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P97441 (ZNT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 3

Short name=ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene names
Name:Slc30a3
Synonyms:Znt3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in accumulation of zinc in synaptic vesicles.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein Probable. Cell junctionsynapsesynaptosome Ref.3.

Tissue specificity

Brain and testis. In the brain, most abundant in hippocampus and cerebral cortex. In the testis, expression is restricted to germ cells and is highest in pachytene spermatocytes and round spermatids.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Zinc transporter 3
PRO_0000206097

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 1059Vacuolar Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 14519Cytoplasmic Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 17711Vacuolar Potential
Transmembrane178 – 19821Helical; Potential
Topological domain199 – 23537Cytoplasmic Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 2637Vacuolar Potential
Transmembrane264 – 28421Helical; Potential
Topological domain285 – 388104Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P97441 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 3CCDD0A37074EF41

FASTA38841,824
        10         20         30         40         50         60 
MEPSLATGGS ETTRLVSARD RSSAGGGLRL KSLFTEPSEP LPEEPKLEGM AFHHCHKDPV 

        70         80         90        100        110        120 
PQSGLSPERV QARRQLYAAC AVCFIFMAGE VVGGYLAHSL AIMTDAAHLL ADIGSMLASL 

       130        140        150        160        170        180 
FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM 

       190        200        210        220        230        240 
LLTASIAVCA NLLMAFVLHQ TGAPHSHGST GAEYAPLEEG HGYPMSLGNT SVRAAFVHVL 

       250        260        270        280        290        300 
GDLLQSFGVL AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV 

       310        320        330        340        350        360 
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF 

       370        380 
GFSSCTLQVE QYQPEMAQCL RCQEPSQA 

« Hide

References

« Hide 'large scale' references
[1]"ZnT-3, a putative transporter of zinc into synaptic vesicles."
Palmiter R.D., Cole T.B., Quaife C.J., Findley S.D.
Proc. Natl. Acad. Sci. U.S.A. 93:14934-14939(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION.
Strain: 129.
Tissue: Brain.
[2]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
[3]"The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U76007 mRNA. Translation: AAB39731.1.
U76009, U76008 Genomic DNA. Translation: AAB39733.1. Sequence problems.
CCDSCCDS51455.1.
RefSeqNP_035903.2. NM_011773.3.
UniGeneMm.1396.

3D structure databases

ProteinModelPortalP97441.
SMRP97441. Positions 76-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP97441. 2 interactions.
MINTMINT-7543457.

PTM databases

PhosphoSiteP97441.

Proteomic databases

PaxDbP97441.
PRIDEP97441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031037; ENSMUSP00000031037; ENSMUSG00000029151.
GeneID22784.
KEGGmmu:22784.
UCSCuc008wxa.2. mouse.

Organism-specific databases

CTD7781.
MGIMGI:1345280. Slc30a3.

Phylogenomic databases

eggNOGCOG1230.
HOGENOMHOG000079023.
HOVERGENHBG003345.
InParanoidP97441.
KOK14690.
OMACREPPQA.
OrthoDBEOG7S4X68.
PhylomeDBP97441.
TreeFamTF313382.

Gene expression databases

ArrayExpressP97441.
BgeeP97441.
GenevestigatorP97441.

Family and domain databases

Gene3D1.20.1510.10. 1 hit.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC30A3. mouse.
NextBio303355.
PROP97441.
SOURCESearch...

Entry information

Entry nameZNT3_MOUSE
AccessionPrimary (citable) accession number: P97441
Secondary accession number(s): P97511
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot