P97479 (MYO7A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Unconventional myosin-VIIa

Gene names

Name:	Myo7a
Synonyms:	Myo7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2215 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Ref.11 Ref.12
Subunit structure	Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. May interact with CALM By similarity. Binds MYRIP and WHRN. Interacts with PLEKHB1 (via PH domain). Identified in a complex with USH1C and USH1G. Interacts with RPE65. Interacts with PCDH15. Interacts with TWF2. Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 Ref.13
Subcellular location	Cytoplasm. Cytoplasm › cell cortex. Cytoplasm › cytoskeleton. Note: In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells By similarity. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin. Ref.12
Tissue specificity	Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver. Ref.4 Ref.11 Ref.12
Developmental stage	In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus.
Involvement in disease	Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti. Ref.1
Sequence similarities	Contains 2 FERM domains. Contains 5 IQ domains. Contains 1 myosin head-like domain. Contains 2 MyTH4 domains. Contains 1 SH3 domain.
Caution	Represents a unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).

Ontologies

Keywords
Biological process	Hearing Transport
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Disease	Deafness Disease mutation
Domain	Coiled coil Repeat SH3 domain
Ligand	ATP-binding Actin-binding Calmodulin-binding Nucleotide-binding
Molecular function	Motor protein Myosin
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament-based movement Inferred from electronic annotation. Source: Compara auditory receptor cell stereocilium organization Inferred from mutant phenotype PubMed 11753415PubMed 12121736PubMed 17050716. Source: MGI equilibrioception Inferred from electronic annotation. Source: Compara intracellular protein transport Inferred from mutant phenotype PubMed 10414956. Source: MGI lysosome organization Inferred from sequence or structural similarity. Source: UniProtKB phagolysosome assembly Inferred from mutant phenotype PubMed 12743369. Source: MGI pigment granule transport Inferred from mutant phenotype PubMed 15572405PubMed 9620764. Source: MGI post-embryonic organ morphogenesis Inferred from mutant phenotype PubMed 13336002PubMed 14198707PubMed 6627025. Source: MGI sensory perception of sound Inferred from sequence or structural similarity. Source: UniProtKB visual perception Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 9620764. Source: MGI cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from sequence or structural similarity. Source: UniProtKB lysosomal membrane Inferred from sequence or structural similarity. Source: UniProtKB melanosome Inferred from direct assay PubMed 14978221PubMed 15572405. Source: MGI myosin complex Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor connecting cilium Inferred from direct assay PubMed 10414956. Source: MGI photoreceptor inner segment Inferred from sequence or structural similarity. Source: UniProtKB photoreceptor outer segment Inferred from sequence or structural similarity. Source: UniProtKB stereocilium Inferred from direct assay PubMed 12485990Ref.8PubMed 20016102. Source: MGI synapse Inferred from direct assay PubMed 11964381. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from sequence or structural similarity. Source: UniProtKB microfilament motor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P97479-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P97479-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1523-1560: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2215

2215

Unconventional myosin-VIIa

PRO_0000123467

Regions

Domain

1 – 729

729

Myosin head-like

Domain

745 – 765

21

IQ 1

Domain

768 – 788

21

IQ 2

Domain

791 – 811

21

IQ 3

Domain

814 – 834

21

IQ 4

Domain

837 – 857

21

IQ 5

Domain

1017 – 1253

237

MyTH4 1

Domain

1258 – 1602

345

FERM 1

Domain

1603 – 1672

70

SH3

Domain

1747 – 1896

150

MyTH4 2

Domain

1902 – 2205

304

FERM 2

Nucleotide binding

158 – 165

8

ATP Probable

Region

632 – 639

8

Actin-binding Probable

Coiled coil

858 – 935

78

Potential

Amino acid modifications

Modified residue

965

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1523 – 1560

38

Missing in isoform 2.

VSP_042238

Natural variant

241

1

R → P in sh-1.

Natural variant

502

1

R → P in sh-1.

Experimental info

Mutagenesis

1189

1

A → E: Strongly reduced affinity for USH1G. Ref.13

Mutagenesis

1473

1

F → Q: Reduced affinity for USH1G. Ref.13

Sequence conflict

85

1

L → R in AAB40708. Ref.1

Sequence conflict

238

1

E → S in AAB40708. Ref.1

Sequence conflict

589

1

I → V in AAB40708. Ref.1

Sequence conflict

682

1

V → G in AAB40708. Ref.1

Sequence conflict

1156

1

F → L in AAB40708. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2215

Helix Strand Turn

Details...

Helix

1001 – 1008

8

Helix

1032 – 1048

17

Helix

1070 – 1075

6

Turn

1076 – 1079

4

Helix

1084 – 1088

5

Helix

1150 – 1163

14

Helix

1165 – 1167

3

Helix

1168 – 1178

11

Helix

1185 – 1201

17

Turn

1206 – 1208

3

Helix

1209 – 1217

9

Turn

1221 – 1223

3

Helix

1224 – 1237

14

Helix

1246 – 1254

9

Beta strand

1258 – 1264

7

Beta strand

1269 – 1274

6

Helix

1280 – 1290

11

Beta strand

1299 – 1305

7

Beta strand

1308 – 1313

6

Helix

1319 – 1331

13

Turn

1332 – 1334

3

Helix

1337 – 1339

3

Beta strand

1343 – 1348

6

Helix

1357 – 1359

3

Helix

1361 – 1376

16

Helix

1385 – 1400

16

Helix

1406 – 1416

11

Helix

1419 – 1421

3

Beta strand

1424 – 1426

3

Helix

1428 – 1444

17

Helix

1451 – 1465

15

Turn

1467 – 1469

3

Beta strand

1472 – 1482

11

Beta strand

1487 – 1494

8

Beta strand

1497 – 1501

5

Beta strand

1507 – 1512

6

Helix

1513 – 1515

3

Beta strand

1516 – 1522

7

Beta strand

1564 – 1566

3

Beta strand

1569 – 1574

6

Beta strand

1579 – 1583

5

Helix

1587 – 1604

18

Beta strand

1607 – 1612

6

Beta strand

1632 – 1634

3

Helix

1640 – 1645

6

Beta strand

1646 – 1653

8

Turn

1654 – 1656

3

Beta strand

1659 – 1663

5

Helix

1664 – 1666

3

Beta strand

1667 – 1669

3

Helix

1678 – 1684

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: D942FC7674B75EC7	FASTA	2,215	254,939
	10 20 30 40 50 60 MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP QNATHIKPMH 70 80 90 100 110 120 PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS ILVAVNPYQL LSIYSPEHIR 130 140 150 160 170 180 QYTNKKIGEM PPHIFAIADN CYFNMKRNNR DQCCIISGES GAGKTESTKL ILQFLAAISG 190 200 210 220 230 240 QHSWIEQQVL EATPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS 250 260 270 280 290 300 RVCRQAPDER NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN 310 320 330 340 350 360 IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP SLATAASLLE 370 380 390 400 410 420 VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK GIYGRLFVWI VEKINAAIYK 430 440 450 460 470 480 PPPLEVKNSR RSIGLLDIFG FENFTVNSFE QLCINFANEH LQQFFVRHVF KLEQEEYDLE 490 500 510 520 530 540 SIDWLHIEFT DNQEALDMIA NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP 550 560 570 580 590 600 PKNSHETQFG INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG 610 620 630 640 650 660 AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH LCVRQLRYSG 670 680 690 700 710 720 MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD LRGTCQRMAE AVLGTHDDWQ 730 740 750 760 770 780 IGKTKIFLKD HHDMLLEVER DKAITDRVIL LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG 790 800 810 820 830 840 HHCRKNYELI RLGFLRLQAL HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV 850 860 870 880 890 900 ITVQAYARGM IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER 910 920 930 940 950 960 LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL GTSGSLPGQE 970 980 990 1000 1010 1020 GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK FAKFAATYFQ GTTTHSYTRR 1030 1040 1050 1060 1070 1080 PLKQPLLYHD DEGDQLAALA VWITILRFMG DLPEPKYHTA MSDGSEKIPV MTKIYETLGK 1090 1100 1110 1120 1130 1140 KTYKRELQAL QGEGETQLPE GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN 1150 1160 1170 1180 1190 1200 SMLEDRPTSN LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG 1210 1220 1230 1240 1250 1260 CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ ATKSKKPIML 1270 1280 1290 1300 1310 1320 PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS LYIALFDKVS SLGSGSDHVM 1330 1340 1350 1360 1370 1380 DAISQCEQYA KEQGAQERNA PWRLFFRKEV FTPWHNPSED NVATNLIYQQ VVRGVKFGEY 1390 1400 1410 1420 1430 1440 RCEKEDDLAE LASQQYFVDY GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK 1450 1460 1470 1480 1490 1500 KGIYAQRRTD SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF 1510 1520 1530 1540 1550 1560 VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP AGPCSPCWSC 1570 1580 1590 1600 1610 1620 RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG LRKRSKYVVA LQDNPNPAGE 1630 1640 1650 1660 1670 1680 ESGFLSFAKG DLIILDHDTG EQVMNSGWAN GINERTKQRG DFPTDCVYVM PTVTLPPREI 1690 1700 1710 1720 1730 1740 VALVTMTPDQ RQDVVRLLQL RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG 1750 1760 1770 1780 1790 1800 KDRLWSHTRE PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF 1810 1820 1830 1840 1850 1860 EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL LPHVQRFLQS 1870 1880 1890 1900 1910 1920 RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT QIFHKVYFPD DTDEAFEVES 1930 1940 1950 1960 1970 1980 STKAKDFCQN IASRLLLKSS EGFSLFVKIA DKVISVPEND FFFDFVRHLT DWIKKARPIK 1990 2000 2010 2020 2030 2040 DGIVPSLTYQ VFFMKKLWTT TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL 2050 2060 2070 2080 2090 2100 IYRVKFEEDK SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF 2110 2120 2130 2140 2150 2160 LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT THPFTKISNW 2170 2180 2190 2200 2210 SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ MLTAMSKQRN SRSGR
	Isoform 2 [UniParc]. Checksum: B11BA144AE43B63D	FASTA	2,177	251,097
	10 20 30 40 50 60 MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP QNATHIKPMH 70 80 90 100 110 120 PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS ILVAVNPYQL LSIYSPEHIR 130 140 150 160 170 180 QYTNKKIGEM PPHIFAIADN CYFNMKRNNR DQCCIISGES GAGKTESTKL ILQFLAAISG 190 200 210 220 230 240 QHSWIEQQVL EATPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS 250 260 270 280 290 300 RVCRQAPDER NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN 310 320 330 340 350 360 IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP SLATAASLLE 370 380 390 400 410 420 VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK GIYGRLFVWI VEKINAAIYK 430 440 450 460 470 480 PPPLEVKNSR RSIGLLDIFG FENFTVNSFE QLCINFANEH LQQFFVRHVF KLEQEEYDLE 490 500 510 520 530 540 SIDWLHIEFT DNQEALDMIA NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP 550 560 570 580 590 600 PKNSHETQFG INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG 610 620 630 640 650 660 AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH LCVRQLRYSG 670 680 690 700 710 720 MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD LRGTCQRMAE AVLGTHDDWQ 730 740 750 760 770 780 IGKTKIFLKD HHDMLLEVER DKAITDRVIL LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG 790 800 810 820 830 840 HHCRKNYELI RLGFLRLQAL HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV 850 860 870 880 890 900 ITVQAYARGM IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER 910 920 930 940 950 960 LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL GTSGSLPGQE 970 980 990 1000 1010 1020 GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK FAKFAATYFQ GTTTHSYTRR 1030 1040 1050 1060 1070 1080 PLKQPLLYHD DEGDQLAALA VWITILRFMG DLPEPKYHTA MSDGSEKIPV MTKIYETLGK 1090 1100 1110 1120 1130 1140 KTYKRELQAL QGEGETQLPE GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN 1150 1160 1170 1180 1190 1200 SMLEDRPTSN LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG 1210 1220 1230 1240 1250 1260 CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ ATKSKKPIML 1270 1280 1290 1300 1310 1320 PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS LYIALFDKVS SLGSGSDHVM 1330 1340 1350 1360 1370 1380 DAISQCEQYA KEQGAQERNA PWRLFFRKEV FTPWHNPSED NVATNLIYQQ VVRGVKFGEY 1390 1400 1410 1420 1430 1440 RCEKEDDLAE LASQQYFVDY GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK 1450 1460 1470 1480 1490 1500 KGIYAQRRTD SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF 1510 1520 1530 1540 1550 1560 VDEQEQVLLE LSFPEIMAVS SSRGTKMMAP SFTLATIKGD EYTFTSSNAE DIRDLVVTFL 1570 1580 1590 1600 1610 1620 EGLRKRSKYV VALQDNPNPA