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P97458

- PROP1_MOUSE

UniProt

P97458 - PROP1_MOUSE

Protein

Homeobox protein prophet of Pit-1

Gene

Prop1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi66 – 12560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. beta-catenin binding Source: MGI
    2. chromatin binding Source: MGI
    3. protein binding Source: IntAct
    4. protein C-terminus binding Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. adenohypophysis development Source: MGI
    2. blood vessel development Source: MGI
    3. canonical Wnt signaling pathway Source: MGI
    4. cell migration Source: MGI
    5. dorsal/ventral pattern formation Source: MGI
    6. gland development Source: MGI
    7. hypophysis morphogenesis Source: MGI
    8. hypothalamus cell differentiation Source: MGI
    9. negative regulation of apoptotic process Source: MGI
    10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    11. organ morphogenesis Source: MGI
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. somatotropin secreting cell differentiation Source: MGI

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein prophet of Pit-1
    Short name:
    PROP-1
    Alternative name(s):
    Pituitary-specific homeodomain factor
    Gene namesi
    Name:Prop1
    Synonyms:Prop-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:109330. Prop1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi83 – 831S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication
    Mutagenesisi85 – 851F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Homeobox protein prophet of Pit-1PRO_0000049272Add
    BLAST

    Proteomic databases

    PRIDEiP97458.

    PTM databases

    PhosphoSiteiP97458.

    Expressioni

    Gene expression databases

    BgeeiP97458.
    CleanExiMM_PROP1.
    GenevestigatoriP97458.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ctnnb1Q022482EBI-937831,EBI-397872

    Protein-protein interaction databases

    BioGridi202394. 4 interactions.
    IntActiP97458. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP97458.
    SMRiP97458. Positions 68-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG293463.
    GeneTreeiENSGT00750000117223.
    HOVERGENiHBG053691.
    InParanoidiQ5NCG9.
    KOiK09327.
    OMAiHQSEDWY.
    OrthoDBiEOG7P8P9G.
    PhylomeDBiP97458.
    TreeFamiTF315976.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97458-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE    50
    LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA 100
    QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY 150
    PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT 200
    GHLPCPPPPP MFPLSLETPK SWN 223
    Length:223
    Mass (Da):25,025
    Last modified:May 1, 1997 - v1
    Checksum:iCD0AC4DFDC383679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77946 mRNA. Translation: AAB38884.1.
    AL627215 Genomic DNA. Translation: CAI35303.1.
    CCDSiCCDS24643.1.
    RefSeqiNP_032962.1. NM_008936.1.
    UniGeneiMm.1386.

    Genome annotation databases

    EnsembliENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542.
    GeneIDi19127.
    KEGGimmu:19127.
    UCSCiuc007itg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U77946 mRNA. Translation: AAB38884.1 .
    AL627215 Genomic DNA. Translation: CAI35303.1 .
    CCDSi CCDS24643.1.
    RefSeqi NP_032962.1. NM_008936.1.
    UniGenei Mm.1386.

    3D structure databases

    ProteinModelPortali P97458.
    SMRi P97458. Positions 68-125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202394. 4 interactions.
    IntActi P97458. 1 interaction.

    PTM databases

    PhosphoSitei P97458.

    Proteomic databases

    PRIDEi P97458.

    Protocols and materials databases

    DNASUi 19127.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051159 ; ENSMUSP00000057231 ; ENSMUSG00000044542 .
    GeneIDi 19127.
    KEGGi mmu:19127.
    UCSCi uc007itg.1. mouse.

    Organism-specific databases

    CTDi 5626.
    MGIi MGI:109330. Prop1.

    Phylogenomic databases

    eggNOGi NOG293463.
    GeneTreei ENSGT00750000117223.
    HOVERGENi HBG053691.
    InParanoidi Q5NCG9.
    KOi K09327.
    OMAi HQSEDWY.
    OrthoDBi EOG7P8P9G.
    PhylomeDBi P97458.
    TreeFami TF315976.

    Miscellaneous databases

    NextBioi 295738.
    PROi P97458.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97458.
    CleanExi MM_PROP1.
    Genevestigatori P97458.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism."
      Sornson M.W., Wu W., Dasen J.S., Flynn S.E., Norman D.J., O'Connell S.M., Gukovsky I., Carriere C., Ryan A.K., Miller A.P., Zuo L., Gleiberman A.S., Andersen B., Beamer W.G., Rosenfeld M.G.
      Nature 384:327-333(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1."
      Osorio M.G., Kopp P., Marui S., Latronico A.C., Mendonca B.B., Arnhold I.J.
      J. Clin. Endocrinol. Metab. 85:2779-2785(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF SER-83 AND PHE-85.

    Entry informationi

    Entry nameiPROP1_MOUSE
    AccessioniPrimary (citable) accession number: P97458
    Secondary accession number(s): Q5NCG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3