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Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. detoxification of zinc ion Source: BHF-UCL
  2. positive regulation of transport Source: MGI
  3. regulation of sequestering of zinc ion Source: BHF-UCL
  4. sequestering of zinc ion Source: BHF-UCL
  5. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_256636. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:Slc30a3
Synonyms:Znt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1345280. Slc30a3.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cell junctionsynapsesynaptosome 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Topological domaini97 – 1059VacuolarSequence Analysis
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 17711VacuolarSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Topological domaini199 – 23537CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 2637VacuolarSequence Analysis
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 388104CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome Source: MGI
  5. neuron projection Source: UniProtKB
  6. synaptic vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Zinc transporter 3PRO_0000206097Add
BLAST

Proteomic databases

MaxQBiP97441.
PaxDbiP97441.
PRIDEiP97441.

PTM databases

PhosphoSiteiP97441.

Expressioni

Tissue specificityi

Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.

Gene expression databases

BgeeiP97441.
ExpressionAtlasiP97441. baseline and differential.
GenevestigatoriP97441.

Interactioni

Protein-protein interaction databases

IntActiP97441. 2 interactions.
MINTiMINT-7543457.

Structurei

3D structure databases

ProteinModelPortaliP97441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiP97441.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiP97441.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

P97441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM
60 70 80 90 100
AFHHCHKDPV PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADIGSMLASL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NLLMAFVLHQ
210 220 230 240 250
TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL GDLLQSFGVL
260 270 280 290 300
AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV
310 320 330 340 350
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA
360 370 380
EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPSQA
Length:388
Mass (Da):41,824
Last modified:May 1, 1997 - v1
Checksum:i3CCDD0A37074EF41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76007 mRNA. Translation: AAB39731.1.
U76009, U76008 Genomic DNA. Translation: AAB39733.1. Sequence problems.
CCDSiCCDS51455.1.
RefSeqiNP_035903.2. NM_011773.3.
UniGeneiMm.1396.

Genome annotation databases

EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151.
GeneIDi22784.
KEGGimmu:22784.
UCSCiuc008wxa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76007 mRNA. Translation: AAB39731.1.
U76009, U76008 Genomic DNA. Translation: AAB39733.1. Sequence problems.
CCDSiCCDS51455.1.
RefSeqiNP_035903.2. NM_011773.3.
UniGeneiMm.1396.

3D structure databases

ProteinModelPortaliP97441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP97441. 2 interactions.
MINTiMINT-7543457.

PTM databases

PhosphoSiteiP97441.

Proteomic databases

MaxQBiP97441.
PaxDbiP97441.
PRIDEiP97441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151.
GeneIDi22784.
KEGGimmu:22784.
UCSCiuc008wxa.2. mouse.

Organism-specific databases

CTDi7781.
MGIiMGI:1345280. Slc30a3.

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiP97441.
KOiK14690.
OMAiCREPPQA.
OrthoDBiEOG7S4X68.
PhylomeDBiP97441.
TreeFamiTF313382.

Enzyme and pathway databases

ReactomeiREACT_256636. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

ChiTaRSiSlc30a3. mouse.
NextBioi303355.
PROiP97441.
SOURCEiSearch...

Gene expression databases

BgeeiP97441.
ExpressionAtlasiP97441. baseline and differential.
GenevestigatoriP97441.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION.
    Strain: 129.
    Tissue: Brain.
  2. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  3. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZNT3_MOUSE
AccessioniPrimary (citable) accession number: P97441
Secondary accession number(s): P97511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.