GEESGFLSFA KGDLIILDHD TGEQVMNSGW ANGINERTKQ 1630 1640 1650 1660 1670 1680 RGDFPTDCVY VMPTVTLPPR EIVALVTMTP DQRQDVVRLL QLRTAEPEVR AKPYTLEEFS 1690 1700 1710 1720 1730 1740 YDYFRPPPKH TLSRVMVSKA RGKDRLWSHT REPLKQALLK KILGSEELSQ EACMAFVAVL 1750 1760 1770 1780 1790 1800 KYMGDYPSKR MRSVNELTDQ IFEWALKAEP LKDEAYVQIL KQLTDNHIRY SEERGWELLW 1810 1820 1830 1840 1850 1860 LCTGLFPPSN ILLPHVQRFL QSRKHCPLAI DCLQRLQKAL RNGSRKYPPH LVEVEAIQHK 1870 1880 1890 1900 1910 1920 TTQIFHKVYF PDDTDEAFEV ESSTKAKDFC QNIASRLLLK SSEGFSLFVK IADKVISVPE 1930 1940 1950 1960 1970 1980 NDFFFDFVRH LTDWIKKARP IKDGIVPSLT YQVFFMKKLW TTTVPGKDPM ADSIFHYYQE 1990 2000 2010 2020 2030 2040 LPKYLRGYHK CTREEVLQLG ALIYRVKFEE DKSYFPSIPK LLRELVPQDL IRQVSPDDWK 2050 2060 2070 2080 2090 2100 RSIVAYFNKH AGKSKEEAKL AFLKLIFKWP TFGSAFFEVK QTTEPNFPEI LLIAINKYGV 2110 2120 2130 2140 2150 2160 SLIDPRTKDI LTTHPFTKIS NWSSGNTYFH ITIGNLVRGS KLLCETSLGY KMDDLLTSYI 2170 SQMLTAMSKQ RNSRSGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A type VII myosin encoded by the mouse deafness gene shaker-1." Gibson F., Walsh J., Mburu P., Varela A., Brown K.A., Antonio M., Beisel K.W., Steel K.P., Brown S.D.M. Nature 374:62-64(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
[2]	"Mutation analysis of the mouse myosin VIIA deafness gene." Mburu P., Liu X.-Z., Walsh J., Saw D. Jr., Cope M.J., Gibson F., Kendrick-Jones J., Steel K.P., Brown S.D.M. Genes Funct. 1:191-203(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia." Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B. Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-2215 (ISOFORM 2), TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: Inner ear.
[5]	"Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin." Fukuda M., Kuroda T.S. J. Biol. Chem. 277:43096-43103(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MYRIP.
[6]	"Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly." Delprat B., Michel V., Goodyear R., Yamasaki Y., Michalski N., El-Amraoui A., Perfettini I., Legrain P., Richardson G., Hardelin J.-P., Petit C. Hum. Mol. Genet. 14:401-410(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WHRN.
[7]	"PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa." Etournay R., El-Amraoui A., Bahloul A., Blanchard S., Roux I., Pezeron G., Michalski N., Daviet L., Hardelin J.-P., Legrain P., Petit C. J. Cell Sci. 118:2891-2899(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLEKHB1.
[8]	"Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells." Senften M., Schwander M., Kazmierczak P., Lillo C., Shin J.B., Hasson T., Geleoc G.S., Gillespie P.G., Williams D., Holt J.R., Muller U. J. Neurosci. 26:2060-2071(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PCDH15.
[9]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-965, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
[10]	"MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear." Rzadzinska A.K., Nevalainen E.M., Prosser H.M., Lappalainen P., Steel K.P. PLoS ONE 4:E7097-E7097(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TWF2. Strain: C3Heb/FeJ. Tissue: Inner ear.
[11]	"The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65." Lopes V.S., Gibbs D., Libby R.T., Aleman T.S., Welch D.L., Lillo C., Jacobson S.G., Radu R.A., Steel K.P., Williams D.S. Hum. Mol. Genet. 20:2560-2570(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RPE65.
[12]	"Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction." Grati M., Kachar B. Proc. Natl. Acad. Sci. U.S.A. 108:11476-11481(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[13]	"Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo." Wu L., Pan L., Wei Z., Zhang M. Science 331:757-760(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 965-1687 IN COMPLEX WITH USH1G, INTERACTION WITH USH1G, MUTAGENESIS OF ALA-1189 AND PHE-1473.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U81453 mRNA. Translation: AAB40708.1.
AC115022 Genomic DNA. No translation available.
AC119880 Genomic DNA. No translation available.
AC157792 Genomic DNA. No translation available.
AY821853 mRNA. Translation: AAV87212.1.

