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P97478

- COQ7_MOUSE

UniProt

P97478 - COQ7_MOUSE

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Protein

Ubiquinone biosynthesis protein COQ7 homolog

Gene

Coq7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator.1 Publication

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron 1By similarity
Metal bindingi90 – 901Iron 1By similarity
Metal bindingi90 – 901Iron 2By similarity
Metal bindingi93 – 931Iron 1By similarity
Metal bindingi142 – 1421Iron 2By similarity
Metal bindingi178 – 1781Iron 1By similarity
Metal bindingi178 – 1781Iron 2By similarity
Metal bindingi181 – 1811Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. age-dependent response to oxidative stress Source: MGI
  2. cellular response to oxidative stress Source: MGI
  3. determination of adult lifespan Source: MGI
  4. in utero embryonic development Source: MGI
  5. mitochondrial ATP synthesis coupled electron transport Source: MGI
  6. mitochondrion morphogenesis Source: MGI
  7. neural tube formation Source: MGI
  8. neurogenesis Source: MGI
  9. respiratory electron transport chain Source: MGI
  10. response to oxidative stress Source: MGI
  11. ubiquinone biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196568. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis protein COQ7 homolog
Alternative name(s):
Coenzyme Q biosynthesis protein 7 homolog
Timing protein clk-1 homolog
Gene namesi
Name:Coq7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107207. Coq7.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication
Note: Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Coq7 start to die after E8. Heterozygous mutant reveal that the reduction of Coq7 levels in these animals profoundly alters their mitochondrial function despite the fact that ubiquinone production is unaffected. The mitochondria of young mutants heterozygous are dysfunctional, exhibiting reduced energy metabolism and a substantial increase in oxidative stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
BLAST
Chaini35 – 217183Ubiquinone biosynthesis protein COQ7 homologPRO_0000079252Add
BLAST

Proteomic databases

MaxQBiP97478.
PaxDbiP97478.
PRIDEiP97478.

PTM databases

PhosphoSiteiP97478.

Expressioni

Tissue specificityi

Highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney.1 Publication

Gene expression databases

BgeeiP97478.
CleanExiMM_COQ7.
ExpressionAtlasiP97478. baseline and differential.
GenevestigatoriP97478.

Interactioni

Subunit structurei

Interacts with ADCK4 and COQ6.By similarity

Protein-protein interaction databases

MINTiMINT-1860620.

Structurei

3D structure databases

ProteinModelPortaliP97478.
SMRiP97478. Positions 49-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 129821Add
BLAST
Repeati130 – 217882Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 2171702 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the COQ7 family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiCOG2941.
GeneTreeiENSGT00390000014520.
HOGENOMiHOG000184972.
HOVERGENiHBG002214.
InParanoidiP97478.
KOiK06134.
OMAiREMEGHE.
PhylomeDBiP97478.
TreeFamiTF314559.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR011566. Ubq_synth_Coq7.
[Graphical view]
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiPF03232. COQ7. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAAGAIAAA SVGRLRTGVR RPFSEYGRGL IIRCHSSGMT LDNINRAAVD
60 70 80 90 100
RIIRVDHAGE YGANRIYAGQ MAVLGRTSVG PVIQKMWDQE KNHLKKFNEL
110 120 130 140 150
MIAFRVRPTV LMPLWNVAGF ALGAGTALLG KEGAMACTVA VEESIANHYN
160 170 180 190 200
NQIRMLMEED PEKYEELLQV IKQFRDEELE HHDTGLDHDA ELAPAYALLK
210
RIIQAGCSAA IYLSERF
Length:217
Mass (Da):24,042
Last modified:July 15, 1999 - v3
Checksum:i3BFA05D64BB42ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080580 mRNA. Translation: AAC31572.1.
AF098949 mRNA. Translation: AAD43649.1.
BC038681 mRNA. Translation: AAH38681.1.
AF053770 mRNA. Translation: AAC69179.1.
U81277 mRNA. Translation: AAC53055.1.
AA030846 mRNA. No translation available.
CCDSiCCDS21771.1.
PIRiJC7756.
RefSeqiNP_034070.1. NM_009940.2.
UniGeneiMm.20634.

