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Protein

Ribosome biogenesis protein BOP1

Gene

Bop1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation3 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • ribonucleoprotein complex binding Source: MGI

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB
  • ribosomal large subunit biogenesis Source: MGI
  • rRNA processing Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:Bop1
Synonyms:Kiaa0124
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1334460. Bop1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508861 – 732Ribosome biogenesis protein BOP1Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphotyrosineBy similarity1
Modified residuei112PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97452.
MaxQBiP97452.
PaxDbiP97452.
PeptideAtlasiP97452.
PRIDEiP97452.

PTM databases

iPTMnetiP97452.
PhosphoSitePlusiP97452.

Expressioni

Tissue specificityi

Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.

Inductioni

Expression in quiescent fibroblasts is induced by serum stimulation.1 Publication

Gene expression databases

BgeeiENSMUSG00000022557.
CleanExiMM_BOP1.
GenevisibleiP97452. MM.

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545, ECO:0000269|PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (By similarity).UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi198380. 2 interactors.
IntActiP97452. 1 interactor.
MINTiMINT-4089312.
STRINGi10090.ENSMUSP00000023217.

Structurei

3D structure databases

ProteinModelPortaliP97452.
SMRiP97452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati397 – 436WD 1Add BLAST40
Repeati438 – 478WD 2Add BLAST41
Repeati518 – 560WD 3Add BLAST43
Repeati563 – 601WD 4Add BLAST39
Repeati604 – 643WD 5Add BLAST40
Repeati647 – 686WD 6Add BLAST40
Repeati702 – 732WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni251 – 413Sufficient for nucleolar localizationAdd BLAST163

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
HOVERGENiHBG008113.
InParanoidiP97452.
KOiK14824.
OMAiRTVKDPQ.
OrthoDBiEOG091G0389.
PhylomeDBiP97452.
TreeFamiTF300437.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGACGKPHM SPASLPGKRR LEPDQELQIQ EPPLLSDPDS SLSDSEESVF
60 70 80 90 100
SGLEDLGSDS SEEDTEGVAG SSGDEDNHRA EETSEELAQA APLCSRTEEA
110 120 130 140 150
GALAQDEYEE DSSDEEDIRN TVGNVPLAWY DEFPHVGYDL DGKRIYKPLR
160 170 180 190 200
TRDELDQFLD KMDDPDFWRT VQDKMTGRDL RLTDEQVALV HRLQRGQFGD
210 220 230 240 250
SGFNPYEPAV DFFSGDIMIH PVTNRPADKR SFIPSLVEKE KVSRMVHAIK
260 270 280 290 300
MGWIKPRRPH DPTPSFYDLW AQEDPNAVLG RHKMHVPAPK LALPGHAESY
310 320 330 340 350
NPPPEYLPTE EERSAWMQQE PVERKLNFLP QKFPSLRTVP AYSRFIQERF
360 370 380 390 400
ERCLDLYLCP RQRKMRVNVD PEDLIPKLPR PRDLQPFPVC QALVYRGHSD
410 420 430 440 450
LVRCLSVSPG GQWLASGSDD GTLKLWEVAT ARCMKTVHVG GVVRSIAWNP
460 470 480 490 500
NPTICLVAAA MDDAVLLLNP ALGDRLLVGS TDQLLEAFTP PEEPALQPAR
510 520 530 540 550
WLEVSEEEHQ RGLRLRICHS KPVTQVTWHG RGDYLAVVLS SQEHTQVLLH
560 570 580 590 600
QVSRRRSQSP FRRSHGQVQC VAFHPSRPFL LVASQRSIRI YHLLRQELTK
610 620 630 640 650
KLMPNCKWVS SMAVHPAGDN IICGSYDSKL VWFDLDLSTK PYKVLRHHKK
660 670 680 690 700
ALRAVAFHPR YPLFASGSDD GSVIVCHGMV YNDLLQNPLL VPVKVLKGHT
710 720 730
LTRDLGVLDV AFHPTQPWVF SSGADGTIRL FS
Length:732
Mass (Da):82,546
Last modified:May 1, 1997 - v1
Checksum:i48939C86071A84A9
GO

Sequence cautioni

The sequence BAC97868 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56L → S in BAC97868 (PubMed:14621295).Curated1
Sequence conflicti56L → S in AAH12693 (PubMed:15489334).Curated1
Sequence conflicti234P → L in BAC97868 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77415 mRNA. Translation: AAB19223.1.
AK129058 mRNA. Translation: BAC97868.1. Different initiation.
AK079627 mRNA. Translation: BAC37708.1.
AK167110 mRNA. Translation: BAE39258.1.
BC012693 mRNA. Translation: AAH12693.1.
AF061503 Genomic DNA. Translation: AAC80429.1.
CCDSiCCDS27570.1.
RefSeqiNP_038509.1. NM_013481.1.
UniGeneiMm.4283.

Genome annotation databases

EnsembliENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557.
GeneIDi12181.
KEGGimmu:12181.
UCSCiuc007wkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77415 mRNA. Translation: AAB19223.1.
AK129058 mRNA. Translation: BAC97868.1. Different initiation.
AK079627 mRNA. Translation: BAC37708.1.
AK167110 mRNA. Translation: BAE39258.1.
BC012693 mRNA. Translation: AAH12693.1.
AF061503 Genomic DNA. Translation: AAC80429.1.
CCDSiCCDS27570.1.
RefSeqiNP_038509.1. NM_013481.1.
UniGeneiMm.4283.

3D structure databases

ProteinModelPortaliP97452.
SMRiP97452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198380. 2 interactors.
IntActiP97452. 1 interactor.
MINTiMINT-4089312.
STRINGi10090.ENSMUSP00000023217.

PTM databases

iPTMnetiP97452.
PhosphoSitePlusiP97452.

Proteomic databases

EPDiP97452.
MaxQBiP97452.
PaxDbiP97452.
PeptideAtlasiP97452.
PRIDEiP97452.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023217; ENSMUSP00000023217; ENSMUSG00000022557.
GeneIDi12181.
KEGGimmu:12181.
UCSCiuc007wkf.1. mouse.

Organism-specific databases

CTDi23246.
MGIiMGI:1334460. Bop1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
HOVERGENiHBG008113.
InParanoidiP97452.
KOiK14824.
OMAiRTVKDPQ.
OrthoDBiEOG091G0389.
PhylomeDBiP97452.
TreeFamiTF300437.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiBop1. mouse.
PROiP97452.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022557.
CleanExiMM_BOP1.
GenevisibleiP97452. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBOP1_MOUSE
AccessioniPrimary (citable) accession number: P97452
Secondary accession number(s): Q3TK87, Q6ZQI9, Q91X31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.