Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal PAS domain-containing protein 1

Gene

Npas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.2 Publications

GO - Molecular functioni

GO - Biological processi

  • maternal behavior Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • startle response Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal PAS domain-containing protein 1
Short name:
Neuronal PAS1
Gene namesi
Name:Npas1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109205. Npas1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Neuronal PAS domain-containing protein 1PRO_0000127405Add
BLAST

Proteomic databases

MaxQBiP97459.
PaxDbiP97459.
PRIDEiP97459.

Expressioni

Tissue specificityi

Expressed in brain in inhibitory interneurons. Also found in spinal cord.1 Publication

Developmental stagei

First detected between embryonic day 15 and day 16.

Gene expression databases

BgeeiP97459.
CleanExiMM_NPAS1.
ExpressionAtlasiP97459. baseline.
GenevisibleiP97459. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002053.

Structurei

3D structure databases

ProteinModelPortaliP97459.
SMRiP97459. Positions 45-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 9854bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini135 – 20571PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 36067PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini366 – 40944PACAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi212 – 22312Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000236298.
HOVERGENiHBG052655.
InParanoidiP97459.
KOiK09098.
OMAiVPWDFLP.
OrthoDBiEOG718KBW.
PhylomeDBiP97459.
TreeFamiTF317772.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPYPRSGG RGEVKCGGGR GAGVPWDFLP GLMVKAPPGP CLQAQRKEKS
60 70 80 90 100
RNAARWRRGK ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF
110 120 130 140 150
AALGAPPWGL RAVGPPAGLA PGRRGPVALV SEVFEQHLGG HILQSLDGFV
160 170 180 190 200
FALNQEGKFL YISETVSIYL GLSQVELTGS SVFDYIHPGD HSEVLEQLGL
210 220 230 240 250
RAASIGPPTP PSVSSSSSSS SSSLVDTPEI EASPTEASPA FRAQERSFFV
260 270 280 290 300
RMKSTLTKRG LNVKASGYKV IHVTGRLRAR ALGLVALGHT LPPAPLAELP
310 320 330 340 350
LHGHMIVFRL SLGLTILACE SRVSDHMDMG PSELVGRSCY QFVHGQDATR
360 370 380 390 400
IRQSHLDLLD KGQVVTGYYR WLQRAGGFVW LQSVATVAGN GKSTGEHHVL
410 420 430 440 450
WVSHVLSNAE GSQTPLDAFQ LPAIVSQEEP SRPGPEPTEE EPPVDGKQAV
460 470 480 490 500
PADQDKDKDP QARGKRIKVE ASPKEARGSE DSGEEELSDP PAPPRPEFTS
510 520 530 540 550
VIRAGALKHD PVLPWGLTTP GDPSPALLHA GFLPPVVRGL CTPGTIRYGP
560 570 580 590
AELSLMYPHL HRLGAGPSLP EAFYPTLGLP YPGPTGTRVQ RKGD
Length:594
Mass (Da):63,737
Last modified:May 1, 1997 - v1
Checksum:iD6477696DF69A4B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77967 mRNA. Translation: AAB47247.1.
CCDSiCCDS20850.1.
RefSeqiNP_032744.1. NM_008718.2.
UniGeneiMm.145821.

Genome annotation databases

EnsembliENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988.
GeneIDi18142.
KEGGimmu:18142.
UCSCiuc009fhv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77967 mRNA. Translation: AAB47247.1.
CCDSiCCDS20850.1.
RefSeqiNP_032744.1. NM_008718.2.
UniGeneiMm.145821.

3D structure databases

ProteinModelPortaliP97459.
SMRiP97459. Positions 45-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002053.

Proteomic databases

MaxQBiP97459.
PaxDbiP97459.
PRIDEiP97459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002053; ENSMUSP00000002053; ENSMUSG00000001988.
GeneIDi18142.
KEGGimmu:18142.
UCSCiuc009fhv.2. mouse.

Organism-specific databases

CTDi4861.
MGIiMGI:109205. Npas1.

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000236298.
HOVERGENiHBG052655.
InParanoidiP97459.
KOiK09098.
OMAiVPWDFLP.
OrthoDBiEOG718KBW.
PhylomeDBiP97459.
TreeFamiTF317772.

Miscellaneous databases

PROiP97459.
SOURCEiSearch...

Gene expression databases

BgeeiP97459.
CleanExiMM_NPAS1.
ExpressionAtlasiP97459. baseline.
GenevisibleiP97459. MM.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR013655. PAS_fold_3.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
PF08447. PAS_3. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system."
    Zhou Y.-D., Barnard M., Tian H., Li X., Ring H.Z., Francke U., Shelton J., Richardson J., Russell D.W., McKnight S.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors."
    Erbel-Sieler C., Dudley C., Zhou Y., Wu X., Estill S.J., Han T., Diaz-Arrastia R., Brunskill E.W., Potter S.S., McKnight S.L.
    Proc. Natl. Acad. Sci. U.S.A. 101:13648-13653(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  3. "Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells."
    Ohsawa S., Hamada S., Kakinuma Y., Yagi T., Miura M.
    J. Neurosci. Res. 79:451-458(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARNT.

Entry informationi

Entry nameiNPAS1_MOUSE
AccessioniPrimary (citable) accession number: P97459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.