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P97430 (SLPI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Antileukoproteinase

Short name=ALP
Alternative name(s):
Secretory leukocyte protease inhibitor
Gene names
Name:Slpi
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues By similarity.

Subcellular location

Secreted.

Tissue specificity

Highest expression in lung, spleen, intestine and epididymis with lower levels in liver and seminal vesicle. No expression in brain, heart, kidney and muscle.

Sequence similarities

Contains 2 WAP domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 By similarity
Chain26 – 131106Antileukoproteinase
PRO_0000041356

Regions

Domain29 – 7749WAP 1
Domain83 – 13149WAP 2
Region26 – 8459Trypsin inhibitory domain
Region85 – 13147Elastase inhibitory domain

Sites

Site46 – 472Reactive bond for trypsin Probable
Site98 – 992Reactive bond for chymotrypsin and elastase Probable

Amino acid modifications

Disulfide bond36 ↔ 65 By similarity
Disulfide bond44 ↔ 69 By similarity
Disulfide bond52 ↔ 64 By similarity
Disulfide bond58 ↔ 73 By similarity
Disulfide bond90 ↔ 119 By similarity
Disulfide bond97 ↔ 123 By similarity
Disulfide bond106 ↔ 118 By similarity
Disulfide bond112 ↔ 127 By similarity

Sequences

Sequence LengthMass (Da)Tools
P97430 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A57C9E30FE711B8F

FASTA13114,308
        10         20         30         40         50         60 
MKSCGLLPFT VLLALGILAP WTVEGGKNDA IKIGACPAKK PAQCLKLEKP QCRTDWECPG 

        70         80         90        100        110        120 
KQRCCQDACG SKCVNPVPIR KPVWRKPGRC VKTQARCMML NPPNVCQRDG QCDGKYKCCE 

       130 
GICGKVCLPP M 

« Hide

References

« Hide 'large scale' references
[1]"Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide."
Jin F.-Y., Nathan C.F., Radzioch D., Ding A.
Cell 88:417-426(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The cloning and characterization of a murine secretory leukocyte protease inhibitor cDNA."
Zitnik R.J., Zhang J., Kashem M.A., Kohno T., Lyons D.E., Wright C.D., Rosen E., Goldberg I., Hayday A.C.
Biochem. Biophys. Res. Commun. 232:687-697(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung."
Abe T., Tominaga Y., Kikuchi T., Watanabe A., Satoh K., Watanabe Y., Nukiwa T.
Am. J. Respir. Crit. Care Med. 156:1235-1240(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Lung.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73004 mRNA. Translation: AAC53047.1.
U88093 mRNA. Translation: AAC53140.1.
U94341 mRNA. Translation: AAC53394.1.
BC028509 mRNA. Translation: AAH28509.1.
CCDSCCDS17033.1.
RefSeqNP_035544.1. NM_011414.3.
UniGeneMm.371583.

3D structure databases

ProteinModelPortalP97430.
SMRP97430. Positions 85-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203333. 1 interaction.
STRING10090.ENSMUSP00000104992.

Proteomic databases

PaxDbP97430.
PRIDEP97430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000109367; ENSMUSP00000104992; ENSMUSG00000017002.
GeneID20568.
KEGGmmu:20568.
UCSCuc008nuj.1. mouse.

Organism-specific databases

CTD6590.
MGIMGI:109297. Slpi.

Phylogenomic databases

eggNOGNOG45457.
HOGENOMHOG000115819.
HOVERGENHBG018073.
InParanoidP97430.
OMARCIWHEK.
OrthoDBEOG7S7SG9.
PhylomeDBP97430.
TreeFamTF338375.

Gene expression databases

ArrayExpressP97430.
BgeeP97430.
CleanExMM_SLPI.
GenevestigatorP97430.

Family and domain databases

Gene3D4.10.75.10. 2 hits.
InterProIPR008197. WAP-type_4-diS_core.
[Graphical view]
PfamPF00095. WAP. 2 hits.
[Graphical view]
PRINTSPR00003. 4DISULPHCORE.
SMARTSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMSSF57256. SSF57256. 2 hits.
PROSITEPS51390. WAP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio298869.
PROP97430.
SOURCESearch...

Entry information

Entry nameSLPI_MOUSE
AccessionPrimary (citable) accession number: P97430
Secondary accession number(s): O09081, O09082
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot