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P97479

- MYO7A_MOUSE

UniProt

P97479 - MYO7A_MOUSE

Protein

Unconventional myosin-VIIa

Gene

Myo7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi158 – 1658ATPCurated

    GO - Molecular functioni

    1. actin-dependent ATPase activity Source: Ensembl
    2. ADP binding Source: Ensembl
    3. ATP binding Source: UniProtKB-KW
    4. calmodulin binding Source: UniProtKB
    5. microfilament motor activity Source: Ensembl
    6. protein binding Source: UniProtKB
    7. protein domain specific binding Source: MGI
    8. spectrin binding Source: MGI

    GO - Biological processi

    1. actin filament-based movement Source: Ensembl
    2. auditory receptor cell differentiation Source: MGI
    3. auditory receptor cell stereocilium organization Source: MGI
    4. cell projection organization Source: MGI
    5. equilibrioception Source: Ensembl
    6. inner ear development Source: MGI
    7. inner ear morphogenesis Source: MGI
    8. inner ear receptor cell differentiation Source: MGI
    9. intracellular protein transport Source: MGI
    10. lysosome organization Source: UniProtKB
    11. mechanoreceptor differentiation Source: MGI
    12. phagocytosis Source: MGI
    13. phagolysosome assembly Source: MGI
    14. pigment granule localization Source: MGI
    15. pigment granule transport Source: MGI
    16. post-embryonic organ morphogenesis Source: MGI
    17. sensory perception Source: MGI
    18. sensory perception of light stimulus Source: MGI
    19. sensory perception of sound Source: UniProtKB
    20. visual perception Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein, Myosin

    Keywords - Biological processi

    Hearing, Transport

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-VIIa
    Gene namesi
    Name:Myo7a
    Synonyms:Myo7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:104510. Myo7a.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcell cortex 1 Publication. Cytoplasmcytoskeleton 1 Publication
    Note: In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells By similarity. Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. cell cortex Source: UniProtKB-SubCell
    3. cytoplasm Source: MGI
    4. cytosol Source: UniProtKB
    5. lysosomal membrane Source: UniProtKB
    6. melanosome Source: MGI
    7. microvillus Source: MGI
    8. myosin VII complex Source: Ensembl
    9. photoreceptor connecting cilium Source: MGI
    10. photoreceptor inner segment Source: UniProtKB
    11. photoreceptor outer segment Source: UniProtKB
    12. stereocilium Source: MGI
    13. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1189 – 11891A → E: Strongly reduced affinity for USH1G. 1 Publication
    Mutagenesisi1473 – 14731F → Q: Reduced affinity for USH1G. 1 Publication

    Keywords - Diseasei

    Deafness, Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22152215Unconventional myosin-VIIaPRO_0000123467Add
    BLAST

    Proteomic databases

    MaxQBiP97479.
    PaxDbiP97479.
    PRIDEiP97479.

    PTM databases

    PhosphoSiteiP97479.

    Expressioni

    Tissue specificityi

    Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver.3 Publications

    Developmental stagei

    In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus.

    Gene expression databases

    ArrayExpressiP97479.
    BgeeiP97479.
    CleanExiMM_MYO7A.
    GenevestigatoriP97479.

    Interactioni

    Subunit structurei

    Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. May interact with CALM By similarity. Binds MYRIP and WHRN. Interacts with PLEKHB1 (via PH domain). Identified in a complex with USH1C and USH1G. Interacts with RPE65. Interacts with PCDH15. Interacts with TWF2.By similarity7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITGB5P180848EBI-1149557,EBI-1223434From a different organism.
    Itgb5O703093EBI-1149557,EBI-8401821
    Ush1gQ80T114EBI-1149557,EBI-7418889

    Protein-protein interaction databases

    IntActiP97479. 4 interactions.
    MINTiMINT-1896820.

