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Protein

Noggin

Gene

Nog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Inhibits chondrocyte differentiation through its interaction with GDF5 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • axial mesoderm development Source: MGI
  • axon guidance Source: MGI
  • BMP signaling pathway Source: MGI
  • brain development Source: MGI
  • cartilage development Source: UniProtKB-KW
  • cell differentiation in hindbrain Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • central nervous system development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • endoderm formation Source: MGI
  • epithelial to mesenchymal transition Source: BHF-UCL
  • face morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: MGI
  • in utero embryonic development Source: MGI
  • limb development Source: MGI
  • lung morphogenesis Source: MGI
  • mesenchymal cell differentiation Source: MGI
  • mesoderm formation Source: MGI
  • middle ear morphogenesis Source: MGI
  • motor neuron axon guidance Source: MGI
  • negative regulation of apoptotic signaling pathway Source: MGI
  • negative regulation of astrocyte differentiation Source: BHF-UCL
  • negative regulation of BMP signaling pathway Source: HGNC
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • negative regulation of cartilage development Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cytokine activity Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neural plate morphogenesis Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • notochord morphogenesis Source: MGI
  • osteoblast differentiation Source: BHF-UCL
  • pattern specification process Source: MGI
  • pituitary gland development Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of glomerulus development Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • prostatic bud formation Source: MGI
  • regulation of BMP signaling pathway Source: MGI
  • regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: MGI
  • regulation of neuron differentiation Source: Ensembl
  • skeletal system development Source: MGI
  • somatic stem cell maintenance Source: MGI
  • somite development Source: MGI
  • spinal cord development Source: MGI
  • ureteric bud development Source: MGI
  • ureteric bud formation Source: UniProtKB
  • urogenital system development Source: MGI
  • wound healing Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation

Enzyme and pathway databases

ReactomeiREACT_334226. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin
Gene namesi
Name:Nog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104327. Nog.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 232205NogginPRO_0000019814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi155 ↔ 192By similarity
Disulfide bondi178 ↔ 228By similarity
Disulfide bondi184 ↔ 230By similarity
Disulfide bondi207 ↔ 215By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP97466.

PTM databases

PhosphoSiteiP97466.

Expressioni

Tissue specificityi

Expressed in condensing cartilage and immature chondrocytes.

Developmental stagei

Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.

Gene expression databases

BgeeiP97466.
CleanExiMM_NOG.
ExpressionAtlasiP97466. baseline and differential.
GenevisibleiP97466. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.By similarity

Protein-protein interaction databases

MINTiMINT-346913.
STRINGi10090.ENSMUSP00000061427.

Structurei

3D structure databases

ProteinModelPortaliP97466.
SMRiP97466. Positions 28-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42124.
GeneTreeiENSGT00390000006009.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiP97466.
KOiK04658.
OMAiQQWLWAY.
OrthoDBiEOG7XSTFS.
PhylomeDBiP97466.
TreeFamiTF353745.

Family and domain databases

Gene3Di2.10.90.10. 2 hits.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494. PTHR10494. 1 hit.
PfamiPF05806. Noggin. 1 hit.
[Graphical view]
PIRSFiPIRSF008129. Noggin. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP
60 70 80 90 100
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED
110 120 130 140 150
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW
160 170 180 190 200
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL
210 220 230
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
Length:232
Mass (Da):25,770
Last modified:May 1, 1997 - v1
Checksum:i0192AF6373B78B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79163 Genomic DNA. Translation: AAB38281.1.
CCDSiCCDS25236.1.
RefSeqiNP_032737.1. NM_008711.2.
UniGeneiMm.135266.

Genome annotation databases

EnsembliENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneIDi18121.
KEGGimmu:18121.
UCSCiuc007kwh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79163 Genomic DNA. Translation: AAB38281.1.
CCDSiCCDS25236.1.
RefSeqiNP_032737.1. NM_008711.2.
UniGeneiMm.135266.

3D structure databases

ProteinModelPortaliP97466.
SMRiP97466. Positions 28-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-346913.
STRINGi10090.ENSMUSP00000061427.

PTM databases

PhosphoSiteiP97466.

Proteomic databases

PRIDEiP97466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneIDi18121.
KEGGimmu:18121.
UCSCiuc007kwh.2. mouse.

Organism-specific databases

CTDi9241.
MGIiMGI:104327. Nog.

Phylogenomic databases

eggNOGiNOG42124.
GeneTreeiENSGT00390000006009.
HOGENOMiHOG000089944.
HOVERGENiHBG006514.
InParanoidiP97466.
KOiK04658.
OMAiQQWLWAY.
OrthoDBiEOG7XSTFS.
PhylomeDBiP97466.
TreeFamiTF353745.

Enzyme and pathway databases

ReactomeiREACT_334226. Signaling by BMP.

Miscellaneous databases

NextBioi293336.
PROiP97466.
SOURCEiSearch...

Gene expression databases

BgeeiP97466.
CleanExiMM_NOG.
ExpressionAtlasiP97466. baseline and differential.
GenevisibleiP97466. MM.

Family and domain databases

Gene3Di2.10.90.10. 2 hits.
InterProiIPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
[Graphical view]
PANTHERiPTHR10494. PTHR10494. 1 hit.
PfamiPF05806. Noggin. 1 hit.
[Graphical view]
PIRSFiPIRSF008129. Noggin. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite."
    McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P.
    Genes Dev. 12:1438-1452(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton."
    Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.
    Science 280:1455-1457(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNOGG_MOUSE
AccessioniPrimary (citable) accession number: P97466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.