ID   NOGG_MOUSE              Reviewed;         232 AA.
AC   P97466;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   27-MAR-2024, entry version 168.
DE   RecName: Full=Noggin {ECO:0000303|PubMed:9585504, ECO:0000303|PubMed:9603738};
DE   Flags: Precursor;
GN   Name=Nog;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, FUNCTION, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=129/Sv;
RX   PubMed=9585504; DOI=10.1101/gad.12.10.1438;
RA   McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M.,
RA   McMahon A.P.;
RT   "Noggin-mediated antagonism of BMP signaling is required for growth and
RT   patterning of the neural tube and somite.";
RL   Genes Dev. 12:1438-1452(1998).
RN   [2]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=9603738; DOI=10.1126/science.280.5368.1455;
RA   Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.;
RT   "Noggin, cartilage morphogenesis, and joint formation in the mammalian
RT   skeleton.";
RL   Science 280:1455-1457(1998).
CC   -!- FUNCTION: Essential for cartilage morphogenesis and joint formation.
CC       Inhibitor of bone morphogenetic proteins (BMP) signaling which is
CC       required for growth and patterning of the neural tube and somite
CC       (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation
CC       through its interaction with GDF5 and, probably, GDF6 (By similarity).
CC       {ECO:0000250|UniProtKB:Q13253, ECO:0000269|PubMed:9585504,
CC       ECO:0000269|PubMed:9603738}.
CC   -!- SUBUNIT: Homodimer. Interacts with GDF5; inhibits chondrocyte
CC       differentiation. {ECO:0000250|UniProtKB:Q13253}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in condensing cartilage and immature
CC       chondrocytes. {ECO:0000269|PubMed:9603738}.
CC   -!- DEVELOPMENTAL STAGE: Embryonic expression was first detected in the
CC       node at 7.5 dpc. By early somite stages, expression extends anteriorly
CC       along the entire length of the notochord and is expressed in the dorsal
CC       neural tube from the caudal hindbrain to the posterior-most region of
CC       the embryo. By the time cranial tube closure is completed expression is
CC       continuous along most of the dorsal midline of the neural tube, to its
CC       rostral termination at the base of the forebrain. Expression in the
CC       neural tube and caudal notochord remains unchanged during early
CC       organogenesis from 9.5 dpc to 10.5 dpc. {ECO:0000269|PubMed:9585504}.
CC   -!- DISRUPTION PHENOTYPE: Defects in Nog are the cause of a recessive
CC       lethal phenotype at birth. Multiple defects include a failure of neural
CC       tube closure, broad club-shaped limbs, loss of caudal vertebrae, a
CC       shortened body axis, and retention of a small vestigial tail.
CC       {ECO:0000269|PubMed:9585504}.
CC   -!- SIMILARITY: Belongs to the noggin family. {ECO:0000305}.
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DR   EMBL; U79163; AAB38281.1; -; Genomic_DNA.
DR   CCDS; CCDS25236.1; -.
DR   RefSeq; NP_032737.1; NM_008711.2.
DR   AlphaFoldDB; P97466; -.
DR   SMR; P97466; -.
DR   STRING; 10090.ENSMUSP00000061427; -.
DR   GlyCosmos; P97466; 1 site, No reported glycans.
DR   GlyGen; P97466; 1 site.
DR   iPTMnet; P97466; -.
DR   PhosphoSitePlus; P97466; -.
DR   PaxDb; 10090-ENSMUSP00000061427; -.
DR   ProteomicsDB; 293589; -.
DR   Antibodypedia; 3149; 643 antibodies from 35 providers.
DR   DNASU; 18121; -.
DR   Ensembl; ENSMUST00000061728.5; ENSMUSP00000061427.4; ENSMUSG00000048616.5.
DR   GeneID; 18121; -.
DR   KEGG; mmu:18121; -.
DR   UCSC; uc007kwh.2; mouse.
DR   AGR; MGI:104327; -.
DR   CTD; 9241; -.
DR   MGI; MGI:104327; Nog.
DR   VEuPathDB; HostDB:ENSMUSG00000048616; -.
DR   eggNOG; KOG4485; Eukaryota.
DR   GeneTree; ENSGT00390000006009; -.
DR   HOGENOM; CLU_085186_1_0_1; -.
DR   InParanoid; P97466; -.
DR   OMA; ECKCACP; -.
DR   OrthoDB; 2908064at2759; -.
DR   PhylomeDB; P97466; -.
DR   TreeFam; TF353745; -.
DR   Reactome; R-MMU-201451; Signaling by BMP.
DR   BioGRID-ORCS; 18121; 1 hit in 76 CRISPR screens.
DR   PRO; PR:P97466; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P97466; Protein.
DR   Bgee; ENSMUSG00000048616; Expressed in notochord and 106 other cell types or tissues.
DR   ExpressionAtlas; P97466; baseline and differential.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:0019955; F:cytokine binding; ISO:MGI.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
DR   GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0048318; P:axial mesoderm development; IMP:MGI.
DR   GO; GO:0007411; P:axon guidance; IMP:MGI.
DR   GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
DR   GO; GO:0007420; P:brain development; IMP:MGI.
DR   GO; GO:0051216; P:cartilage development; IDA:MGI.
