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Protein

Homeobox protein prophet of Pit-1

Gene

Prop1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 125HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • chromatin binding Source: MGI
  • protein C-terminus binding Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • adenohypophysis development Source: MGI
  • animal organ morphogenesis Source: MGI
  • blood vessel development Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell migration Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • gland development Source: MGI
  • hypophysis morphogenesis Source: MGI
  • hypothalamus cell differentiation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • somatotropin secreting cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein prophet of Pit-1
Short name:
PROP-1
Alternative name(s):
Pituitary-specific homeodomain factor
Gene namesi
Name:Prop1
Synonyms:Prop-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109330 Prop1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication1
Mutagenesisi85F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492721 – 223Homeobox protein prophet of Pit-1Add BLAST223

Proteomic databases

PaxDbiP97458
PRIDEiP97458

PTM databases

PhosphoSitePlusiP97458

Expressioni

Gene expression databases

BgeeiENSMUSG00000044542
CleanExiMM_PROP1
ExpressionAtlasiP97458 baseline
GenevisibleiP97458 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctnnb1Q022482EBI-937831,EBI-397872

GO - Molecular functioni

  • beta-catenin binding Source: MGI
  • protein C-terminus binding Source: MGI

Protein-protein interaction databases

BioGridi202394, 4 interactors
IntActiP97458, 1 interactor
STRINGi10090.ENSMUSP00000057231

Structurei

3D structure databases

ProteinModelPortaliP97458
SMRiP97458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00860000133740
HOVERGENiHBG053691
InParanoidiP97458
KOiK09327
OMAiTCFPHPY
OrthoDBiEOG091G0R1U
PhylomeDBiP97458
TreeFamiTF315976

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE
60 70 80 90 100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA
110 120 130 140 150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY
160 170 180 190 200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT
210 220
GHLPCPPPPP MFPLSLETPK SWN
Length:223
Mass (Da):25,025
Last modified:May 1, 1997 - v1
Checksum:iCD0AC4DFDC383679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77946 mRNA Translation: AAB38884.1
AL627215 Genomic DNA No translation available.
CCDSiCCDS24643.1
RefSeqiNP_032962.1, NM_008936.1
UniGeneiMm.1386

Genome annotation databases

EnsembliENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542
GeneIDi19127
KEGGimmu:19127
UCSCiuc007itg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPROP1_MOUSE
AccessioniPrimary (citable) accession number: P97458
Secondary accession number(s): Q5NCG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health