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P97441

- ZNT3_MOUSE

UniProt

P97441 - ZNT3_MOUSE

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Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. detoxification of zinc ion Source: BHF-UCL
  2. positive regulation of transport Source: MGI
  3. regulation of sequestering of zinc ion Source: BHF-UCL
  4. sequestering of zinc ion Source: BHF-UCL
  5. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:Slc30a3
Synonyms:Znt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1345280. Slc30a3.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell junctionsynapsesynaptosome 1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: Ensembl
  4. neuron projection Source: UniProtKB
  5. synaptic vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Zinc transporter 3PRO_0000206097Add
BLAST

Proteomic databases

MaxQBiP97441.
PaxDbiP97441.
PRIDEiP97441.

PTM databases

PhosphoSiteiP97441.

Expressioni

Tissue specificityi

Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.

Gene expression databases

BgeeiP97441.
ExpressionAtlasiP97441. baseline and differential.
GenevestigatoriP97441.

Interactioni

Protein-protein interaction databases

IntActiP97441. 2 interactions.
MINTiMINT-7543457.

Structurei

3D structure databases

ProteinModelPortaliP97441.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini97 – 1059VacuolarSequence Analysis
Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini167 – 17711VacuolarSequence AnalysisAdd
BLAST
Topological domaini199 – 23537CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini257 – 2637VacuolarSequence Analysis
Topological domaini285 – 388104CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiP97441.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiP97441.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

P97441 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM
60 70 80 90 100
AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV
310 320 330 340 350
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA
Length:388
Mass (Da):41,824
Last modified:May 1, 1997 - v1
Checksum:i3CCDD0A37074EF41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76007 mRNA. Translation: AAB39731.1.
U76009, U76008 Genomic DNA. Translation: AAB39733.1. Sequence problems.
CCDSiCCDS51455.1.
RefSeqiNP_035903.2. NM_011773.3.
UniGeneiMm.1396.

Genome annotation databases

EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151.
GeneIDi22784.
KEGGimmu:22784.
UCSCiuc008wxa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U76007 mRNA. Translation: AAB39731.1 .
U76009 , U76008 Genomic DNA. Translation: AAB39733.1 . Sequence problems.
CCDSi CCDS51455.1.
RefSeqi NP_035903.2. NM_011773.3.
UniGenei Mm.1396.

3D structure databases

ProteinModelPortali P97441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P97441. 2 interactions.
MINTi MINT-7543457.

PTM databases

PhosphoSitei P97441.

Proteomic databases

MaxQBi P97441.
PaxDbi P97441.
PRIDEi P97441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031037 ; ENSMUSP00000031037 ; ENSMUSG00000029151 .
GeneIDi 22784.
KEGGi mmu:22784.
UCSCi uc008wxa.2. mouse.

Organism-specific databases

CTDi 7781.
MGIi MGI:1345280. Slc30a3.

Phylogenomic databases

eggNOGi COG1230.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi P97441.
KOi K14690.
OMAi CREPPQA.
OrthoDBi EOG7S4X68.
PhylomeDBi P97441.
TreeFami TF313382.

Miscellaneous databases

ChiTaRSi SLC30A3. mouse.
NextBioi 303355.
PROi P97441.
SOURCEi Search...

Gene expression databases

Bgeei P97441.
ExpressionAtlasi P97441. baseline and differential.
Genevestigatori P97441.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION.
    Strain: 129.
    Tissue: Brain.
  2. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  3. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZNT3_MOUSE
AccessioniPrimary (citable) accession number: P97441
Secondary accession number(s): P97511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3