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P97458

- PROP1_MOUSE

UniProt

P97458 - PROP1_MOUSE

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Protein

Homeobox protein prophet of Pit-1

Gene

Prop1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi66 – 12560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. chromatin binding Source: MGI
  3. protein C-terminus binding Source: MGI
  4. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. adenohypophysis development Source: MGI
  2. blood vessel development Source: MGI
  3. canonical Wnt signaling pathway Source: MGI
  4. cell migration Source: MGI
  5. dorsal/ventral pattern formation Source: MGI
  6. gland development Source: MGI
  7. hypophysis morphogenesis Source: MGI
  8. hypothalamus cell differentiation Source: MGI
  9. negative regulation of apoptotic process Source: MGI
  10. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  11. organ morphogenesis Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. somatotropin secreting cell differentiation Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein prophet of Pit-1
Short name:
PROP-1
Alternative name(s):
Pituitary-specific homeodomain factor
Gene namesi
Name:Prop1
Synonyms:Prop-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:109330. Prop1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi83 – 831S → P: Shows very weak DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to 43% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication
Mutagenesisi85 – 851F → S: Shows no significant DNA binding to a Prop1 response element in gel shift assays; transcriptional activation of a luciferase reporter gene is reduced to approximately 34% compared with that of wild-type Prop1 in transiently transfected human embryonic kidney cells. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Homeobox protein prophet of Pit-1PRO_0000049272Add
BLAST

Proteomic databases

PRIDEiP97458.

PTM databases

PhosphoSiteiP97458.

Expressioni

Gene expression databases

BgeeiP97458.
CleanExiMM_PROP1.
ExpressionAtlasiP97458. baseline.
GenevestigatoriP97458.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ctnnb1Q022482EBI-937831,EBI-397872

Protein-protein interaction databases

BioGridi202394. 4 interactions.
IntActiP97458. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP97458.
SMRiP97458. Positions 68-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG293463.
GeneTreeiENSGT00760000119319.
HOVERGENiHBG053691.
InParanoidiP97458.
KOiK09327.
OMAiHQSEDWY.
OrthoDBiEOG7P8P9G.
PhylomeDBiP97458.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97458 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE
60 70 80 90 100
LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA
110 120 130 140 150
QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY
160 170 180 190 200
PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT
210 220
GHLPCPPPPP MFPLSLETPK SWN
Length:223
Mass (Da):25,025
Last modified:May 1, 1997 - v1
Checksum:iCD0AC4DFDC383679
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77946 mRNA. Translation: AAB38884.1.
AL627215 Genomic DNA. Translation: CAI35303.1.
CCDSiCCDS24643.1.
RefSeqiNP_032962.1. NM_008936.1.
UniGeneiMm.1386.

Genome annotation databases

EnsembliENSMUST00000051159; ENSMUSP00000057231; ENSMUSG00000044542.
GeneIDi19127.
KEGGimmu:19127.
UCSCiuc007itg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77946 mRNA. Translation: AAB38884.1 .
AL627215 Genomic DNA. Translation: CAI35303.1 .
CCDSi CCDS24643.1.
RefSeqi NP_032962.1. NM_008936.1.
UniGenei Mm.1386.

3D structure databases

ProteinModelPortali P97458.
SMRi P97458. Positions 68-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202394. 4 interactions.
IntActi P97458. 1 interaction.

PTM databases

PhosphoSitei P97458.

Proteomic databases

PRIDEi P97458.

Protocols and materials databases

DNASUi 19127.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051159 ; ENSMUSP00000057231 ; ENSMUSG00000044542 .
GeneIDi 19127.
KEGGi mmu:19127.
UCSCi uc007itg.1. mouse.

Organism-specific databases

CTDi 5626.
MGIi MGI:109330. Prop1.

Phylogenomic databases

eggNOGi NOG293463.
GeneTreei ENSGT00760000119319.
HOVERGENi HBG053691.
InParanoidi P97458.
KOi K09327.
OMAi HQSEDWY.
OrthoDBi EOG7P8P9G.
PhylomeDBi P97458.
TreeFami TF315976.

Miscellaneous databases

NextBioi 295738.
PROi P97458.
SOURCEi Search...

Gene expression databases

Bgeei P97458.
CleanExi MM_PROP1.
ExpressionAtlasi P97458. baseline.
Genevestigatori P97458.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism."
    Sornson M.W., Wu W., Dasen J.S., Flynn S.E., Norman D.J., O'Connell S.M., Gukovsky I., Carriere C., Ryan A.K., Miller A.P., Zuo L., Gleiberman A.S., Andersen B., Beamer W.G., Rosenfeld M.G.
    Nature 384:327-333(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1."
    Osorio M.G., Kopp P., Marui S., Latronico A.C., Mendonca B.B., Arnhold I.J.
    J. Clin. Endocrinol. Metab. 85:2779-2785(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF SER-83 AND PHE-85.

Entry informationi

Entry nameiPROP1_MOUSE
AccessioniPrimary (citable) accession number: P97458
Secondary accession number(s): Q5NCG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3