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P97466 (NOGG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Noggin
Gene names
Name:Nog
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Ref.2

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed in condensing cartilage and immature chondrocytes.

Developmental stage

Embryonic expression was first detected in the node at 7.5 dpc. By early somite stages, expression extends anteriorly along the entire length of the notochord and is expressed in the dorsal neural tube from the caudal hindbrain to the posterior-most region of the embryo. By the time cranial tube closure is completed expression is continuous along most of the dorsal midline of the neural tube, to its rostral termination at the base of the forebrain. Expression in the neural tube and caudal notochord remains unchanged during early organogenesis from 9.5 dpc to 10.5 dpc.

Involvement in disease

Defects in Nog are the cause of a recessive lethal phenotype at birth. Multiple defects include a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.

Sequence similarities

Belongs to the noggin family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 15110716. Source: MGI

anatomical structure formation involved in morphogenesis

Inferred from mutant phenotype PubMed 16916379. Source: MGI

axial mesoderm development

Inferred from mutant phenotype PubMed 16712836. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 12435358. Source: MGI

brain development

Inferred from mutant phenotype PubMed 12397106. Source: MGI

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation in hindbrain

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from direct assay PubMed 20501701. Source: MGI

central nervous system development

Inferred from mutant phenotype PubMed 10688202. Source: MGI

dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal joint morphogenesis

Inferred from electronic annotation. Source: Ensembl

endoderm formation

Inferred from direct assay PubMed 18462699. Source: MGI

epithelial to mesenchymal transition

Inferred from mutant phenotype PubMed 17218603. Source: BHF-UCL

face morphogenesis

Inferred from mutant phenotype PubMed 16712836. Source: MGI

fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

lung morphogenesis

Inferred from mutant phenotype PubMed 16712836. Source: MGI

mesenchymal cell differentiation

Inferred from mutant phenotype PubMed 18028901. Source: MGI

mesoderm formation

Inferred from direct assay PubMed 18462699. Source: MGI

middle ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

motor neuron axon guidance

Inferred from mutant phenotype PubMed 12435358. Source: MGI

negative regulation of BMP signaling pathway

Inferred from direct assay PubMed 17400546. Source: HGNC

negative regulation of apoptotic signaling pathway

Inferred from mutant phenotype PubMed 16712836. Source: MGI

negative regulation of astrocyte differentiation

Inferred from mutant phenotype PubMed 18028109. Source: BHF-UCL

negative regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cardiac muscle cell proliferation

Inferred from mutant phenotype PubMed 17218603. Source: BHF-UCL

negative regulation of cartilage development

Inferred from direct assay PubMed 10684250. Source: MGI

negative regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cytokine activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of pathway-restricted SMAD protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17360443. Source: MGI

neural plate morphogenesis

Inferred from mutant phenotype PubMed 16712836. Source: MGI

neural tube closure

Inferred from mutant phenotype PubMed 16712836. Source: MGI

neural tube development

Inferred from mutant phenotype Ref.1. Source: MGI

notochord morphogenesis

Inferred from mutant phenotype PubMed 16916379. Source: MGI

osteoblast differentiation

Inferred from mutant phenotype PubMed 10780858. Source: BHF-UCL

pattern specification process

Inferred from mutant phenotype PubMed 12397106. Source: MGI

pituitary gland development

Inferred from mutant phenotype PubMed 17359964. Source: MGI

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from direct assay PubMed 12141440PubMed 17522159. Source: UniProtKB

positive regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 18028901. Source: MGI

positive regulation of glomerulus development

Inferred from direct assay PubMed 12141440. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 17360443Ref.1. Source: MGI

prostatic bud formation

Inferred from mutant phenotype PubMed 18028901. Source: MGI

regulation of BMP signaling pathway

Inferred from mutant phenotype PubMed 17359964. Source: MGI

regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

Inferred from electronic annotation. Source: Ensembl

skeletal system development

Inferred from mutant phenotype PubMed 11784076. Source: MGI

somatic stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

somite development

Inferred from mutant phenotype PubMed 16712836. Source: MGI

spinal cord development

Inferred from mutant phenotype PubMed 16712836. Source: MGI

ureteric bud development

Inferred from direct assay PubMed 12141440. Source: MGI

ureteric bud formation

Inferred from direct assay PubMed 17522159. Source: UniProtKB

urogenital system development

Inferred from mutant phenotype PubMed 18028901. Source: MGI

wound healing

Inferred from mutant phenotype PubMed 18028109. Source: BHF-UCL

   Cellular_componentextracellular space

Inferred from direct assay PubMed 15110716. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 232205Noggin
PRO_0000019814

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Disulfide bond155 ↔ 192 By similarity
Disulfide bond178 ↔ 228 By similarity
Disulfide bond184 ↔ 230 By similarity
Disulfide bond207 ↔ 215 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97466 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0192AF6373B78B74

FASTA23225,770
        10         20         30         40         50         60 
MERCPSLGVT LYALVVVLGL RAAPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD 

        70         80         90        100        110        120 
LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGPAGGAED LAELDQLLRQ RPSGAMPSEI 

       130        140        150        160        170        180 
KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS 

       190        200        210        220        230 
KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC 

« Hide

References

[1]"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite."
McMahon J.A., Takada S., Zimmerman L.B., Fan C.-M., Harland R.M., McMahon A.P.
Genes Dev. 12:1438-1452(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton."
Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M.
Science 280:1455-1457(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79163 Genomic DNA. Translation: AAB38281.1.
RefSeqNP_032737.1. NM_008711.2.
UniGeneMm.135266.

3D structure databases

ProteinModelPortalP97466.
SMRP97466. Positions 28-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-346913.

PTM databases

PhosphoSiteP97466.

Proteomic databases

PRIDEP97466.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061728; ENSMUSP00000061427; ENSMUSG00000048616.
GeneID18121.
KEGGmmu:18121.
UCSCuc007kwh.2. mouse.

Organism-specific databases

CTD9241.
MGIMGI:104327. Nog.

Phylogenomic databases

eggNOGNOG42124.
GeneTreeENSGT00390000006009.
HOGENOMHOG000089944.
HOVERGENHBG006514.
InParanoidP97466.
KOK04658.
OMAAPGKKQR.
OrthoDBEOG7XSTFS.
PhylomeDBP97466.
TreeFamTF353745.

Gene expression databases

ArrayExpressP97466.
BgeeP97466.
CleanExMM_NOG.
GenevestigatorP97466.

Family and domain databases

InterProIPR008717. Noggin.
[Graphical view]
PANTHERPTHR10494. PTHR10494. 1 hit.
PfamPF05806. Noggin. 1 hit.
[Graphical view]
PIRSFPIRSF008129. Noggin. 1 hit.
ProtoNetSearch...

Other

NextBio293336.
PROP97466.
SOURCESearch...

Entry information

Entry nameNOGG_MOUSE
AccessionPrimary (citable) accession number: P97466
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot