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P97479

- MYO7A_MOUSE

UniProt

P97479 - MYO7A_MOUSE

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Protein

Unconventional myosin-VIIa

Gene

Myo7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 1658ATPCurated

GO - Molecular functioni

  1. actin-dependent ATPase activity Source: Ensembl
  2. ADP binding Source: Ensembl
  3. ATP binding Source: UniProtKB-KW
  4. calmodulin binding Source: UniProtKB
  5. microfilament motor activity Source: Ensembl
  6. protein domain specific binding Source: MGI
  7. spectrin binding Source: MGI

GO - Biological processi

  1. actin filament-based movement Source: Ensembl
  2. auditory receptor cell differentiation Source: MGI
  3. auditory receptor cell stereocilium organization Source: MGI
  4. cell projection organization Source: MGI
  5. equilibrioception Source: Ensembl
  6. inner ear development Source: MGI
  7. inner ear morphogenesis Source: MGI
  8. inner ear receptor cell differentiation Source: MGI
  9. intracellular protein transport Source: MGI
  10. lysosome organization Source: UniProtKB
  11. mechanoreceptor differentiation Source: MGI
  12. phagocytosis Source: MGI
  13. phagolysosome assembly Source: MGI
  14. pigment granule localization Source: MGI
  15. pigment granule transport Source: MGI
  16. post-embryonic organ morphogenesis Source: MGI
  17. sensory perception Source: MGI
  18. sensory perception of light stimulus Source: MGI
  19. sensory perception of sound Source: UniProtKB
  20. visual perception Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Hearing, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188277. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-VIIa
Gene namesi
Name:Myo7a
Synonyms:Myo7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:104510. Myo7a.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmcell cortex 1 Publication. Cytoplasmcytoskeleton 1 Publication
Note: In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region. Colocalizes with a subset of melanosomes in retinal pigment epithelium cells (By similarity). Detected at the tip of cochlear hair cell stereocilia. The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin.By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. cytoplasm Source: MGI
  3. cytosol Source: UniProtKB
  4. lysosomal membrane Source: UniProtKB
  5. melanosome Source: MGI
  6. microvillus Source: MGI
  7. myosin VII complex Source: Ensembl
  8. photoreceptor connecting cilium Source: MGI
  9. photoreceptor inner segment Source: UniProtKB
  10. photoreceptor outer segment Source: UniProtKB
  11. stereocilium Source: MGI
  12. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1189 – 11891A → E: Strongly reduced affinity for USH1G. 1 Publication
Mutagenesisi1473 – 14731F → Q: Reduced affinity for USH1G. 1 Publication

Keywords - Diseasei

Deafness, Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22152215Unconventional myosin-VIIaPRO_0000123467Add
BLAST

Proteomic databases

MaxQBiP97479.
PaxDbiP97479.
PRIDEiP97479.

PTM databases

PhosphoSiteiP97479.

Expressioni

Tissue specificityi

Detected in mechanosensory stereocilia of cochlea hair cells (at protein level). Expressed in the retina, cochlea, kidney and liver.3 Publications

Developmental stagei

In the inner ear of the 16.5 day old embryo, expressed only in the cochlear and vestibular sensory hair cells. In addition, expression also occurs in the epithelial cells of the small intestine, hepatocytes, and choroidal plexus.

Gene expression databases

BgeeiP97479.
CleanExiMM_MYO7A.
ExpressionAtlasiP97479. baseline and differential.
GenevestigatoriP97479.

Interactioni

Subunit structurei

Might homodimerize in a two headed molecule through the formation of a coiled-coil rod. May interact with CALM (By similarity). Binds MYRIP and WHRN. Interacts with PLEKHB1 (via PH domain). Identified in a complex with USH1C and USH1G. Interacts with RPE65. Interacts with PCDH15. Interacts with TWF2.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB5P180848EBI-1149557,EBI-1223434From a different organism.
Itgb5O703093EBI-1149557,EBI-8401821
Ush1gQ80T114EBI-1149557,EBI-7418889

Protein-protein interaction databases

IntActiP97479. 4 interactions.
MINTiMINT-1896820.

