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P97431

- IRF6_MOUSE

UniProt

P97431 - IRF6_MOUSE

Protein

Interferon regulatory factor 6

Gene

Irf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi7 – 115109IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. regulatory region DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. cell development Source: MGI
    3. keratinocyte differentiation Source: MGI
    4. keratinocyte proliferation Source: MGI
    5. mammary gland epithelial cell differentiation Source: UniProtKB
    6. negative regulation of cell proliferation Source: MGI
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. skin development Source: MGI
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198660. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon regulatory factor 6
    Short name:
    IRF-6
    Gene namesi
    Name:Irf6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1859211. Irf6.

    Subcellular locationi

    Nucleus Curated. Cytoplasm 1 Publication
    Note: Translocates to nucleus in response to an activating signal.Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi84 – 841R → C: Mice show an atypical limb development, are covered by an abnormal smooth skin and die shortly after birth. The esophageal lumen is obliterated by adhesion of the stratified, squamous epithelium lining this structure. The hindlimbs, tail and body are fused together by a thickened epidermis. Epidermis is hyperproliferative but does not undergo a normal differentiation program. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Interferon regulatory factor 6PRO_0000154561Add
    BLAST

    Post-translational modificationi

    Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiP97431.
    PaxDbiP97431.
    PRIDEiP97431.

    PTM databases

    PhosphoSiteiP97431.

    Expressioni

    Tissue specificityi

    High levels of expression along the medial edge of the fusing palate, tooth buds, hair follicles, genitalia and skin.1 Publication

    Gene expression databases

    BgeeiP97431.
    CleanExiMM_IRF6.
    GenevestigatoriP97431.

    Interactioni

    Subunit structurei

    Interacts with SERPINB5.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000075839.

    Structurei

    3D structure databases

    ProteinModelPortaliP97431.
    SMRiP97431. Positions 12-112, 214-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IRF family.PROSITE-ProRule annotation
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG45968.
    GeneTreeiENSGT00740000115254.
    HOGENOMiHOG000037433.
    HOVERGENiHBG105715.
    InParanoidiQ91VD0.
    KOiK10154.
    OMAiHEEENTI.
    OrthoDBiEOG7CCBR1.
    TreeFamiTF328512.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.200.10. 1 hit.
    InterProiIPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR019471. Interferon_reg_factor-3.
    IPR017855. SMAD_dom-like.
    IPR008984. SMAD_FHA_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00605. IRF. 1 hit.
    PF10401. IRF-3. 1 hit.
    [Graphical view]
    PRINTSiPR00267. INTFRNREGFCT.
    SMARTiSM00348. IRF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P97431-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ    50
    EEENTIFKAW AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT 100
    KEVPMNPVKI YQVCDIPQTQ GSVINPGSTG SAPWDEKDND VDEDEEEDEL 150
    EQSQHHVPIQ DTFPFLNING SPMAPASVGN CSVGNCSPES VWPKTEPLEM 200
    EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT MTVSNPQGCR 250
    LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR 300
    GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LAAPNLIERQ KKVKLFCLET 350
    FLSELIAHQK GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR 400
    MIYEMFSGDF TRSFDSGSVR LQISTPDIKD NIVAQLKQLY RILQTQESWQ 450
    PMQPAPSMQL PQALPAQ 467
    Length:467
    Mass (Da):53,111
    Last modified:July 27, 2011 - v2
    Checksum:i1C564BC8D79C5259
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191T → P in AAB36714. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73029 mRNA. Translation: AAB36714.1.
    AK143299 mRNA. Translation: BAE25338.1.
    AK143954 mRNA. Translation: BAE25628.1.
    AL365322 Genomic DNA. Translation: CAX15615.1.
    CH466555 Genomic DNA. Translation: EDL12956.1.
    BC008515 mRNA. Translation: AAH08515.1.
    CCDSiCCDS15632.1.
    RefSeqiNP_058547.2. NM_016851.2.
    XP_006497325.1. XM_006497262.1.
    XP_006497326.1. XM_006497263.1.
    UniGeneiMm.273695.