DR   GO; GO:0021533; P:cell differentiation in hindbrain; ISO:MGI.
DR   GO; GO:0008283; P:cell population proliferation; IGI:MGI.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
DR   GO; GO:0007417; P:central nervous system development; IMP:MGI.
DR   GO; GO:1904888; P:cranial skeletal system development; IGI:MGI.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:MGI.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; ISO:MGI.
DR   GO; GO:0060272; P:embryonic skeletal joint morphogenesis; ISO:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; ISO:MGI.
DR   GO; GO:0003272; P:endocardial cushion formation; IMP:BHF-UCL.
DR   GO; GO:0007492; P:endoderm development; IDA:MGI.
DR   GO; GO:0001706; P:endoderm formation; IDA:MGI.
DR   GO; GO:0050673; P:epithelial cell proliferation; IMP:MGI.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; IMP:BHF-UCL.
DR   GO; GO:0035640; P:exploration behavior; IMP:MGI.
DR   GO; GO:0060325; P:face morphogenesis; IMP:MGI.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR   GO; GO:0030900; P:forebrain development; IGI:MGI.
DR   GO; GO:0061384; P:heart trabecula morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   GO; GO:0060173; P:limb development; ISO:MGI.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IMP:MGI.
DR   GO; GO:0060425; P:lung morphogenesis; IMP:MGI.
DR   GO; GO:0003149; P:membranous septum morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0007613; P:memory; ISO:MGI.
DR   GO; GO:0048762; P:mesenchymal cell differentiation; IMP:MGI.
DR   GO; GO:0001707; P:mesoderm formation; IDA:MGI.
DR   GO; GO:0042474; P:middle ear morphogenesis; ISO:MGI.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
DR   GO; GO:0048712; P:negative regulation of astrocyte differentiation; IMP:BHF-UCL.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; IDA:HGNC-UCL.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:MGI.
DR   GO; GO:0062044; P:negative regulation of cardiac epithelial to mesenchymal transition; IMP:BHF-UCL.
DR   GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IMP:BHF-UCL.
DR   GO; GO:0061037; P:negative regulation of cartilage development; IDA:MGI.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:MGI.
DR   GO; GO:0045668; P:negative regulation of osteoblast differentiation; ISO:MGI.
DR   GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
DR   GO; GO:0021999; P:neural plate anterior/posterior regionalization; ISO:MGI.
DR   GO; GO:0001839; P:neural plate morphogenesis; IMP:MGI.
DR   GO; GO:0001843; P:neural tube closure; IMP:MGI.
DR   GO; GO:0021915; P:neural tube development; IMP:MGI.
DR   GO; GO:0038092; P:nodal signaling pathway; ISO:MGI.
DR   GO; GO:0048570; P:notochord morphogenesis; IMP:MGI.
DR   GO; GO:0001649; P:osteoblast differentiation; IMP:BHF-UCL.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0007389; P:pattern specification process; IMP:MGI.
DR   GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0021983; P:pituitary gland development; IMP:MGI.
DR   GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL.
DR   GO; GO:0090193; P:positive regulation of glomerulus development; IDA:UniProtKB.
DR   GO; GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; IDA:MGI.
DR   GO; GO:0060513; P:prostatic bud formation; IMP:MGI.
DR   GO; GO:0030510; P:regulation of BMP signaling pathway; IMP:MGI.
DR   GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR   GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:MGI.
DR   GO; GO:1990926; P:short-term synaptic potentiation; IMP:MGI.
DR   GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR   GO; GO:0007224; P:smoothened signaling pathway; IGI:MGI.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; ISO:MGI.
DR   GO; GO:0061053; P:somite development; IMP:MGI.
DR   GO; GO:0042305; P:specification of segmental identity, mandibular segment; IGI:MGI.
DR   GO; GO:0021510; P:spinal cord development; IMP:MGI.
DR   GO; GO:0048863; P:stem cell differentiation; IMP:MGI.
DR   GO; GO:0001657; P:ureteric bud development; IDA:MGI.
DR   GO; GO:0060676; P:ureteric bud formation; IDA:UniProtKB.
DR   GO; GO:0001655; P:urogenital system development; IMP:MGI.
DR   GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0008542; P:visual learning; IMP:MGI.
DR   GO; GO:0042060; P:wound healing; IMP:BHF-UCL.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   Gene3D; 1.10.287.520; Helix hairpin bin; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR008717; Noggin.
DR   PANTHER; PTHR10494; BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN; 1.
DR   PANTHER; PTHR10494:SF5; NOGGIN; 1.
DR   Pfam; PF05806; Noggin; 1.
DR   PIRSF; PIRSF008129; Noggin; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   Genevisible; P97466; MM.
PE   2: Evidence at transcript level;
KW   Chondrogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..232
FT                   /note="Noggin"
FT                   /id="PRO_0000019814"
FT   REGION          77..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        155..192
FT                   /evidence="ECO:0000250"
FT   DISULFID        178..228
FT                   /evidence="ECO:0000250"
FT   DISULFID        184..230
FT                   /evidence="ECO:0000250"
FT   DISULFID        207..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   232 AA;  25770 MW;  0192AF6373B78B74 CRC64;
     MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD
     LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED LAELDQLLRQ RPSGAMPSEI
     KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS
     KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
//