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P97466

- NOGG_MOUSE

UniProt

P97466 - NOGG_MOUSE

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Protein
Noggin
Gene
Nog
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.1 Publication

GO - Biological processi

  1. BMP signaling pathway Source: MGI
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. axial mesoderm development Source: MGI
  4. axon guidance Source: MGI
  5. brain development Source: MGI
  6. cartilage development Source: UniProtKB-KW
  7. cell differentiation in hindbrain Source: Ensembl
  8. cellular response to BMP stimulus Source: MGI
  9. central nervous system development Source: MGI
  10. dorsal/ventral pattern formation Source: Ensembl
  11. embryonic digit morphogenesis Source: Ensembl
  12. embryonic skeletal joint morphogenesis Source: Ensembl
  13. endoderm formation Source: MGI
  14. epithelial to mesenchymal transition Source: BHF-UCL
  15. face morphogenesis Source: MGI
  16. fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: Ensembl
  17. in utero embryonic development Source: MGI
  18. lung morphogenesis Source: MGI
  19. mesenchymal cell differentiation Source: MGI
  20. mesoderm formation Source: MGI
  21. middle ear morphogenesis Source: Ensembl
  22. motor neuron axon guidance Source: MGI
  23. negative regulation of BMP signaling pathway Source: HGNC
  24. negative regulation of apoptotic signaling pathway Source: MGI
  25. negative regulation of astrocyte differentiation Source: BHF-UCL
  26. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  27. negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
  28. negative regulation of cartilage development Source: MGI
  29. negative regulation of cell migration Source: Ensembl
  30. negative regulation of cytokine activity Source: Ensembl
  31. negative regulation of gene expression Source: MGI
  32. negative regulation of osteoblast differentiation Source: Ensembl
  33. negative regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  34. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  35. neural plate morphogenesis Source: MGI
  36. neural tube closure Source: MGI
  37. neural tube development Source: MGI
  38. notochord morphogenesis Source: MGI
  39. osteoblast differentiation Source: BHF-UCL
  40. pattern specification process Source: MGI
  41. pituitary gland development Source: MGI
  42. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  43. positive regulation of epithelial cell proliferation Source: MGI
  44. positive regulation of glomerulus development Source: UniProtKB
  45. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  46. prostatic bud formation Source: MGI
  47. regulation of BMP signaling pathway Source: MGI
  48. regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: Ensembl
  49. skeletal system development Source: MGI
  50. somatic stem cell maintenance Source: Ensembl
  51. somite development Source: MGI
  52. spinal cord development Source: MGI
  53. ureteric bud development Source: MGI
  54. ureteric bud formation Source: UniProtKB
  55. urogenital system development Source: MGI
  56. wound healing Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin
Gene namesi
Name:Nog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104327. Nog.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 232205Noggin
PRO_0000019814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 192 By similarity
Disulfide bondi178 ↔ 228 By similarity
Disulfide bondi184 ↔ 230 By similarity
Disulfide bondi207 ↔ 215 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97466.

PTM databases

PhosphoSiteiP97466.

Expressioni

Tissue specificityi

Expressed in condensing cartilage and immature chondrocytes.

Developmental stagei

Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.

Gene expression databases

ArrayExpressiP97466.
BgeeiP97466.
CleanExiMM_NOG.
GenevestigatoriP97466.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

MINTiMINT-346913.

Structurei

3D structure databases

ProteinModelPortaliP97466.
SMRiP97466. Positions 28-232.

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42124.
GeneTreeiENSGT00390000006009.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiP97466.
KOiK04658.
OMAiRFWPRFV.
OrthoDBiEOG7XSTFS.
PhylomeDBiP97466.
TreeFamiTF353745.

Family and domain databases

Gene3Di2.10.90.10. 2 hits.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494. PTHR10494. 1 hit.
PfamiPF05806. Noggin. 1 hit.
[Graphical view]
PIRSFiPIRSF008129. Noggin. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97466-1 [UniParc]FASTAAdd to Basket

« Hide

MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP    50
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED 100
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW 150
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL 200
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC 232
Length:232
Mass (Da):25,770
Last modified:May 1, 1997 - v1
Checksum:i0192AF6373B78B74
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79163 Genomic DNA. Translation: AAB38281.1.
CCDSiCCDS25236.1.
RefSeqiNP_032737.1. NM_008711.2.
UniGeneiMm.135266.

Genome annotation databases

EnsembliENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneIDi18121.
KEGGimmu:18121.
UCSCiuc007kwh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79163 Genomic DNA. Translation: AAB38281.1 .
CCDSi CCDS25236.1.
RefSeqi NP_032737.1. NM_008711.2.
UniGenei Mm.135266.

3D structure databases

ProteinModelPortali P97466.
SMRi P97466. Positions 28-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-346913.

PTM databases

PhosphoSitei P97466.

Proteomic databases

PRIDEi P97466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061728 ; ENSMUSP00000061427 ; ENSMUSG00000048616 .
GeneIDi 18121.
KEGGi mmu:18121.
UCSCi uc007kwh.2. mouse.

Organism-specific databases

CTDi 9241.
MGIi MGI:104327. Nog.

Phylogenomic databases

eggNOGi NOG42124.
GeneTreei ENSGT00390000006009.
HOGENOMi HOG000089944.
HOVERGENi HBG006514.
InParanoidi P97466.
KOi K04658.
OMAi RFWPRFV.
OrthoDBi EOG7XSTFS.
PhylomeDBi P97466.
TreeFami TF353745.

Enzyme and pathway databases

Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

NextBioi 293336.
PROi P97466.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97466.
Bgeei P97466.
CleanExi MM_NOG.
Genevestigatori P97466.

Family and domain databases

Gene3Di 2.10.90.10. 2 hits.
InterProi IPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view ]
PANTHERi PTHR10494. PTHR10494. 1 hit.
Pfami PF05806. Noggin. 1 hit.
[Graphical view ]
PIRSFi PIRSF008129. Noggin. 1 hit.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite."
    McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P.
    Genes Dev. 12:1438-1452(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton."
    Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.
    Science 280:1455-1457(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNOGG_MOUSE
AccessioniPrimary (citable) accession number: P97466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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