Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase-coupling factor 6, mitochondrial

Gene

Atp5j

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase-coupling factor 6, mitochondrial
Short name:
ATPase subunit F6
Gene namesi
Name:Atp5j
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107777 Atp5j

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionBy similarityAdd BLAST32
ChainiPRO_000000252933 – 108ATP synthase-coupling factor 6, mitochondrialAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-acetyllysineCombined sources1
Modified residuei46N6-acetyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei84N6-acetyllysine; alternateCombined sources1
Modified residuei84N6-succinyllysine; alternateCombined sources1
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateCombined sources1
Modified residuei99N6-acetyllysine; alternateCombined sources1
Modified residuei99N6-succinyllysine; alternateCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei108PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP97450
MaxQBiP97450
PaxDbiP97450
PeptideAtlasiP97450
PRIDEiP97450

2D gel databases

SWISS-2DPAGEP97450

PTM databases

iPTMnetiP97450
PhosphoSitePlusiP97450

Expressioni

Gene expression databases

BgeeiENSMUSG00000022890
ExpressionAtlasiP97450 baseline and differential
GenevisibleiP97450 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

IntActiP97450, 2 interactors
MINTiP97450
STRINGi10090.ENSMUSP00000023608

Structurei

3D structure databases

ProteinModelPortaliP97450
SMRiP97450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4634 Eukaryota
ENOG41122G1 LUCA
GeneTreeiENSGT00390000008902
HOGENOMiHOG000261672
HOVERGENiHBG062261
InParanoidiP97450
KOiK02131
OMAiYKQKSSG
OrthoDBiEOG091G10KV
PhylomeDBiP97450
TreeFamiTF318998

Family and domain databases

InterProiView protein in InterPro
IPR008387 ATP_synth_f6_mt
IPR036204 ATP_synth_f6_sf_mt
PANTHERiPTHR12441 PTHR12441, 1 hit
PfamiView protein in Pfam
PF05511 ATP-synt_F6, 1 hit
PIRSFiPIRSF002455 ATP_synthase_coupling_factor_6, 1 hit
SUPFAMiSSF111357 SSF111357, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLQRIFRLS SVLRSAVSVH LKRNIGVTAV AFNKELDPVQ KLFVDKIREY
60 70 80 90 100
KSKRQASGGP VDIGPEYQQD LDRELYKLKQ MYGKGEMDTF PTFKFDDPKF

EVIDKPQS
Length:108
Mass (Da):12,496
Last modified:May 1, 1997 - v1
Checksum:iE2A2E63F7F23CEBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77128 mRNA Translation: AAB19213.1
AK078484 mRNA Translation: BAC37301.1
BC010766 mRNA Translation: AAH10766.1
CCDSiCCDS28283.1
PIRiPD0444
RefSeqiNP_001289142.1, NM_001302213.1
NP_001289143.1, NM_001302214.1
NP_001289144.1, NM_001302215.1
NP_001289145.1, NM_001302216.1
NP_058035.1, NM_016755.3
XP_006522939.1, XM_006522876.2
XP_006522940.1, XM_006522877.3
XP_011244394.1, XM_011246092.2
UniGeneiMm.353

Genome annotation databases

EnsembliENSMUST00000023608; ENSMUSP00000023608; ENSMUSG00000022890
ENSMUST00000114191; ENSMUSP00000109829; ENSMUSG00000022890
ENSMUST00000114193; ENSMUSP00000109831; ENSMUSG00000022890
GeneIDi11957
KEGGimmu:11957
UCSCiuc007zth.2 mouse

Similar proteinsi

Entry informationi

Entry nameiATP5J_MOUSE
AccessioniPrimary (citable) accession number: P97450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health