    Structurei

    Secondary structure

    1
    2215
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1001 – 10088
    Helixi1032 – 104817
    Helixi1070 – 10756
    Turni1076 – 10794
    Helixi1084 – 10885
    Helixi1150 – 116314
    Helixi1165 – 11673
    Helixi1168 – 117811
    Helixi1185 – 120117
    Turni1206 – 12083
    Helixi1209 – 12179
    Turni1221 – 12233
    Helixi1224 – 123714
    Helixi1246 – 12549
    Beta strandi1258 – 12647
    Beta strandi1269 – 12746
    Helixi1280 – 129011
    Beta strandi1299 – 13057
    Beta strandi1308 – 13136
    Helixi1319 – 133113
    Turni1332 – 13343
    Helixi1337 – 13393
    Beta strandi1343 – 13486
    Helixi1357 – 13593
    Helixi1361 – 137616
    Helixi1385 – 140016
    Helixi1406 – 141611
    Helixi1419 – 14213
    Beta strandi1424 – 14263
    Helixi1428 – 144417
    Helixi1451 – 146515
    Turni1467 – 14693
    Beta strandi1472 – 148211
    Beta strandi1487 – 14948
    Beta strandi1497 – 15015
    Beta strandi1507 – 15126
    Helixi1513 – 15153
    Beta strandi1516 – 15227
    Beta strandi1564 – 15663
    Beta strandi1569 – 15746
    Beta strandi1579 – 15835
    Helixi1587 – 160418
    Beta strandi1607 – 16126
    Beta strandi1632 – 16343
    Helixi1640 – 16456
    Beta strandi1646 – 16538
    Turni1654 – 16563
    Beta strandi1659 – 16635
    Helixi1664 – 16663
    Beta strandi1667 – 16693
    Helixi1678 – 16847

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PVLX-ray2.80A965-1687[»]
    ProteinModelPortaliP97479.
    SMRiP97479. Positions 993-1686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 741677Myosin motorAdd
    BLAST
    Domaini745 – 76521IQ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini768 – 78821IQ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini791 – 81121IQ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini814 – 83421IQ 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini837 – 85721IQ 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1017 – 1253237MyTH4 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1258 – 1602345FERM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1603 – 167270SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1747 – 1896150MyTH4 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1902 – 2205304FERM 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni632 – 6398Actin-bindingCurated

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili858 – 93578Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 2 FERM domains.PROSITE-ProRule annotation
    Contains 5 IQ domains.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 2 MyTH4 domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00750000117545.
    HOGENOMiHOG000007836.
    HOVERGENiHBG052557.
    KOiK10359.
    OMAiTPWHNPS.
    OrthoDBiEOG7QG433.
    TreeFamiTF335306.

    Family and domain databases

    Gene3Di1.20.80.10. 2 hits.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00373. FERM_M. 1 hit.
    PF00612. IQ. 3 hits.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00295. B41. 2 hits.
    SM00015. IQ. 4 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 2 hits.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54236. SSF54236. 2 hits.
    PROSITEiPS50057. FERM_3. 2 hits.
    PS50096. IQ. 3 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P97479-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP     50
    QNATHIKPMH PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS 100
    ILVAVNPYQL LSIYSPEHIR QYTNKKIGEM PPHIFAIADN CYFNMKRNNR 150
    DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL EATPILEAFG 200
    NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQAPDER 250
    NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN 300
    IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP 350
    SLATAASLLE VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK 400
    GIYGRLFVWI VEKINAAIYK PPPLEVKNSR RSIGLLDIFG FENFTVNSFE 450
    QLCINFANEH LQQFFVRHVF KLEQEEYDLE SIDWLHIEFT DNQEALDMIA 500
    NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP PKNSHETQFG 550
    INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG 600
    AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH 650
    LCVRQLRYSG MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD 700
    LRGTCQRMAE AVLGTHDDWQ IGKTKIFLKD HHDMLLEVER DKAITDRVIL 750
    LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG HHCRKNYELI RLGFLRLQAL 800
    HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV ITVQAYARGM 850
    IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER 900
    LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL 950
    GTSGSLPGQE GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK 1000
    FAKFAATYFQ GTTTHSYTRR PLKQPLLYHD DEGDQLAALA VWITILRFMG 1050
    DLPEPKYHTA MSDGSEKIPV MTKIYETLGK KTYKRELQAL QGEGETQLPE 1100
    GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN SMLEDRPTSN 1150
    LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG 1200
    CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ 1250
    ATKSKKPIML PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS 1300
    LYIALFDKVS SLGSGSDHVM DAISQCEQYA KEQGAQERNA PWRLFFRKEV 1350
    FTPWHNPSED NVATNLIYQQ VVRGVKFGEY RCEKEDDLAE LASQQYFVDY 1400
    GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK KGIYAQRRTD 1450
    SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF 1500
    VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP 1550
    AGPCSPCWSC RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG 1600
    LRKRSKYVVA LQDNPNPAGE ESGFLSFAKG DLIILDHDTG EQVMNSGWAN 1650
    GINERTKQRG DFPTDCVYVM PTVTLPPREI VALVTMTPDQ RQDVVRLLQL 1700
    RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG KDRLWSHTRE 1750
    PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF 1800
    EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL 1850
    LPHVQRFLQS RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT 1900
    QIFHKVYFPD DTDEAFEVES STKAKDFCQN IASRLLLKSS EGFSLFVKIA 1950
    DKVISVPEND FFFDFVRHLT DWIKKARPIK DGIVPSLTYQ VFFMKKLWTT 2000
    TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL IYRVKFEEDK 2050
    SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF 2100
    LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT 2150
    THPFTKISNW SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ 2200
    MLTAMSKQRN SRSGR 2215
    Length:2,215
    Mass (Da):254,939
    Last modified:July 27, 2011 - v2
    Checksum:iD942FC7674B75EC7
    GO
    Isoform 2 (identifier: P97479-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1523-1560: Missing.

