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P97463

- NRTN_MOUSE

UniProt

P97463 - NRTN_MOUSE

Protein

Neurturin

Gene

Nrtn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

    GO - Molecular functioni

    1. growth factor activity Source: MGI

    GO - Biological processi

    1. nerve development Source: MGI
    2. neural crest cell migration Source: Ensembl
    3. neuron projection development Source: Ensembl
    4. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurturin
    Gene namesi
    Name:Nrtn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:108417. Nrtn.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 9576By similarityPRO_0000034012Add
    BLAST
    Chaini96 – 195100NeurturinPRO_0000034013Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi101 ↔ 163By similarity
    Disulfide bondi128 ↔ 192By similarity
    Disulfide bondi132 ↔ 194By similarity
    Disulfide bondi162 – 162InterchainBy similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP97463.

    PTM databases

    PhosphoSiteiP97463.

    Expressioni

    Tissue specificityi

    Widespread distribution.

    Gene expression databases

    BgeeiP97463.
    CleanExiMM_NRTN.
    GenevestigatoriP97463.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Protein-protein interaction databases

    BioGridi201850. 1 interaction.
    STRINGi10090.ENSMUSP00000046512.

    Structurei

    3D structure databases

    ProteinModelPortaliP97463.
    SMRiP97463. Positions 98-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family. GDNF subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42785.
    GeneTreeiENSGT00520000055559.
    HOGENOMiHOG000220877.
    HOVERGENiHBG003694.
    InParanoidiP97463.
    OMAiMCREGLL.
    OrthoDBiEOG75XGNJ.
    PhylomeDBiP97463.
    TreeFamiTF332366.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    [Graphical view]
    PfamiPF00019. TGF_beta. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97463-1 [UniParc]FASTAAdd to Basket

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    MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR    50
    IARLAQYRAL LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP 100
    CGLRELEVRV SELGLGYTSD ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR 150
    RVRRERARAH PCCRPTAYED EVSFLDVHSR YHTLQELSAR ECACV 195
    Length:195
    Mass (Da):22,219
    Last modified:May 1, 1997 - v1
    Checksum:iABE21BB35D417448
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78109 mRNA. Translation: AAC52954.1.
    BC057993 mRNA. Translation: AAH57993.1.
    CCDSiCCDS28913.1.
    RefSeqiNP_032764.1. NM_008738.2.
    XP_006523864.1. XM_006523801.1.
    UniGeneiMm.8074.

    Genome annotation databases

    EnsembliENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
    GeneIDi18188.
    KEGGimmu:18188.
    UCSCiuc008ddc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78109 mRNA. Translation: AAC52954.1 .
    BC057993 mRNA. Translation: AAH57993.1 .
    CCDSi CCDS28913.1.
    RefSeqi NP_032764.1. NM_008738.2.
    XP_006523864.1. XM_006523801.1.
    UniGenei Mm.8074.

    3D structure databases

    ProteinModelPortali P97463.
    SMRi P97463. Positions 98-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201850. 1 interaction.
    STRINGi 10090.ENSMUSP00000046512.

    PTM databases

    PhosphoSitei P97463.

    Proteomic databases

    PRIDEi P97463.

    Protocols and materials databases

    DNASUi 18188.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044752 ; ENSMUSP00000046512 ; ENSMUSG00000039481 .
    GeneIDi 18188.
    KEGGi mmu:18188.
    UCSCi uc008ddc.1. mouse.

    Organism-specific databases

    CTDi 4902.
    MGIi MGI:108417. Nrtn.

    Phylogenomic databases

    eggNOGi NOG42785.
    GeneTreei ENSGT00520000055559.
    HOGENOMi HOG000220877.
    HOVERGENi HBG003694.
    InParanoidi P97463.
    OMAi MCREGLL.
    OrthoDBi EOG75XGNJ.
    PhylomeDBi P97463.
    TreeFami TF332366.

    Miscellaneous databases

    NextBioi 293524.
    PROi P97463.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97463.
    CleanExi MM_NRTN.
    Genevestigatori P97463.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    [Graphical view ]
    Pfami PF00019. TGF_beta. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neurturin, a relative of glial-cell-line-derived neurotrophic factor."
      Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson E.M. Jr., Milbrandt J.
      Nature 384:467-470(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-110; 127-135; 155-177 AND 181-190.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiNRTN_MOUSE
    AccessioniPrimary (citable) accession number: P97463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3