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Protein

Next to BRCA1 gene 1 protein

Gene

Nbr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 25847ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • macroautophagy Source: UniProtKB
  • negative regulation of osteoblast differentiation Source: BHF-UCL
  • protein oligomerization Source: UniProtKB
  • regulation of bone mineralization Source: BHF-UCL
  • regulation of stress-activated MAPK cascade Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Next to BRCA1 gene 1 protein
Alternative name(s):
Membrane component chromosome 17 surface marker 2 homolog
Neighbor of BRCA1 gene 1 protein
Gene namesi
Name:Nbr1
Synonyms:M17s2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108498. Nbr1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmic vesicleautophagosome By similarity
  • Lysosome By similarity
  • CytoplasmmyofibrilsarcomereM line By similarity

  • Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (By similarity).By similarity

GO - Cellular componenti

  • autophagosome Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: UniProtKB-KW
  • cytosol Source: UniProtKB
  • extracellular exosome Source: MGI
  • late endosome Source: UniProtKB
  • lysosome Source: UniProtKB-SubCell
  • M band Source: UniProtKB-SubCell
  • membrane Source: MGI
  • mitochondrion Source: Ensembl
  • pre-autophagosomal structure Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 988988Next to BRCA1 gene 1 proteinPRO_0000096747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei591 – 5911PhosphoserineBy similarity
Modified residuei597 – 5971PhosphoserineBy similarity
Modified residuei626 – 6261PhosphoserineBy similarity
Modified residuei860 – 8601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP97432.
MaxQBiP97432.
PaxDbiP97432.
PRIDEiP97432.

PTM databases

iPTMnetiP97432.
PhosphoSiteiP97432.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

BgeeiENSMUSG00000017119.
CleanExiMM_NBR1.
ExpressionAtlasiP97432. baseline and differential.
GenevisibleiP97432. MM.

Interactioni

Subunit structurei

Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN, TRIM55, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP1LC3BQ9GZQ82EBI-642554,EBI-373144From a different organism.

GO - Molecular functioni

  • mitogen-activated protein kinase binding Source: BHF-UCL
  • ubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi201698. 11 interactions.
IntActiP97432. 8 interactions.
MINTiMINT-1591819.
STRINGi10090.ENSMUSP00000099387.

Structurei

3D structure databases

ProteinModelPortaliP97432.
SMRiP97432. Positions 1-86, 368-484, 935-981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8683PB1PROSITE-ProRule annotationAdd
BLAST
Domaini935 – 97945UBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni543 – 63795ATG8 family proteins-bindingBy similarityAdd
BLAST
Regioni745 – 75612ATG8 family proteins-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi729 – 7335Poly-Glu

Domaini

The PB1 domain mediates interaction with SQSTM1.By similarity

Sequence similaritiesi

Contains 1 PB1 domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri212 – 25847ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
GeneTreeiENSGT00390000016335.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.
InParanoidiP97432.
KOiK17987.
OMAiAHLFEMG.
PhylomeDBiP97432.
TreeFamiTF328428.