IPI

IPI00125593.
IPI00775946.

PIR

T30870.

RefSeq

NP_001243010.1. NM_001256081.1.
NP_001243012.1. NM_001256083.1.
NP_032689.2. NM_008663.2.

UniGene

Mm.1403.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PVL	X-ray	2.80	A	965-1687	[»]

ProteinModelPortal

P97479.

SMR

P97479. Positions 993-1686.

ModBase

Search...

Protein-protein interaction databases

IntAct

P97479. 1 interaction.

MINT

MINT-1896820.

PTM databases

PhosphoSite

P97479.

Proteomic databases

PaxDb

P97479.

PRIDE

P97479.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000084979; ENSMUSP00000082046; ENSMUSG00000030761.
ENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761.
ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761.

GeneID

17921.

KEGG

mmu:17921.

Organism-specific databases

CTD

4647.

MGI

MGI:104510. Myo7a.

Phylogenomic databases

eggNOG

COG5022.

GeneTree

ENSGT00700000104100.

HOGENOM

HOG000007836.

HOVERGEN

HBG052557.

KO

K10359.

OMA

GACQPFF.

OrthoDB

EOG4S1T67.

Gene expression databases

ArrayExpress

P97479.

Bgee

P97479.

CleanEx

MM_MYO7A.

Genevestigator

P97479.

GermOnline

ENSMUSG00000030761. Mus musculus.

Family and domain databases

Gene3D

1.20.80.10. 2 hits.
2.30.29.30. 1 hit.

InterPro

IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 2 hits.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view]

PRINTS

PR00193. MYOSINHEAVY.

SMART

SM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF47031. FERM_3-hlx. 2 hits.
SSF50044. SH3. 1 hit.

PROSITE

PS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MYO7A. mouse.

NextBio

292781.

SOURCE

Search...

Entry information

Entry name

MYO7A_MOUSE

Accession

Primary (citable) accession number: P97479
Secondary accession number(s): E9QLP7, Q5MJ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program