    Show »
    Length:2,177
    Mass (Da):251,097
    Checksum:iB11BA144AE43B63D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851L → R in AAB40708. (PubMed:7870172)Curated
    Sequence conflicti238 – 2381E → S in AAB40708. (PubMed:7870172)Curated
    Sequence conflicti589 – 5891I → V in AAB40708. (PubMed:7870172)Curated
    Sequence conflicti682 – 6821V → G in AAB40708. (PubMed:7870172)Curated
    Sequence conflicti1156 – 11561F → L in AAB40708. (PubMed:7870172)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti241 – 2411R → P in sh-1.
    Natural varianti502 – 5021R → P in sh-1.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1523 – 156038Missing in isoform 2. 1 PublicationVSP_042238Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81453 mRNA. Translation: AAB40708.1.
    AC115022 Genomic DNA. No translation available.
    AC119880 Genomic DNA. No translation available.
    AC157792 Genomic DNA. No translation available.
    AY821853 mRNA. Translation: AAV87212.1.
    CCDSiCCDS40026.1. [P97479-2]
    CCDS57565.1. [P97479-1]
    PIRiT30870.
    RefSeqiNP_001243010.1. NM_001256081.1. [P97479-1]
    NP_001243012.1. NM_001256083.1.
    NP_032689.2. NM_008663.2. [P97479-2]
    UniGeneiMm.1403.

    Genome annotation databases

    EnsembliENSMUST00000084979; ENSMUSP00000082046; ENSMUSG00000030761.
    ENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761. [P97479-2]
    ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761. [P97479-1]
    GeneIDi17921.
    KEGGimmu:17921.
    UCSCiuc009ijy.2. mouse. [P97479-2]
    uc009ijz.2. mouse. [P97479-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81453 mRNA. Translation: AAB40708.1 .
    AC115022 Genomic DNA. No translation available.
    AC119880 Genomic DNA. No translation available.
    AC157792 Genomic DNA. No translation available.
    AY821853 mRNA. Translation: AAV87212.1 .
    CCDSi CCDS40026.1. [P97479-2 ]
    CCDS57565.1. [P97479-1 ]
    PIRi T30870.
    RefSeqi NP_001243010.1. NM_001256081.1. [P97479-1 ]
    NP_001243012.1. NM_001256083.1.
    NP_032689.2. NM_008663.2. [P97479-2 ]
    UniGenei Mm.1403.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PVL X-ray 2.80 A 965-1687 [» ]
    ProteinModelPortali P97479.
    SMRi P97479. Positions 993-1686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97479. 4 interactions.
    MINTi MINT-1896820.

    PTM databases

    PhosphoSitei P97479.

