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P97441

- ZNT3_MOUSE

UniProt

P97441 - ZNT3_MOUSE

Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Involved in accumulation of zinc in synaptic vesicles.

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. detoxification of zinc ion Source: BHF-UCL
    2. positive regulation of transport Source: MGI
    3. regulation of sequestering of zinc ion Source: BHF-UCL
    4. sequestering of zinc ion Source: BHF-UCL
    5. zinc ion transport Source: BHF-UCL

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 3
    Short name:
    ZnT-3
    Alternative name(s):
    Solute carrier family 30 member 3
    Gene namesi
    Name:Slc30a3
    Synonyms:Znt3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1345280. Slc30a3.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell junctionsynapsesynaptosome 1 Publication

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: Ensembl
    4. neuron projection Source: UniProtKB
    5. synaptic vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Zinc transporter 3PRO_0000206097Add
    BLAST

    Proteomic databases

    PaxDbiP97441.
    PRIDEiP97441.

    PTM databases

    PhosphoSiteiP97441.

    Expressioni

    Tissue specificityi

    Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.

    Gene expression databases

    ArrayExpressiP97441.
    BgeeiP97441.
    GenevestigatoriP97441.

    Interactioni

    Protein-protein interaction databases

    IntActiP97441. 2 interactions.
    MINTiMINT-7543457.

    Structurei

    3D structure databases

    ProteinModelPortaliP97441.
    SMRiP97441. Positions 76-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini97 – 1059VacuolarSequence Analysis
    Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 17711VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini199 – 23537CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 2637VacuolarSequence Analysis
    Topological domaini285 – 388104CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000079023.
    HOVERGENiHBG003345.
    InParanoidiP97441.
    KOiK14690.
    OMAiCREPPQA.
    OrthoDBiEOG7S4X68.
    PhylomeDBiP97441.
    TreeFamiTF313382.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P97441-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM    50
    AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL 100
    AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV 150
    VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ 200
    TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL 250
    AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV 300
    EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA 350
    EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA 388
    Length:388
    Mass (Da):41,824
    Last modified:May 1, 1997 - v1
    Checksum:i3CCDD0A37074EF41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76007 mRNA. Translation: AAB39731.1.
    U76009, U76008 Genomic DNA. Translation: AAB39733.1. Sequence problems.
    CCDSiCCDS51455.1.
    RefSeqiNP_035903.2. NM_011773.3.
    UniGeneiMm.1396.

    Genome annotation databases

    EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151.
    GeneIDi22784.
    KEGGimmu:22784.
    UCSCiuc008wxa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U76007 mRNA. Translation: AAB39731.1 .
    U76009 , U76008 Genomic DNA. Translation: AAB39733.1 . Sequence problems.
    CCDSi CCDS51455.1.
    RefSeqi NP_035903.2. NM_011773.3.
    UniGenei Mm.1396.

    3D structure databases

    ProteinModelPortali P97441.
    SMRi P97441. Positions 76-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P97441. 2 interactions.
    MINTi MINT-7543457.

    PTM databases

    PhosphoSitei P97441.

    Proteomic databases

    PaxDbi P97441.
    PRIDEi P97441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031037 ; ENSMUSP00000031037 ; ENSMUSG00000029151 .
    GeneIDi 22784.
    KEGGi mmu:22784.
    UCSCi uc008wxa.2. mouse.

    Organism-specific databases

    CTDi 7781.
    MGIi MGI:1345280. Slc30a3.

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000079023.
    HOVERGENi HBG003345.
    InParanoidi P97441.
    KOi K14690.
    OMAi CREPPQA.
    OrthoDBi EOG7S4X68.
    PhylomeDBi P97441.
    TreeFami TF313382.

    Miscellaneous databases

    ChiTaRSi SLC30A3. mouse.
    NextBioi 303355.
    PROi P97441.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97441.
    Bgeei P97441.
    Genevestigatori P97441.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION.
      Strain: 129.
      Tissue: Brain.
    2. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    3. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
      Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
      Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiZNT3_MOUSE
    AccessioniPrimary (citable) accession number: P97441
    Secondary accession number(s): P97511
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3