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P97430

- SLPI_MOUSE

UniProt

P97430 - SLPI_MOUSE

Protein

Antileukoproteinase

Gene

Slpi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei46 – 472Reactive bond for trypsinCurated
    Sitei98 – 992Reactive bond for chymotrypsin and elastaseCurated

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of protein binding Source: Ensembl
    2. negative regulation of viral genome replication Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antileukoproteinase
    Short name:
    ALP
    Alternative name(s):
    Secretory leukocyte protease inhibitor
    Gene namesi
    Name:Slpi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:109297. Slpi.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525By similarityAdd
    BLAST
    Chaini26 – 131106AntileukoproteinasePRO_0000041356Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 65PROSITE-ProRule annotation
    Disulfide bondi44 ↔ 69PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi58 ↔ 73PROSITE-ProRule annotation
    Disulfide bondi90 ↔ 119PROSITE-ProRule annotation
    Disulfide bondi97 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi106 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi112 ↔ 127PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP97430.
    PRIDEiP97430.

    Expressioni

    Tissue specificityi

    Highest expression in lung, spleen, intestine and epididymis with lower levels in liver and seminal vesicle. No expression in brain, heart, kidney and muscle.

    Gene expression databases

    ArrayExpressiP97430.
    BgeeiP97430.
    CleanExiMM_SLPI.
    GenevestigatoriP97430.

    Interactioni

    Protein-protein interaction databases

    BioGridi203333. 1 interaction.
    STRINGi10090.ENSMUSP00000104992.

    Structurei

    3D structure databases

    ProteinModelPortaliP97430.
    SMRiP97430. Positions 85-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 7749WAP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini83 – 13149WAP 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 8459Trypsin inhibitory domainAdd
    BLAST
    Regioni85 – 13147Elastase inhibitory domainAdd
    BLAST

    Sequence similaritiesi

    Contains 2 WAP domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45457.
    HOGENOMiHOG000115819.
    HOVERGENiHBG018073.
    InParanoidiP97430.
    OMAiRCIWHEK.
    OrthoDBiEOG7S7SG9.
    PhylomeDBiP97430.
    TreeFamiTF338375.

    Family and domain databases

    Gene3Di4.10.75.10. 2 hits.
    InterProiIPR008197. WAP.
    [Graphical view]
    PfamiPF00095. WAP. 2 hits.
    [Graphical view]
    PRINTSiPR00003. 4DISULPHCORE.
    SMARTiSM00217. WAP. 2 hits.
    [Graphical view]
    SUPFAMiSSF57256. SSF57256. 2 hits.
    PROSITEiPS51390. WAP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P97430-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSCGLLPFT VLLALGILAP WTVEGGKNDA IKIGACPAKK PAQCLKLEKP    50
    QCRTDWECPG KQRCCQDACG SKCVNPVPIR KPVWRKPGRC VKTQARCMML 100
    NPPNVCQRDG QCDGKYKCCE GICGKVCLPP M 131
    Length:131
    Mass (Da):14,308
    Last modified:May 1, 1997 - v1
    Checksum:iA57C9E30FE711B8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73004 mRNA. Translation: AAC53047.1.
    U88093 mRNA. Translation: AAC53140.1.
    U94341 mRNA. Translation: AAC53394.1.
    BC028509 mRNA. Translation: AAH28509.1.
    CCDSiCCDS17033.1.
    RefSeqiNP_035544.1. NM_011414.3.
    UniGeneiMm.371583.

    Genome annotation databases

    EnsembliENSMUST00000109367; ENSMUSP00000104992; ENSMUSG00000017002.
    GeneIDi20568.
    KEGGimmu:20568.
    UCSCiuc008nuj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73004 mRNA. Translation: AAC53047.1 .
    U88093 mRNA. Translation: AAC53140.1 .
    U94341 mRNA. Translation: AAC53394.1 .
    BC028509 mRNA. Translation: AAH28509.1 .
    CCDSi CCDS17033.1.
    RefSeqi NP_035544.1. NM_011414.3.
    UniGenei Mm.371583.

    3D structure databases

    ProteinModelPortali P97430.
    SMRi P97430. Positions 85-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203333. 1 interaction.
    STRINGi 10090.ENSMUSP00000104992.

    Proteomic databases

    PaxDbi P97430.
    PRIDEi P97430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109367 ; ENSMUSP00000104992 ; ENSMUSG00000017002 .
    GeneIDi 20568.
    KEGGi mmu:20568.
    UCSCi uc008nuj.1. mouse.

    Organism-specific databases

    CTDi 6590.
    MGIi MGI:109297. Slpi.

    Phylogenomic databases

    eggNOGi NOG45457.
    HOGENOMi HOG000115819.
    HOVERGENi HBG018073.
    InParanoidi P97430.
    OMAi RCIWHEK.
    OrthoDBi EOG7S7SG9.
    PhylomeDBi P97430.
    TreeFami TF338375.

    Miscellaneous databases

    NextBioi 298869.
    PROi P97430.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P97430.
    Bgeei P97430.
    CleanExi MM_SLPI.
    Genevestigatori P97430.

    Family and domain databases

    Gene3Di 4.10.75.10. 2 hits.
    InterProi IPR008197. WAP.
    [Graphical view ]
    Pfami PF00095. WAP. 2 hits.
    [Graphical view ]
    PRINTSi PR00003. 4DISULPHCORE.
    SMARTi SM00217. WAP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57256. SSF57256. 2 hits.
    PROSITEi PS51390. WAP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide."
      Jin F.-Y., Nathan C.F., Radzioch D., Ding A.
      Cell 88:417-426(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The cloning and characterization of a murine secretory leukocyte protease inhibitor cDNA."
      Zitnik R.J., Zhang J., Kashem M.A., Kohno T., Lyons D.E., Wright C.D., Rosen E., Goldberg I., Hayday A.C.
      Biochem. Biophys. Res. Commun. 232:687-697(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung."
      Abe T., Tominaga Y., Kikuchi T., Watanabe A., Satoh K., Watanabe Y., Nukiwa T.
      Am. J. Respir. Crit. Care Med. 156:1235-1240(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Lung.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSLPI_MOUSE
    AccessioniPrimary (citable) accession number: P97430
    Secondary accession number(s): O09081, O09082
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3