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Protein

Neuronal PAS domain-containing protein 1

Gene

Npas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.2 Publications

GO - Molecular functioni

GO - Biological processi

  • developmental process Source: GO_Central
  • maternal behavior Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • startle response Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 1
Short name:
Neuronal PAS1
Gene namesi
Name:Npas1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109205. Npas1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274051 – 594Neuronal PAS domain-containing protein 1Add BLAST594

Proteomic databases

PaxDbiP97459.
PRIDEiP97459.

PTM databases

PhosphoSitePlusiP97459.

Expressioni

Tissue specificityi

Expressed in brain in inhibitory interneurons. Also found in spinal cord.1 Publication

Developmental stagei

First detected between embryonic day 15 and day 16.

Gene expression databases

BgeeiENSMUSG00000001988.
CleanExiMM_NPAS1.
ExpressionAtlasiP97459. baseline and differential.
GenevisibleiP97459. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002053.

Structurei

Secondary structure

1594
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 71Combined sources19
Beta strandi72 – 74Combined sources3
Helixi76 – 79Combined sources4
Helixi84 – 102Combined sources19
Beta strandi103 – 106Combined sources4
Turni130 – 134Combined sources5
Helixi138 – 145Combined sources8
Beta strandi146 – 153Combined sources8
Beta strandi158 – 162Combined sources5
Helixi166 – 169Combined sources4
Helixi174 – 177Combined sources4
Helixi182 – 184Combined sources3
Helixi191 – 198Combined sources8
Beta strandi245 – 253Combined sources9
Beta strandi268 – 276Combined sources9
Beta strandi285 – 290Combined sources6
Beta strandi305 – 310Combined sources6
Beta strandi315 – 319Combined sources5
Helixi321 – 325Combined sources5
Helixi331 – 334Combined sources4
Helixi339 – 342Combined sources4
Turni345 – 347Combined sources3
Helixi348 – 361Combined sources14
Beta strandi362 – 365Combined sources4
Beta strandi368 – 372Combined sources5
Beta strandi374 – 376Combined sources3
Beta strandi378 – 387Combined sources10
Beta strandi399 – 405Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SY5X-ray3.20B/D/F43-423[»]
ProteinModelPortaliP97459.
SMRiP97459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 98bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini135 – 205PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini294 – 360PAS 2PROSITE-ProRule annotationAdd BLAST67
Domaini366 – 409PACAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi212 – 223Poly-SerAdd BLAST12

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000236298.
HOVERGENiHBG052655.
InParanoidiP97459.
KOiK09098.
OMAiVPWDFLP.
OrthoDBiEOG091G02J4.
PhylomeDBiP97459.
TreeFamiTF317772.

Family and domain databases

CDDicd00130. PAS. 2 hits.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.

Sequencei

Sequence statusi: Complete.

P97459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPYPRSGG RGEVKCGGGR GAGVPWDFLP GLMVKAPPGP CLQAQRKEKS
60 70 80 90 100
RNAARWRRGK ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF
110 120 130 140 150
AALGAPPWGL RAVGPPAGLA PGRRGPVALV SEVFEQHLGG HILQSLDGFV
160 170 180 190 200
FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYIHPGD HSEVLEQLGL
210 220 230 240 250
RAASIGPPTP PSVSSSSSSS SSSLVDTPEI EASPTEASPA FRAQERSFFV
260 270 280 290 300
RMKSTLTKRG LNVKASGYKV IHVTGRLRAR ALGLVALGHT LPPAPLAELP
310 320 330 340 350
LHGHMIVFRL SLGLTILACE SRVSDHMDMG PSELVGRSCY QFVHGQDATR
360 370 380 390 400
IRQSHLDLLD KGQVVTGYYR WLQRAGGFVW LQSVATVAGN GKSTGEHHVL
410 420 430 440 450
WVSHVLSNAE GSQTPLDAFQ LPAIVSQEEP SRPGPEPTEE EPPVDGKQAV
460 470 480 490 500
PADQDKDKDP QARGKRIKVE ASPKEARGSE DSGEEELSDP PAPPRPEFTS
510 520 530 540 550
VIRAGALKHD PVLPWGLTTP GDPSPALLHA GFLPPVVRGL CTPGTIRYGP
560 570 580 590
AELSLMYPHL HRLGAGPSLP EAFYPTLGLP YPGPTGTRVQ RKGD
Length:594
Mass (Da):63,737
Last modified:May 1, 1997 - v1
Checksum:iD6477696DF69A4B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77967 mRNA. Translation: AAB47247.1.
CCDSiCCDS20850.1.
RefSeqiNP_032744.1. NM_008718.2.
XP_017177510.1. XM_017322021.1.
UniGeneiMm.145821.

Genome annotation databases

EnsembliENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988.
ENSMUST00000210748; ENSMUSP00000147412; ENSMUSG00000001988.
GeneIDi18142.
KEGGimmu:18142.
UCSCiuc009fhv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77967 mRNA. Translation: AAB47247.1.
CCDSiCCDS20850.1.
RefSeqiNP_032744.1. NM_008718.2.
XP_017177510.1. XM_017322021.1.
UniGeneiMm.145821.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SY5X-ray3.20B/D/F43-423[»]
ProteinModelPortaliP97459.
SMRiP97459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002053.

PTM databases

PhosphoSitePlusiP97459.

Proteomic databases

PaxDbiP97459.
PRIDEiP97459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988.
ENSMUST00000210748; ENSMUSP00000147412; ENSMUSG00000001988.
GeneIDi18142.
KEGGimmu:18142.
UCSCiuc009fhv.2. mouse.

Organism-specific databases

CTDi4861.
MGIiMGI:109205. Npas1.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000236298.
HOVERGENiHBG052655.
InParanoidiP97459.
KOiK09098.
OMAiVPWDFLP.
OrthoDBiEOG091G02J4.
PhylomeDBiP97459.
TreeFamiTF317772.

Miscellaneous databases

PROiPR:P97459.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001988.
CleanExiMM_NPAS1.
ExpressionAtlasiP97459. baseline and differential.
GenevisibleiP97459. MM.

Family and domain databases

CDDicd00130. PAS. 2 hits.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPAS1_MOUSE
AccessioniPrimary (citable) accession number: P97459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: March 15, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.