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P97445

- CAC1A_MOUSE

UniProt

P97445 - CAC1A_MOUSE

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Protein
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Gene
Cacna1a, Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei320 – 3201Calcium ion selectivity and permeability By similarity
Sitei670 – 6701Calcium ion selectivity and permeability By similarity
Sitei1411 – 14111Calcium ion selectivity and permeability By similarity
Sitei1600 – 16001Binds to omega-Aga-IVA By similarity
Sitei1707 – 17071Calcium ion selectivity and permeability By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi1791 – 180212 By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. high voltage-gated calcium channel activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: MGI
  5. voltage-gated calcium channel activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. behavioral response to pain Source: MGI
  3. calcium ion import Source: RefGenome
  4. calcium ion transport Source: MGI
  5. calcium ion-dependent exocytosis Source: MGI
  6. calcium ion-dependent exocytosis of neurotransmitter Source: MGI
  7. cell death Source: Ensembl
  8. cell growth Source: MGI
  9. cellular chloride ion homeostasis Source: MGI
  10. central nervous system neuron differentiation Source: MGI
  11. cerebellar Purkinje cell differentiation Source: MGI
  12. cerebellar Purkinje cell layer development Source: MGI
  13. cerebellar molecular layer development Source: MGI
  14. cerebellum maturation Source: MGI
  15. dendrite morphogenesis Source: MGI
  16. gamma-aminobutyric acid secretion Source: MGI
  17. gamma-aminobutyric acid signaling pathway Source: MGI
  18. glucose metabolic process Source: MGI
  19. hormone metabolic process Source: MGI
  20. membrane depolarization Source: MGI
  21. membrane depolarization during action potential Source: RefGenome
  22. musculoskeletal movement, spinal reflex action Source: MGI
  23. negative regulation of hormone biosynthetic process Source: MGI
  24. negative regulation of neuron apoptotic process Source: MGI
  25. neurological system process Source: MGI
  26. neuromuscular process Source: MGI
  27. neuromuscular process controlling balance Source: MGI
  28. neuromuscular synaptic transmission Source: MGI
  29. neuron-neuron synaptic transmission Source: MGI
  30. neurotransmitter metabolic process Source: MGI
  31. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  32. receptor clustering Source: MGI
  33. regulation of acetylcholine secretion, neurotransmission Source: MGI
  34. regulation of axonogenesis Source: MGI
  35. regulation of calcium ion-dependent exocytosis Source: MGI
  36. regulation of membrane potential Source: MGI
  37. response to pain Source: MGI
  38. rhythmic synaptic transmission Source: MGI
  39. spinal cord motor neuron differentiation Source: MGI
  40. sulfur amino acid metabolic process Source: MGI
  41. synapse assembly Source: MGI
  42. synaptic transmission Source: MGI
  43. synaptic transmission, glutamatergic Source: MGI
  44. transmission of nerve impulse Source: MGI
  45. vestibular nucleus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Alternative name(s):
Brain calcium channel I
Short name:
BI
Calcium channel, L type, alpha-1 polypeptide isoform 4
Voltage-gated calcium channel subunit alpha Cav2.1
Gene namesi
Name:Cacna1a
Synonyms:Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109482. Cacna1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 100100Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei101 – 11919Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini120 – 13819Extracellular Reviewed prediction
Add
BLAST
Transmembranei139 – 15618Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini157 – 16812Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei169 – 18416Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini185 – 1928Extracellular Reviewed prediction
Transmembranei193 – 21119Helical; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini212 – 23019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei231 – 25020Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini251 – 33787Extracellular Reviewed prediction
Add
BLAST
Transmembranei338 – 36225Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Topological domaini363 – 489127Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei490 – 50920Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini510 – 52314Extracellular Reviewed prediction
Add
BLAST
Transmembranei524 – 54320Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini544 – 5518Cytoplasmic Reviewed prediction
Transmembranei552 – 57019Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini571 – 58010Extracellular Reviewed prediction
Transmembranei581 – 59919Helical; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini600 – 61819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei619 – 63820Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini639 – 69153Extracellular Reviewed prediction
Add
BLAST
Transmembranei692 – 71625Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Topological domaini717 – 1190474Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1191 – 121424Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1215 – 123117Extracellular Reviewed prediction
Add
BLAST
Transmembranei1232 – 125120Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1252 – 12587Cytoplasmic Reviewed prediction
Transmembranei1259 – 128224Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1283 – 129311Extracellular Reviewed prediction
Add
BLAST
Transmembranei1294 – 131118Helical; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1312 – 133019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1331 – 135020Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1351 – 143787Extracellular Reviewed prediction
Add
BLAST
Transmembranei1438 – 146225Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Topological domaini1463 – 151856Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1519 – 153719Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1538 – 155114Extracellular Reviewed prediction
Add
BLAST
Transmembranei1552 – 157322Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1574 – 15807Cytoplasmic Reviewed prediction
Transmembranei1581 – 160020Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1601 – 16077Extracellular Reviewed prediction
Transmembranei1608 – 162619Helical; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1627 – 164519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1646 – 166520Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1666 – 173772Extracellular Reviewed prediction
Add
BLAST
Transmembranei1738 – 176326Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST
Topological domaini1764 – 2368605Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. dendrite Source: MGI
  3. neuronal cell body Source: MGI
  4. nucleus Source: Ensembl
  5. voltage-gated calcium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Cacna1a are the cause of a delayed-onset, recessive neurological disorder seen in tottering (tg) mutants, resulting in ataxia, motor seizures and behavioral absence seizures resembling petit mal epilepsy (or absence epilepsy) in humans. There are two more alleles: leaner (tg(lA)), that is characterized by severe ataxia and frequent death past weaning, but no motor seizures; and rolling Nagoya (tg(rol)), that presents an intermediary phenotype, the ataxia being somewhat more severe that with tg, but without motors seizures. Selective degeneration of cerebellar Purkinje cells has been shown for all these types of mutants.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23682368Voltage-dependent P/Q-type calcium channel subunit alpha-1A
PRO_0000053917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi285 – 2851N-linked (GlcNAc...) Reviewed prediction
Modified residuei792 – 7921Phosphoserine1 Publication
Glycosylationi1607 – 16071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP97445.
PaxDbiP97445.
PRIDEiP97445.

