P97463 (NRTN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurturin

Gene names

Name:

Nrtn

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted.
Tissue specificity	Widespread distribution.
Sequence similarities	Belongs to the TGF-beta family. GDNF subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	nerve development Inferred from mutant phenotype PubMed 10069332. Source: MGI neural crest cell migration Inferred from electronic annotation. Source: Compara neuron projection development Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from genetic interaction PubMed 9576965. Source: MGI
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	growth factor activity Inferred from direct assay PubMed 9576965. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 95	76	By similarity		PRO_0000034012
	Chain	96 – 195	100	Neurturin		PRO_0000034013
Amino acid modifications
	Disulfide bond	101 ↔ 163		By similarity
	Disulfide bond	128 ↔ 192		By similarity
	Disulfide bond	132 ↔ 194		By similarity
	Disulfide bond	162		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	P97463 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: ABE21BB35D417448	FASTA	195	22,219
	10 20 30 40 50 60 MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR IARLAQYRAL 70 80 90 100 110 120 LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP CGLRELEVRV SELGLGYTSD 130 140 150 160 170 180 ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR RVRRERARAH PCCRPTAYED EVSFLDVHSR 190 YHTLQELSAR ECACV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neurturin, a relative of glial-cell-line-derived neurotrophic factor." Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson E.M. Jr., Milbrandt J. Nature 384:467-470(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-110; 127-135; 155-177 AND 181-190.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78109 mRNA. Translation: AAC52954.1. BC057993 mRNA. Translation: AAH57993.1.
IPI	IPI00125527.
RefSeq	NP_032764.1. NM_008738.2.
UniGene	Mm.8074.
3D structure databases
ProteinModelPortal	P97463.
SMR	P97463. Positions 98-195.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000046512.
PTM databases
PhosphoSite	P97463.
Proteomic databases
PRIDE	P97463.
Protocols and materials databases
DNASU	18188.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
GeneID	18188.
KEGG	mmu:18188.
UCSC	uc008ddc.1. mouse.
Organism-specific databases
CTD	4902.
MGI	MGI:108417. Nrtn.
Phylogenomic databases
eggNOG	NOG42785.
GeneTree	ENSGT00520000055559.
HOGENOM	HOG000220877.
HOVERGEN	HBG003694.
InParanoid	P97463.
OMA	HTVHELS.
OrthoDB	EOG4JHCH2.
Gene expression databases
Bgee	P97463.
CleanEx	MM_NRTN.
Genevestigator	P97463.
GermOnline	ENSMUSG00000039481. Mus musculus.
Family and domain databases
InterPro	IPR001839. TGF-b_C. [Graphical view]
Pfam	PF00019. TGF_beta. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. False negative. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	293524.
SOURCE	Search...

Entry information

Entry name

NRTN_MOUSE

Accession

Primary (citable) accession number: P97463

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program