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Protein

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 258ZZ-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • macroautophagy Source: UniProtKB
  • negative regulation of osteoblast differentiation Source: BHF-UCL
  • protein complex oligomerization Source: UniProtKB
  • regulation of bone mineralization Source: BHF-UCL
  • regulation of stress-activated MAPK cascade Source: BHF-UCL

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Membrane component chromosome 17 surface marker 2 homolog
Neighbor of BRCA1 gene 1 protein
Gene namesi
Name:Nbr1
Synonyms:M17s2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498 Nbr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000967471 – 988Next to BRCA1 gene 1 proteinAdd BLAST988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineBy similarity1
Modified residuei591PhosphoserineBy similarity1
Modified residuei597PhosphoserineBy similarity1
Modified residuei626PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97432
MaxQBiP97432
PaxDbiP97432
PRIDEiP97432

PTM databases

iPTMnetiP97432
PhosphoSitePlusiP97432

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

BgeeiENSMUSG00000017119
CleanExiMM_NBR1
ExpressionAtlasiP97432 baseline and differential
GenevisibleiP97432 MM

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN, TRIM55, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP1LC3BQ9GZQ82EBI-642554,EBI-373144From Homo sapiens.

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi201698, 11 interactors
IntActiP97432, 8 interactors
MINTiP97432
STRINGi10090.ENSMUSP00000099387

Structurei

3D structure databases

ProteinModelPortaliP97432
SMRiP97432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86PB1PROSITE-ProRule annotationAdd BLAST83
Domaini935 – 979UBAPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni543 – 637ATG8 family proteins-bindingBy similarityAdd BLAST95
Regioni745 – 756ATG8 family proteins-bindingBy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi729 – 733Poly-Glu5

Domaini

The PB1 domain mediates interaction with SQSTM1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 258ZZ-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4351 Eukaryota
KOG4582 Eukaryota
ENOG4111TKN LUCA
GeneTreeiENSGT00390000016335
HOGENOMiHOG000220861
HOVERGENiHBG052578
InParanoidiP97432
KOiK17987
OMAiAYKALFA
PhylomeDBiP97432
TreeFamiTF328428

Family and domain databases

CDDicd14947 NBR1_like, 1 hit
cd06396 PB1_NBR1, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR032350 N_BRCA1_central
IPR033513 NBR1
IPR000270 PB1_dom
IPR034852 PB1_NBR1
IPR015940 UBA
IPR009060 UBA-like_sf
IPR000433 Znf_ZZ
PANTHERiPTHR20930:SF2 PTHR20930:SF2, 1 hit
PfamiView protein in Pfam
PF16158 N_BRCA1_IG, 1 hit
PF00564 PB1, 1 hit
PF00569 ZZ, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50030 UBA, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P97432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDMTPCM SPLPHDSPLI
610 620 630 640 650
EKPGLGQIQE ESEGAGFKAP PDSTVSAKRK AETPASVEET EEDLSGTQFV
660 670 680 690 700
CETVIRSLTL DAAPDHNPPC RQRSPQRELQ LYSTEGQQPL VLPGFCRKDS
710 720 730 740 750
SLKFALPEEG PRGDEREEIV HIVEEEVVEE EEEVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GLEPTEARER
810 820 830 840 850
LPERESQPQE QSISDILTTS QPLDTVPLVP EVAGLPAALS RSAPCGQCES
860 870 880 890 900
SGVDSPGVDS PATMHEVPPA PDDIRGEPRG STGLANSRQR SCDHSRHHNG
910 920 930 940 950
SSIAGGLVKG ALSVAASAYK ALFSGPPVTA QPIVSEDQTT ALMAHLFEMG
960 970 980
FCDRQLNLRL LRKHNYNILQ VVTELLQVNN NDWYSHRY
Length:988
Mass (Da):109,958
Last modified:May 1, 1997 - v1
Checksum:iE5BB4B281FE33CE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti807Q → R in AAF74118 (PubMed:11179671).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73039 mRNA Translation: AAC53025.1
AF227188 mRNA Translation: AAF74118.1
CCDSiCCDS25475.1
RefSeqiNP_001239149.1, NM_001252220.1
NP_032702.1, NM_008676.3
UniGeneiMm.489817
Mm.784

Genome annotation databases

EnsembliENSMUST00000103098; ENSMUSP00000099387; ENSMUSG00000017119
ENSMUST00000103099; ENSMUSP00000099388; ENSMUSG00000017119
ENSMUST00000107218; ENSMUSP00000102836; ENSMUSG00000017119
GeneIDi17966
KEGGimmu:17966
UCSCiuc007lpg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNBR1_MOUSE
AccessioniPrimary (citable) accession number: P97432
Secondary accession number(s): Q9JIH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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