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Protein

Annexin A4

Gene

Anxa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.By similarity

Miscellaneous

Seems to bind one calcium ion with high affinity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
Annexin IV
Annexin-4
Gene namesi
Name:Anxa4
Synonyms:Anx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88030. Anxa4.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674832 – 319Annexin A4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei213N6-acetyllysineBy similarity1
Modified residuei293N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP97429.
MaxQBiP97429.
PaxDbiP97429.
PeptideAtlasiP97429.
PRIDEiP97429.

PTM databases

iPTMnetiP97429.
PhosphoSitePlusiP97429.
SwissPalmiP97429.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029994.
CleanExiMM_ANXA4.
ExpressionAtlasiP97429. baseline and differential.
GenevisibleiP97429. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP97429. 10 interactors.
MINTiMINT-4087883.
STRINGi10090.ENSMUSP00000001187.

Structurei

3D structure databases

ProteinModelPortaliP97429.
SMRiP97429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 83Annexin 1Add BLAST61
Repeati95 – 155Annexin 2Add BLAST61
Repeati179 – 239Annexin 3Add BLAST61
Repeati254 – 314Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP97429.
KOiK17093.
OMAiILCGGDD.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. ANX4.
PANTHERiPTHR10502:SF166. PTHR10502:SF166. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P97429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKGGTVKA ASGFNATEDA QTLRKAMKGL GTDEDAIIGI LAYRNTAQRQ
60 70 80 90 100
EIRSAYKSTI GRDLIEDLKS ELSSNFEQVI LGLMTPTVLY DVQELRRAMK
110 120 130 140 150
GAGTDEGCLI EILASRTPEE IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR
160 170 180 190 200
VLVSLSAAGR DEGNYLDDAL MKQDAQELYE AGEKRWGTDE VKFLSILCSR
210 220 230 240 250
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRSKPSYF
260 270 280 290 300
AERLYKSMKG LGTDDNTLIR VMVSRAEIDM LDIRASFKRL YGKSLYSFIK
310
GDTSGDYRKV LLVLCGGDD
Length:319
Mass (Da):35,916
Last modified:July 27, 2011 - v4
Checksum:iD962B63D7933EBB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154S → F in AAB40697 (Ref. 1) Curated1
Sequence conflicti313V → I in AAB40697 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72941 mRNA. Translation: AAB40697.1.
AK132293 mRNA. Translation: BAE21085.1.
AK150486 mRNA. Translation: BAE29602.1.
AK150614 mRNA. Translation: BAE29705.1.
AK151054 mRNA. Translation: BAE30071.1.
AK151236 mRNA. Translation: BAE30228.1.
AK167338 mRNA. Translation: BAE39439.1.
AK168390 mRNA. Translation: BAE40316.1.
AK168487 mRNA. Translation: BAE40374.1.
AK168917 mRNA. Translation: BAE40730.1.
AK170447 mRNA. Translation: BAE41805.1.
CH466523 Genomic DNA. Translation: EDK99195.1.
CCDSiCCDS39543.1.
RefSeqiNP_001318049.1. NM_001331120.1.
NP_038499.2. NM_013471.2.
XP_006505460.1. XM_006505397.2.
XP_006505461.1. XM_006505398.2.
UniGeneiMm.259702.

Genome annotation databases

EnsembliENSMUST00000001187; ENSMUSP00000001187; ENSMUSG00000029994.
ENSMUST00000113675; ENSMUSP00000109305; ENSMUSG00000029994.
GeneIDi11746.
KEGGimmu:11746.
UCSCiuc009csm.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiANXA4_MOUSE
AccessioniPrimary (citable) accession number: P97429
Secondary accession number(s): Q3UCL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families