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P97466

- NOGG_MOUSE

UniProt

P97466 - NOGG_MOUSE

Protein

Noggin

Gene

Nog

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.1 Publication

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: MGI
    2. axial mesoderm development Source: MGI
    3. axon guidance Source: MGI
    4. BMP signaling pathway Source: MGI
    5. brain development Source: MGI
    6. cartilage development Source: UniProtKB-KW
    7. cell differentiation in hindbrain Source: Ensembl
    8. cellular response to BMP stimulus Source: MGI
    9. central nervous system development Source: MGI
    10. dorsal/ventral pattern formation Source: Ensembl
    11. embryonic digit morphogenesis Source: Ensembl
    12. embryonic skeletal joint morphogenesis Source: Ensembl
    13. endoderm formation Source: MGI
    14. epithelial to mesenchymal transition Source: BHF-UCL
    15. face morphogenesis Source: MGI
    16. fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: Ensembl
    17. in utero embryonic development Source: MGI
    18. lung morphogenesis Source: MGI
    19. mesenchymal cell differentiation Source: MGI
    20. mesoderm formation Source: MGI
    21. middle ear morphogenesis Source: Ensembl
    22. motor neuron axon guidance Source: MGI
    23. negative regulation of apoptotic signaling pathway Source: MGI
    24. negative regulation of astrocyte differentiation Source: BHF-UCL
    25. negative regulation of BMP signaling pathway Source: HGNC
    26. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    27. negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
    28. negative regulation of cartilage development Source: MGI
    29. negative regulation of cell migration Source: Ensembl
    30. negative regulation of cytokine activity Source: Ensembl
    31. negative regulation of gene expression Source: MGI
    32. negative regulation of osteoblast differentiation Source: Ensembl
    33. negative regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    34. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    35. neural plate morphogenesis Source: MGI
    36. neural tube closure Source: MGI
    37. neural tube development Source: MGI
    38. notochord morphogenesis Source: MGI
    39. osteoblast differentiation Source: BHF-UCL
    40. pattern specification process Source: MGI
    41. pituitary gland development Source: MGI
    42. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    43. positive regulation of epithelial cell proliferation Source: MGI
    44. positive regulation of glomerulus development Source: UniProtKB
    45. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    46. prostatic bud formation Source: MGI
    47. regulation of BMP signaling pathway Source: MGI
    48. regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Source: Ensembl
    49. skeletal system development Source: MGI
    50. somatic stem cell maintenance Source: Ensembl
    51. somite development Source: MGI
    52. spinal cord development Source: MGI
    53. ureteric bud development Source: MGI
    54. ureteric bud formation Source: UniProtKB
    55. urogenital system development Source: MGI
    56. wound healing Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_220505. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Noggin
    Gene namesi
    Name:Nog
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104327. Nog.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 232205NogginPRO_0000019814Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 192By similarity
    Disulfide bondi178 ↔ 228By similarity
    Disulfide bondi184 ↔ 230By similarity
    Disulfide bondi207 ↔ 215By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP97466.

    PTM databases

    PhosphoSiteiP97466.

    Expressioni

    Tissue specificityi

    Expressed in condensing cartilage and immature chondrocytes.

    Developmental stagei

    Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.

    Gene expression databases

    ArrayExpressiP97466.
    BgeeiP97466.
    CleanExiMM_NOG.
    GenevestigatoriP97466.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    MINTiMINT-346913.

    Structurei

    3D structure databases

    ProteinModelPortaliP97466.
    SMRiP97466. Positions 28-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the noggin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42124.
    GeneTreeiENSGT00390000006009.
    HOGENOMiHOG000089944.
    HOVERGENiHBG006514.
    InParanoidiP97466.
    KOiK04658.
    OMAiRFWPRFV.
    OrthoDBiEOG7XSTFS.
    PhylomeDBiP97466.
    TreeFamiTF353745.

    Family and domain databases

    Gene3Di2.10.90.10. 2 hits.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR008717. Noggin.
    [Graphical view]
    PANTHERiPTHR10494. PTHR10494. 1 hit.
    PfamiPF05806. Noggin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008129. Noggin. 1 hit.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97466-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP    50
    DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED 100
    LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW 150
    SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL 200
    TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC 232
    Length:232
    Mass (Da):25,770
    Last modified:May 1, 1997 - v1
    Checksum:i0192AF6373B78B74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79163 Genomic DNA. Translation: AAB38281.1.
    CCDSiCCDS25236.1.
    RefSeqiNP_032737.1. NM_008711.2.
    UniGeneiMm.135266.

    Genome annotation databases

    EnsembliENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
    GeneIDi18121.
    KEGGimmu:18121.
    UCSCiuc007kwh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79163 Genomic DNA. Translation: AAB38281.1 .
    CCDSi CCDS25236.1.
    RefSeqi NP_032737.1. NM_008711.2.
    UniGenei Mm.135266.

    3D structure databases

    ProteinModelPortali P97466.
    SMRi P97466. Positions 28-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-346913.

    PTM databases

    PhosphoSitei P97466.

    Proteomic databases

    PRIDEi P97466.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061728 ; ENSMUSP00000061427 ; ENSMUSG00000048616 .
    GeneIDi 18121.
    KEGGi mmu:18121.
    UCSCi uc007kwh.2. mouse.

    Organism-specific databases

    CTDi 9241.
    MGIi MGI:104327. Nog.

    Phylogenomic databases

    eggNOGi NOG42124.
    GeneTreei ENSGT00390000006009.
    HOGENOMi HOG000089944.
    HOVERGENi HBG006514.
    InParanoidi P97466.
    KOi K04658.
    OMAi RFWPRFV.
    OrthoDBi EOG7XSTFS.
    PhylomeDBi P97466.
    TreeFami TF353745.

    Enzyme and pathway databases

    Reactomei REACT_220505. Signaling by BMP.

    Miscellaneous databases

    NextBioi 293336.
    PROi P97466.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97466.
    Bgeei P97466.
    CleanExi MM_NOG.
    Genevestigatori P97466.

    Family and domain databases

    Gene3Di 2.10.90.10. 2 hits.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR008717. Noggin.
    [Graphical view ]
    PANTHERi PTHR10494. PTHR10494. 1 hit.
    Pfami PF05806. Noggin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008129. Noggin. 1 hit.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite."
      McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P.
      Genes Dev. 12:1438-1452(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton."
      Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.
      Science 280:1455-1457(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNOGG_MOUSE
    AccessioniPrimary (citable) accession number: P97466
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3