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Protein

Noggin

Gene

Nog

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  • axial mesoderm development Source: MGI
  • axon guidance Source: MGI
  • BMP signaling pathway Source: MGI
  • BMP signaling pathway involved in heart development Source: BHF-UCL
  • brain development Source: MGI
  • cartilage development Source: UniProtKB-KW
  • cell differentiation in hindbrain Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • central nervous system development Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • endocardial cushion morphogenesis Source: BHF-UCL
  • endoderm development Source: MGI
  • endoderm formation Source: MGI
  • epithelial to mesenchymal transition Source: BHF-UCL
  • face morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: MGI
  • heart trabecula morphogenesis Source: BHF-UCL
  • in utero embryonic development Source: MGI
  • limb development Source: MGI
  • lung morphogenesis Source: MGI
  • membranous septum morphogenesis Source: BHF-UCL
  • memory Source: MGI
  • mesenchymal cell differentiation Source: MGI
  • mesoderm formation Source: MGI
  • middle ear morphogenesis Source: MGI
  • motor neuron axon guidance Source: MGI
  • negative regulation of apoptotic signaling pathway Source: MGI
  • negative regulation of astrocyte differentiation Source: BHF-UCL
  • negative regulation of BMP signaling pathway Source: HGNC
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • negative regulation of cartilage development Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of cytokine activity Source: MGI
  • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  • negative regulation of gene expression Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neural plate morphogenesis Source: MGI
  • neural tube closure Source: MGI
  • neural tube development Source: MGI
  • notochord morphogenesis Source: MGI
  • osteoblast differentiation Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • pattern specification process Source: MGI
  • pharyngeal arch artery morphogenesis Source: BHF-UCL
  • pituitary gland development Source: MGI
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of gene expression Source: BHF-UCL
  • positive regulation of glomerulus development Source: UniProtKB
  • positive regulation of oligodendrocyte progenitor proliferation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • prostatic bud formation Source: MGI
  • regulation of BMP signaling pathway Source: MGI
  • regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: MGI
  • skeletal system development Source: MGI
  • somatic stem cell population maintenance Source: MGI
  • somite development Source: MGI
  • spinal cord development Source: MGI
  • ureteric bud development Source: MGI
  • ureteric bud formation Source: UniProtKB
  • urogenital system development Source: MGI
  • ventricular compact myocardium morphogenesis Source: BHF-UCL
  • ventricular septum morphogenesis Source: BHF-UCL
  • visual learning Source: MGI
  • wound healing Source: BHF-UCL

Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin2 Publications
Gene namesi
Name:Nog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104327 Nog

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001981428 – 232NogginAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 192By similarity
Disulfide bondi178 ↔ 228By similarity
Disulfide bondi184 ↔ 230By similarity
Disulfide bondi207 ↔ 215By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP97466
PRIDEiP97466

PTM databases

iPTMnetiP97466
PhosphoSitePlusiP97466

Expressioni

Tissue specificityi

Expressed in condensing cartilage and immature chondrocytes.1 Publication

Developmental stagei

Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000048616
CleanExiMM_NOG
ExpressionAtlasiP97466 baseline and differential
GenevisibleiP97466 MM

Interactioni

Subunit structurei

Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061427

Structurei

3D structure databases

ProteinModelPortaliP97466
SMRiP97466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIR6 Eukaryota
ENOG410Z62S LUCA
GeneTreeiENSGT00390000006009
HOGENOMiHOG000089944
HOVERGENiHBG006514
InParanoidiP97466
KOiK04658
OMAiRCTWIPI
OrthoDBiEOG091G0HWR
PhylomeDBiP97466
TreeFamiTF353745

Family and domain databases

Gene3Di2.10.90.10, 2 hits
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR008717 Noggin
PANTHERiPTHR10494 PTHR10494, 1 hit
PIRSFiPIRSF008129 Noggin, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP
60 70 80 90 100
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED
110 120 130 140 150
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW
160 170 180 190 200
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL
210 220 230
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
Length:232
Mass (Da):25,770
Last modified:May 1, 1997 - v1
Checksum:i0192AF6373B78B74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79163 Genomic DNA Translation: AAB38281.1
CCDSiCCDS25236.1
RefSeqiNP_032737.1, NM_008711.2
UniGeneiMm.135266

Genome annotation databases

EnsembliENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616
GeneIDi18121
KEGGimmu:18121
UCSCiuc007kwh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNOGG_MOUSE
AccessioniPrimary (citable) accession number: P97466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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