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Protein

Interferon regulatory factor 6

Gene

Irf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi7 – 115IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • regulatory region DNA binding Source: InterPro
  • sequence-specific DNA binding Source: Ensembl
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: MGI
  • cell development Source: MGI
  • keratinocyte differentiation Source: MGI
  • keratinocyte proliferation Source: MGI
  • mammary gland epithelial cell differentiation Source: UniProtKB
  • negative regulation of cell proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • skin development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 6
Short name:
IRF-6
Gene namesi
Name:Irf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1859211. Irf6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi84R → C: Mice show an atypical limb development, are covered by an abnormal smooth skin and die shortly after birth. The esophageal lumen is obliterated by adhesion of the stratified, squamous epithelium lining this structure. The hindlimbs, tail and body are fused together by a thickened epidermis. Epidermis is hyperproliferative but does not undergo a normal differentiation program. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545611 – 467Interferon regulatory factor 6Add BLAST467

Post-translational modificationi

Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP97431.
PaxDbiP97431.
PeptideAtlasiP97431.
PRIDEiP97431.

PTM databases

iPTMnetiP97431.
PhosphoSitePlusiP97431.

Expressioni

Tissue specificityi

High levels of expression along the medial edge of the fusing palate, tooth buds, hair follicles, genitalia and skin.1 Publication

Gene expression databases

BgeeiENSMUSG00000026638.
CleanExiMM_IRF6.
GenevisibleiP97431. MM.

Interactioni

Subunit structurei

Interacts with SERPINB5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075839.

Structurei

3D structure databases

ProteinModelPortaliP97431.
SMRiP97431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV. Eukaryota.
ENOG410XRXT. LUCA.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000037433.
HOVERGENiHBG105715.
InParanoidiP97431.
KOiK10154.
OMAiPQHEEEN.
OrthoDBiEOG091G067P.
TreeFamiTF328512.

Family and domain databases

CDDicd00103. IRF. 1 hit.
Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SM01243. IRF-3. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P97431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ
60 70 80 90 100
EEENTIFKAW AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT
110 120 130 140 150
KEVPMNPVKI YQVCDIPQTQ GSVINPGSTG SAPWDEKDND VDEDEEEDEL
160 170 180 190 200
EQSQHHVPIQ DTFPFLNING SPMAPASVGN CSVGNCSPES VWPKTEPLEM
210 220 230 240 250
EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT MTVSNPQGCR
260 270 280 290 300
LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR
310 320 330 340 350
GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LAAPNLIERQ KKVKLFCLET
360 370 380 390 400
FLSELIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR
410 420 430 440 450
MIYEMFSGDF TRSFDSGSVR LQISTPDIKD NIVAQLKQLY RILQTQESWQ
460
PMQPAPSMQL PQALPAQ
Length:467
Mass (Da):53,111
Last modified:July 27, 2011 - v2
Checksum:i1C564BC8D79C5259
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119T → P in AAB36714 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73029 mRNA. Translation: AAB36714.1.
AK143299 mRNA. Translation: BAE25338.1.
AK143954 mRNA. Translation: BAE25628.1.
AL365322 Genomic DNA. Translation: CAX15615.1.
CH466555 Genomic DNA. Translation: EDL12956.1.
BC008515 mRNA. Translation: AAH08515.1.
CCDSiCCDS15632.1.
RefSeqiNP_058547.2. NM_016851.2.
XP_006497325.1. XM_006497262.3.
XP_006497326.1. XM_006497263.3.
UniGeneiMm.273695.

Genome annotation databases

EnsembliENSMUST00000076521; ENSMUSP00000075839; ENSMUSG00000026638.
GeneIDi54139.
KEGGimmu:54139.
UCSCiuc007edy.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiIRF6_MOUSE
AccessioniPrimary (citable) accession number: P97431
Secondary accession number(s): Q91VD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families