Structurei

Secondary structure

1
2215
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1001 – 10088Combined sources
Helixi1032 – 104817Combined sources
Helixi1070 – 10756Combined sources
Turni1076 – 10794Combined sources
Helixi1084 – 10885Combined sources
Helixi1150 – 116314Combined sources
Helixi1165 – 11673Combined sources
Helixi1168 – 117811Combined sources
Helixi1185 – 120117Combined sources
Turni1206 – 12083Combined sources
Helixi1209 – 12179Combined sources
Turni1221 – 12233Combined sources
Helixi1224 – 123714Combined sources
Helixi1246 – 12549Combined sources
Beta strandi1258 – 12647Combined sources
Beta strandi1269 – 12746Combined sources
Helixi1280 – 129011Combined sources
Beta strandi1299 – 13057Combined sources
Beta strandi1308 – 13136Combined sources
Helixi1319 – 133113Combined sources
Turni1332 – 13343Combined sources
Helixi1337 – 13393Combined sources
Beta strandi1343 – 13486Combined sources
Helixi1357 – 13593Combined sources
Helixi1361 – 137616Combined sources
Helixi1385 – 140016Combined sources
Helixi1406 – 141611Combined sources
Helixi1419 – 14213Combined sources
Beta strandi1424 – 14263Combined sources
Helixi1428 – 144417Combined sources
Helixi1451 – 146515Combined sources
Turni1467 – 14693Combined sources
Beta strandi1472 – 148211Combined sources
Beta strandi1487 – 14948Combined sources
Beta strandi1497 – 15015Combined sources
Beta strandi1507 – 15126Combined sources
Helixi1513 – 15153Combined sources
Beta strandi1516 – 15227Combined sources
Beta strandi1564 – 15663Combined sources
Beta strandi1569 – 15746Combined sources
Beta strandi1579 – 15835Combined sources
Helixi1587 – 160418Combined sources
Beta strandi1607 – 16126Combined sources
Beta strandi1632 – 16343Combined sources
Helixi1640 – 16456Combined sources
Beta strandi1646 – 16538Combined sources
Turni1654 – 16563Combined sources
Beta strandi1659 – 16635Combined sources
Helixi1664 – 16663Combined sources
Beta strandi1667 – 16693Combined sources
Helixi1678 – 16847Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PVLX-ray2.80A965-1687[»]
ProteinModelPortaliP97479.
SMRiP97479. Positions 993-1686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 741677Myosin motorAdd
BLAST
Domaini745 – 76521IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini768 – 78821IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini791 – 81121IQ 3PROSITE-ProRule annotationAdd
BLAST
Domaini814 – 83421IQ 4PROSITE-ProRule annotationAdd
BLAST
Domaini837 – 85721IQ 5PROSITE-ProRule annotationAdd
BLAST
Domaini1017 – 1253237MyTH4 1PROSITE-ProRule annotationAdd
BLAST
Domaini1258 – 1602345FERM 1PROSITE-ProRule annotationAdd
BLAST
Domaini1603 – 167270SH3PROSITE-ProRule annotationAdd
BLAST
Domaini1747 – 1896150MyTH4 2PROSITE-ProRule annotationAdd
BLAST
Domaini1902 – 2205304FERM 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni632 – 6398Actin-bindingCurated

