Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase-coupling factor 6, mitochondrial

Gene

Atp5j

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase-coupling factor 6, mitochondrial
Short name:
ATPase subunit F6
Gene namesi
Name:Atp5j
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107777. Atp5j.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Chaini33 – 10876ATP synthase-coupling factor 6, mitochondrialPRO_0000002529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411N6-acetyllysineCombined sources
Modified residuei46 – 461N6-acetyllysineCombined sources
Modified residuei79 – 791N6-acetyllysineCombined sources
Modified residuei84 – 841N6-acetyllysine; alternateCombined sources
Modified residuei84 – 841N6-succinyllysine; alternateCombined sources
Modified residuei94 – 941N6-acetyllysine; alternateCombined sources
Modified residuei94 – 941N6-succinyllysine; alternateCombined sources
Modified residuei99 – 991N6-acetyllysine; alternateCombined sources
Modified residuei99 – 991N6-succinyllysine; alternateCombined sources
Modified residuei105 – 1051N6-acetyllysineCombined sources
Modified residuei108 – 1081PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP97450.
MaxQBiP97450.
PaxDbiP97450.
PeptideAtlasiP97450.
PRIDEiP97450.

2D gel databases

SWISS-2DPAGEP97450.

PTM databases

iPTMnetiP97450.
PhosphoSiteiP97450.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022890.
ExpressionAtlasiP97450. baseline and differential.
GenevisibleiP97450. MM.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

IntActiP97450. 2 interactions.
MINTiMINT-1843958.
STRINGi10090.ENSMUSP00000023608.

Structurei

3D structure databases

ProteinModelPortaliP97450.
SMRiP97450. Positions 36-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4634. Eukaryota.
ENOG41122G1. LUCA.
GeneTreeiENSGT00390000008902.
HOGENOMiHOG000261672.
HOVERGENiHBG062261.
InParanoidiP97450.
KOiK02131.
OMAiYKQKSSG.
OrthoDBiEOG091G10KV.
PhylomeDBiP97450.
TreeFamiTF318998.

Family and domain databases

InterProiIPR008387. ATPase_F0-cplx_f6su_mt.
IPR016349. ATPase_F0-cplx_f6su_mt_subgr.
[Graphical view]
PfamiPF05511. ATP-synt_F6. 1 hit.
[Graphical view]
PIRSFiPIRSF002455. ATP_synthase_coupling_factor_6. 1 hit.
SUPFAMiSSF111357. SSF111357. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLQRIFRLS SVLRSAVSVH LKRNIGVTAV AFNKELDPVQ KLFVDKIREY
60 70 80 90 100
KSKRQASGGP VDIGPEYQQD LDRELYKLKQ MYGKGEMDTF PTFKFDDPKF

EVIDKPQS
Length:108
Mass (Da):12,496
Last modified:May 1, 1997 - v1
Checksum:iE2A2E63F7F23CEBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77128 mRNA. Translation: AAB19213.1.
AK078484 mRNA. Translation: BAC37301.1.
BC010766 mRNA. Translation: AAH10766.1.
CCDSiCCDS28283.1.
PIRiPD0444.
RefSeqiNP_001289142.1. NM_001302213.1.
NP_001289143.1. NM_001302214.1.
NP_001289144.1. NM_001302215.1.
NP_001289145.1. NM_001302216.1.
NP_058035.1. NM_016755.3.
XP_006522939.1. XM_006522876.1.
XP_006522940.1. XM_006522877.2.
XP_011244394.1. XM_011246092.1.
UniGeneiMm.353.

Genome annotation databases

EnsembliENSMUST00000023608; ENSMUSP00000023608; ENSMUSG00000022890.
ENSMUST00000114191; ENSMUSP00000109829; ENSMUSG00000022890.
ENSMUST00000114193; ENSMUSP00000109831; ENSMUSG00000022890.
GeneIDi11957.
KEGGimmu:11957.
UCSCiuc007zth.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77128 mRNA. Translation: AAB19213.1.
AK078484 mRNA. Translation: BAC37301.1.
BC010766 mRNA. Translation: AAH10766.1.
CCDSiCCDS28283.1.
PIRiPD0444.
RefSeqiNP_001289142.1. NM_001302213.1.
NP_001289143.1. NM_001302214.1.
NP_001289144.1. NM_001302215.1.
NP_001289145.1. NM_001302216.1.
NP_058035.1. NM_016755.3.
XP_006522939.1. XM_006522876.1.
XP_006522940.1. XM_006522877.2.
XP_011244394.1. XM_011246092.1.
UniGeneiMm.353.

3D structure databases

ProteinModelPortaliP97450.
SMRiP97450. Positions 36-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97450. 2 interactions.
MINTiMINT-1843958.
STRINGi10090.ENSMUSP00000023608.

PTM databases

iPTMnetiP97450.
PhosphoSiteiP97450.

2D gel databases

SWISS-2DPAGEP97450.

Proteomic databases

EPDiP97450.
MaxQBiP97450.
PaxDbiP97450.
PeptideAtlasiP97450.
PRIDEiP97450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023608; ENSMUSP00000023608; ENSMUSG00000022890.
ENSMUST00000114191; ENSMUSP00000109829; ENSMUSG00000022890.
ENSMUST00000114193; ENSMUSP00000109831; ENSMUSG00000022890.
GeneIDi11957.
KEGGimmu:11957.
UCSCiuc007zth.2. mouse.

Organism-specific databases

CTDi522.
MGIiMGI:107777. Atp5j.

Phylogenomic databases

eggNOGiKOG4634. Eukaryota.
ENOG41122G1. LUCA.
GeneTreeiENSGT00390000008902.
HOGENOMiHOG000261672.
HOVERGENiHBG062261.
InParanoidiP97450.
KOiK02131.
OMAiYKQKSSG.
OrthoDBiEOG091G10KV.
PhylomeDBiP97450.
TreeFamiTF318998.

Enzyme and pathway databases

ReactomeiR-MMU-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

ChiTaRSiAtp5j. mouse.
PROiP97450.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022890.
ExpressionAtlasiP97450. baseline and differential.
GenevisibleiP97450. MM.

Family and domain databases

InterProiIPR008387. ATPase_F0-cplx_f6su_mt.
IPR016349. ATPase_F0-cplx_f6su_mt_subgr.
[Graphical view]
PfamiPF05511. ATP-synt_F6. 1 hit.
[Graphical view]
PIRSFiPIRSF002455. ATP_synthase_coupling_factor_6. 1 hit.
SUPFAMiSSF111357. SSF111357. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5J_MOUSE
AccessioniPrimary (citable) accession number: P97450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.