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Protein

Chemokine-like receptor 1

Gene

Cmklr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism.By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled receptor DEZ
Gene namesi
Name:Cmklr1
Synonyms:Dez, Gpcr27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:109603. Cmklr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 62Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini63 – 73CytoplasmicSequence analysisAdd BLAST11
Transmembranei74 – 95Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini96 – 112ExtracellularSequence analysisAdd BLAST17
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 152CytoplasmicSequence analysisAdd BLAST19
Transmembranei153 – 174Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini175 – 222ExtracellularSequence analysisAdd BLAST48
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 259CytoplasmicSequence analysisAdd BLAST16
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 298ExtracellularSequence analysisAdd BLAST18
Transmembranei299 – 318Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini319 – 371CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693081 – 371Chemokine-like receptor 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Modified residuei337PhosphoserineCombined sources1
Modified residuei340PhosphothreonineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei356PhosphoserineBy similarity1
Modified residuei370PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP97468.
PRIDEiP97468.

PTM databases

iPTMnetiP97468.
PhosphoSitePlusiP97468.

Expressioni

Tissue specificityi

Expressed in the differentiated adipocytes (at protein level). Ubiquitous. Highly expressed in adipose tissue and immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from different tissues, including peritoneal cavities, pleural cavities and spleen.5 Publications

Developmental stagei

Expressed during bone development and in adult parathyroid glands. Expressed at day E11 in the caudal part of the tongue and the umbilical cord and the expression in the tongue was maintained throughout adulthood. Expression increases in bone and cartilaginous forming zones of embryo up to stage E14.5 and at E16.5 expression is seen in the lung.1 Publication

Inductioni

Down-regulated by bacterial lipopolysaccharide (LPS), IFN-alpha and TNF on macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000042190.
CleanExiMM_CMKLR1.
ExpressionAtlasiP97468. baseline and differential.
GenevisibleiP97468. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036316.

Structurei

3D structure databases

ProteinModelPortaliP97468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP97468.
KOiK04245.
OMAiHITYAAM.
OrthoDBiEOG091G0AR8.
PhylomeDBiP97468.
TreeFamiTF330976.

Family and domain databases

InterProiIPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYDAYNDSG IYDDEYSDGF GYFVDLEEAS PWEAKVAPVF LVVIYSLVCF
60 70 80 90 100
LGLLGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PMHITYAAMD
110 120 130 140 150
YHWVFGKAMC KISNFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS
160 170 180 190 200
IRLAYMTCSA VWVLAFFLSS PSLVFRDTAN IHGKITCFNN FSLAAPESSP
210 220 230 240 250
HPAHSQVVST GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRL
260 270 280 290 300
AKNKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPSS VFSLGLPLAT
310 320 330 340 350
AVAIANSCMN PILYVFMGHD FRKFKVALFS RLANALSEDT GPSSYPSHRS
360 370
FTKMSSLNEK ASVNEKETST L
Length:371
Mass (Da):41,815
Last modified:May 1, 1997 - v1
Checksum:iCDBE19305244C0B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79525 mRNA. Translation: AAB53789.1.
CCDSiCCDS19551.1.
PIRiJC5498.
RefSeqiNP_032179.1. NM_008153.3.
XP_006530227.1. XM_006530164.3.
XP_006530228.1. XM_006530165.2.
XP_006530229.1. XM_006530166.2.
UniGeneiMm.5196.

Genome annotation databases

EnsembliENSMUST00000047936; ENSMUSP00000036316; ENSMUSG00000042190.
GeneIDi14747.
KEGGimmu:14747.
UCSCiuc012ebo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79525 mRNA. Translation: AAB53789.1.
CCDSiCCDS19551.1.
PIRiJC5498.
RefSeqiNP_032179.1. NM_008153.3.
XP_006530227.1. XM_006530164.3.
XP_006530228.1. XM_006530165.2.
XP_006530229.1. XM_006530166.2.
UniGeneiMm.5196.

3D structure databases

ProteinModelPortaliP97468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036316.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP97468.
PhosphoSitePlusiP97468.

Proteomic databases

PaxDbiP97468.
PRIDEiP97468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047936; ENSMUSP00000036316; ENSMUSG00000042190.
GeneIDi14747.
KEGGimmu:14747.
UCSCiuc012ebo.1. mouse.

Organism-specific databases

CTDi1240.
MGIiMGI:109603. Cmklr1.

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP97468.
KOiK04245.
OMAiHITYAAM.
OrthoDBiEOG091G0AR8.
PhylomeDBiP97468.
TreeFamiTF330976.

Miscellaneous databases

ChiTaRSiCmklr1. mouse.
PROiP97468.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042190.
CleanExiMM_CMKLR1.
ExpressionAtlasiP97468. baseline and differential.
GenevisibleiP97468. MM.

Family and domain databases

InterProiIPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCML1_MOUSE
AccessioniPrimary (citable) accession number: P97468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.