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P97478

- COQ7_MOUSE

UniProt

P97478 - COQ7_MOUSE

Protein

Ubiquinone biosynthesis protein COQ7 homolog

Gene

Coq7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator.1 Publication

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron 1By similarity
    Metal bindingi90 – 901Iron 1By similarity
    Metal bindingi90 – 901Iron 2By similarity
    Metal bindingi93 – 931Iron 1By similarity
    Metal bindingi142 – 1421Iron 2By similarity
    Metal bindingi178 – 1781Iron 1By similarity
    Metal bindingi178 – 1781Iron 2By similarity
    Metal bindingi181 – 1811Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. age-dependent response to oxidative stress Source: MGI
    2. cellular response to oxidative stress Source: MGI
    3. determination of adult lifespan Source: MGI
    4. in utero embryonic development Source: MGI
    5. mitochondrial ATP synthesis coupled electron transport Source: MGI
    6. mitochondrion morphogenesis Source: MGI
    7. neural tube formation Source: MGI
    8. neurogenesis Source: MGI
    9. respiratory electron transport chain Source: MGI
    10. response to oxidative stress Source: MGI
    11. ubiquinone biosynthetic process Source: MGI

    Keywords - Biological processi

    Ubiquinone biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196568. Ubiquinol biosynthesis.
    UniPathwayiUPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone biosynthesis protein COQ7 homolog
    Alternative name(s):
    Coenzyme Q biosynthesis protein 7 homolog
    Timing protein clk-1 homolog
    Gene namesi
    Name:Coq7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107207. Coq7.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication
    Note: Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane.

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking Coq7 start to die after E8. Heterozygous mutant reveal that the reduction of Coq7 levels in these animals profoundly alters their mitochondrial function despite the fact that ubiquinone production is unaffected. The mitochondria of young mutants heterozygous are dysfunctional, exhibiting reduced energy metabolism and a substantial increase in oxidative stress.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionSequence AnalysisAdd
    BLAST
    Chaini35 – 217183Ubiquinone biosynthesis protein COQ7 homologPRO_0000079252Add
    BLAST

    Proteomic databases

    MaxQBiP97478.
    PaxDbiP97478.
    PRIDEiP97478.

    PTM databases

    PhosphoSiteiP97478.

    Expressioni

    Tissue specificityi

    Highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney.1 Publication

    Gene expression databases

    ArrayExpressiP97478.
    BgeeiP97478.
    CleanExiMM_COQ7.
    GenevestigatoriP97478.

    Interactioni

    Subunit structurei

    Interacts with ADCK4 and COQ6.By similarity

    Protein-protein interaction databases

    MINTiMINT-1860620.

    Structurei

    3D structure databases

    ProteinModelPortaliP97478.
    SMRiP97478. Positions 49-109.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati48 – 129821Add
    BLAST
    Repeati130 – 217882Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni48 – 2171702 X approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the COQ7 family.Curated

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    eggNOGiCOG2941.
    GeneTreeiENSGT00390000014520.
    HOGENOMiHOG000184972.
    HOVERGENiHBG002214.
    KOiK06134.
    OMAiREMEGHE.
    PhylomeDBiP97478.
    TreeFamiTF314559.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR011566. Ubq_synth_Coq7.
    [Graphical view]
    PANTHERiPTHR11237. PTHR11237. 1 hit.
    PfamiPF03232. COQ7. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97478-1 [UniParc]FASTAAdd to Basket

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    MSAAGAIAAA SVGRLRTGVR RPFSEYGRGL IIRCHSSGMT LDNINRAAVD    50
    RIIRVDHAGE YGANRIYAGQ MAVLGRTSVG PVIQKMWDQE KNHLKKFNEL 100
    MIAFRVRPTV LMPLWNVAGF ALGAGTALLG KEGAMACTVA VEESIANHYN 150
    NQIRMLMEED PEKYEELLQV IKQFRDEELE HHDTGLDHDA ELAPAYALLK 200
    RIIQAGCSAA IYLSERF 217
    Length:217
    Mass (Da):24,042
    Last modified:July 15, 1999 - v3
    Checksum:i3BFA05D64BB42ACC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080580 mRNA. Translation: AAC31572.1.
    AF098949 mRNA. Translation: AAD43649.1.
    BC038681 mRNA. Translation: AAH38681.1.
    AF053770 mRNA. Translation: AAC69179.1.
    U81277 mRNA. Translation: AAC53055.1.
    AA030846 mRNA. No translation available.
    CCDSiCCDS21771.1.
    PIRiJC7756.
    RefSeqiNP_034070.1. NM_009940.2.
    UniGeneiMm.20634.

    Genome annotation databases

    EnsembliENSMUST00000032887; ENSMUSP00000032887; ENSMUSG00000030652.
    GeneIDi12850.
    KEGGimmu:12850.
    UCSCiuc009jjy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080580 mRNA. Translation: AAC31572.1 .
    AF098949 mRNA. Translation: AAD43649.1 .
    BC038681 mRNA. Translation: AAH38681.1 .
    AF053770 mRNA. Translation: AAC69179.1 .
    U81277 mRNA. Translation: AAC53055.1 .
    AA030846 mRNA. No translation available.
    CCDSi CCDS21771.1.
    PIRi JC7756.
    RefSeqi NP_034070.1. NM_009940.2.
    UniGenei Mm.20634.

    3D structure databases

    ProteinModelPortali P97478.
    SMRi P97478. Positions 49-109.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1860620.

    PTM databases

    PhosphoSitei P97478.

    Proteomic databases

    MaxQBi P97478.
    PaxDbi P97478.
    PRIDEi P97478.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032887 ; ENSMUSP00000032887 ; ENSMUSG00000030652 .
    GeneIDi 12850.
    KEGGi mmu:12850.
    UCSCi uc009jjy.1. mouse.

    Organism-specific databases

    CTDi 10229.
    MGIi MGI:107207. Coq7.

    Phylogenomic databases

    eggNOGi COG2941.
    GeneTreei ENSGT00390000014520.
    HOGENOMi HOG000184972.
    HOVERGENi HBG002214.
    KOi K06134.
    OMAi REMEGHE.
    PhylomeDBi P97478.
    TreeFami TF314559.

    Enzyme and pathway databases

    UniPathwayi UPA00232 .
    Reactomei REACT_196568. Ubiquinol biosynthesis.

    Miscellaneous databases

    NextBioi 282400.
    PROi P97478.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97478.
    Bgeei P97478.
    CleanExi MM_COQ7.
    Genevestigatori P97478.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR011566. Ubq_synth_Coq7.
    [Graphical view ]
    PANTHERi PTHR11237. PTHR11237. 1 hit.
    Pfami PF03232. COQ7. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of murine clk-1."
      Kim H.J., Moon Y.I., Lee J.E., Lee H.W., Seo J.S.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129.
    2. "Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human."
      Asaumi S., Kuroyanagi H., Seki N., Shirasawa T.
      Genomics 58:293-301(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging."
      Vajo Z., King L.M., Jonassen T., Wilkin D.J., Ho N., Munnich A., Clarke C.F., Francomano C.A.
      Mamm. Genome 10:1000-1004(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-217.
    5. "Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1."
      Ewbank J.J., Barnes T.M., Lakowski B., Lussier M., Bussey H., Hekimi S.
      Science 275:980-983(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-175.
      Tissue: Embryo.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 146-217.
      Strain: C57BL/6J.
      Tissue: Embryo.
    7. "Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans."
      Takahashi M., Asaumi S., Honda S., Suzuki Y., Nakai D., Kuroyanagi H., Shimizu T., Honda Y., Shirasawa T.
      Biochem. Biophys. Res. Commun. 286:534-540(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, TRANSGENIC MICE.
    8. "Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential."
      Jiang N., Levavasseur F., McCright B., Shoubridge E.A., Hekimi S.
      J. Biol. Chem. 276:29218-29225(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice."
      Lapointe J., Stepanyan Z., Bigras E., Hekimi S.
      J. Biol. Chem. 284:20364-20374(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiCOQ7_MOUSE
    AccessioniPrimary (citable) accession number: P97478
    Secondary accession number(s): Q9R0D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In life-span analysis, transgenic expression reverted the extended life span of clk-1 to the comparable level with wild-type control.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3