PTM databases

PhosphoSiteiP97445.

Expressioni

Tissue specificityi

Brain specific; mainly found in the cerebellum, olfactory bulb, cerebral cortex, hippocampus, and inferior colliculus. In the hippocampus, expression occurs in pyramidal and granule neurons, as well as in interneurons. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.

Gene expression databases

ArrayExpressiP97445.
BgeeiP97445.
GenevestigatoriP97445.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CABP1 By similarity.

Protein-protein interaction databases

BioGridi198430. 4 interactions.
IntActiP97445. 1 interaction.
MINTiMINT-4997013.

Structurei

3D structure databases

ProteinModelPortaliP97445.
SMRiP97445. Positions 102-412, 491-742, 1191-1462, 1509-1763, 1846-1923.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati65 – 365301I
Add
BLAST
Repeati475 – 719245II
Add
BLAST
Repeati1182 – 1465284III
Add
BLAST
Repeati1502 – 1765264IV
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni385 – 40218Binding to the beta subunit By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi729 – 7346Poly-Glu
Compositional biasi1155 – 11584Poly-Glu

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00750000117449.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.
InParanoidiP97445.
KOiK04344.
OMAiQPGFWEG.
OrthoDBiEOG7T1RBQ.
PhylomeDBiP97445.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005448. VDCC_P/Q_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF59. PTHR10037:SF59. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01632. PQVDCCALPHA1.
SMARTiSM00384. AT_hook. 1 hit.
SM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97445-1 [UniParc]FASTAAdd to Basket

« Hide

MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY     50
KQSMAQRART MALYNPIPVR QNCLTVNRSL FLFSEDNVVR KYAKKITEWP 100
PFEYMILATI IANCIVLALE QHLPDDDKTP MSERLDDTEP YFIGIFCFEA 150
GIKIVALGFA FHKGSYLRNG WNVMDFVVVL TGILATVGTE FDLRTLRAVR 200
VLRPLKLVSG IPSLQVVLKS IMKAMIPLLQ IGLLLFFAIL IFAIIGLEFY 250
MGKFHTTCFE EGTDDIQGES PAPCGTEEPA RTCPNGTKCQ PYWEGPNNGI 300
TQFDNILFAV LTVFQCITME GWTDLLYNSN DASGNTWNWL YFIPLIIIGS 350
FFMLNLVLGV LSGEFAKERE RVENRRAFLK LRRQQQIERE LNGYMEWISK 400
AEEVILAEDE TDVEQRHPFD GALRRATLKK SKTDLLNPEE AEDQLADIAS 450
VGSPFARASI KSAKLENSTF FHKKERRMRF YIRRMVKTQA FYWTVLSLVA 500
LNTLCVAIVH YNQPEWLSDF LYYAEFIFLG LFMSEMFIKM YGLGTRPYFH 550
SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG ISVLRALRLL RIFKVTKYWA 600
SLRNLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFDEGTPP 650
TNFDTFPAAI MTVFQILTGE DWNEVMYDGI KSQGGVQGGM VFSIYFIVLT 700
LFGNYTLLNV FLAIAVDNLA NAQELTKDEQ EEEEAANQKL ALQKAKEVAE 750
VSPLSAANMS IAVKEQQKNQ KPTKSVWEQR TSEMRKQNLL ASREALYGDA 800
AERWPTPYAR PLRPDVKTHL DRPLVVDPQE NRNNNTNKSR APEALRPTAR 850
PRESARDPDA RRAWPGSPER APGREGPYGR ESEPQQREHA PPREHAPWDA 900
DTERAKAGDA PRRHTHRPVA EGEPRRHRAR RRPGDEPDDR PERRPRPRDA 950
TRPARAADGE GDDGERKRRH RHGPPAHDDR ERRHRRRKEN QGSGVPVSGP 1000
NLSTTRPIQQ DLGRQDLPLA EDLDNMKNNK LATGEPASPH DSLGHSGLPP 1050
SPAKIGNSTN PGPALATNPQ NAASRRTPNN PGNPSNPGPP KTPENSLIVT 1100
NPSSTQPNSA KTARKPEHMA VEIPPACPPL NHTVVQVNKN ANPDPLPKKE 1150
EEKKEEEEAD PGEDGPKPMP PYSSMFILST TNPLRRLCHY ILNLRYFEMC 1200
ILMVIAMSSI ALAAEDPVQP NAPRNNVLRY FDYVFTGVFT FEMVIKMIDL 1250
GLVLHQGAYF RDLWNILDFI VVSGALVAFA FTGNSKGKDI NTIKSLRVLR 1300
VLRPLKTIKR LPKLKAVFDC VVNSLKNVFN ILIVYMLFMF IFAVVAVQLF 1350
KGKFFHCTDE SKEFERDCRG KYLLYEKNEV KARDREWKKY EFHYDNVLWA 1400
LLTLFTVSTG EGWPQVLKHS VDATFENQGP SPGYRMEMSI FYVVYFVVFP 1450
FFFVNIFVAL IIITFQEQGD KMMEEYSLEK NERACIDFAI SAKPLTRHMP 1500
QNKQSFQYRM WQFVVSPPFE YTIMAMIALN TIVLMMKFYG ASVAYENALR 1550
VFNIVFTSLF SLECVLKVMA FGILNYFRDA WNIFDFVTVL GSITDILVTE 1600
FGNNFINLSF LRLFRAARLI KLLRQGYTIR ILLWTFVQSF KALPYVCLLI 1650
AMLFFIYAII GMQVFGNIGI DGEDEDSDED EFQITEHNNF RTFFQALMLL 1700
FRSATGEAWH NIMLSCLSGK PCDKNSGILT ADCGNEFAYF YFVSFIFLCS 1750
FLMLNLFVAV IMDNFEYLTR DSSILGPHHL DEYVRVWAEY DPAACGRIHY 1800
KDMYSLLRVI SPPLGLGKKC PHRVACKRLL RMDLPVADDN TVHFNSTLMA 1850
LIRTALDIKI AKGGADKQQM DAELRKEMMA IWPNLSQKTL DLLVTPHKST 1900
DLTVGKIYAA MMIMEYYRQS KAKKLQAMRE EQNRTPLMFQ RMEPPSPTQE 1950
GGPSQNALPS TQLDPGGGLM AHEGGMKESP SWVTQRAQEM FQKTGTWSPE 2000
RGPPIDMPNS QPNSQSVEMR EMGTDGYSDS EHYLPMEGQT RAASMPRLPA 2050
ENQRRRGRPR GNDLSTISDT SPMKRSASVL GPKARRLDDY SLERVPPEEN 2100
QRYHQRRRDR GHRTSERSLG RYTDVDTGLG TDLSMTTQSG DLPSKDRDQD 2150
RGRPKDRKHR PHHHHHHHHH HPPAPDRDRY AQERPDTGRA RAREQRWSRS 2200
PSEGREHTTH RQGSSSVSGS PAPSTSGTST PRRGRRQLPQ TPCTPRPLVS 2250
YSPAPRRPAA RRMAGPAAPP GGSPRGCRRA PRWPAHAPEG PRPRGADYTE 2300
PDSPREPPGG AHDPAPRSPR TPRAAGCASP RHGRRLPNGY YAGHGAPRPR 2350
TARRGAHDAY SESEDDWC 2368
Length:2,368
Mass (Da):267,647
Last modified:February 6, 2007 - v2
Checksum:iE7B573BA005E5CB1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti649 – 6491P → L in tg. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791S → P in AAC52940. 1 Publication
Sequence conflicti82 – 821L → F in AAC52940. 1 Publication
Sequence conflicti884 – 8841P → L in AAC52940. 1 Publication
Sequence conflicti888 – 8881E → D in AAW56205. 1 Publication
Sequence conflicti1083 – 10831N → D in AAC52940. 1 Publication
Sequence conflicti1349 – 13491L → F in AAC52940. 1 Publication
Sequence conflicti1373 – 13731L → F in AAC52940. 1 Publication
Sequence conflicti2161 – 21611P → PH in AAW56205. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY714490 mRNA. Translation: AAW56205.1.
U76716 mRNA. Translation: AAC52940.1.
CCDSiCCDS52618.1.
RefSeqiNP_031604.3. NM_007578.3.
UniGeneiMm.334658.

