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P97435

- ENTK_MOUSE

UniProt

P97435 - ENTK_MOUSE

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Protein

Enteropeptidase

Gene

Tmprss15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity).By similarity

Catalytic activityi

Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei874 – 8741Charge relay systemBy similarity
Active sitei925 – 9251Charge relay systemBy similarity
Active sitei1021 – 10211Charge relay systemBy similarity

GO - Molecular functioni

  1. scavenger receptor activity Source: InterPro
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.156.

Names & Taxonomyi

Protein namesi
Recommended name:
Enteropeptidase (EC:3.4.21.9)
Alternative name(s):
Enterokinase
Serine protease 7
Transmembrane protease serine 15
Cleaved into the following 2 chains:
Gene namesi
Name:Tmprss15
Synonyms:Entk, Prss7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1197523. Tmprss15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 4729Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini48 – 10691022ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Enteropeptidase non-catalytic heavy chainPRO_0000027721Add
BLAST
Chaini830 – 1069240Enteropeptidase catalytic light chainPRO_0000027722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi229 ↔ 242By similarity
Disulfide bondi236 ↔ 255By similarity
Disulfide bondi249 ↔ 266By similarity
Disulfide bondi270 ↔ 298By similarity
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi569 ↔ 597By similarity
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi688 ↔ 700By similarity
Disulfide bondi695 ↔ 713By similarity
Disulfide bondi707 ↔ 722By similarity
Glycosylationi727 – 7271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi751 – 7511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi802 ↔ 812By similarity
Disulfide bondi817 ↔ 945Interchain (between heavy and light chains)PROSITE-ProRule annotation
Disulfide bondi859 ↔ 875By similarity
Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi936 – 9361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi959 ↔ 1027By similarity
Disulfide bondi991 ↔ 1006By similarity
Glycosylationi999 – 9991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1017 ↔ 1045By similarity

Post-translational modificationi

The chains are derived from a single precursor that is cleaved by a trypsin-like protease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP97435.
PaxDbiP97435.
PRIDEiP97435.

PTM databases

PhosphoSiteiP97435.

Expressioni

Gene expression databases

BgeeiP97435.
CleanExiMM_PRSS7.
GenevestigatoriP97435.

Interactioni

Subunit structurei

Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond.By similarity

Structurei

3D structure databases

ProteinModelPortaliP97435.
SMRiP97435. Positions 392-547, 568-704, 830-1064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 169116SEAPROSITE-ProRule annotationAdd
BLAST
Domaini227 – 26842LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 379110CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 549163MAMPROSITE-ProRule annotationAdd
BLAST
Domaini569 – 679111CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini686 – 72439LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini723 – 81694SRCRPROSITE-ProRule annotationAdd
BLAST
Domaini830 – 1069240Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112380.
HOVERGENiHBG005588.
InParanoidiP97435.
KOiK01316.
OMAiFEDGFCF.
OrthoDBiEOG7RNK07.
PhylomeDBiP97435.
TreeFamiTF351678.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
3.10.250.10. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR011163. Pept_S1A_enterop.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 1 hit.
PF00629. MAM. 1 hit.
PF01390. SEA. 1 hit.
PF00530. SRCR. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001138. Enteropeptidase. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 2 hits.
SM00137. MAM. 1 hit.
SM00200. SEA. 1 hit.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
SSF82671. SSF82671. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50024. SEA. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97435-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSSRDEAVG HHSISSFEVM LSALFIMLMV FSIGLIAVSW LAVKESEGDA
60 70 80 90 100
ALGKSHEVRG TFKITSGVTY NPNLQDKHSV DFKVLAFDLQ QMIDEIFESS
110 120 130 140 150
SLKNEYEKSK VFQFEKGSVI VLFDLFFAQW VSDKNVKEEL IQGIEANISS
160 170 180 190 200
QLVTLHIDLN SIDITASLSD FTTAVPVTTS DKLTTSSPMT TSASLGNLST
210 220 230 240 250
TVAATTSAPL CNLSTATFAT TSGHVSIECQ PGSRPCAHAW NCVATDLFCD
260 270 280 290 300
GEVNCPDGSD EDTGLCATAC DGRFLLTGDS GVFQADRYPR PDESGVVCRW
310 320 330 340 350
IIRVNQGLSI RMNFGSFIPH YTDVLDIYEG IGPSKILRGS FWETDPGTIR
360 370 380 390 400
IFSNLVTVTF LIKSDEYDYI GFNATYSTFN NSELNNYEKI DCTFDDGFCF
410 420 430 440 450
WTQDLDDDNE WERIQVTTFP CYTGPRFDHT YGNGSGFYIS TPTEQGWRSE
460 470 480 490 500
RVGLSSLSLD LTSEPVCLHF WYYMCCENVY NLNIHISSAE TTDKIVFQRK
510 520 530 540 550
GNYGRNWNYG QVTLNETGEF KVVFNAFRNR GCSTIALDDI SLTNGICSQS
560 570 580 590 600
PYPEPTLVPT PPPELPTDCG GPFELWEPNS TFSSPNFPDK YPNQASCIWN
610 620 630 640 650
LNAQRGKNIQ LHFQEFDLEN INDVVEVRDG GEFDSLLLAV YTGPGPVKDL
660 670 680 690 700
FSTTNRMTVI FTTNMETRRK GFKANFTSGY YLGIPEPCQD DEFQCKDGNC
710 720 730 740 750
IPLGNLCDSY PHCRDGSDEA SCVRFLNGTR SNNGLVQFNI HSIWHIACAE
760 770 780 790 800
NWTTQISNEV CHLLGLGSAN SSMPISSTGG GPFVRVNQAP NGSLILTPSL
810 820 830 840 850
QCSQDSLILL QCNHKSCGEK KVTQKVSPKI VGGSDAQAGA WPWVVALYHR
860 870 880 890 900
DRSTDRLLCG ASLVSSDWLV SAAHCVYRRN LDPTRWTAVL GLHMQSNLTS
910 920 930 940 950
PQVVRRVVDQ IVINPHYDRR RKVNDIAMMH LEFKVNYTDY IQPICLPEEN
960 970 980 990 1000
QIFIPGRTCS IAGWGYDKIN AGSTVDVLKE ADVPLISNEK CQQQLPEYNI
1010 1020 1030 1040 1050
TESMICAGYE EGGIDSCQGD SGGPLMCQEN NRWFLVGVTS FGVQCALPNH
1060
PGVYVRVSQF IEWIHSFLH
Length:1,069
Mass (Da):118,735
Last modified:May 1, 1997 - v1
Checksum:iE62549E463743C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73378 mRNA. Translation: AAB37317.1.
BC117917 mRNA. Translation: AAI17918.1.
BC117918 mRNA. Translation: AAI17919.1.
CCDSiCCDS28280.1.
RefSeqiNP_032967.1. NM_008941.3.
NP_849186.2. NM_178855.4.
UniGeneiMm.5184.

Genome annotation databases

EnsembliENSMUST00000023566; ENSMUSP00000023566; ENSMUSG00000022857.
GeneIDi19146.
KEGGimmu:19146.
UCSCiuc007zsy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73378 mRNA. Translation: AAB37317.1 .
BC117917 mRNA. Translation: AAI17918.1 .
BC117918 mRNA. Translation: AAI17919.1 .
CCDSi CCDS28280.1.
RefSeqi NP_032967.1. NM_008941.3.
NP_849186.2. NM_178855.4.
UniGenei Mm.5184.

3D structure databases

ProteinModelPortali P97435.
SMRi P97435. Positions 392-547, 568-704, 830-1064.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.156.

PTM databases

PhosphoSitei P97435.

Proteomic databases

MaxQBi P97435.
PaxDbi P97435.
PRIDEi P97435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023566 ; ENSMUSP00000023566 ; ENSMUSG00000022857 .
GeneIDi 19146.
KEGGi mmu:19146.
UCSCi uc007zsy.1. mouse.

Organism-specific databases

CTDi 5651.
MGIi MGI:1197523. Tmprss15.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118962.
HOGENOMi HOG000112380.
HOVERGENi HBG005588.
InParanoidi P97435.
KOi K01316.
OMAi FEDGFCF.
OrthoDBi EOG7RNK07.
PhylomeDBi P97435.
TreeFami TF351678.

Miscellaneous databases

NextBioi 295786.
PROi P97435.
SOURCEi Search...

Gene expression databases

Bgeei P97435.
CleanExi MM_PRSS7.
Genevestigatori P97435.

Family and domain databases

Gene3Di 2.60.120.290. 2 hits.
3.10.250.10. 1 hit.
3.30.70.960. 1 hit.
4.10.400.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR011163. Pept_S1A_enterop.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 1 hit.
PF00629. MAM. 1 hit.
PF01390. SEA. 1 hit.
PF00530. SRCR. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001138. Enteropeptidase. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00042. CUB. 2 hits.
SM00192. LDLa. 2 hits.
SM00137. MAM. 1 hit.
SM00200. SEA. 1 hit.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
SSF82671. SSF82671. 1 hit.
PROSITEi PS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS50024. SEA. 1 hit.
PS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development."
    Yuan X., Zheng X., Lu D., Rubin D.C., Pung C.Y.M., Sadler J.E.
    Am. J. Physiol. 274:G342-G349(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Duodenum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiENTK_MOUSE
AccessioniPrimary (citable) accession number: P97435
Secondary accession number(s): Q148Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3