Family and domain databases

CDDicd14947. NBR1_like. 1 hit.
InterProiIPR032350. N_BRCA1_central.
IPR033513. NBR1.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR20930:SF2. PTHR20930:SF2. 3 hits.
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P97432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD
60 70 80 90 100
EENEEISINS QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE
110 120 130 140 150
NQAAARTGKK PLAHYSSLVR VLGSDMKTTE EPAPEQCSSA PCDTDQPQDK
160 170 180 190 200
PPDWFTSYLE MFREQVVKET VEKLEQRLQE KLVLQKPLLS SSPTEVSMPI
210 220 230 240 250
SEETLFLPEN QFSWHIACSH CQKRIVGVRY QCSLCPSYNI CEDCEAGPYT
260 270 280 290 300
HDTNHVLLKL RRPVVISSEP FFYSKYSAPR LPAALEQVRL QKQVDKNFVK
310 320 330 340 350
AEKQRLRAEK KQRKAEVKEL KKQLKLHRKI HLWNSIHGLQ SPKSPLGRPE
360 370 380 390 400
SLLQSNTLML PLQPCAPVMP TLSAAFVDEN LPDGTHLQPG TKFIKHWRMK
410 420 430 440 450
NTGNVKWNTD TKLKFMWGNL TLASTEKKDV LVPCLKAGHV GVVSVEFIAP
460 470 480 490 500
TLEGTYTSHW RLSHKGQQFG PRVWCSIIVD PFPSSESPDN VEGDRISSSK
510 520 530 540 550
ADDFSCEQEE AFLLAEEEIP LGEVTKQTEG TGASASQKTR RAASERELYI
560 570 580 590 600
PSVDLLTAQD LLSFELLDIN IVQELERVPH NTPVDMTPCM SPLPHDSPLI
610 620 630 640 650
EKPGLGQIQE ESEGAGFKAP PDSTVSAKRK AETPASVEET EEDLSGTQFV
660 670 680 690 700
CETVIRSLTL DAAPDHNPPC RQRSPQRELQ LYSTEGQQPL VLPGFCRKDS
710 720 730 740 750
SLKFALPEEG PRGDEREEIV HIVEEEVVEE EEEVQDEEVQ SQSSASSEDY
760 770 780 790 800
IIILPECFDT SRPLGDSMYS SALSQPGLER GAEGEPGIES GLEPTEARER
810 820 830 840 850
LPERESQPQE QSISDILTTS QPLDTVPLVP EVAGLPAALS RSAPCGQCES
860 870 880 890 900
SGVDSPGVDS PATMHEVPPA PDDIRGEPRG STGLANSRQR SCDHSRHHNG
910 920 930 940 950
SSIAGGLVKG ALSVAASAYK ALFSGPPVTA QPIVSEDQTT ALMAHLFEMG
960 970 980
FCDRQLNLRL LRKHNYNILQ VVTELLQVNN NDWYSHRY
Length:988
Mass (Da):109,958
Last modified:May 1, 1997 - v1
Checksum:iE5BB4B281FE33CE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti807 – 8071Q → R in AAF74118 (PubMed:11179671).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73039 mRNA. Translation: AAC53025.1.
AF227188 mRNA. Translation: AAF74118.1.
CCDSiCCDS25475.1.
RefSeqiNP_001239149.1. NM_001252220.1.
NP_032702.1. NM_008676.3.
UniGeneiMm.489817.
Mm.784.

Genome annotation databases

EnsembliENSMUST00000103098; ENSMUSP00000099387; ENSMUSG00000017119.
ENSMUST00000103099; ENSMUSP00000099388; ENSMUSG00000017119.
ENSMUST00000107218; ENSMUSP00000102836; ENSMUSG00000017119.
GeneIDi17966.
KEGGimmu:17966.
UCSCiuc007lpg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73039 mRNA. Translation: AAC53025.1.
AF227188 mRNA. Translation: AAF74118.1.
CCDSiCCDS25475.1.
RefSeqiNP_001239149.1. NM_001252220.1.
NP_032702.1. NM_008676.3.
UniGeneiMm.489817.
Mm.784.

3D structure databases

ProteinModelPortaliP97432.
SMRiP97432. Positions 1-86, 368-484, 935-981.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201698. 11 interactions.
IntActiP97432. 8 interactions.
MINTiMINT-1591819.
STRINGi10090.ENSMUSP00000099387.

PTM databases

iPTMnetiP97432.
PhosphoSiteiP97432.

Proteomic databases

EPDiP97432.
MaxQBiP97432.
PaxDbiP97432.
PRIDEiP97432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103098; ENSMUSP00000099387; ENSMUSG00000017119.
ENSMUST00000103099; ENSMUSP00000099388; ENSMUSG00000017119.
ENSMUST00000107218; ENSMUSP00000102836; ENSMUSG00000017119.
GeneIDi17966.
KEGGimmu:17966.
UCSCiuc007lpg.2. mouse.

Organism-specific databases

CTDi4077.
MGIiMGI:108498. Nbr1.

Phylogenomic databases

eggNOGiKOG4351. Eukaryota.
KOG4582. Eukaryota.
ENOG4111TKN. LUCA.
GeneTreeiENSGT00390000016335.
HOGENOMiHOG000220861.
HOVERGENiHBG052578.
InParanoidiP97432.
KOiK17987.
OMAiAHLFEMG.
PhylomeDBiP97432.
TreeFamiTF328428.

Miscellaneous databases

ChiTaRSiNbr1. mouse.
PROiP97432.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017119.
CleanExiMM_NBR1.
ExpressionAtlasiP97432. baseline and differential.
GenevisibleiP97432. MM.

Family and domain databases

CDDicd14947. NBR1_like. 1 hit.
InterProiIPR032350. N_BRCA1_central.
IPR033513. NBR1.
IPR000270. PB1_dom.
IPR015940. UBA.
IPR009060. UBA-like.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR20930:SF2. PTHR20930:SF2. 3 hits.
PfamiPF16158. N_BRCA1_IG. 1 hit.
PF00564. PB1. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51745. PB1. 1 hit.
PS50030. UBA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNBR1_MOUSE
AccessioniPrimary (citable) accession number: P97432
Secondary accession number(s): Q9JIH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.