    Genome annotation databases

    EnsembliENSMUST00000076521; ENSMUSP00000075839; ENSMUSG00000026638.
    GeneIDi54139.
    KEGGimmu:54139.
    UCSCiuc007edy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73029 mRNA. Translation: AAB36714.1 .
    AK143299 mRNA. Translation: BAE25338.1 .
    AK143954 mRNA. Translation: BAE25628.1 .
    AL365322 Genomic DNA. Translation: CAX15615.1 .
    CH466555 Genomic DNA. Translation: EDL12956.1 .
    BC008515 mRNA. Translation: AAH08515.1 .
    CCDSi CCDS15632.1.
    RefSeqi NP_058547.2. NM_016851.2.
    XP_006497325.1. XM_006497262.1.
    XP_006497326.1. XM_006497263.1.
    UniGenei Mm.273695.

    3D structure databases

    ProteinModelPortali P97431.
    SMRi P97431. Positions 12-112, 214-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000075839.

    PTM databases

    PhosphoSitei P97431.

    Proteomic databases

    MaxQBi P97431.
    PaxDbi P97431.
    PRIDEi P97431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076521 ; ENSMUSP00000075839 ; ENSMUSG00000026638 .
    GeneIDi 54139.
    KEGGi mmu:54139.
    UCSCi uc007edy.1. mouse.

    Organism-specific databases

    CTDi 3664.
    MGIi MGI:1859211. Irf6.

    Phylogenomic databases

    eggNOGi NOG45968.
    GeneTreei ENSGT00740000115254.
    HOGENOMi HOG000037433.
    HOVERGENi HBG105715.
    InParanoidi Q91VD0.
    KOi K10154.
    OMAi HEEENTI.
    OrthoDBi EOG7CCBR1.
    TreeFami TF328512.

    Enzyme and pathway databases

    Reactomei REACT_198660. Interferon gamma signaling.

    Miscellaneous databases

    NextBioi 310957.
    PROi P97431.
    SOURCEi Search...

    Gene expression databases

    Bgeei P97431.
    CleanExi MM_IRF6.
    Genevestigatori P97431.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.200.10. 1 hit.
    InterProi IPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR019471. Interferon_reg_factor-3.
    IPR017855. SMAD_dom-like.
    IPR008984. SMAD_FHA_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00605. IRF. 1 hit.
    PF10401. IRF-3. 1 hit.
    [Graphical view ]
    PRINTSi PR00267. INTFRNREGFCT.
    SMARTi SM00348. IRF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Grossman A., Mittrucker H.W., Antonio L., Mak T.W.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Colon.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney and Oviduct.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    6. Cited for: TISSUE SPECIFICITY.
    7. "Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch."
      Richardson R.J., Dixon J., Malhotra S., Hardman M.J., Knowles L., Boot-Handford R.P., Shore P., Whitmarsh A., Dixon M.J.
      Nat. Genet. 38:1329-1334(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ARG-84.
    8. "Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner."
      Bailey C.M., Abbott D.E., Margaryan N.V., Khalkhali-Ellis Z., Hendrix M.J.C.
      Mol. Cell. Biol. 28:2235-2243(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6."
      Little H.J., Rorick N.K., Su L.-I., Baldock C., Malhotra S., Jowitt T., Gakhar L., Subramanian R., Schutte B.C., Dixon M.J., Shore P.
      Hum. Mol. Genet. 18:535-545(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, SUBUNIT, SUBCELLULAR LOCATION.
    10. "Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome."
      Rorick N.K., Kinoshita A., Weirather J.L., Peyrard-Janvid M., de Lima R.L., Dunnwald M., Shanske A.L., Moretti-Ferreira D., Koillinen H., Kere J., Mansilla M.A., Murray J.C., Goudy S.L., Schutte B.C.
      Am. J. Med. Genet. A 155:1314-1321(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiIRF6_MOUSE
    AccessioniPrimary (citable) accession number: P97431
    Secondary accession number(s): Q91VD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3