Genome annotation databases

EnsembliENSMUST00000032887; ENSMUSP00000032887; ENSMUSG00000030652.
GeneIDi12850.
KEGGimmu:12850.
UCSCiuc009jjy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080580 mRNA. Translation: AAC31572.1 .
AF098949 mRNA. Translation: AAD43649.1 .
BC038681 mRNA. Translation: AAH38681.1 .
AF053770 mRNA. Translation: AAC69179.1 .
U81277 mRNA. Translation: AAC53055.1 .
AA030846 mRNA. No translation available.
CCDSi CCDS21771.1.
PIRi JC7756.
RefSeqi NP_034070.1. NM_009940.2.
UniGenei Mm.20634.

3D structure databases

ProteinModelPortali P97478.
SMRi P97478. Positions 49-109.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1860620.

PTM databases

PhosphoSitei P97478.

Proteomic databases

MaxQBi P97478.
PaxDbi P97478.
PRIDEi P97478.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032887 ; ENSMUSP00000032887 ; ENSMUSG00000030652 .
GeneIDi 12850.
KEGGi mmu:12850.
UCSCi uc009jjy.1. mouse.

Organism-specific databases

CTDi 10229.
MGIi MGI:107207. Coq7.

Phylogenomic databases

eggNOGi COG2941.
GeneTreei ENSGT00390000014520.
HOGENOMi HOG000184972.
HOVERGENi HBG002214.
InParanoidi P97478.
KOi K06134.
OMAi REMEGHE.
PhylomeDBi P97478.
TreeFami TF314559.

Enzyme and pathway databases

UniPathwayi UPA00232 .
Reactomei REACT_196568. Ubiquinol biosynthesis.

Miscellaneous databases

NextBioi 282400.
PROi P97478.
SOURCEi Search...

Gene expression databases

Bgeei P97478.
CleanExi MM_COQ7.
ExpressionAtlasi P97478. baseline and differential.
Genevestigatori P97478.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR011566. Ubq_synth_Coq7.
[Graphical view ]
PANTHERi PTHR11237. PTHR11237. 1 hit.
Pfami PF03232. COQ7. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine clk-1."
    Kim H.J., Moon Y.I., Lee J.E., Lee H.W., Seo J.S.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
  2. "Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human."
    Asaumi S., Kuroyanagi H., Seki N., Shirasawa T.
    Genomics 58:293-301(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging."
    Vajo Z., King L.M., Jonassen T., Wilkin D.J., Ho N., Munnich A., Clarke C.F., Francomano C.A.
    Mamm. Genome 10:1000-1004(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-217.
  5. "Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1."
    Ewbank J.J., Barnes T.M., Lakowski B., Lussier M., Bussey H., Hekimi S.
    Science 275:980-983(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-175.
    Tissue: Embryo.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 146-217.
    Strain: C57BL/6J.
    Tissue: Embryo.
  7. "Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans."
    Takahashi M., Asaumi S., Honda S., Suzuki Y., Nakai D., Kuroyanagi H., Shimizu T., Honda Y., Shirasawa T.
    Biochem. Biophys. Res. Commun. 286:534-540(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, TRANSGENIC MICE.
  8. "Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential."
    Jiang N., Levavasseur F., McCright B., Shoubridge E.A., Hekimi S.
    J. Biol. Chem. 276:29218-29225(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice."
    Lapointe J., Stepanyan Z., Bigras E., Hekimi S.
    J. Biol. Chem. 284:20364-20374(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCOQ7_MOUSE
AccessioniPrimary (citable) accession number: P97478
Secondary accession number(s): Q9R0D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: November 26, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In life-span analysis, transgenic expression reverted the extended life span of clk-1 to the comparable level with wild-type control.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3