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili858 – 93578Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 FERM domains.PROSITE-ProRule annotation
Contains 5 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 2 MyTH4 domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00770000120461.
HOGENOMiHOG000007836.
HOVERGENiHBG052557.
InParanoidiP97479.
KOiK10359.
OMAiTPWHNPS.
OrthoDBiEOG7QG433.
TreeFamiTF335306.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 1 hit.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P97479-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP
60 70 80 90 100
QNATHIKPMH PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS
110 120 130 140 150
ILVAVNPYQL LSIYSPEHIR QYTNKKIGEM PPHIFAIADN CYFNMKRNNR
160 170 180 190 200
DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL EATPILEAFG
210 220 230 240 250
NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQAPDER
260 270 280 290 300
NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN
310 320 330 340 350
IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP
360 370 380 390 400
SLATAASLLE VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK
410 420 430 440 450
GIYGRLFVWI VEKINAAIYK PPPLEVKNSR RSIGLLDIFG FENFTVNSFE
460 470 480 490 500
QLCINFANEH LQQFFVRHVF KLEQEEYDLE SIDWLHIEFT DNQEALDMIA
510 520 530 540 550
NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP PKNSHETQFG
560 570 580 590 600
INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG
610 620 630 640 650
AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH
660 670 680 690 700
LCVRQLRYSG MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD
710 720 730 740 750
LRGTCQRMAE AVLGTHDDWQ IGKTKIFLKD HHDMLLEVER DKAITDRVIL
760 770 780 790 800
LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG HHCRKNYELI RLGFLRLQAL
810 820 830 840 850
HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV ITVQAYARGM
860 870 880 890 900
IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER
910 920 930 940 950
LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL
960 970 980 990 1000
GTSGSLPGQE GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK
1010 1020 1030 1040 1050
FAKFAATYFQ GTTTHSYTRR PLKQPLLYHD DEGDQLAALA VWITILRFMG
1060 1070 1080 1090 1100
DLPEPKYHTA MSDGSEKIPV MTKIYETLGK KTYKRELQAL QGEGETQLPE
1110 1120 1130 1140 1150
GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN SMLEDRPTSN
1160 1170 1180 1190 1200
LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG
1210 1220 1230 1240 1250
CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ
1260 1270 1280 1290 1300
ATKSKKPIML PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS
1310 1320 1330 1340 1350
LYIALFDKVS SLGSGSDHVM DAISQCEQYA KEQGAQERNA PWRLFFRKEV
1360 1370 1380 1390 1400
FTPWHNPSED NVATNLIYQQ VVRGVKFGEY RCEKEDDLAE LASQQYFVDY
1410 1420 1430 1440 1450
GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK KGIYAQRRTD
1460 1470 1480 1490 1500
SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF
1510 1520 1530 1540 1550
VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP
1560 1570 1580 1590 1600
AGPCSPCWSC RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG
1610 1620 1630 1640 1650
LRKRSKYVVA LQDNPNPAGE ESGFLSFAKG DLIILDHDTG EQVMNSGWAN
1660 1670 1680 1690 1700
GINERTKQRG DFPTDCVYVM PTVTLPPREI VALVTMTPDQ RQDVVRLLQL
1710 1720 1730 1740 1750
RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG KDRLWSHTRE
1760 1770 1780 1790 1800
PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF
1810 1820 1830 1840 1850
EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL
1860 1870 1880 1890 1900
LPHVQRFLQS RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT
1910 1920 1930 1940 1950
QIFHKVYFPD DTDEAFEVES STKAKDFCQN IASRLLLKSS EGFSLFVKIA
1960 1970 1980 1990 2000
DKVISVPEND FFFDFVRHLT DWIKKARPIK DGIVPSLTYQ VFFMKKLWTT
2010 2020 2030 2040 2050
TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL IYRVKFEEDK
2060 2070 2080 2090 2100
SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF
2110 2120 2130 2140 2150
LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT
2160 2170 2180 2190 2200
THPFTKISNW SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ
2210
MLTAMSKQRN SRSGR
Length:2,215
Mass (Da):254,939
Last modified:July 27, 2011 - v2
Checksum:iD942FC7674B75EC7
GO
Isoform 2 (identifier: P97479-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1523-1560: Missing.

Show »
Length:2,177
Mass (Da):251,097
Checksum:iB11BA144AE43B63D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851L → R in AAB40708. (PubMed:7870172)Curated
Sequence conflicti238 – 2381E → S in AAB40708. (PubMed:7870172)Curated
Sequence conflicti589 – 5891I → V in AAB40708. (PubMed:7870172)Curated
Sequence conflicti682 – 6821V → G in AAB40708. (PubMed:7870172)Curated
Sequence conflicti1156 – 11561F → L in AAB40708. (PubMed:7870172)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411R → P in sh-1.
Natural varianti502 – 5021R → P in sh-1.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1523 – 156038Missing in isoform 2. 1 PublicationVSP_042238Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81453 mRNA. Translation: AAB40708.1.
AC115022 Genomic DNA. No translation available.
AC119880 Genomic DNA. No translation available.
AC157792 Genomic DNA. No translation available.
AY821853 mRNA. Translation: AAV87212.1.
CCDSiCCDS40026.1. [P97479-2]
CCDS57565.1. [P97479-1]
PIRiT30870.
RefSeqiNP_001243010.1. NM_001256081.1. [P97479-1]
NP_001243012.1. NM_001256083.1.
NP_032689.2. NM_008663.2. [P97479-2]
UniGeneiMm.1403.

Genome annotation databases

EnsembliENSMUST00000084979; ENSMUSP00000082046; ENSMUSG00000030761.
ENSMUST00000107127; ENSMUSP00000102744; ENSMUSG00000030761. [P97479-2]
ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761. [P97479-1]
GeneIDi17921.
KEGGimmu:17921.
UCSCiuc009ijy.2. mouse. [P97479-2]
uc009ijz.2. mouse. [P97479-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81453 mRNA. Translation: AAB40708.1 .
AC115022 Genomic DNA. No translation available.
AC119880 Genomic DNA. No translation available.
AC157792 Genomic DNA. No translation available.
AY821853 mRNA. Translation: AAV87212.1 .
CCDSi CCDS40026.1. [P97479-2 ]
CCDS57565.1. [P97479-1 ]
PIRi T30870.
RefSeqi NP_001243010.1. NM_001256081.1. [P97479-1 ]
NP_001243012.1. NM_001256083.1.
NP_032689.2. NM_008663.2. [P97479-2 ]
UniGenei Mm.1403.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PVL X-ray 2.80 A 965-1687 [» ]
ProteinModelPortali P97479.
SMRi P97479. Positions 993-1686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97479. 4 interactions.
MINTi MINT-1896820.

