P97466 (NOGG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Noggin

Gene names

Name:

Nog

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Ref.2
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed in condensing cartilage and immature chondrocytes.
Developmental stage	Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.
Involvement in disease	Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.
Sequence similarities	Belongs to the noggin family.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from direct assay PubMed 15110716. Source: MGI axial mesoderm development Inferred from mutant phenotype PubMed 16712836. Source: MGI cartilage development Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation in hindbrain Inferred from electronic annotation. Source: Compara cellular response to BMP stimulus Inferred from direct assay PubMed 20501701. Source: MGI dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal joint morphogenesis Inferred from electronic annotation. Source: Compara endoderm formation Inferred from direct assay PubMed 18462699. Source: MGI epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 17218603. Source: BHF-UCL face morphogenesis Inferred from mutant phenotype PubMed 16712836. Source: MGI fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from mutant phenotype PubMed 17359964. Source: MGI lung morphogenesis Inferred from mutant phenotype PubMed 16712836. Source: MGI mesoderm formation Inferred from direct assay PubMed 18462699. Source: MGI middle ear morphogenesis Inferred from electronic annotation. Source: Compara motor neuron axon guidance Inferred from mutant phenotype PubMed 12435358. Source: MGI negative regulation of BMP signaling pathway Inferred from direct assay PubMed 17400546. Source: HGNC negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16712836. Source: MGI negative regulation of astrocyte differentiation Inferred from mutant phenotype PubMed 18028109. Source: BHF-UCL negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle cell proliferation Inferred from mutant phenotype PubMed 17218603. Source: BHF-UCL negative regulation of cartilage development Inferred from direct assay PubMed 10684250. Source: MGI negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cytokine activity Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17360443. Source: MGI neural plate morphogenesis Inferred from mutant phenotype PubMed 16712836. Source: MGI neural tube closure Inferred from mutant phenotype PubMed 16712836. Source: MGI notochord morphogenesis Inferred from mutant phenotype PubMed 16916379. Source: MGI osteoblast differentiation Inferred from mutant phenotype PubMed 10780858. Source: BHF-UCL pattern specification process Inferred from mutant phenotype PubMed 12397106. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 17359964. Source: MGI positive regulation of branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 12141440PubMed 17522159. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 18028901. Source: MGI positive regulation of glomerulus development Inferred from direct assay PubMed 12141440. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17360443Ref.1. Source: MGI prostatic bud formation Inferred from mutant phenotype PubMed 18028901. Source: MGI regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Inferred from electronic annotation. Source: Compara skeletal system development Inferred from mutant phenotype PubMed 11784076. Source: MGI somatic stem cell maintenance Inferred from electronic annotation. Source: Compara somite development Inferred from mutant phenotype PubMed 16712836. Source: MGI spinal cord development Inferred from mutant phenotype PubMed 16712836. Source: MGI ureteric bud formation Inferred from direct assay PubMed 17522159. Source: UniProtKB wound healing Inferred from mutant phenotype PubMed 18028109. Source: BHF-UCL
Cellular_component	extracellular space Inferred from direct assay PubMed 15110716. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 232	205	Noggin		PRO_0000019814
Amino acid modifications
	Glycosylation	62	1	N-linked (GlcNAc...) Potential
	Disulfide bond	155 ↔ 192		By similarity
	Disulfide bond	178 ↔ 228		By similarity
	Disulfide bond	184 ↔ 230		By similarity
	Disulfide bond	207 ↔ 215		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97466 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0192AF6373B78B74	FASTA	232	25,770
	10 20 30 40 50 60 MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD 70 80 90 100 110 120 LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED LAELDQLLRQ RPSGAMPSEI 130 140 150 160 170 180 KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS 190 200 210 220 230 KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC

References

[1]	"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite." McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P. Genes Dev. 12:1438-1452(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton." Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M. Science 280:1455-1457(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79163 Genomic DNA. Translation: AAB38281.1.
IPI	IPI00125542.
RefSeq	NP_032737.1. NM_008711.2.
UniGene	Mm.135266.
3D structure databases
ProteinModelPortal	P97466.
SMR	P97466. Positions 28-232.
ModBase	Search...
PTM databases
PhosphoSite	P97466.
Proteomic databases
PRIDE	P97466.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneID	18121.
KEGG	mmu:18121.
Organism-specific databases
CTD	9241.
MGI	MGI:104327. Nog.
Phylogenomic databases
eggNOG	NOG42124.
GeneTree	ENSGT00390000006009.
HOGENOM	HOG000089944.
HOVERGEN	HBG006514.
InParanoid	P97466.
KO	K04658.
OMA	RFWPRFV.
OrthoDB	EOG4QNMX6.
Gene expression databases
ArrayExpress	P97466.
Bgee	P97466.
CleanEx	MM_NOG.
Genevestigator	P97466.
GermOnline	ENSMUSG00000048616. Mus musculus.
Family and domain databases
InterPro	IPR008717. Noggin. [Graphical view]
PANTHER	PTHR10494. PTHR10494. 1 hit.
Pfam	PF05806. Noggin. 1 hit. [Graphical view]
PIRSF	PIRSF008129. Noggin. 1 hit.
ProtoNet	Search...
Other
NextBio	293336.
SOURCE	Search...

Entry information

Entry name

NOGG_MOUSE

Accession

Primary (citable) accession number: P97466

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program