    Proteomic databases

    MaxQBi P97479.
    PaxDbi P97479.
    PRIDEi P97479.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084979 ; ENSMUSP00000082046 ; ENSMUSG00000030761 .
    ENSMUST00000107127 ; ENSMUSP00000102744 ; ENSMUSG00000030761 . [P97479-2 ]
    ENSMUST00000107128 ; ENSMUSP00000102745 ; ENSMUSG00000030761 . [P97479-1 ]
    GeneIDi 17921.
    KEGGi mmu:17921.
    UCSCi uc009ijy.2. mouse. [P97479-2 ]
    uc009ijz.2. mouse. [P97479-1 ]

    Organism-specific databases

    CTDi 4647.
    MGIi MGI:104510. Myo7a.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00750000117545.
    HOGENOMi HOG000007836.
    HOVERGENi HBG052557.
    KOi K10359.
    OMAi TPWHNPS.
    OrthoDBi EOG7QG433.
    TreeFami TF335306.

    Enzyme and pathway databases

    Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).

    Miscellaneous databases

    ChiTaRSi MYO7A. mouse.
    NextBioi 292781.
    PROi P97479.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97479.
    Bgeei P97479.
    CleanExi MM_MYO7A.
    Genevestigatori P97479.

    Family and domain databases

    Gene3Di 1.20.80.10. 2 hits.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR000299. FERM_domain.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00373. FERM_M. 1 hit.
    PF00612. IQ. 3 hits.
    PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 2 hits.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00295. B41. 2 hits.
    SM00015. IQ. 4 hits.
    SM00242. MYSc. 1 hit.
    SM00139. MyTH4. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 2 hits.
    SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54236. SSF54236. 2 hits.
    PROSITEi PS50057. FERM_3. 2 hits.
    PS50096. IQ. 3 hits.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
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    Publicationsi

    1. "A type VII myosin encoded by the mouse deafness gene shaker-1."
      Gibson F., Walsh J., Mburu P., Varela A., Brown K.A., Antonio M., Beisel K.W., Steel K.P., Brown S.D.M.
      Nature 374:62-64(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
    2. "Mutation analysis of the mouse myosin VIIA deafness gene."
      Mburu P., Liu X.-Z., Walsh J., Saw D. Jr., Cope M.J., Gibson F., Kendrick-Jones J., Steel K.P., Brown S.D.M.
      Genes Funct. 1:191-203(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia."
      Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B.
      Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-2215 (ISOFORM 2), TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Inner ear.
    5. "Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin."
      Fukuda M., Kuroda T.S.
      J. Biol. Chem. 277:43096-43103(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYRIP.
    6. "Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly."
      Delprat B., Michel V., Goodyear R., Yamasaki Y., Michalski N., El-Amraoui A., Perfettini I., Legrain P., Richardson G., Hardelin J.-P., Petit C.
      Hum. Mol. Genet. 14:401-410(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WHRN.
    7. "PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa."
      Etournay R., El-Amraoui A., Bahloul A., Blanchard S., Roux I., Pezeron G., Michalski N., Daviet L., Hardelin J.-P., Legrain P., Petit C.
      J. Cell Sci. 118:2891-2899(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLEKHB1.
    8. "Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells."
      Senften M., Schwander M., Kazmierczak P., Lillo C., Shin J.B., Hasson T., Geleoc G.S., Gillespie P.G., Williams D., Holt J.R., Muller U.
      J. Neurosci. 26:2060-2071(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PCDH15.
    9. "MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear."
      Rzadzinska A.K., Nevalainen E.M., Prosser H.M., Lappalainen P., Steel K.P.
      PLoS ONE 4:E7097-E7097(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TWF2.
      Strain: C3Heb/FeJ.
      Tissue: Inner ear.
    10. "The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65."
      Lopes V.S., Gibbs D., Libby R.T., Aleman T.S., Welch D.L., Lillo C., Jacobson S.G., Radu R.A., Steel K.P., Williams D.S.
      Hum. Mol. Genet. 20:2560-2570(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RPE65.
    11. "Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction."
      Grati M., Kachar B.
      Proc. Natl. Acad. Sci. U.S.A. 108:11476-11481(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    12. "Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo."
      Wu L., Pan L., Wei Z., Zhang M.
      Science 331:757-760(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 965-1687 IN COMPLEX WITH USH1G, INTERACTION WITH USH1G, MUTAGENESIS OF ALA-1189 AND PHE-1473.

    Entry informationi

    Entry nameiMYO7A_MOUSE
    AccessioniPrimary (citable) accession number: P97479
    Secondary accession number(s): E9QLP7, Q5MJ57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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