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Protein

Antileukoproteinase

Gene

Slpi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei46 – 472Reactive bond for trypsinCurated
Sitei98 – 992Reactive bond for chymotrypsin and elastaseCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Antileukoproteinase
Short name:
ALP
Alternative name(s):
Secretory leukocyte protease inhibitor
Gene namesi
Name:Slpi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:109297. Slpi.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 131106AntileukoproteinasePRO_0000041356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 65PROSITE-ProRule annotation
Disulfide bondi44 ↔ 69PROSITE-ProRule annotation
Disulfide bondi52 ↔ 64PROSITE-ProRule annotation
Disulfide bondi58 ↔ 73PROSITE-ProRule annotation
Disulfide bondi90 ↔ 119PROSITE-ProRule annotation
Disulfide bondi97 ↔ 123PROSITE-ProRule annotation
Disulfide bondi106 ↔ 118PROSITE-ProRule annotation
Disulfide bondi112 ↔ 127PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP97430.
PRIDEiP97430.

Expressioni

Tissue specificityi

Highest expression in lung, spleen, intestine and epididymis with lower levels in liver and seminal vesicle. No expression in brain, heart, kidney and muscle.

Gene expression databases

BgeeiP97430.
CleanExiMM_SLPI.
ExpressionAtlasiP97430. baseline and differential.
GenevisibleiP97430. MM.

Interactioni

Protein-protein interaction databases

BioGridi203333. 1 interaction.
STRINGi10090.ENSMUSP00000104992.

Structurei

3D structure databases

ProteinModelPortaliP97430.
SMRiP97430. Positions 85-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 7749WAP 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 13149WAP 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 8459Trypsin inhibitory domainAdd
BLAST
Regioni85 – 13147Elastase inhibitory domainAdd
BLAST

Sequence similaritiesi

Contains 2 WAP domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45457.
GeneTreeiENSGT00730000111217.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiP97430.
OMAiRCIWHEK.
OrthoDBiEOG7S7SG9.
PhylomeDBiP97430.
TreeFamiTF338375.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR029712. ALP.
IPR008197. WAP.
[Graphical view]
PANTHERiPTHR19441:SF24. PTHR19441:SF24. 1 hit.
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSCGLLPFT VLLALGILAP WTVEGGKNDA IKIGACPAKK PAQCLKLEKP
60 70 80 90 100
QCRTDWECPG KQRCCQDACG SKCVNPVPIR KPVWRKPGRC VKTQARCMML
110 120 130
NPPNVCQRDG QCDGKYKCCE GICGKVCLPP M
Length:131
Mass (Da):14,308
Last modified:May 1, 1997 - v1
Checksum:iA57C9E30FE711B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73004 mRNA. Translation: AAC53047.1.
U88093 mRNA. Translation: AAC53140.1.
U94341 mRNA. Translation: AAC53394.1.
BC028509 mRNA. Translation: AAH28509.1.
CCDSiCCDS17033.1.
RefSeqiNP_035544.1. NM_011414.3.
UniGeneiMm.371583.

Genome annotation databases

EnsembliENSMUST00000109367; ENSMUSP00000104992; ENSMUSG00000017002.
GeneIDi20568.
KEGGimmu:20568.
UCSCiuc008nuj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73004 mRNA. Translation: AAC53047.1.
U88093 mRNA. Translation: AAC53140.1.
U94341 mRNA. Translation: AAC53394.1.
BC028509 mRNA. Translation: AAH28509.1.
CCDSiCCDS17033.1.
RefSeqiNP_035544.1. NM_011414.3.
UniGeneiMm.371583.

3D structure databases

ProteinModelPortaliP97430.
SMRiP97430. Positions 85-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203333. 1 interaction.
STRINGi10090.ENSMUSP00000104992.

Protein family/group databases

MEROPSiI17.001.

Proteomic databases

PaxDbiP97430.
PRIDEiP97430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109367; ENSMUSP00000104992; ENSMUSG00000017002.
GeneIDi20568.
KEGGimmu:20568.
UCSCiuc008nuj.1. mouse.

Organism-specific databases

CTDi6590.
MGIiMGI:109297. Slpi.

Phylogenomic databases

eggNOGiNOG45457.
GeneTreeiENSGT00730000111217.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiP97430.
OMAiRCIWHEK.
OrthoDBiEOG7S7SG9.
PhylomeDBiP97430.
TreeFamiTF338375.

Miscellaneous databases

NextBioi298869.
PROiP97430.
SOURCEiSearch...

Gene expression databases

BgeeiP97430.
CleanExiMM_SLPI.
ExpressionAtlasiP97430. baseline and differential.
GenevisibleiP97430. MM.

Family and domain databases

Gene3Di4.10.75.10. 2 hits.
InterProiIPR029712. ALP.
IPR008197. WAP.
[Graphical view]
PANTHERiPTHR19441:SF24. PTHR19441:SF24. 1 hit.
PfamiPF00095. WAP. 2 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 2 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 2 hits.
PROSITEiPS51390. WAP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide."
    Jin F.-Y., Nathan C.F., Radzioch D., Ding A.
    Cell 88:417-426(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The cloning and characterization of a murine secretory leukocyte protease inhibitor cDNA."
    Zitnik R.J., Zhang J., Kashem M.A., Kohno T., Lyons D.E., Wright C.D., Rosen E., Goldberg I., Hayday A.C.
    Biochem. Biophys. Res. Commun. 232:687-697(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung."
    Abe T., Tominaga Y., Kikuchi T., Watanabe A., Satoh K., Watanabe Y., Nukiwa T.
    Am. J. Respir. Crit. Care Med. 156:1235-1240(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Lung.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiSLPI_MOUSE
AccessioniPrimary (citable) accession number: P97430
Secondary accession number(s): O09081, O09082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.