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Protein

Neurturin

Gene

Nrtn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

GO - Molecular functioni

  1. growth factor activity Source: MGI

GO - Biological processi

  1. nerve development Source: MGI
  2. neural crest cell migration Source: MGI
  3. neuron projection development Source: MGI
  4. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_319054. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurturin
Gene namesi
Name:Nrtn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:108417. Nrtn.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 9576By similarityPRO_0000034012Add
BLAST
Chaini96 – 195100NeurturinPRO_0000034013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi101 ↔ 163By similarity
Disulfide bondi128 ↔ 192By similarity
Disulfide bondi132 ↔ 194By similarity
Disulfide bondi162 – 162InterchainBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP97463.

PTM databases

PhosphoSiteiP97463.

Expressioni

Tissue specificityi

Widespread distribution.

Gene expression databases

BgeeiP97463.
CleanExiMM_NRTN.
GenevestigatoriP97463.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

BioGridi201850. 1 interaction.
STRINGi10090.ENSMUSP00000046512.

Structurei

3D structure databases

SMRiP97463. Positions 98-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42785.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG003694.
InParanoidiP97463.
OMAiDAHSRYH.
OrthoDBiEOG75XGNJ.
PhylomeDBiP97463.
TreeFamiTF332366.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR
60 70 80 90 100
IARLAQYRAL LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP
110 120 130 140 150
CGLRELEVRV SELGLGYTSD ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR
160 170 180 190
RVRRERARAH PCCRPTAYED EVSFLDVHSR YHTLQELSAR ECACV
Length:195
Mass (Da):22,219
Last modified:May 1, 1997 - v1
Checksum:iABE21BB35D417448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78109 mRNA. Translation: AAC52954.1.
BC057993 mRNA. Translation: AAH57993.1.
CCDSiCCDS28913.1.
RefSeqiNP_032764.1. NM_008738.2.
XP_006523864.1. XM_006523801.2.
UniGeneiMm.8074.

Genome annotation databases

EnsembliENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
GeneIDi18188.
KEGGimmu:18188.
UCSCiuc008ddc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78109 mRNA. Translation: AAC52954.1.
BC057993 mRNA. Translation: AAH57993.1.
CCDSiCCDS28913.1.
RefSeqiNP_032764.1. NM_008738.2.
XP_006523864.1. XM_006523801.2.
UniGeneiMm.8074.

3D structure databases

SMRiP97463. Positions 98-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201850. 1 interaction.
STRINGi10090.ENSMUSP00000046512.

PTM databases

PhosphoSiteiP97463.

Proteomic databases

PRIDEiP97463.

Protocols and materials databases

DNASUi18188.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
GeneIDi18188.
KEGGimmu:18188.
UCSCiuc008ddc.1. mouse.

Organism-specific databases

CTDi4902.
MGIiMGI:108417. Nrtn.

Phylogenomic databases

eggNOGiNOG42785.
GeneTreeiENSGT00520000055559.
HOGENOMiHOG000220877.
HOVERGENiHBG003694.
InParanoidiP97463.
OMAiDAHSRYH.
OrthoDBiEOG75XGNJ.
PhylomeDBiP97463.
TreeFamiTF332366.

Enzyme and pathway databases

ReactomeiREACT_319054. NCAM1 interactions.

Miscellaneous databases

NextBioi293524.
PROiP97463.
SOURCEiSearch...

Gene expression databases

BgeeiP97463.
CleanExiMM_NRTN.
GenevestigatoriP97463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
[Graphical view]
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neurturin, a relative of glial-cell-line-derived neurotrophic factor."
    Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson E.M. Jr., Milbrandt J.
    Nature 384:467-470(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-110; 127-135; 155-177 AND 181-190.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiNRTN_MOUSE
AccessioniPrimary (citable) accession number: P97463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 1, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.