Genome annotation databases

EnsembliENSMUST00000121390; ENSMUSP00000112436; ENSMUSG00000034656.
GeneIDi12286.
KEGGimmu:12286.
UCSCiuc009mmn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY714490 mRNA. Translation: AAW56205.1 .
U76716 mRNA. Translation: AAC52940.1 .
CCDSi CCDS52618.1.
RefSeqi NP_031604.3. NM_007578.3.
UniGenei Mm.334658.

3D structure databases

ProteinModelPortali P97445.
SMRi P97445. Positions 102-412, 491-742, 1191-1462, 1509-1763, 1846-1923.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198430. 4 interactions.
IntActi P97445. 1 interaction.
MINTi MINT-4997013.

PTM databases

PhosphoSitei P97445.

Proteomic databases

MaxQBi P97445.
PaxDbi P97445.
PRIDEi P97445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000121390 ; ENSMUSP00000112436 ; ENSMUSG00000034656 .
GeneIDi 12286.
KEGGi mmu:12286.
UCSCi uc009mmn.2. mouse.

Organism-specific databases

CTDi 773.
MGIi MGI:109482. Cacna1a.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00750000117449.
HOGENOMi HOG000231530.
HOVERGENi HBG050763.
InParanoidi P97445.
KOi K04344.
OMAi QPGFWEG.
OrthoDBi EOG7T1RBQ.
PhylomeDBi P97445.
TreeFami TF312805.

Enzyme and pathway databases

Reactomei REACT_225645. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.

Miscellaneous databases

NextBioi 280756.
PROi P97445.
SOURCEi Search...

Gene expression databases

ArrayExpressi P97445.
Bgeei P97445.
Genevestigatori P97445.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005448. VDCC_P/Q_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
PANTHERi PTHR10037:SF59. PTHR10037:SF59. 1 hit.
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01632. PQVDCCALPHA1.
SMARTi SM00384. AT_hook. 1 hit.
SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identity of P-type calcium current in Purkinje neurons."
    Richards K.S., Swensen A.M., Lipscombe D.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Brain.
  2. "Absence epilepsy in tottering mutant mice is associated with calcium channel defects."
    Fletcher C.F., Lutz C.M., O'Sullivan T.N., Shaughnessy J.D. Jr., Hawkes R., Frankel W.N., Copeland N.G., Jenkins N.A.
    Cell 87:607-617(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-2212, VARIANT TG LEU-649.
    Strain: DBA/2J.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-792, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiCAC1A_MOUSE
AccessioniPrimary (citable) accession number: P97445
Secondary accession number(s): Q2TPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi