA. Translation: AAV87212.1.
CCDSiCCDS40026.1. [P97479-2]
CCDS57565.1. [P97479-1]
PIRiT30870.
RefSeqiNP_001243010.1. NM_001256081.1. [P97479-1]
NP_001243012.1. NM_001256083.1.
NP_032689.2. NM_008663.2. [P97479-2]
UniGeneiMm.1403.

Genome annotation databases

EnsembliENSMUST00000084979; ENSMUSP00000082046; ENSMUSG00000030761.
ENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761. [P97479-2]
ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761. [P97479-1]
GeneIDi17921.
KEGGimmu:17921.
UCSCiuc009ijy.2. mouse. [P97479-2]
uc009ijz.2. mouse. [P97479-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81453 mRNA. Translation: AAB40708.1 .
AC115022 Genomic DNA. No translation available.
AC119880 Genomic DNA. No translation available.
AC157792 Genomic DNA. No translation available.
AY821853 mRNA. Translation: AAV87212.1 .
CCDSi CCDS40026.1. [P97479-2 ]
CCDS57565.1. [P97479-1 ]
PIRi T30870.
RefSeqi NP_001243010.1. NM_001256081.1. [P97479-1 ]
NP_001243012.1. NM_001256083.1.
NP_032689.2. NM_008663.2. [P97479-2 ]
UniGenei Mm.1403.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PVL X-ray 2.80 A 965-1687 [» ]
ProteinModelPortali P97479.
SMRi P97479. Positions 993-1686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97479. 2 interactions.
MINTi MINT-1896820.

PTM databases

PhosphoSitei P97479.

Proteomic databases

MaxQBi P97479.
PaxDbi P97479.
PRIDEi P97479.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084979 ; ENSMUSP00000082046 ; ENSMUSG00000030761 .
ENSMUST00000107127 ; ENSMUSP00000102744 ; ENSMUSG00000030761 . [P97479-2 ]
ENSMUST00000107128 ; ENSMUSP00000102745 ; ENSMUSG00000030761 . [P97479-1 ]
GeneIDi 17921.
KEGGi mmu:17921.
UCSCi uc009ijy.2. mouse. [P97479-2 ]
uc009ijz.2. mouse. [P97479-1 ]

Organism-specific databases

CTDi 4647.
MGIi MGI:104510. Myo7a.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00750000117545.
HOGENOMi HOG000007836.
HOVERGENi HBG052557.
KOi K10359.
OMAi TPWHNPS.
OrthoDBi EOG7QG433.
TreeFami TF335306.

Enzyme and pathway databases

Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

ChiTaRSi MYO7A. mouse.
NextBioi 292781.
PROi P97479.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97479.
Bgeei P97479.
CleanExi MM_MYO7A.
Genevestigatori P97479.

Family and domain databases

Gene3Di 1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00373. FERM_M. 1 hit.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEi PS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A type VII myosin encoded by the mouse deafness gene shaker-1."
    Gibson F., Walsh J., Mburu P., Varela A., Brown K.A., Antonio M., Beisel K.W., Steel K.P., Brown S.D.M.
    Nature 374:62-64(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
  2. "Mutation analysis of the mouse myosin VIIA deafness gene."
    Mburu P., Liu X.-Z., Walsh J., Saw D. Jr., Cope M.J., Gibson F., Kendrick-Jones J., Steel K.P., Brown S.D.M.
    Genes Funct. 1:191-203(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia."
    Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B.
    Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-2215 (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Inner ear.
  5. "Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin."
    Fukuda M., Kuroda T.S.
    J. Biol. Chem. 277:43096-43103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYRIP.
  6. "Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly."
    Delprat B., Michel V., Goodyear R., Yamasaki Y., Michalski N., El-Amraoui A., Perfettini I., Legrain P., Richardson G., Hardelin J.-P., Petit C.
    Hum. Mol. Genet. 14:401-410(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WHRN.
  7. "PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa."
    Etournay R., El-Amraoui A., Bahloul A., Blanchard S., Roux I., Pezeron G., Michalski N., Daviet L., Hardelin J.-P., Legrain P., Petit C.
    J. Cell Sci. 118:2891-2899(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLEKHB1.
  8. "Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells."
    Senften M., Schwander M., Kazmierczak P., Lillo C., Shin J.B., Hasson T., Geleoc G.S., Gillespie P.G., Williams D., Holt J.R., Muller U.
    J. Neurosci. 26:2060-2071(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCDH15.
  9. "MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear."
    Rzadzinska A.K., Nevalainen E.M., Prosser H.M., Lappalainen P., Steel K.P.
    PLoS ONE 4:E7097-E7097(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWF2.
    Strain: C3Heb/FeJ.
    Tissue: Inner ear.
  10. "The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65."
    Lopes V.S., Gibbs D., Libby R.T., Aleman T.S., Welch D.L., Lillo C., Jacobson S.G., Radu R.A., Steel K.P., Williams D.S.
    Hum. Mol. Genet. 20:2560-2570(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RPE65.
  11. "Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction."
    Grati M., Kachar B.
    Proc. Natl. Acad. Sci. U.S.A. 108:11476-11481(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  12. "Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo."
    Wu L., Pan L., Wei Z., Zhang M.
    Science 331:757-760(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 965-1687 IN COMPLEX WITH USH1G, INTERACTION WITH USH1G, MUTAGENESIS OF ALA-1189 AND PHE-1473.

Entry informationi

Entry nameiMYO7A_MOUSE
AccessioniPrimary (citable) accession number: P97479
Secondary accession number(s): E9QLP7, Q5MJ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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