PTM databases

PhosphoSitei P97479.

Proteomic databases

MaxQBi P97479.
PaxDbi P97479.
PRIDEi P97479.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084979 ; ENSMUSP00000082046 ; ENSMUSG00000030761 .
ENSMUST00000107127 ; ENSMUSP00000102744 ; ENSMUSG00000030761 . [P97479-2 ]
ENSMUST00000107128 ; ENSMUSP00000102745 ; ENSMUSG00000030761 . [P97479-1 ]
GeneIDi 17921.
KEGGi mmu:17921.
UCSCi uc009ijy.2. mouse. [P97479-2 ]
uc009ijz.2. mouse. [P97479-1 ]

Organism-specific databases

CTDi 4647.
MGIi MGI:104510. Myo7a.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00770000120461.
HOGENOMi HOG000007836.
HOVERGENi HBG052557.
InParanoidi P97479.
KOi K10359.
OMAi TPWHNPS.
OrthoDBi EOG7QG433.
TreeFami TF335306.

Enzyme and pathway databases

Reactomei REACT_188277. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

ChiTaRSi Myo7a. mouse.
NextBioi 292781.
PROi P97479.
SOURCEi Search...

Gene expression databases

Bgeei P97479.
CleanExi MM_MYO7A.
ExpressionAtlasi P97479. baseline and differential.
Genevestigatori P97479.

Family and domain databases

Gene3Di 1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00373. FERM_M. 1 hit.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00295. B41. 2 hits.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54236. SSF54236. 2 hits.
PROSITEi PS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
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Publicationsi

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  1. "A type VII myosin encoded by the mouse deafness gene shaker-1."
    Gibson F., Walsh J., Mburu P., Varela A., Brown K.A., Antonio M., Beisel K.W., Steel K.P., Brown S.D.M.
    Nature 374:62-64(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DISEASE.
  2. "Mutation analysis of the mouse myosin VIIA deafness gene."
    Mburu P., Liu X.-Z., Walsh J., Saw D. Jr., Cope M.J., Gibson F., Kendrick-Jones J., Steel K.P., Brown S.D.M.
    Genes Funct. 1:191-203(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia."
    Belyantseva I.A., Boger E.T., Naz S., Frolenkov G.I., Sellers J.R., Ahmed Z.M., Griffith A.J., Friedman T.B.
    Nat. Cell Biol. 7:148-156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-2215 (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Inner ear.
  5. "Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin."
    Fukuda M., Kuroda T.S.
    J. Biol. Chem. 277:43096-43103(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYRIP.
  6. "Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly."
    Delprat B., Michel V., Goodyear R., Yamasaki Y., Michalski N., El-Amraoui A., Perfettini I., Legrain P., Richardson G., Hardelin J.-P., Petit C.
    Hum. Mol. Genet. 14:401-410(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WHRN.
  7. "PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa."
    Etournay R., El-Amraoui A., Bahloul A., Blanchard S., Roux I., Pezeron G., Michalski N., Daviet L., Hardelin J.-P., Legrain P., Petit C.
    J. Cell Sci. 118:2891-2899(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLEKHB1.
  8. "Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells."
    Senften M., Schwander M., Kazmierczak P., Lillo C., Shin J.B., Hasson T., Geleoc G.S., Gillespie P.G., Williams D., Holt J.R., Muller U.
    J. Neurosci. 26:2060-2071(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PCDH15.
  9. "MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear."
    Rzadzinska A.K., Nevalainen E.M., Prosser H.M., Lappalainen P., Steel K.P.
    PLoS ONE 4:E7097-E7097(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWF2.
    Strain: C3Heb/FeJ.
    Tissue: Inner ear.
  10. "The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65."
    Lopes V.S., Gibbs D., Libby R.T., Aleman T.S., Welch D.L., Lillo C., Jacobson S.G., Radu R.A., Steel K.P., Williams D.S.
    Hum. Mol. Genet. 20:2560-2570(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH RPE65.
  11. "Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction."
    Grati M., Kachar B.
    Proc. Natl. Acad. Sci. U.S.A. 108:11476-11481(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  12. "Structure of MyTH4-FERM domains in myosin VIIa tail bound to cargo."
    Wu L., Pan L., Wei Z., Zhang M.
    Science 331:757-760(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 965-1687 IN COMPLEX WITH USH1G, INTERACTION WITH USH1G, MUTAGENESIS OF ALA-1189 AND PHE-1473.

Entry informationi

Entry nameiMYO7A_MOUSE
AccessioniPrimary (citable) accession number: P97479
Secondary accession number(s): E9QLP7, Q5MJ57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3