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P97463 (NRTN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurturin
Gene names
Name:Nrtn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length195 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

Subunit structure

Homodimer; disulfide-linked.

Subcellular location

Secreted.

Tissue specificity

Widespread distribution.

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 9576 By similarity
PRO_0000034012
Chain96 – 195100Neurturin
PRO_0000034013

Amino acid modifications

Disulfide bond101 ↔ 163 By similarity
Disulfide bond128 ↔ 192 By similarity
Disulfide bond132 ↔ 194 By similarity
Disulfide bond162Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P97463 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: ABE21BB35D417448

FASTA19522,219
        10         20         30         40         50         60 
MRRWKAAALV SLICSSLLSV WMCQEGLLLG HRLGPALAPL RRPPRTLDAR IARLAQYRAL 

        70         80         90        100        110        120 
LQGAPDAVEL RELSPWAARI PGPRRRAGPR RRRARPGARP CGLRELEVRV SELGLGYTSD 

       130        140        150        160        170        180 
ETVLFRYCAG ACEAAIRIYD LGLRRLRQRR RVRRERARAH PCCRPTAYED EVSFLDVHSR 

       190 
YHTLQELSAR ECACV 

« Hide

References

« Hide 'large scale' references
[1]"Neurturin, a relative of glial-cell-line-derived neurotrophic factor."
Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson E.M. Jr., Milbrandt J.
Nature 384:467-470(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 96-110; 127-135; 155-177 AND 181-190.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78109 mRNA. Translation: AAC52954.1.
BC057993 mRNA. Translation: AAH57993.1.
RefSeqNP_032764.1. NM_008738.2.
XP_006523864.1. XM_006523801.1.
UniGeneMm.8074.

3D structure databases

ProteinModelPortalP97463.
SMRP97463. Positions 98-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201850. 1 interaction.
STRING10090.ENSMUSP00000046512.

PTM databases

PhosphoSiteP97463.

Proteomic databases

PRIDEP97463.

Protocols and materials databases

DNASU18188.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044752; ENSMUSP00000046512; ENSMUSG00000039481.
GeneID18188.
KEGGmmu:18188.
UCSCuc008ddc.1. mouse.

Organism-specific databases

CTD4902.
MGIMGI:108417. Nrtn.

Phylogenomic databases

eggNOGNOG42785.
GeneTreeENSGT00520000055559.
HOGENOMHOG000220877.
HOVERGENHBG003694.
InParanoidP97463.
OMAMCREGLL.
OrthoDBEOG75XGNJ.
PhylomeDBP97463.
TreeFamTF332366.

Gene expression databases

BgeeP97463.
CleanExMM_NRTN.
GenevestigatorP97463.

Family and domain databases

InterProIPR001839. TGF-b_C.
[Graphical view]
PfamPF00019. TGF_beta. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293524.
PROP97463.
SOURCESearch...

Entry information

Entry nameNRTN_MOUSE
AccessionPrimary (citable) accession number: P97463
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot